Culture media for the differentiation of mesenchymal stromal cells

Acta Biomaterialia

Volumn 7, Issue 2, 2011, Pages 463-477

  Vater, Corina ^a   Kasten, Philip ^a   Stiehler, Maik ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Cell culture medium; Differentiation; Mesenchymal stromal cell; Osteoblast; Proliferation

Indexed keywords

BODY FLUIDS; CELL CULTURE; CLINICAL RESEARCH; FLOWCHARTING; OSTEOBLASTS; TISSUE;

BONE MARROW; CELL CULTURE MEDIA; CHONDROCYTE CELLS; CULTURE MEDIUM; DIFFERENTIATION; IN-VITRO; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS CELLS; PROLIFERATION; UMBILICAL CORD BLOOD;

TISSUE REGENERATION;

CYTOKINE; GROWTH FACTOR;

ADIPOCYTE; ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; MUSCLE CELL; OSTEOBLAST; PRIORITY JOURNAL; STROMA CELL; UMBILICAL CORD;

EID: 78650754334     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.07.037     Document Type: Review

References (273)

1. M. Owen, and A.J. Friedenstein Stromal stem cells: marrow-derived osteogenic precursors Ciba Found Symp 136 1988 42 60
2. A.M. Mackay, S.C. Beck, J.M. Murphy, F.P. Barry, C.O. Chichester, and M.F. Pittenger Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow Tissue Eng 4 1998 415 428
3. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, and J.D. Mosca Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
4. A.C. Drost, S. Weng, G. Feil, J. Schäfer, S. Baumann, and L. Kanz In vitro myogenic differentiation of human bone marrow-derived mesenchymal stem cells as a potential treatment for urethral sphincter muscle repair Ann NY Acad Sci 1176 2009 135 143
5. J. Oswald, S. Boxberger, B. Jørgensen, S. Feldmann, G. Ehninger, and M. Bornhäuser Mesenchymal stem cells can be differentiated into endothelial cells in vitro Stem Cells 22 2004 377 384 (Pubitemid 38736621)
6. Z. Gong, G. Calkins, E. Cheng, D. Krause, and L.E. Niklason Influence of culture medium on smooth muscle cell differentiation from human bone marrow-derived mesenchymal stem cells Tissue Eng Part A 15 2009 319 330
7. M. Dominici, K. Le Blanc, I. Mueller, I. Slaper-Cortenbach, F. Marini, and D. Krause Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Cytotherapy 8 2006 315 317
8. L.E. Kokai, J.P. Rubin, and K.G. Marra The potential of adipose-derived adult stem cells as a source of neuronal progenitor cells Plast Reconstr Surg 116 2005 1453 1460
9. K.M. Safford, and H.E. Rice Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells Curr Drug Targets 6 2005 57 62
10. D.G. Phinney, and I. Isakova Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system Curr Pharm Des 11 2005 1255 1265
11. M. Kassem Mesenchymal stem cells: biological characteristics and potential clinical applications Cloning Stem Cells 6 2004 369 374
12. G. Di Gioacchino, C. Di Campli, M.A. Zocco, A.C. Piscaglia, M. Novi, and M. Santoro Transdifferentiation of stem cells in pancreatic cells: state of the art Transplant Proc 37 2005 2662 2663
13. K. Timper, D. Seboek, M. Eberhardt, P. Linscheid, M. Christ-Crain, and U. Keller Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells Biochem Biophys Res Commun 341 2006 1135 1140
14. C. Moriscot, F. de Fraipont, M. Richard, M. Marchand, P. Savatier, and D. Bosco Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro Stem Cells 23 2005 594 603
15. L. Chen, X. Jiang, and L. Yang Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells World J Gastroenterol 10 2004 3016 3020 (Pubitemid 39303055)
16. C. Kruse, J. Kajahn, A.E. Petschnik, A. Maass, E. Klink, and D.H. Rapoport Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures Ann Anat 188 2006 503 517
17. P. De Coppi, G.J. Bartsch, M.M. Siddiqui, T. Xu, C.C. Santos, and L. Perin Isolation of amniotic stem cell lines with potential for therapy Nat Biotechnol 25 2007 100 106
18. X. Meng, T.E. Ichim, J. Zhong, A. Rogers, Z. Yin, and J. Jackson Endometrial regenerative cells: a novel stem cell population J Transl Med 5 2007 57
19. K. Guan, K. Nayernia, L.S. Maier, S. Wagner, R. Dressel, and J.H. Lee Pluripotency of spermatogonial stem cells from adult mouse testis Nature 440 2006 1199 1203
20. P. in't Anker, W. Noort, S. Scherjon, C. Kleijburg-van der Keur, A. Kruisselbrink, and R. van Bezooijen Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential Haematologica 88 2003 845 852
21. E.H. Javazon, K.J. Beggs, and A.W. Flake Mesenchymal stem cells: paradoxes of passaging Exp Hematol 32 2004 414 425
22. G. Chamberlain, J. Fox, B. Ashton, and J. Middleton Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing Stem Cells 25 2007 2739 2749
23. S. Haynesworth, M. Baber, and A. Caplan Cell surface antigens on human marrow-derived mensenchymal cells are detected by monoclonal antibodies Bone 13 1 1992 69 80
24. T.A. Lodie, C.E. Blickarz, T.J. Devarakonda, C. He, A.B. Dash, and J. Clarke Systematic analysis of reportedly distinct populations of multipotent bone marrow-derived stem cells reveals a lack of distinction Tissue Eng 8 2002 739 751
25. D. Suva, G. Garavaglia, J. Menetrey, B. Chapuis, P. Hoffmeyer, and L. Bernheim Non-hematopoietic human bone marrow contains long-lasting, pluripotential mesenchymal stem cells J Cell Physiol 198 2004 110 118
26. P. Niemeyer, A. Seckinger, H.G. Simank, P. Kasten, N. Südkamp, and U. Krause Allogenic transplantation of human mesenchymal stem cells for tissue engineering purposes: an in vitro study Orthopade 33 2004 1346 1353
27. M. Di Nicola, C. Carlo-Stella, M. Magni, M. Milanesi, P.D. Longoni, and P. Matteucci Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli Blood 99 2002 3838 3843
28. A. Bartholomew, C. Sturgeon, M. Siatskas, K. Ferrer, K. McIntosh, and S. Patil Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo Exp Hematol 30 2002 42 48
29. S. Aggarwal, and M.F. Pittenger Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 105 2005 1815 1822
30. X. Jiang, Y. Zhang, B. Liu, S. Zhang, Y. Wu, and X. Yu Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells Blood 105 2005 4120 4126 (Pubitemid 40656164)
