Biology of TGF-β in knockout and transgenic mouse models

Kidney International

Volumn 51, Issue 5, 1997, Pages 1355-1360

  Bottinger, E P ^a   Letterio, J J ^a   Roberts, A B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; AUTOANTIBODY; CD4 ANTIGEN; CELL NUCLEUS ANTIGEN; CELL SURFACE RECEPTOR; COMPLEMENT; CYTOKINE; CYTOPLASM PROTEIN; DNA; ENDOGLIN; FC RECEPTOR; GLYCINE; IMMUNOGLOBULIN G; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; PROTEIN; PROTEIN SERINE THREONINE KINASE; RECEPTOR; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SERINE; THREONINE; THROMBOSPONDIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ATHEROSCLEROSIS; AUTOIMMUNITY; CARCINOGENESIS; DNA REPAIR; FIBROSIS; GENE DELETION; GENE EXPRESSION; GENE TARGETING; GLOMERULONEPHRITIS; IMMUNOHISTOCHEMISTRY; LIVER REGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

EID: 0030987180     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.185     Document Type: Article

References (69)

1. A.B. Roberts M.B. Sporn The transforming growth factors- β M.B. Sporn A.B. Roberts Handbook of Experimental Pharmacology. Peptide Growth Factors and Their Receptors 1990 Springer-Verlag New York 419
2. J. Massagué The transforming growth factor-beta family Annu Rev Cell Biol 6 1990 597 641
3. P. Ten Dijke P. Franzen H. Yamashita H. Ichijo C.H. Heldin K. Miyazono Serine/threonine kinase receptors Prog Growth Factor Res 5 1994 55 72
4. R. Derynck TGF-beta-receptor-mediated signaling Trends Biochem Sci 19 1994 548 553
5. L. Attisano J.L. Wrana F. Lopez-Casillas J. Massagué TGF-beta receptors and actions Biochim Biophys Acta 1222 1994 71 80
6. A.B. Roberts M.B. Sporn Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta) Growth Factors 8 1993 1 9
7. A.B. Roberts Transforming growth factor- β : Activity and efficacy in animal models of wound healing Wound Rep Reg 3 1995 408 418
8. M.K. Racke B. Cannella P. Albert M. Sporn C.S. Raine D.E. McFarlin Evidence of endogenous regulatory function of transforming growth factor-beta 1 in experimental allergic encephalomyelitis Int Immunol 4 1992 615 620
9. A.P. Kuruvilla R. Shah G.M. Hochwald H.D. Liggitt M.A. Palladino G.J. Thorbecke Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice Proc Natl Acad Sci USA 88 1991 2918 2921
10. W.A. Border N.A. Noble Transforming growth factor beta in tissue fibrosis N Engl J Med 331 1994 1286 1292
11. N.L. McCartney-Francis S.M. Wahl Transforming growth factor beta: A matter of life and death J Leuk Biol 55 1994 401 409
12. A. Barral M. Teixeira P. Reis V. Vinhas J. Costa H. Lessa A.L. Bittencourt S. Reed E.M. Carvalho M. Barral-Netto Transforming growth factor-beta in human cutaneous leishmaniasis Am J Pathol 147 1995 947 954
13. K.C. Flanders C.F. Lippa TGF- β 2 in chronic neurodegenerative disease Neural Notes 2 1996 8 10
14. L.M. Wakefield J.J. Letterio Chent D. Danielpour R.S.H. Allison L.H. Pai A.M. Denicoff M.H. Noone K.H. Cowan J.A. O'Shaughnessy M.B. Sporn Transforming growth factor- β 1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer Clin Cancer Res 1 1995 129 136
15. S.D. Markowitz A.B. Roberts Tumor suppressor activity of the TGF- β pathway in human cancers Cytokine Growth Factor Rev 7 1996 93 102
16. D.H. Kim S.-J. Kim Transforming growth factor- β receptors: Role in physiology and disease J Biomed Sci 3 1996 143 158
17. J.L. Wrana L. Attisano R. Wieser F. Ventura J. Massagué Mechanism of activation of the TGF-beta receptor Nature 370 1994 341 347
