Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Biochemical Journal

Volumn 433, Issue 2, 2011, Pages 357-369

  Najafov, Ayaz ^a   Sommer, Eeva M ^a   Axten, Jeffrey M ^b   DeYoung, M Phillip ^b   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

3 phosphoinositide dependent protein kinase; Akt Akt1; Cancer; Kinase inhibitor; p70 ribosomal S6 kinase (S6K); p90 ribosomal S6 kinase (RSK); PDK1; Phosphoinositide 3 kinase (PI3K); Serum and glucocorticoid induced protein kinase (SGK)

Indexed keywords

FIBRINOGEN; GSK 2334470; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PLECKSTRIN; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P90; PROTEIN SERINE THREONINE KINASE INHIBITOR; S6 KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOSOL; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PKA; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; STIMULUS RESPONSE; T WAVE;

ANIMALS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; INDAZOLES; MICE; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 78651284004     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101732     Document Type: Article

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