31. S. Beyth, Z. Borovsky, D. Mevorach, M. Liebergall, Z. Gazit, and H. Aslan Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness Blood 105 2005 2214 2219
32. A. Corcione, F. Benvenuto, E. Ferretti, D. Giunti, V. Cappiello, and F. Cazzanti Human mesenchymal stem cells modulate B-cell functions Blood 107 2006 367 372
33. P. Bernstein, M. Bornhäuser, K. Günther, and M. Stiehler Bone tissue engineering in clinical application: assessment of the current situation Orthopäde 38 11 2009 1029 1037
34. D. Orlic, J. Kajstura, S. Chimenti, F. Limana, I. Jakoniuk, and F. Quaini Mobilized bone marrow cells repair the infarcted heart, improving function and survival Proc Natl Acad Sci USA 98 2001 10344 10349
35. S.T. Lee, J.H. Jang, J. Cheong, J.S. Kim, H. Maemg, and J.S. Hahn Treatment of high-risk acute myelogenous leukaemia by myeloablative chemoradiotherapy followed by co-infusion of T cell-depleted haematopoietic stem cells and culture-expanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype Br J Haematol 118 2002 1128 1131
36. V.S. Urbán, J. Kiss, J. Kovács, E. Gócza, V. Vas, and E. Monostori Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes Stem Cells 26 2008 244 253
37. S. Guhathakurta, U.R. Subramanyan, R. Balasundari, C.K. Das, N. Madhusankar, and K.M. Cherian Stem cell experiments and initial clinical trial of cellular cardiomyoplasty Asian Cardiovasc Thorac Ann 17 2009 581 586
38. E.M. Horwitz, P.L. Gordon, W.K.K. Koo, J.C. Marx, M.D. Neel, and R.Y. McNall Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone Proc Natl Acad Sci USA 99 2002 8932 8937
39. G. Constantin, S. Marconi, B. Rossi, S. Angiari, L. Calderan, and E. Anghileri Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis Stem Cells 27 2009 2624 2635
40. R.E. Newman, D. Yoo, M.A. LeRoux, and A. Danilkovitch-Miagkova Treatment of inflammatory diseases with mesenchymal stem cells Inflamm Allergy Drug Targets 8 2009 110 123
41. J. Sorger, F. Hornicek, M. Zavatta, J. Menzner, M. Gebhardt, and W. Tomford Allograft fractures revisited Clin Orthop Relat Res Jan 382 2001 66 74
42. I. Song, A.I. Caplan, and J.E. Dennis In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo J Orthop Res 27 2009 916 921
43. P. Ducy, R. Zhang, V. Geoffroy, A.L. Ridall, and G. Karsenty Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Cell 89 1997 747 754
44. P. Ducy, M. Starbuck, M. Priemel, J. Shen, G. Pinero, and V. Geoffroy A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development Genes Dev 13 1999 1025 1036
45. B. Kern, J. Shen, M. Starbuck, and G. Karsenty Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes J Biol Chem 276 2001 7101 7107
46. K. Nakashima, X. Zhou, G. Kunkel, Z. Zhang, J.M. Deng, and R.R. Behringer The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation Cell 108 2002 17 29
47. J.B. Lian, G.S. Stein, A. Javed, A.J. van Wijnen, J.L. Stein, and M. Montecino Networks and hubs for the transcriptional control of osteoblastogenesis Rev Endocr Metab Disord 7 2006 1 16
48. M. Romero-Prado, C. Blázquez, C. Rodríguez-Navas, J. Muñoz, I. Guerrero, and E. Delgado-Baeza Functional characterization of human mesenchymal stem cells that maintain osteochondral fates J Cell Biochem 98 2006 1457 1470
49. J.A. Spector, J.S. Luchs, B.J. Mehrara, J.A. Greenwald, L.P. Smith, and M.T. Longaker Expression of bone morphogenetic proteins during membranous bone healing Plast Reconstr Surg 107 2001 124 134
50. J.X. Zhu, Y. Sasano, I. Takahashi, I. Mizoguchi, and M. Kagayama Temporal and spatial gene expression of major bone extracellular matrix molecules during embryonic mandibular osteogenesis in rats Histochem J 33 2001 25 35
51. M.W. Long Osteogenesis and bone-marrow-derived cells Blood Cells Molecules Dis 27 2001 677 690
52. M.F. Young Bone matrix proteins: their function, regulation, and relationship to osteoporosis Osteoporos Int 14 Suppl. 3 2003 S35 S42
53. P.S. Leboy, J.N. Beresford, C. Devlin, and M.E. Owen Dexamethasone induction of osteoblast mRNAs in rat marrow stromal cell cultures J Cell Physiol 146 1991 370 378
54. A. Herbertson, and J.E. Aubin Dexamethasone alters the subpopulation make-up of rat bone marrow stromal cell cultures J Bone Miner Res 10 1995 285 294
55. C. Hildebrandt, H. Büth, and H. Thielecke Influence of cell culture media conditions on the osteogenic differentiation of cord blood-derived mesenchymal stem cells Ann Anat 191 2009 23 32
56. Y. Ogata, M. Yamauchi, R. Kim, J. Li, L. Freedman, and J. Sodek Glucocorticoid regulation of bone sialoprotein (BSP) gene expression. Identification of a glucocorticoid response element in the bone sialoprotein gene promoter Eur J Biochem 230 1 1995 183 192
57. D. Hong, H. Chen, Y. Xue, D. Li, X. Wan, and R. Ge Osteoblastogenic effects of dexamethasone through upregulation of TAZ expression in rat mesenchymal stem cells J Steroid Biochem Mol Biol 116 2009 86 92
58. Z. Hamidouche, O. Fromigué, J. Ringe, T. Häupl, P. Vaudin, and J. Pags Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis Proc Natl Acad Sci USA 106 44 2009 18587 18591
59. N.R. Jørgensen, Z. Henriksen, O.H. Sørensen, and R. Civitelli Dexamethasone, BMP-2, and 1, 25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts Steroids 69 2004 219 226
60. S. Walsh, G.R. Jordan, C. Jefferiss, K. Stewart, and J.N. Beresford High concentrations of dexamethasone suppress the proliferation but not the differentiation or further maturation of human osteoblast precursors in vitro: relevance to glucocorticoid-induced osteoporosis Rheumatology (Oxford) 40 2001 74 83
61. B.P. Lukert Clinical and basic aspects of glucocorticoids action in bone J.P. Bilezikian, L.G. Raisz, G.A. Rodan, Principles of bone biology 1996 Academic Press San Diego 533 548
62. Gundle R. Microscopical and biochemical studies of mineralized matrix production by human bone derived cells. Ph.D. Thesis, University of Oxford; 1995.