18. J.J. Sekelsky S.J. Newfeld L.A. Raftery E.H. Chartoff W.M. Gelbart Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophilia melano-gaster Genetics 139 1995 1347 1358
19. J. Massagué TGF- β signaling: Receptors, transducers and Mad proteins Cell 85 1996 947 950
20. C. Savage P. Das A. Finelli S. Townsend C. Sun S. Baird R. Padgett The C. elegans sma-2, sma-3 , and sma-4 genes define a novel conserved family of TGF- β pathway components Proc Natl Acad Sci USA 93 1996 790 794
21. J.M. Graff A. Bansal D.A. Melton Xenopus Mad proteins transduce distinct subsets of signals for the TGF- β superfamily Cell 85 1996 479 487
22. P.A. Hoodless T. Haerry S. Abdollah M. Stapleton M.B. O'Connor L. Attisano J.L. Wrana MADR1, a MAD-related protein that functions in BMP2 signaling pathways Cell 85 1996 489 500
23. F. Liu A. Hata J. Baker J. Doody J. Carcamo R. Harland J. Massagué A human Mad protein acting as a BMP-regulated transcriptional activator Nature 381 1996 620 623
24. R.J. Lechleider M.P. Decaestecker A. Dehejia M.H. Polymeropoulos A.B. Roberts Serine phosphorylation, chromosomal localization, and transforming growth factor- β signal transduction by human bsp-l J Biol Chem 271 1996 17617 17620
25. J. Eshelman S. Markowitz Microsatellite instability in inherited and sporadic neoplasms Curr Opin Oncol 7 1995 83 89
26. S. Markowitz J. Wang L. Myeroff Inactivation of the type II TGF- β receptor in colon cancer cells with microsatellite instability Science 268 1995 1336 1338
27. L. Garrigue-Antar T. Munoz-Antonia S. Antonia J. Gesmonde V. Vellucci M. Reiss Mis-sense mutations of the transforming growth factor β type II receptor in human head and neck squamous carcinoma cells Cancer Res 55 1995 3982 3987
28. I.Y. Kim H.-J. Ahn D. Zelner Genetic change in transforming growth factor β (TGF- β ) receptor type I gene correlates with insensitivity to TGF- β 1 in human prostate cancer cells Cancer Res 56 1996 44 48
29. P.I. Knaus D. Lindemann J.F. Decoteau R. Perlman H. Yankelev M. Hille M.E. Kadin H.F. Lodish A dominant inhibitory mutant of the type II transforming growth factor β receptor in the malignant progression of a cutaneous T-cell lymphoma Mol Cell Biol 16 1996 3480 3489
30. L. Myeroff R. Parsons S.-J. Kim L. Hedrick K.R. Cho K. Orth M. Mathis K.W. Kinsler J. Lutterbaugh K. Park Y.-J. Bang H.W. Lee J.-G. Park H.T. Lynch A.B. Roberts B. Vogelstein S.A. Markowitz TGF-beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability Cancer Res 55 1995 5545 5547
31. S.A. Hahn M. Schutte A.T.M. Shamsul Hoque Moskalukca L.T. Da Costa E.M. Rozenblum C.L. Weinstein A. Fischer C.J. Yeo R.H. Hruban S.E. Kern DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 Science 271 1996 350 353
32. K. Eppert S.W. Scherer H. Ozcelik R. Pirone J.P. Hoodless H. Kim L.-C. Tsui B. Bapat S. Gallinger I.L. Andrulis G.H. Thomsen J.L. Wrana L. Attisano MADR2 maps to 18q21 and encodes a TGF- β -regulated MAD-related protein that is functionally mutated in colorectal carcinoma Cell 86 1996 543 552
33. G.J. Riggins S. Thiagalingam E. Rozenblum C.L. Weinstein S.E. Kern S.R. Hamilton J.K.V. Willson S.D. Markowitz K.W. Kinzler B. Vogelstein MAD-related genes in the human Nature Genet 13 1996 347 349
34. Zhang Y, Feng X-H, Wu R-Y, Derynck R: Receptor-associated Mad homologues synergize as effectors of the TGF- β response. Nature (in press)
35. W.A. Border S. Okuda L.R. Languino M.B. Sporn E. Ruoslahti Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1 Nature 346 1990 371 374
