Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin

Molecular Pharmacology

Volumn 73, Issue 3, 2008, Pages 718-726

  Raccor, Brianne S ^a   Vogt, Andreas ^a,b   Sikorski, Rachel P ^b   Madiraju, Charitha ^a   Balachandran, Raghavan ^a   Montgomery, Kia ^a   Shin, Youseung ^a   Fukui, Yoshikazu ^a   Jung, Won Hyuk ^a   Curran, Dennis P ^a   Day, Billy W ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16 EPIISODICTYIOSTATIN; 16 EPISECODICTYOSTATIN METHYL ESTER; 16 NORMETHYLDICTYOSTATIN; 6 EPIDICTYOSTATIN; 7 EPIDICTYOSTATIN; 9 EPI 16 NORMETHYLDICTYOSTATIN; ANTINEOPLASTIC AGENT; BETA TUBULIN; CARBON 14; DICTYOSTATIN; EPOTHILONE B; PACLITAXEL; PHENYLALANINE; TAXOID; TUBULIN; UNCLASSIFIED DRUG; VALINE;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CELL ASSAY; CHROMATIN CONDENSATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; EQUILIBRIUM CONSTANT; FLUORESCENCE ANALYSIS; GENE MUTATION; HUMAN; HUMAN CELL; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MORPHOLOGY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION;

ALKANES; ANIMALS; BENZIMIDAZOLES; BINDING SITES; BRAIN CHEMISTRY; CARBAMATES; CARCINOMA; CATTLE; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; EPOTHILONES; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORESCENT DYES; G2 PHASE; HELA CELLS; HISTONES; HUMANS; KINETICS; LACTONES; MACROLIDES; MICROTUBULES; MOLECULAR STRUCTURE; OVARIAN NEOPLASMS; PACLITAXEL; PHOSPHORYLATION; PROTEIN BINDING; PYRONES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; TUBULIN; TUBULIN MODULATORS;

EID: 40849111666     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.042598     Document Type: Article

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