63. I. Song, A.I. Caplan, and J.E. Dennis Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells J Orthop Res 27 2009 216 221
64. Y.L. Chang, C.M. Stanford, and J.C. Keller Calcium and phosphate supplementation promotes bone cell mineralization: implications for hydroxyapatite (HA)-enhanced bone formation J Biomed Mater Res 52 2000 270 278
65. C. Chung, E. Golub, E. Forbes, T. Tokuoka, and I. Shapiro Mechanism of action of beta-glycerophosphate on bone cell mineralization Calcif Tissue Int 51 4 1992 305 311
66. M. Chen, P. Lie, Z. Li, and X. Wei Endothelial differentiation of Wharton's jelly-derived mesenchymal stem cells in comparison with bone marrow-derived mesenchymal stem cells Exp Hematol 37 2009 629 640
67. C. Kielty, I. Hopkinson, and M. Grant Collagen: the collagen family: structure, assembly, and organization in the extracellular matrix S.B. Royce, B. Steinmann, Connective tissue and its heritable disorders. Molecular, genetic, and medical aspects 1993 Wiley-Liss New York 103 147
68. D.J. Prockop, and K.I. Kivirikko Collagens: molecular biology, diseases, and potentials for therapy Annu Rev Biochem 64 1995 403 434
69. S. Takamizawa, Y. Maehata, K. Imai, H. Senoo, S. Sato, and R. Hata Effects of ascorbic acid and ascorbic acid 2-phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like cells Cell Biol Int 28 2004 255 265
70. Y. Maehata, S. Takamizawa, S. Ozawa, Y. Kato, S. Sato, and E. Kubota Both direct and collagen-mediated signals are required for active vitamin D3-elicited differentiation of human osteoblastic cells: roles of osterix, an osteoblast-related transcription factor Matrix Biol 25 2006 47 58
71. R. Hata, and H. Senoo l-Ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissue-like substance by skin fibroblasts J Cell Physiol 138 1989 8 16
72. H. Fernandes, A. Mentink, R.A. Bank, R. Stoop, C. van Blitterswijk, and J. De Boer Endogenous collagen influences differentiation of human multipotent mesenchymal stromal cells Tissue Eng Part A 16 5 2009 1693 1702
73. R. Pytlík, D. Stehlík, T. Soukup, M. Kalbá cová, F. Rypácek, and T. Trc The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering Biomaterials 30 2009 3415 3427
74. Q.M. Wang, J.B. Jones, and G.P. Studzinski Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells Cancer Res 56 1996 264 267
75. L. Verlinden, A. Verstuyf, R. Convents, S. Marcelis, M. Van Camp, and R. Bouillon Action of 1,25(OH)2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells Mol Cell Endocrinol 142 1998 57 65
76. K. Nakagawa, N. Tsugawa, T. Okamoto, T. Kishi, T. Ono, and N. Kubodera Rapid control of transmembrane calcium influx by 1alpha, 25-dihydroxyvitamin D3 and its analogues in rat osteoblast-like cells Biol Pharm Bull 22 1999 1058 1063
77. O. Fromigué, P.J. Marie, and A. Lomri Differential effects of transforming growth factor beta2, dexamethasone and 1, 25-dihydroxyvitamin D on human bone marrow stromal cells Cytokine 9 1997 613 623
78. N. Jaiswal, S.E. Haynesworth, A.I. Caplan, and S.P. Bruder Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro J Cell Biochem 64 1997 295 312
79. L.F. Bonewald, L. Wakefield, R.O. Oreffo, A. Escobedo, D.R. Twardzik, and G.R. Mundy Latent forms of transforming growth factor-beta (TGF beta) derived from bone cultures: identification of a naturally occurring 100-kDa complex with similarity to recombinant latent TGF beta Mol Endocrinol 5 1991 741 751
80. S.L. Dallas, S. Park-Snyder, K. Miyazono, D. Twardzik, G.R. Mundy, and L.F. Bonewald Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein J Biol Chem 269 1994 6815 6821
81. M. Centrella, T.L. McCarthy, and E. Canalis Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone J Biol Chem 262 1987 2869 2874
82. M. Centrella, T.L. McCarthy, and E. Canalis Transforming growth factor-beta and remodeling of bone J Bone Joint Surg Am 73 1991 1418 1428
83. M. Jäger, M. Sager, A. Knipper, O. Degistirici, J. Fischer, and G. Kögler In vivo and in vitro bone regeneration from cord blood derived mesenchymal stem cells Orthopäde 33 2004 1361 1372
84. B.L. Hogan Bone morphogenetic proteins in development Curr Opin Genet Dev 6 1996 432 438
85. N. Holleville, A. Quilhac, M. Bontoux, and A.H. Monsoro-Burq BMP signals regulate Dlx5 during early avian skull development Dev Biol 257 2003 177 189
86. K. Hanada, J.E. Dennis, and A.I. Caplan Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells J Bone Miner Res 12 1997 1606 1614
87. D.L. Diefenderfer, A.M. Osyczka, G.C. Reilly, and P.S. Leboy BMP responsiveness in human mesenchymal stem cells Connect Tissue Res 44 Suppl. 1 2003 305 311
88. M. Knippenberg, M.N. Helder, B. Zandieh Doulabi, P.I.J.M. Wuisman, and J. Klein-Nulend Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells Biochem Biophys Res Commun 342 2006 902 908
89. E. Abe, M. Yamamoto, Y. Taguchi, B. Lecka-Czernik, C.A. O'Brien, and A.N. Economides Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin J Bone Miner Res 15 2000 663 673
90. J. Lou, Y. Tu, S. Li, and P.R. Manske Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2 Biochem Biophys Res Commun 268 2000 757 762
91. H. Cheng, W. Jiang, F.M. Phillips, R.C. Haydon, Y. Peng, and L. Zhou Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs) J Bone Joint Surg Am 85-A 2003 1544 1552
92. A.M. Osyczka, D.L. Diefenderfer, G. Bhargave, and P.S. Leboy Different effects of BMP-2 on marrow stromal cells from human and rat bone Cells Tissues Organs 176 2004 109 119
93. S. Cheifetz, I.W. Li, C.A. McCulloch, K. Sampath, and J. Sodek Influence of osteogenic protein-1 (OP-1;BMP-7) and transforming growth factor-beta 1 on bone formation in vitro Connect Tissue Res 35 1996 71 78 (Pubitemid 27118838)
94. I.W. Li, S. Cheifetz, C.A. McCulloch, K.T. Sampath, and J. Sodek Effects of osteogenic protein-1 (OP-1, BMP-7) on bone matrix protein expression by fetal rat calvarial cells are differentiation stage specific J Cell Physiol 169 1996 115 125