36. Y. Isaka D.K. Brees K. Ikegaya Y. Kaneda E. Imai N.A. Noble W.A. Border Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney Nature Med 2 1996 418 423
37. H. Dang A.G. Geiser J.J. Letterio T. Nakabayashi L. Kong G. Fernandes Talal SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF- β 1 knockout mice J Immunol 155 1995 3205 3212
38. A.B. Kulkarni C.G. Huh D. Becker A. Geiser M. Lyght K.C. Flanders A.B. Roberts M.B. Sporn J.M. Ward S. Karlsson Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death Proc Natl Acad Sci USA 90 1993 770 774
39. M.M. Schull I. Ormsby A.B. Kier S. Pawlowski R.J. Diebold M. Yin R. Allen C. Sidman B. Proetzel D. Calvin N. Annunziata T. Doetschman Targeted disruption of the mouse transforming growth factor- β 1 gene results in multifocal inflammatory disease Nature 359 1992 693 699
40. G. Proetzel S.A. Pawlowski M.V. Wiles M. Yin G.P. Boivin P.N. Howles J. Ding W.J. Ferguson T. Doetschman Transforming growth factor- β 3 is required for secondary palate fusion Nature Genet 11 1995 409 414
41. V. Kaartinen J.W. Voncken C. Shuler D. Warburton D. Bu N. Heisterkamp J. Groffen Abnormal lung development and cleft palate in mice lacking TGF^3 indicates defects of epithelial-mesen-chymal interaction Nature Genet 11 1995 415 420
42. A.B. Kulkarni J.M. Ward A.G. Geiser J.J. Letterio K.L. Hines M. Christ R.N. D'Souza C. Huh A.B. Roberts M.B. Sporn N. McArt-Ney-Francis S.M. Wahl A.B. Glick S.H. Yuspa C. MacKall R.E. Gress S. Karlsson TGF- β 1 knockout mice: Immune dysregulation and pathology N.G. Abraham R.K. Shadduck A.S. Levine F. Takaku Molecular Biology of Haematopoiesis 1994 Intecept Paris 749 757
43. M.M. Schull A.B. Kier R.J. Diebold Y. Moying T. Doetschman The importance of transforming growth factor β 1 in immunological homeostasis, as revealed by gene ablation in mice Overexpression and Knockout of Cytokines in Transgenic Mice 1994 Academic Press Ltd New York 135 159
44. Letterio JJ, Geiser AG, Kulkarni AB, Dang H, Kong L, Nakabayashi T, Roberts AB: Autoimmunity associated with TGF- β - deficiency in mice is dependent on MHC class II antigen expression. J Clin Invest (in press)
45. J.H. Lowrance F.X. O'Sullivan T.E. Caver W. Waegell H.D. Gresham Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice J Exp Med 180 1994 1693 1703
46. A.G. Geiser J.J. Letterio A.B. Kulkarni S. Karlsson A.B. Roberts M.B. Sporn Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: Aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype Proc Natl Acad Sci USA 90 1993 9944 9948
47. R. Pujol-Borrell I. Todd M. Londei A. Foulis M. Feldmann G.F. Bottazzo Inappropriate major histocompatibility complex class II expression by thyroid follicular cells in thyroid autoimmune disease, and by pancreatic beta cells in type I diabetes Mol Biol Med 3 1986 159
48. R.S. Schwartz Dsk Autoimmunity and autoimmune disease W.E. Paul Fundamental Immunology 1989 Raven Press New York 819 866
49. L. Steinman Escape from “Horror Autotoxicus”: Pathogenesis and treatment of autoimmune disease Cell 80 1995 7 10
50. L. Yaswen A. Kulkarni T. Frederickson B. Mittleman R. Schiffman S. Payne G. Longenecker E. Mozes S. Karlsson Autoimmune manifestations in the TGF- β 1 knockout mouse Blood 87 1995 1439 1445
51. K. Tamaki S. Okuda T. Ando T. Iwamoto M. Nakayama M. Fujishima TGF-beta 1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy Kidney Int 45 1994 525 536
52. S.J. Shankland J. Pippin R.H. Pichler K.L. Gordon S. Friedman L.I. Gold R.J. Johnson W.G. Couser Differential expression of transforming growth factor- β isoforms and receptors in experimental membranous nephropathy Kidney Int 50 1996 116 124
