Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells

Biochemical and Biophysical Research Communications

Volumn 341, Issue 4, 2006, Pages 1135-1140

  Timper, Katharina ^a   Seboek, Dalma ^a   Eberhardt, Michael ^a   Linscheid, Philippe ^a   Christ Crain, Mirjam ^a   Keller, Ulrich ^a   Müller, Beat ^a   Zulewski, Henryk ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

ABCG2; Adipose tissue; Differentiation; Glucagon; Human; Insulin; Isl 1; Mesenchymal stem cells; Nestin

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; GLUCAGON; INSULIN; NESTIN; SOMATOSTATIN; STEM CELL FACTOR; THY 1 ANTIGEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IPF 1; TRANSCRIPTION FACTOR ISL 1; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; GLUCAGON RELEASE; HORMONE RELEASE; HUMAN; HUMAN CELL; INSULIN RELEASE; MESENCHYMAL STEM CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATOSTATIN RELEASE;

ADIPOSE TISSUE; ANTIGENS, THY-1; ATP-BINDING CASSETTE TRANSPORTERS; CELL DIFFERENTIATION; CELLS, CULTURED; GLUCAGON; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INTERMEDIATE FILAMENT PROTEINS; MESENCHYMAL STEM CELLS; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; SOMATOSTATIN; STEM CELL FACTOR;

ANIMALIA;

EID: 32344451060     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.01.072     Document Type: Article

References (33)