95. F. Lecanda, L.V. Avioli, and S.L. Cheng Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2 J Cell Biochem 67 1997 386 396
96. R.M. Locklin, B.L. Riggs, K.C. Hicok, H.F. Horton, M.C. Byrne, and S. Khosla Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology J Bone Miner Res 16 2001 2192 2204
97. J.A. Fuller, and F.N. Ghadially Ultrastructural observations on surgically produced partial-thickness defects in articular cartilage Clin Orthop Relat Res 86 1972 193 205
98. D. Nesic, R. Whiteside, M. Brittberg, D. Wendt, I. Martin, and P. Mainil-Varlet Cartilage tissue engineering for degenerative joint disease Adv Drug Deliv Rev 58 2006 300 322 (Pubitemid 44294527)
99. H. Koga, L. Engebretsen, J.E. Brinchmann, T. Muneta, and I. Sekiya Mesenchymal stem cell-based therapy for cartilage repair: a review Knee Surg Sports Traumatol Arthrosc 17 2009 1289 1297
100. T.E. Hardingham, R.A. Oldershaw, and S.R. Tew Cartilage, SOX9 and Notch signals in chondrogenesis J Anat 209 2006 469 480
101. Y. Chang, S.W.N. Ueng, S. Lin-Chao, and C.C. Chao Involvement of Gas7 along the ERK1/2 MAP kinase and SOX9 pathway in chondrogenesis of human marrow-derived mesenchymal stem cells Osteoarthritis Cartilage 16 2008 1403 1412
102. C. An, Y. Cheng, Q. Yuan, and J. Li IGF-1 and BMP-2 induces differentiation of adipose-derived mesenchymal stem cells into chondrocytes-like cells Ann Biomed Eng 38 4 2010 1647 1654
103. K. Choi, Y. Seo, H. Yoon, K. Song, S. Kwon, and H. Lee Effect of ascorbic acid on bone marrow-derived mesenchymal stem cell proliferation and differentiation J Biosci Bioeng 105 2008 586 594
104. V. Lefebvre, W. Huang, V.R. Harley, P.N. Goodfellow, and B. de Crombrugghe SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene Mol Cell Biol 17 1997 2336 2346
105. L.C. Bridgewater, V. Lefebvre, and B. de Crombrugghe Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer J Biol Chem 273 1998 14998 15006 (Pubitemid 28272793)
106. I. Sekiya, K. Tsuji, P. Koopman, H. Watanabe, Y. Yamada, and K. Shinomiya SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6 J Biol Chem 275 2000 10738 10744
107. P. Zhang, S.A. Jimenez, and D.G. Stokes Regulation of human COL9A1 gene expression. Activation of the proximal promoter region by SOX9 J Biol Chem 278 2003 117 123
108. I. Kou, and S. Ikegawa SOX9-dependent and -independent transcriptional regulation of human cartilage link protein J Biol Chem 279 2004 50942 50948
109. W. Huang, N. Lu, H. Eberspaecher, and B. De Crombrugghe A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene J Biol Chem 277 2002 50668 50675
110. M. Tsuda, S. Takahashi, Y. Takahashi, and H. Asahara Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9 J Biol Chem 278 2003 27224 27229
111. T.M. Schmid, and T.F. Linsenmayer Immunohistochemical localization of short chain cartilage collagen (type X) in avian tissues J Cell Biol 100 1985 598 605
112. D.M. Ornitz, and P.J. Marie FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease Genes Dev 16 2002 1446 1465
113. G. Shen The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage Orthod Craniofac Res 8 2005 11 17
114. F. Mwale, D. Stachura, P. Roughley, and J. Antoniou Limitations of using aggrecan and type X collagen as markers of chondrogenesis in mesenchymal stem cell differentiation J Orthop Res 24 2006 1791 1798
115. B. Johnstone, T.M. Hering, A.I. Caplan, V.M. Goldberg, and J.U. Yoo In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells Exp Cell Res 238 1998 265 272
116. E.A. Jones, S.E. Kinsey, A. English, R.A. Jones, L. Straszynski, and D.M. Meredith Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells Arthritis Rheum 46 2002 3349 3360
117. S. Jingushi, A. Heydemann, S.K. Kana, L.R. Macey, and M.E. Bolander Acidic fibroblast growth factor (aFGF) injection stimulates cartilage enlargement and inhibits cartilage gene expression in rat fracture healing J Orthop Res 8 1990 364 371
118. J.U. Yoo, T.S. Barthel, K. Nishimura, L. Solchaga, A.I. Caplan, and V.M. Goldberg The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells J Bone Joint Surg Am 80 1998 1745 1757
119. M. Mastrogiacomo, R. Cancedda, and R. Quarto Effect of different growth factors on the chondrogenic potential of human bone marrow stromal cells Osteoarthritis Cartilage 9 Suppl. A 2001 S36 S40
120. K. Na, S. Choi, S. Kim, B.K. Sun, D.G. Woo, and H. Chung Enhancement of cell proliferation and differentiation by combination of ascorbate and dexamethasone in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes Biotechnol Lett 29 2007 1453 1457 (Pubitemid 47301360)
121. A. Derfoul, G.L. Perkins, D.J. Hall, and R.S. Tuan Glucocorticoids promote chondrogenic differentiation of adult human mesenchymal stem cells by enhancing expression of cartilage extracellular matrix genes Stem Cells 24 2006 1487 1495
122. W. Richter Mesenchymal stem cells and cartilage in situ regeneration J Intern Med 266 2009 390 405
123. K. Miyazono Positive and negative regulation of TGF-beta signaling J Cell Sci 113 Pt. 7 2000 1101 1109 (Pubitemid 30229527)
124. J.W. Lee, Y.H. Kim, S. Kim, S.H. Han, and S.B. Hahn Chondrogenic differentiation of mesenchymal stem cells and its clinical applications Yonsei Med J 45 Suppl. 2004 41 47 (Pubitemid 39010732)
125. F. Barry, R.E. Boynton, B. Liu, and J.M. Murphy Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation- dependent gene expression of matrix components Exp Cell Res 268 2001 189 200
126. D. Bosnakovski, M. Mizuno, G. Kim, T. Ishiguro, M. Okumura, and T. Iwanaga Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells in pellet cultural system Exp Hematol 32 2004 502 509
127. X. Zhang, N. Ziran, J.J. Goater, E.M. Schwarz, J.E. Puzas, and R.N. Rosier Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation Bone 34 2004 809 817
128. R. Pogue, and K. Lyons BMP signaling in the cartilage growth plate Curr Top Dev Biol 76 2006 1 48
129. D. Xu, Z. Gechtman, A. Hughes, A. Collins, R. Dodds, and X. Cui Potential involvement of BMP receptor type IB activation in a synergistic effect of chondrogenic promotion between rhTGFbeta3 and rhGDF5 or rhBMP7 in human mesenchymal stem cells Growth Factors 24 2006 268 278
