In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron

Chemosphere

Volumn 74, Issue 1, 2008, Pages 155-165

  Takeuchi, Shinji ^a   Iida, Mitsuru ^b   Yabushita, Hisatoshi ^b   Matsuda, Tadashi ^c   Kojima, Hiroyuki ^a  

^a HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Aryl hydrocarbon receptor; CYP1A; Mouse; Pesticide; Reporter gene assay

Indexed keywords

ACIDS; AGRICULTURAL CHEMICALS; AMIDES; BIOCHEMISTRY; CELL CULTURE; CELL PROLIFERATION; CELLS; CHEMICAL SENSORS; CYTOLOGY; DIFFERENTIATION (CALCULUS); ESTERS; ETHERS; GENE EXPRESSION; HYDROCARBONS; LIVER; METABOLISM; ORGANIC COMPOUNDS; PEST CONTROL; PESTICIDES; TRANSCRIPTION; TRANSCRIPTION FACTORS; UREA; WEED CONTROL;

ACIFLUORFEN; AGONISTIC ACTIVITIES; ARYL HYDROCARBON RECEPTOR; ARYL HYDROCARBON RECEPTORS; BIFENOX; C57BL/6 MOUSE; CELLULAR PROLIFERATIONS; CHEMICAL STRUCTURES; CHLORPYRIFOS; CYP1A; CYTOCHROME P450; DIPHENYL ETHERS; ENVIRONMENTAL CHEMICALS; HIGHLY SENSITIVES; IN VITRO; IN-VIVO; INTRAPERITONEALLY; LINURON; MOUSE; MOUSE LIVERS; ORGANOCHLORINES; ORGANOPHOSPHORUS PESTICIDES; PROPANIL; PYRETHROIDS; QUINALPHOS; REPORTER CELL LINES; REPORTER GENE ASSAY; REPORTER GENE ASSAYS; TRANSACTIVATION; TRANSCRIPTIONAL ACTIVITIES; XENOBIOTIC METABOLISMS;

HERBICIDES;

ACIFLUORFEN METHYL; AMIDE; AROMATIC HYDROCARBON RECEPTOR; BIFENOX; CARBAMIC ACID DERIVATIVE; CHLORPROPHAM; CHLORPYRIFOS; CYTOCHROME P450 1A; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DIETHOFENCARB; DIOXIN; DIPHENYL ETHER; DIURON; HERBICIDE; ISOXATHION; LINURON; MESSENGER RNA; ORGANOCHLORINE DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; PESTICIDE; PROCHLORAZ; PROPANIL; PYRETHROID; QUINALPHOS; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UREA;

GENE EXPRESSION; HYDROCARBON; METABOLISM; PESTICIDE; POLYMERASE CHAIN REACTION; RODENT;

AGONIST; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DR ECOSCREEN CELL; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATOMA CELL; MOUSE; NONHUMAN; PLASMID; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; TRANSACTIVATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DIOXINS; DIURON; FEMALE; LINURON; LIVER; MICE; MICE, INBRED C57BL; PESTICIDES; PROPANIL; RECEPTORS, ARYL HYDROCARBON; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

MUS;

EID: 55649118438     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2008.08.015     Document Type: Article

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