In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)α and PPARγ and quantitative analysis of in vivo induction pathway

Toxicology and Applied Pharmacology

Volumn 217, Issue 3, 2006, Pages 235-244

  Takeuchi, Shinji ^a   Matsuda, Tadashi ^b   Kobayashi, Satoshi ^a   Takahashi, Tetsuo ^a   Kojima, Hiroyuki ^a  

^a HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

CYP4A; Peroxisome proliferator activated receptor ; Peroxisome proliferator activated receptor ; Pesticide; Reporter gene assay

Indexed keywords

AMINE; CARBAMIC ACID; CYTOCHROME P450 4A; CYTOCHROME P450 4A10; CYTOCHROME P450 4A14; DICLOFOP METHYL; DIPHENYL ETHER; ENILCONAZOLE; MESSENGER RNA; ORGANOCHLORINE PESTICIDE; ORGANOPHOSPHATE PESTICIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PESTICIDE; PIRINIXIC ACID; PYRETHRIN; PYRETHROID; TRIAZINE; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; MONKEY; MOUSE; NONHUMAN; PROTEIN INDUCTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

ALKANE 1-MONOOXYGENASE; ANIMALS; CELL LINE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; MICE; MICE, INBRED C57BL; PESTICIDES; PPAR ALPHA; PPAR GAMMA; RNA, MESSENGER; TOXICITY TESTS; TRANS-ACTIVATION (GENETICS);

EID: 33845275122     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.08.011     Document Type: Article

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