130. T. Hennig, H. Lorenz, A. Thiel, K. Goetzke, A. Dickhut, and F. Geiger Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6 J Cell Physiol 211 2007 682 691
131. I. Sekiya, B.L. Larson, J.T. Vuoristo, R.L. Reger, and D.J. Prockop Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma Cell Tissue Res 320 2005 269 276
132. L.A. Solchaga, K. Penick, J.D. Porter, V.M. Goldberg, A.I. Caplan, and J.F. Welter FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells J Cell Physiol 203 2005 398 409
133. A.A. Stewart, C.R. Byron, H.C. Pondenis, and M.C. Stewart Effect of dexamethasone supplementation on chondrogenesis of equine mesenchymal stem cells Am J Vet Res 69 2008 1013 1021
134. F.P. Luyten, V.C. Hascall, S.P. Nissley, T.I. Morales, and A.H. Reddi Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants Arch Biochem Biophys 267 1988 416 425
135. L. Longobardi, L. O'Rear, S. Aakula, B. Johnstone, K. Shimer, and A. Chytil Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling J Bone Miner Res 21 2006 626 636
136. A.J. Nixon, L.R. Goodrich, M.S. Scimeca, T.H. Witte, L.V. Schnabel, and A.E. Watts Gene therapy in musculoskeletal repair Ann NY Acad Sci 1117 2007 310 327
137. A.J. Nixon, L.A. Fortier, J. Williams, and H. Mohammed Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites J Orthop Res 17 1999 475 487
138. S. Weiss, T. Hennig, R. Bock, E. Steck, and W. Richter Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells J Cell Physiol 223 2010 84 93
139. M. Milne, J.M. Quail, C.J. Rosen, and D.T. Baran Insulin-like growth factor binding proteins in femoral and vertebral bone marrow stromal cells: expression and regulation by thyroid hormone and dexamethasone J Cell Biochem 81 2001 229 240
140. N. Indrawattana, G. Chen, M. Tadokoro, L.H. Shann, H. Ohgushi, and T. Tateishi Growth factor combination for chondrogenic induction from human mesenchymal stem cell Biochem Biophys Res Commun 320 2004 914 919
141. C. Matsuda, M. Takagi, T. Hattori, S. Wakitani, and T. Yoshida Differentiation of human bone marrow mesenchymal stem cells to chondrocytes for construction of three-dimensional cartilage tissue Cytotechnology 47 2005 11 17
142. C. Wang, L. Chen, P. Kuo, J. Chang, Y. Wang, and S. Hung Apoptosis in chondrogenesis of human mesenchymal stem cells: effect of serum and medium supplements Apoptosis 15 4 2010 439 449
143. B.L. Eppley, J.E. Woodell, and J. Higgins Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing Plast Reconstr Surg 114 2004 1502 1508
144. A. Mishra, P. Tummala, A. King, B. Lee, M. Kraus, and V. Tse Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation Tissue Eng Part C Methods 15 2009 431 435
145. D.C. Colter, I. Sekiya, and D.J. Prockop Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells Proc Natl Acad Sci USA 98 2001 7841 7845 (Pubitemid 32642648)
146. J.I. Huang, N. Kazmi, M.M. Durbhakula, T.M. Hering, J.U. Yoo, and B. Johnstone Chondrogenic potential of progenitor cells derived from human bone marrow and adipose tissue: a patient-matched comparison J Orthop Res 23 2005 1383 1389
147. T.M. Liu, M. Martina, D.W. Hutmacher, J.H.P. Hui, E.H. Lee, and B. Lim Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages Stem Cells 25 2007 750 760
148. D.J. Prockop, C.A. Gregory, and J.L. Spees One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues Proc Natl Acad Sci USA 100 Suppl. 1 2003 11917 11923
149. Y. Sakaguchi, I. Sekiya, K. Yagishita, and T. Muneta Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source Arthritis Rheum 52 2005 2521 2529
150. H. Hauner, and G. Löffler Adipose tissue development: the role of precursor cells and adipogenic factors. Part I: Adipose tissue development and the role of precursor cells Klin Wochenschr 65 1987 803 811 (Pubitemid 17123337)
151. H.N. Langstein, and G.L. Robb Reconstructive approaches in soft tissue sarcoma Semin Surg Oncol 17 1999 52 65
152. C.T. Gomillion, and K.J. Burg Stem cells and adipose tissue engineering Biomaterials 27 2006 6052 6063
153. R. Ashinoff Overview: soft tissue augmentation Clin Plast Surg 27 2000 479 487
154. A.W. Klein, and M.L. Elson The history of substances for soft tissue augmentation Dermatol Surg 26 2000 1096 1105
155. C.W.J. Patrick Adipose tissue engineering: the future of breast and soft tissue reconstruction following tumor resection Semin Surg Oncol 19 2000 302 311
156. C.W.J. Patrick Tissue engineering strategies for adipose tissue repair Anat Rec 263 2001 361 366
157. C.W. Patrick, A.G. Mikos, and L.V. McIntire Frontiers in tissue engineering 1st ed. 1998 Pergamon Press Oxford and New York
158. C. Dani Embryonic stem cell-derived adipogenesis Cells Tissues Organs 165 1999 173 180
159. Y. Kubo, S. Kaidzu, I. Nakajima, K. Takenouchi, and F. Nakamura Organization of extracellular matrix components during differentiation of adipocytes in long-term culture In Vitro Cell Dev Biol Anim 36 2000 38 44
160. E.D. Rosen, and O.A. MacDougald Adipocyte differentiation from the inside out Nat Rev Mol Cell Biol 7 2006 885 896
161. M. Vallée, J. Côté, and J. Fradette Adipose-tissue engineering: taking advantage of the properties of human adipose-derived stem/stromal cells Pathol Biol 57 2009 309 317
162. J. Pairault, and H. Green A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker Proc Natl Acad Sci USA 76 1979 5138 5142
163. K. Hemmrich, D. von Heimburg, K. Cierpka, S. Haydarlioglu, and N. Pallua Optimization of the differentiation of human preadipocytes in vitro Differentiation 73 2005 28 35
164. W. Tsuji, T. Inamoto, H. Yamashiro, T. Ueno, H. Kato, and Y. Kimura Adipogenesis induced by human adipose tissue derived stem cells Tissue Eng Part A 15 2008 83 93
165. P. Tontonoz, E. Hu, and B.M. Spiegelman Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor Cell 79 1994 1147 1156
166. E.D. Rosen, P. Sarraf, A.E. Troy, G. Bradwin, K. Moore, and D.S. Milstone PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro Mol Cell 4 1999 611 617
167. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432
168. F.M. Gregoire, C.M. Smas, and H.S. Sul Understanding adipocyte differentiation Physiol Rev 78 1998 783 809
169. R. Zechner, J. Strauss, S. Frank, E. Wagner, W. Hofmann, and D. Kratky The role of lipoprotein lipase in adipose tissue development and metabolism Int J Obes Relat Metab Disord 24 Suppl. 4 2000 S53 S56
170. M. Obregon Thyroid hormone and adipocyte differentiation Thyroid 18 2008 185 195
171. E.C. Shugart, and R.M. Umek Dexamethasone signaling is required to establish the postmitotic state of adipocyte development Cell Growth Differ 8 1997 1091 1098
172. Q. Cui, G.J. Wang, and G. Balian Steroid-induced adipogenesis in a pluripotential cell line from bone marrow J Bone Joint Surg Am 79 1997 1054 1063
173. H. Hauner, P. Schmid, and E.F. Pfeiffer Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells J Clin Endocrinol Metab 64 1987 832 835
174. J. Prawitt, A. Niemeier, M. Kassem, U. Beisiegel, and J. Heeren Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells Exp Cell Res 314 2008 814 824
175. J. Deree, J.O. Martins, H. Melbostad, W.H. Loomis, and R. Coimbra Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition Clinics (Sao Paulo) 63 2008 321 328
176. D. Yang, H. Tsay, S. Lin, S. Chiou, M. Li, and T. Chang CAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin PLoS One 3 2008 e1540
177. D.J. Klemm, J.W. Leitner, P. Watson, A. Nesterova, J.E. Reusch, and M.L. Goalstone Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation J Biol Chem 276 2001 28430 28435
178. G. Löffler, and H. Hauner Adipose tissue development: the role of precursor cells and adipogenic factors. Part II: The regulation of the adipogenic conversion by hormones and serum factors Klin Wochenschr 65 1987 812 817 (Pubitemid 17127385)
179. H.H. Zhang, J. Huang, K. Düvel, B. Boback, S. Wu, and R.M. Squillace Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway PLoS One 4 2009 e6189
180. M. Rydén, A. Dicker, C. Götherström, G. Aström, C. Tammik, and P. Arner Functional characterization of human mesenchymal stem cell-derived adipocytes Biochem Biophys Res Commun 311 2003 391 397
181. T. Skurk, M. Birgel, Y. Lee, and H. Hauner Effect of troglitazone on tumor necrosis factor alpha and transforming growth factor beta expression and action in human adipocyte precursor cells in primary culture Metabolism 55 2006 309 316
182. C. Leyvraz, M. Suter, C. Verdumo, J. Calmes, A. Paroz, and C. Darimont Selective effects of PPARgamma agonists and antagonists on human pre-adipocyte differentiation Diabetes Obes Metab 12 3 2010 195 203
183. G.M. Ringold, A.B. Chapman, D.M. Knight, and F.M. Torti Hormonal control of adipogenesis Ann NY Acad Sci 478 1986 109 119
184. M. Kellinsalmi, V. Parikka, J. Risteli, T. Hentunen, H. Leskelä, and S. Lehtonen Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro Eur J Pharmacol 572 2007 102 110
185. J.M. Lehmann, J.M. Lenhard, B.B. Oliver, G.M. Ringold, and S.A. Kliewer Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs J Biol Chem 272 1997 3406 3410
186. H. Ye, and G. Serrero Stimulation of adipose differentiation related protein (ADRP) expression by ibuprofen and indomethacin in adipocyte precursors and in adipocytes Biochem J 330 Pt. 2 1998 803 809 (Pubitemid 28111981)
187. S. Mandrup, and M.D. Lane Regulating adipogenesis J Biol Chem 272 1997 5367 5370
188. N. Kawaguchi, K. Toriyama, E. Nicodemou-Lena, K. Inou, S. Torii, and Y. Kitagawa De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor Proc Natl Acad Sci USA 95 1998 1062 1066
189. A.J. Katz, R. Llull, M.H. Hedrick, and J.W. Futrell Emerging approaches to the tissue engineering of fat Clin Plast Surg 26 1999 587 603 [viii]
190. D. Gospodarowicz, N. Ferrara, L. Schweigerer, and G. Neufeld Structural characterization and biological functions of fibroblast growth factor Endocr Rev 8 1987 95 114
191. M. Neubauer, C. Fischbach, P. Bauer-Kreisel, E. Lieb, M. Hacker, and J. Tessmar Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells FEBS Lett 577 2004 277 283
192. S. Inoue, Y. Hori, Y. Hirano, T. Inamoto, and Y. Tabata Effect of culture substrate and fibroblast growth factor addition on the proliferation and differentiation of human adipo-stromal cells J Biomater Sci Polym Ed 16 2005 57 77
193. N. Kakudo, A. Shimotsuma, and K. Kusumoto Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells Biochem Biophys Res Commun 359 2007 239 244
194. Y. Kimura, M. Ozeki, T. Inamoto, and Y. Tabata Time course of de novo adipogenesis in matrigel by gelatin microspheres incorporating basic fibroblast growth factor Tissue Eng 8 2002 603 613
195. Y. Tabata, M. Miyao, T. Inamoto, T. Ishii, Y. Hirano, and Y. Yamaoki De novo formation of adipose tissue by controlled release of basic fibroblast growth factor Tissue Eng 6 2000 279 289
196. H. Hauner, G. Entenmann, M. Wabitsch, D. Gaillard, G. Ailhaud, and R. Negrel Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium J Clin Invest 84 1989 1663 1670
197. S. Levenberg, J. Rouwkema, M. Macdonald, E.S. Garfein, D.S. Kohane, and D.C. Darland Engineering vascularized skeletal muscle tissue Nat Biotechnol 23 2005 879 884
198. O. Tsigkou, I. Pomerantseva, J.A. Spencer, P.A. Redondo, A.R. Hart, and E. O'Doherty Regenerative medicine special feature: engineered vascularized bone grafts Proc Natl Acad Sci USA 107 8 2010 3311 3316
199. P. Niemeyer, K. Fechner, S. Milz, W. Richter, N.P. Suedkamp, and A.T. Mehlhorn Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma Biomaterials 31 13 2010 3572 3579
200. N.F. Huang, and S. Li Mesenchymal stem cells for vascular regeneration Regen Med 3 2008 877 892
201. N. Ferrara Vascular endothelial growth factor: basic science and clinical progress Endocr Rev 25 2004 581 611 (Pubitemid 39099316)
202. K. Bai, Y. Huang, X. Jia, Y. Fan, and W. Wang Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations J Biomech 43 6 2010 1176 1181