1. A.J. Friedenstein, R.K. Chailakhyan, N.V. Latsinik, A.F. Panasyuk, and I.V. Keiliss-Borok Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo Transplantation 17 1974 331 340
2. R.F. Pereira, K.W. Halford, M.D. O'Hara, D.B. Leeper, B.P. Sokolov, M.D. Pollard, O. Bagasra, and D.J. Prockop Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice Proc. Natl. Acad. Sci. USA 92 1995 4857 4861
3. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, M.A. Moorman, D.W. Simonetti, S. Craig, and D.R. Marshak Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
4. Y. Jiang, B.N. Jahagirdar, R.L. Reinhardt, R.E. Schwartz, C.D. Keene, X.R. Ortiz-Gonzalez, M. Reyes, T. Lenvik, T. Lund, M. Blackstad, J. Du, S. Aldrich, A. Lisberg, W.C. Low, D.A. Largaespada, and C.M. Verfaillie Pluripotency of mesenchymal stem cells derived from adult marrow Nature 418 2002 41 49
5. Y. Jiang, B. Vaessen, T. Lenvik, M. Blackstad, M. Reyes, and C. Verfaillie Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain Exp. Hematol. 30 2002 896
6. P.A. Zuk, M. Zhu, P. Ashjian, D.A. De Ugarte, J.I. Huang, H. Mizuno, Z.C. Alfonso, J.K. Fraser, P. Benhaim, and M.H. Hedrick Human adipose tissue is a source of multipotent stem cells Mol. Biol. Cell 13 2002 4279 4295
7. S.A. Azizi, D. Stokes, B.J. Augelli, C. DiGirolamo, and D.J. Prockop Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts Proc. Natl. Acad. Sci. USA 95 1998 3908 3913
8. E. Mezey, K.J. Chandross, G. Harta, R.A. Maki, and S.R. McKercher Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow Science 290 2000 1779 1782
9. D. Woodbury, E.J. Schwarz, D.J. Prockop, and I.B. Black Adult rat and human bone marrow stromal cells differentiate into neurons J. Neurosci. Res. 61 2000 364 370
10. Y. Jiang, D. Henderson, M. Blackstad, A. Chen, R.F. Miller, and C.M. Verfaillie Neuroectodermal differentiation from mouse multipotent adult progenitor cells Proc. Natl. Acad. Sci. USA 100 Suppl. 1 2003 11854 11860
11. G. Munoz-Elias, A.J. Marcus, T.M. Coyne, D. Woodbury, and I.B. Black Adult bone marrow stromal cells in the embryonic brain: engraftment, migration, differentiation, and long-term survival J. Neurosci. 24 2004 4585 4595
12. Y. Sato, H. Araki, J. Kato, K. Nakamura, Y. Kawano, M. Kobune, T. Sato, K. Miyanishi, T. Takayama, M. Takahashi, R. Takimoto, S. Iyama, T. Matsunaga, S. Ohtani, A. Matsuura, H. Hamada, and Y. Niitsu Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion Blood 106 2005 756 763
13. W. Vogel, F. Grunebach, C.A. Messam, L. Kanz, W. Brugger, and H.J. Buhring Heterogeneity among human bone marrow-derived mesenchymal stem cells and neural progenitor cells Haematologica 88 2003 126 133
14. U. Lendahl, L.B. Zimmerman, and R.D. McKay CNS stem cells express a new class of intermediate filament protein Cell 60 1990 585 595
15. H. Zulewski, E.J. Abraham, M.J. Gerlach, P.B. Daniel, W. Moritz, B. Muller, M. Vallejo, M.K. Thomas, and J.F. Habener Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes Diabetes 50 2001 521 533
16. D.Q. Tang, L.Z. Cao, B.R. Burkhardt, C.Q. Xia, S.A. Litherland, M.A. Atkinson, and L.J. Yang In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow Diabetes 53 2004 1721 1732
17. S. Kodama, W. Kuhtreiber, S. Fujimura, E.A. Dale, and D.L. Faustman Islet regeneration during the reversal of autoimmune diabetes in NOD mice Science 302 2003 1223 1227
18. D.A. De Ugarte, K. Morizono, A. Elbarbary, Z. Alfonso, P.A. Zuk, M. Zhu, J.L. Dragoo, P. Ashjian, B. Thomas, P. Benhaim, I. Chen, J. Fraser, and M.H. Hedrick Comparison of multi-lineage cells from human adipose tissue and bone marrow Cells Tissues Organs 174 2003 101 109
19. R.H. Lee, B. Kim, I. Choi, H. Kim, H.S. Choi, K. Suh, Y.C. Bae, and J.S. Jung Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue Cell. Physiol. Biochem. 14 2004 311 324
20. A. Dicker, K. Le Blanc, G. Astrom, V. van Harmelen, C. Gotherstrom, L. Blomqvist, P. Arner, and M. Ryden Functional studies of mesenchymal stem cells derived from adult human adipose tissue Exp. Cell Res. 308 2005 283 290
21. P. Linscheid, D. Seboek, E.S. Nylen, I. Langer, M. Schlatter, K.L. Becker, U. Keller, and B. Muller In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue Endocrinology 144 2003 5578 5584
22. S. Zhou, J.D. Schuetz, K.D. Bunting, A.M. Colapietro, J. Sampath, J.J. Morris, I. Lagutina, G.C. Grosveld, M. Osawa, H. Nakauchi, and B.P. Sorrentino The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype Nat. Med. 7 2001 1028 1034
23. A. Lechner, C.A. Leech, E.J. Abraham, A.L. Nolan, and J.F. Habener Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter Biochem. Biophys. Res. Commun. 293 2002 670 674
24. J. Cai, A. Cheng, Y. Luo, C. Lu, M.P. Mattson, M.S. Rao, and K. Furukawa Membrane properties of rat embryonic multipotent neural stem cells J. Neurochem. 88 2004 212 226
25. U. Ahlgren, S.L. Pfaff, T.M. Jessell, T. Edlund, and H. Edlund Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells Nature 385 1997 257 260
26. I. Rooman, J. Lardon, and L. Bouwens Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue Diabetes 51 2002 686 690
27. E.J. Abraham, C.A. Leech, J.C. Lin, H. Zulewski, and J.F. Habener Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells Endocrinology 143 2002 3152 3161
28. H. Mashima, H. Ohnishi, K. Wakabayashi, T. Mine, J. Miyagawa, T. Hanafusa, M. Seno, H. Yamada, and I. Kojima Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells J. Clin. Invest. 97 1996 1647 1654
29. L. Yang, S. Li, H. Hatch, K. Ahrens, J.G. Cornelius, B.E. Petersen, and A.B. Peck In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells Proc. Natl. Acad. Sci. USA 99 2002 8078 8083
30. H. Kojima, M. Fujimiya, K. Matsumura, T. Nakahara, M. Hara, and L. Chan Extrapancreatic insulin-producing cells in multiple organs in diabetes Proc. Natl. Acad. Sci. USA 101 2004 2458 2463
31. A. Ianus, G.G. Holz, N.D. Theise, and M.A. Hussain In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion J. Clin. Invest. 111 2003 843 850
32. A. Lechner, Y.G. Yang, R.A. Blacken, L. Wang, A.L. Nolan, and J.F. Habener No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo Diabetes 53 2004 616 623
33. Y. Dor, J. Brown, O.I. Martinez, and D.A. Melton Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation Nature 429 2004 41 46