Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: Preparation and biological activity

Journal of Natural Products

Volumn 65, Issue 12, 2002, Pages 1830-1837

  Gunasekera, Sarath P ^a   Longley, Ross E ^a   Isbrucker, Richard A ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

19 DES AMINOCARBONYL 6,7 SECO DISCODERMOLIDE; 21,23 TETRAHYDRODISCODERMOLIDE; 3 DEOXYDISCODERMOLID 2 EN 11 ACETATE; 3 DEOXYDISCODERMOLID 2 EN 11,17 DIACETATE; 3 DEOXYDISCODERMOLID 2 EN 17 ACETATE; 3 DEOXYDISCODERMOLID 2 EN 7,11,17 TRIACETATE; 3 DEOXYDISCODERMOLID 2 ENE; 6,7 SECO DISCODERMOLIDE; 7 DEOXY 8,21,23 HEXAHYDRODISCODERMOLIDE; 7 DEOXY 8,21,23 HEXAHYDRODISCODERMOLIDE 3,11,17 TRIACETATE; 8,13,21,23 OCTAHYDRODISCODERMOLIDE; 8,21,23 HEXAHYDRODISCODERMOLIDE; DISCODERMOLIDE; HYDROXYL GROUP; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL BOND; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA P 388; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; ALKANES; ANIMALS; ANTINEOPLASTIC AGENTS; CARBAMATES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTONES; LEUKEMIA P388; MICE; MICROTUBULES; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PORIFERA; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0036932485     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np0203234     Document Type: Article

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