203. H.F. Dvorak, L.F. Brown, M. Detmar, and A.M. Dvorak Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis Am J Pathol 146 1995 1029 1039
204. C.J. Robinson, and S.E. Stringer The splice variants of vascular endothelial growth factor (VEGF) and their receptors J Cell Sci 114 2001 853 865
205. B.M. Beckermann, G. Kallifatidis, A. Groth, D. Frommhold, A. Apel, and J. Mattern VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma Br J Cancer 99 2008 622 631
206. J.A. Nagy, L. Benjamin, H. Zeng, A.M. Dvorak, and H.F. Dvorak Vascular permeability, vascular hyperpermeability and angiogenesis Angiogenesis 11 2008 109 119
207. S.G. Ball, C.A. Shuttleworth, and C.M. Kielty Mesenchymal stem cells and neovascularization: role of platelet-derived growth factor receptors J Cell Mol Med 11 2007 1012 1030
208. E.A. Streeten, and M.L. Brandi Biology of bone endothelial cells Bone Miner 10 1990 85 94
209. H.P. Gerber, T.H. Vu, A.M. Ryan, J. Kowalski, Z. Werb, and N. Ferrara VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation Nat Med 5 1999 623 628
210. M.T. Engsig, Q.J. Chen, T.H. Vu, A.C. Pedersen, B. Therkidsen, and L.R. Lund Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones J Cell Biol 151 2000 879 889
211. M. Nakagawa, T. Kaneda, T. Arakawa, S. Morita, T. Sato, and T. Yomada Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts FEBS Lett 473 2000 161 164
212. D.T. Connolly, D.M. Heuvelman, R. Nelson, J.V. Olander, B.L. Eppley, and J.J. Delfino Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis J Clin Invest 84 1989 1470 1478
213. B.H. Schönmeyr, M. Soares, T. Avraham, N.W. Clavin, F. Gewalli, and B.J. Mehrara VEGF inhibits BMP2 expression in rat mesenchymal stem cells Tissue Eng Part A 16 2 2010 653 662
214. V.P. Terranova, R. DiFlorio, R.M. Lyall, S. Hic, R. Friesel, and T. Maciag Human endothelial cells are chemotactic to endothelial cell growth factor and heparin J Cell Biol 101 1985 2330 2334
215. B. Millauer, S. Wizigmann-Voos, H. Schnürch, R. Martinez, N.P. Møller, and W. Risau High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis Cell 72 1993 835 846
216. A. Perets, Y. Baruch, F. Weisbuch, G. Shoshany, G. Neufeld, and S. Cohen Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres J Biomed Mater Res A 65 2003 489 497
217. D.L. Miller, S. Ortega, O. Bashayan, R. Basch, and C. Basilico Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice Mol Cell Biol 20 2000 2260 2268
218. X. Li, and U. Eriksson Novel PDGF family members: PDGF-C and PDGF-D Cytokine Growth Factor Rev 14 2003 91 98
219. E. Solheim Growth factors in bone Int Orthop 22 1998 410 416
220. M. Papetti, and I.M. Herman Mechanisms of normal and tumor-derived angiogenesis Am J Physiol Cell Physiol 282 2002 C947 C970
221. R.S. Bar, M. Boes, B.A. Booth, B.L. Dake, S. Henley, and M.N. Hart The effects of platelet-derived growth factor in cultured microvessel endothelial cells Endocrinology 124 1989 1841 1848
222. E.J. Battegay, J. Rupp, L. Iruela-Arispe, E.H. Sage, and M. Pech PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors J Cell Biol 125 1994 917 928
223. R.F. Nicosia, S.V. Nicosia, and M. Smith Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro Am J Pathol 145 1994 1023 1029
224. G.K. Owens, M.S. Kumar, and B.R. Wamhoff Molecular regulation of vascular smooth muscle cell differentiation in development and disease Physiol Rev 84 2004 767 801
225. J.A. McKee, S.S.R. Banik, M.J. Boyer, N.M. Hamad, J.H. Lawson, and L.E. Niklason Human arteries engineered in vitro EMBO Rep 4 2003 633 638
226. M. Poh, M. Boyer, A. Solan, S.L.M. Dahl, D. Pedrotty, and S.S.R. Banik Blood vessels engineered from human cells Lancet 365 2005 2122 2124
227. L.J. Harris, H. Abdollahi, P. Zhang, S. McIlhenny, T.N. Tulenko, and P.J. DiMuzio Differentiation of adult stem cells into smooth muscle for vascular tissue engineering J Surg Res 2009 [Epub ahead of print]
228. M.B. Chan-Park, J.Y. Shen, Y. Cao, Y. Xiong, Y. Liu, and S. Rayatpisheh Biomimetic control of vascular smooth muscle cell morphology and phenotype for functional tissue-engineered small-diameter blood vessels J Biomed Mater Res A 88 2009 1104 1121
229. S. Moosmang, P. Lenhardt, N. Haider, F. Hofmann, and J.W. Wegener Mouse models to study L-type calcium channel function Pharmacol Ther 106 2005 347 355
230. J.J. Ross, Z. Hong, B. Willenbring, L. Zeng, B. Isenberg, and E.H. Lee Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells J Clin Invest 116 2006 3139 3149
231. C. Wang, L. Cen, S. Yin, Q. Liu, W. Liu, and Y. Cao A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells Biomaterials 31 2010 621 630
232. J. Solway, J. Seltzer, F.F. Samaha, S. Kim, L.E. Alger, and Q. Niu Structure and expression of a smooth muscle cell-specific gene, SM22 alpha J Biol Chem 270 1995 13460 13469
233. F.T. van der Loop, G. Schaart, E.D. Timmer, F.C. Ramaekers, and G.J. van Eys Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells J Cell Biol 134 1996 401 411
234. Z. Gong, and L.E. Niklason Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs) FASEB J 22 2008 1635 1648
235. S. Sinha, M.H. Hoofnagle, P.A. Kingston, M.E. McCanna, and G.K. Owens Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells Am J Physiol Cell Physiol 287 2004 C1560 C1568
236. K.K. Hirschi, S.A. Rohovsky, and P.A. D'Amore PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate J Cell Biol 141 1998 805 814
237. R.A. Deaton, C. Su, T.G. Valencia, and S.R. Grant Transforming growth factor-beta1-induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK J Biol Chem 280 2005 31172 31181
238. C.S. Madsen, J.C. Hershey, M.B. Hautmann, S.L. White, and G.K. Owens Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich element located between two positive-acting serum response factor-binding elements J Biol Chem 272 1997 6332 6340
239. L. Li, Z. Liu, B. Mercer, P. Overbeek, and E.N. Olson Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells Dev Biol 187 1997 311 321
