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0000813445
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33646093186
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note
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10; cf. Figure 1.
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21
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33646104091
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note
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13 As we show in the text, there are nearly 100 PTX conformations that meet the REDOR constraints including T-Taxol. Consequently, we refer to the Geney-Ojima model as New York-Taxol (NY-Taxol).
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Although the coordinates from the original PTX X-ray structure have never been deposited, the paper provides enough information to permit reconstruction.
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13,30
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42
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Paclitaxel resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules
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