Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-β signaling

Journal of Bone and Mineral Research

Volumn 21, Issue 4, 2006, Pages 626-636

  Longobardi, Lara ^a   O'Rear, Lynda ^a   Aakula, Srikanth ^a   Johnstone, Brian ^b   Shimer, Kimberly ^a   Chytil, Anna ^a   Horton, William A ^c   Moses, Harold L ^a   Spagnoli, Anna ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c SHRINERS HOSPITAL FOR CHILDREN   (United States)

Author keywords

Bone marrow; Chondrocytes; Growth factors; Molecular pathways; Stem cells

Indexed keywords

CASPASE 3; COLLAGEN TYPE 2; GREEN FLUORESCENT PROTEIN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SOMATOMEDIN C; THYMIDINE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL ISOLATION; CELL PROLIFERATION; CHONDROGENESIS; CHONDROPATHY; CONTROLLED STUDY; EVALUATION RESEARCH; IMMUNOPATHOLOGY; MESENCHYME CELL; MOUSE; NICK END LABELING; NONHUMAN; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; CHONDROCYTES; CHONDROGENESIS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MESENCHYMAL STEM CELLS; MICE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33645337383     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.051213     Document Type: Article

References (37)

1. Hall BK, Miyake T 2000 All for one and one for all: Condensations and the initiation of skeletal development. Bioessays 22:138-147.
2. Caplan AI 1991 Mesenchymal stem cells. J Orthop Res 9:641-650.
3. Sekiya I, Vuoristo JT, Larson BL, Prockop DJ 2002 In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci USA 99:4397-4402.
4. Baddoo M, Hill K, Wilkinson R, Gaupp D, Hughes C, Kopen GC, Phinney DG 2003 Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection. J Cell Biochem 89:1235-1249.
5. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU 1998 In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 238:265-272.
6. Trippel SB, Ghivizzani SC, Nixon AJ 2004 Gene-based approaches for the repair of articular cartilage. Gene Ther 11:351-359.
7. Spagnoli A, Rosenfeld RG 1996 The mechanisms by which growth hormone brings about growth. The relative contributions of growth hormone and insulin-like growth factors. Endocrinol Metab Clin North Am 25:615-631.
8. Baker J, Liu JP, Robertson EJ, Efstratiadis A 1993 Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73-82.
9. DeChiara TM, Efstratiadis A, Robertson EJ 1990 A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345:78-80.
10. Milne M, Quail JM, Rosen CJ, Baran DT 2001 Insulin-like growth factor binding proteins in femoral and vertebral bone marrow stromal cells: Expression and regulation by thyroid hormone and dexamethasone. J Cell Biochem 81:229-240.
11. Indrawattana N, Chen G, Tadokoro M, Shann LH, Ohgushi H, Tateishi T, Tanaka J, Bunyaratvej A 2004 Growth factor combination for chondrogenic induction from human mesenchymal stem cell. Biochem Biophys Res Commun 320:914-919.
12. Serra R, Johnson M, Filvaroff EH, LaBorde J, Sheehan DM, Derynck R, Moses HL 1997 Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol 139:541-552.
13. Grimaud E, Heymann D, Redini F 2002 Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders. Cytokine Growth Factor Rev 13:241-257.
14. Dunker N, Krieglstein K 2000 Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. Eur J Biochem 267:6982-6988.
15. Pelton RW, Dickinson ME, Moses HL, Hogan BL 1990 In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: Comparative studies with TGF beta 1 and beta 2. Development 110:609-620.
16. Pelton RW, Saxena B, Jones M, Moses HL, Gold LI 1991 Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development. J Cell Biol 115:1091-1105.
17. Derynck R, Zhang YE 2003 Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577-584.
18. Oshima M, Oshima H, Taketo MM 1996 TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol 179:297-302.
19. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR 1999 Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147.
20. Spagnoli A, Longobardi L, O'Rear L 2005 Cartilage disorders: Potential therapeutic use of mesenchymal stem cells. Endocr Dev 9:17-30.
21. Chytil A, Magnuson MA, Wright CV, Moses HL 2002 Conditional inactivation of the TGF-beta type II receptor using Cre: Lox. Genesis 32:73-75.
22. Silver DP, Livingston DM 2001 Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell 8:233-243.
23. Soneoka Y, Cannon PM, Ramsdale EE, Griffiths JC, Romano G, Kingsman SM, Kingsman AJ 1995 A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res 23:628-633.
24. Spagnoli A, Hwa V, Horton WA, Lunstrum GP, Roberts CT Jr, Chiarelli F, Torello M, Rosenfeld RG 2001 Antiproliferative effects of insulin-like growth factor-binding protein-3 in mesenchymal chondrogenic cell line RCJ3.1C5.18. relationship to differentiation stage. J Biol Chem 276:5533-5540.
25. Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM 1998 Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17:3091-3100.
26. Francis GL, Ross M, Ballard FJ, Milner SJ, Senn C, McNeil KA, Wallace JC, King R, Wells JR 1992 Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. J Mol Endocrinol 8:213-223.
27. Francis GL, Aplin SE, Milner SJ, McNeil KA, Ballard FJ, Wallace JC 1993 Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II. Biochem J 293:713-719.
28. Spagnoli A, Torello M, Nagalla SR, Horton WA, Pattee P, Hwa V, Chiarelli F, Roberts CT Jr, Rosenfeld RG 2002 Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis. J Biol Chem 277:18860-18867.
29. Stringa E, Love JM, McBride SC, Suyama E, Tuan RS 1997 In vitro characterization of chondrogenic cells isolated from chick embryonic muscle using peanut agglutinin affinity chromatography. Exp Cell Res 232:287-294.
30. Kim YJ, Sah RL, Doong JY, Grodzinsky AJ 1988 Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 174:168-176.
31. Grant TD, Cho J, Ariail KS, Weksler NB, Smith RW, Horton WA 2000 Col2-GFP reporter marks chondrocyte lineage and chondrogenesis during mouse skeletal development. Dev Dyn 218:394-400.
32. Mariani FV, Martin GR 2003 Deciphering skeletal patterning: Clues from the limb. Nature 423:319-325.
33. Dietrich P, Dragatsis I, Xuan S, Zeitlin S, Efstratiadis A 2000 Conditional mutagenesis in mice with heat shock promoter-driven ere transgenes. Mamm Genome 11:196-205.
34. Chimal-Monroy J, Diaz de Leon L 1999 Expression of N-cadherin, N-CAM, fibronectin and tenascin is stimulated by TGF-beta1, beta2, beta3 and beta5 during the formation of precartilage condensations. Int J Dev Biol 43:59-67.
35. Tuli R, Tuli S, Nandi S, Huang X, Manner PA, Hozack WJ, Danielson KG, Hall DJ, Tuan RS 2003 Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. J Biol Chem 278:41227-41236.
36. Watanabe H, de Caestecker MP, Yamada Y 2001 Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells. J Biol Chem 276:14466-14473.
37. Phornphutkul C, Wu KY, Yang X, Chen Q, Gruppuso PA 2004 Insulin-like growth factor-I signaling is modified during chondrocyte differentiation. J Endocrinol 183:477-486.