240. B.P. Herring, and A.F. Smith Telokin expression in A10 smooth muscle cells requires serum response factor Am J Physiol 272 1997 C1394 C1404
241. J.M. Miano, M.J. Carlson, J.A. Spencer, and R.P. Misra Serum response factor-dependent regulation of the smooth muscle calponin gene J Biol Chem 275 2000 9814 9822
242. E.P. Böttinger, J.J. Letterio, and A.B. Roberts Biology of TGF-beta in knockout and transgenic mouse models Kidney Int 51 1997 1355 1360
243. L.P. Sanford, I. Ormsby, A.C. Gittenberger-de Groot, H. Sariola, R. Friedman, and G.P. Boivin TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes Development 124 1997 2659 2670
244. J.E. Hungerford, and C.D. Little Developmental biology of the vascular smooth muscle cell: building a multilayered vessel wall J Vasc Res 36 1999 2 27
245. M. Hellström, M. Kalén, P. Lindahl, A. Abramsson, and C. Betsholtz Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse Development 126 1999 3047 3055
246. F. Dandré, and G.K. Owens Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes Am J Physiol Heart Circ Physiol 286 2004 H2042 H2051
247. Y.M. Kim, E.S. Jeon, M.R. Kim, S.K. Jho, S.W. Ryu, and J.H. Kim Angiotensin II-induced differentiation of adipose tissue-derived mesenchymal stem cells to smooth muscle-like cells Int J Biochem Cell Biol 40 2008 2482 2491
248. E.S. Jeon, H.J. Moon, M.J. Lee, H.Y. Song, Y.M. Kim, and Y.C. Bae Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism J Cell Sci 119 2006 4994 5005
249. Y. Narita, A. Yamawaki, H. Kagami, M. Ueda, and Y. Ueda Effects of transforming growth factor-beta 1 and ascorbic acid on differentiation of human bone-marrow-derived mesenchymal stem cells into smooth muscle cell lineage Cell Tissue Res 333 2008 449 459
250. M.C. Galmiche, V.E. Koteliansky, J. Brire, P. Hervé, and P. Charbord Stromal cells from human long-term marrow cultures are mesenchymal cells that differentiate following a vascular smooth muscle differentiation pathway Blood 82 1993 66 76
251. Y. Chang, S. Hwang, C. Tseng, F. Cheng, S. Huang, and L. Hsu Isolation of mesenchymal stem cells with neurogenic potential from the mesoderm of the amniotic membrane Cells Tissues Organs 192 2010 93 105
252. K. Sellheyer, and D. Krahl Cutaneous mesenchymal stem cells: status of current knowledge, implications for dermatopathology J Cutan Pathol 37 2010 624 634
253. L. Pierdomenico, L. Bonsi, M. Calvitti, D. Rondelli, M. Arpinati, and G. Chirumbolo Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp Transplantation 80 2005 836 842
254. J. Ringe, I. Leinhase, S. Stich, A. Loch, K. Neumann, and A. Haisch Human mastoid periosteum-derived stem cells: promising candidates for skeletal tissue engineering J Tissue Eng Regen Med 2 2008 136 146
255. F. Sabatini, L. Petecchia, M. Tavian, V. Jodon de Villeroché, G.A. Rossi, and D. Brouty-Boyé Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities Lab Invest 85 2005 962 971
256. D.J. Prockop Marrow stromal cells as stem cells for nonhematopoietic tissues Science 276 1997 71 74
257. A. Erices, P. Conget, and J.J. Minguell Mesenchymal progenitor cells in human umbilical cord blood Br J Haematol 109 2000 235 242
258. K. Bieback, S. Kern, H. Klüter, and H. Eichler Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood Stem Cells 22 2004 625 634
259. A.I. Caplan The mesengenic process Clin Plast Surg 21 1994 429 435
260. H. Prins, H. Rozemuller, S. Vonk-Griffioen, V.G.M. Verweij, W.J.A. Dhert, and I.C.M. Slaper-Cortenbach Bone-forming capacity of mesenchymal stromal cells when cultured in the presence of human platelet lysate as substitute for fetal bovine serum Tissue Eng Part A 15 2009 3741 3751
261. A. Shahdadfar, K. Frønsdal, T. Haug, F.P. Reinholt, and J.E. Brinchmann In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability Stem Cells 23 2005 1357 1366
262. M.S. Friedman, M.W. Long, and K.D. Hankenson Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6 J Cell Biochem 98 2006 538 554
263. M. Stiehler, C. Bünger, A. Baatrup, M. Lind, M. Kassem, and T. Mygind Effect of dynamic 3-D culture on proliferation, distribution, and osteogenic differentiation of human mesenchymal stem cells J Biomed Mater Res A 89 2009 96 107
264. J.P. Vogel, K. Szalay, F. Geiger, M. Kramer, W. Richter, and P. Kasten Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics Platelets 17 2006 462 469 (Pubitemid 44665569)
265. B. Shen, A. Wei, S. Whittaker, L.A. Williams, H. Tao, and D.D.F. Ma The role of BMP-7 in chondrogenic and osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in vitro J Cell Biochem 109 2 2010 406 416
266. B.O. Diekman, C.R. Rowland, A.I. Caplan, D. Lennon, and F. Guilak Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage derived matrix Tissue Eng Part A 16 2 2010 523 533
267. V. van Harmelen, K. Röhrig, and H. Hauner Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects Metabolism 53 2004 632 637
268. B.A. Bunnell, M. Flaat, C. Gagliardi, B. Patel, and C. Ripoll Adipose-derived stem cells: isolation, expansion and differentiation Methods 45 2008 115 120
269. A.V. Vashi, E. Keramidaris, K.M. Abberton, W.A. Morrison, J.L. Wilson, and A.J. O'Connor Adipose differentiation of bone marrow-derived mesenchymal stem cells using Pluronic F-127 hydrogel in vitro Biomaterials 29 2008 573 579
270. Y. Jiang, B.N. Jahagirdar, R.L. Reinhardt, R.E. Schwartz, C.D. Keene, and X.R. Ortiz-Gonzalez Pluripotency of mesenchymal stem cells derived from adult marrow Nature 418 2002 41 49
271. A. Kanematsu, S. Yamamoto, E. Iwai-Kanai, I. Kanatani, M. Imamura, and R.M. Adam Induction of smooth muscle cell-like phenotype in marrow-derived cells among regenerating urinary bladder smooth muscle cells Am J Pathol 166 2005 565 573
272. D. Shukla, G.N. Box, R.A. Edwards, and D.R. Tyson Bone marrow stem cells for urologic tissue engineering World J Urol 26 2008 341 349
273. K. Kurpinski, J. Chu, D. Wang, and S. Li Proteomic profiling of mesenchymal stem cell responses to mechanical strain and TGF-beta1 Cell Mol Bioeng 2 2009 606 614