Total synthesis and biological evaluation of potent analogues of dictyostatin: Modification of the C2-C6 dienoate region

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6268-6272

  Paterson, Ian ^a   Gardner, Nicola M ^a   Guzmán, Esther ^b   Wright, Amy E ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Anticancer; Macrolide; Total synthesis; Tubulin

Indexed keywords

2,3 DIHYDRODICTYOSTATIN; 2,3,4,5 TETRAHYDRODICTYOSTATIN; 6 NORDICTYOSTATIN; BETA KETOPHOSPHONATE; DICTYOSTATIN DERIVATIVE; DISCODERMOLIDE; MACROLIDE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; OLEFINATION;

ALKANES; ANIMALS; ANTINEOPLASTIC AGENTS; CARBAMATES; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTONES; MACROLIDES; MOLECULAR STRUCTURE; PACLITAXEL; PORIFERA; PYRONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 55549134958     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.109     Document Type: Article

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