53. N. Sanderson V. Factor P. Nagy J. Kopp P. Kondaiah L. Wakefield A.B. Roberts M.B. Sporn S.S. Thorgeirsson Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions Proc Natl Acad Sci USA 92 1995 2572 2576
54. J.B. Kopp V.M. Factor M. Mozes P. Nagy N. Sanderson E.P. Böttinger P.E. Klotman S.S. Thorgeirsson Transgenic mice with increased plasma levels of TGF- β 1 develop progressive renal disease Lab Invest 74 1996 991 1003
55. J.J. Letterio A.G. Geiser A.B. Kulkarni N.S. Roche M.B. Sporn A.B. Roberts Maternal rescue of transforming growth factor-beta 1 null mice Science 264 1994 1936 1938
56. R.M. Stach D.A. Rowley A first or dominant immunization. II. Induced immunoglobulin carries transforming growth factor beta and suppresses cytolytic T cell responses to unrelated alloantigens J Exp Med 178 1993 841 852
57. D.A. Rowley E.T. Becken R.M. Stach Autoantibodies produced spontaneously by young lpr mice carry transforming growth factor beta and suppress cytotoxic T lymphocyte responses J Exp Med 181 1995 1875 1880
58. L.M. Wakefield T.S. Winokur R.S. Hollands K. Christopherson A.D. Levinson M.B. Sporn Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution J Clin Invest 86 1990 1976 1984
59. V. Ivanovic A. Melman B. Davis-Joseph M. Valcic J. Geliebter Elevated plasma levels of TGF- β 1 in patients with invasive prostate cancer Nature Med 1 1995 282 284
60. M.S. Anscher W.P. Peters H. Reisenbichler W.P. Petros R.L. Jirtle Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer N Engl J Med 328 1993 1592 1598
61. G. Zauli G. Visani L. Catani N. Vianelli L. Gugliotta S. Capitani Reduced responsiveness of bone marrow megakaryocyte progeni tors to platelet-derived transforming growth factor beta 1, produced in normal amount, in patients with essential thrombocythaemia Br J Haematol 83 1993 14 20
62. F.M. Kong M.S. Anscher T. Murase B.D. Abbott J.D. Iglehart R.L. Jirtle Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor Ann Surg 222 1995 155 162
63. D.J. Grainger P.R. Kemp J.C. Metcalfe A.C. Liu R.M. Lawn N.R. Williams A.A. Grace P.M. Schofield A. Chauhan The serum concentration of active transforming growth factor- β is severely depressed in advanced atherosclerosis Nature Med 1 1995 74 79
64. K.A. McAllister K.M. Grogg D.W. Johnson C.J. Gallione M.A. Baldwin C.E. Jackson E.A. Helmbold D.S. Markel W.C. McKinnon J. Murrell Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1 Nature Genet 8 1994 345 351
65. P. Lastres A. Letamendia H. Zhang C. Rius N. Almendro U. Raab L.A. Lopez C. Langa A. Fabra M. Letarte C. Bernabeu Endoglin modulates cellular responses to TGF- β 1 J Cell Biol 133 1996 1109 1121
66. J.G. Harpel C.N. Metz S. Kojima D.B. Rifkin Control of transforming growth factor-beta activity: Latency vs. activation Prog Growth Factor Res 4 1992 321 335
67. L.E. Gentry M.N. Lioubin A.F. Purchio H. Marquardt Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide Mol Cell Biol 8 1988 4162 4186
68. L.E. Gentry B.W. Nash The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor Biochemistry 29 1990 6851 6857
69. E.P. Böttinger V.M. Factor M.L-.S. Tsang J.A. Weatherbee J.B. Kopp S.W. Qian L.M. Wakefield A.B. Roberts S.S. Thorgeirsson M.B. Sporn The recombinant proregion of transforming growth factor β 1 (latency-associated peptide) inhibits active transforming growth factor β 1 in transgenic mice Proc Natl Acad Sci USA 93 1996 5877 5882