Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology

Journal of Bone and Mineral Research

Volumn 16, Issue 12, 2001, Pages 2192-2204

  Locklin, R M ^a   Riggs, B L ^a   Hicok, K C ^a   Horton, H F ^b,c   Byrne, M C ^b,c   Khosla, S ^a  

^a MAYO CLINIC   (United States)

^b PFIZER INC   (United States)

^c Genetics Institute Wyeth Research   (United States)

Author keywords

Bone morphogenetic protein 2; Gene array; Osteoblasts; Stromal cells; Transcription factors

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CELL SURFACE PROTEIN; GROWTH FACTOR; HELIX LOOP HELIX PROTEIN; RNA; TRANSCRIPTION FACTOR;

ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RNA ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035200233     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.12.2192     Document Type: Article

References (52)

1. Bone: Formation by auto-induction
2. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
3. Human type II receptor for bone morphogenetic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
4. Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts
5. The tumour suppressor Smad4/DPC 4 as a central mediator of Smad function
6. Differentiation of human MS precursor cells: Bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation
7. Preparation of mRNA for expression monitoring
8. Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma
9. Immortalized osteoblast cell system (new human fetal osteoblast system)
10. Stromal stem cells: Marrow-derived osteogenic precursors
11. Osteogenic stem cells and the stromal system of bone and marrow
12. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
13. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
14. Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: Identification of functionally conserved residues common to Id proteins
15. Molecular cloning of the cDNA encoding a helix-loop-helix protein, mouse ID1B: Tissue-specific expression of ID1A and ID1B genes
16. Identification of a DNA sequence involved in osteoblast-specific gene expression via interaction with helix-loop-helix (HLH)-type transcription factors
17. Differential biological activities of mammalian Id proteins in muscle cells
18. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins
19. Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors
20. Id-1 as a possible transcriptional mediator of muscle disuse atrophy
21. Id3 prevents differentiation of preadipose cells
22. Bone morphogenetic protein 2 transiently enhances expression of a gene Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells
23. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
24. Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7
25. Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD-1/SREBP-1c) Trans factors for the regulation of fatty acid synthase promoter in adipocytes
26. Helix-loop-helix transcription factors regulate Id2 gene promoter activity
27. The E-box motif, recognized by tissue-specific nuclear factor(s), is important for BMP-4 gene expression in osteogenic cells
28. JunB is involved in the inhibition of myogenic differentiation by bone morphogenetic protein-2
29. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer
30. Signal transduction by bone morphogenetic protein receptors: Functional roles of SMAD proteins
31. Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development
32. Distalless and other homeobox genes in the development of the dentition
33. Dlx and other homeobox genes in the morphological development of the dentition
34. Role of D1x-1 and D1x-2 genes in patterning of the murine dentition
35. Role of the D1x homeobox genes in proximodistal patterning of the branchial arches: Mutations of Dlx-1, Dlx-2 and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches
36. The origin and evolution of animal appendages
37. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
38. Groucho acts as a corepressor for a subset of negative regulators, including hairy and engrailed
39. Groucho-dependent and -independent repression activities of runt domain proteins
40. 3 enhancement of osteopontin gene expression
41. The mammalian basic helix-loop-helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa-1
42. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction
43. Intefieukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gene using CCAAT/enhancer binding protein-beta (C/EBP-β)
44. Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells
45. A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
46. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
47. Differentiation dependent expression and distinct subcellular localization of the protooncogene product PEBP2beta/CBFbeta, in muscle development
48. Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
49. DNA binding through distinct domains of zinc-finger-homeodomain protein AREB6 has different effects on gene transcription
50. Diversification pattern of the HMG and SOX family members during evolution
51. Regulation of the expression and activity by progestins of a member of the SOX gene family of transcriptional modulators
52. Roles of SOX4 in central nervous system development