Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential

Haematologica

Volumn 88, Issue 8, 2003, Pages 845-852

  In 't Anker, Pieternella S ^a   Noort, Willy A ^a   Scherjon, Sicco A ^a   Kleijburg Van der Keur, Carin ^a   Kruisselbrink, Alwine B ^a   Van Bezooijen, Rutger L ^a   Beekhuizen, Willem ^b   Willemze, Roelof ^a   Kanhai, Humphrey H H ^a   Fibbe, Willem E ^c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Center of Human Reproduction   (Netherlands)

^c Department of Hematology ^*  (Netherlands)

Author keywords

Fetal tissues; Limiting dilution assay; Mesenchymal stem cells; Multilineage differentiation potential

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; CD34 ANTIGEN; CD45 ANTIGEN; ENDOGLIN; HLA ANTIGEN; HLA DR ANTIGEN; SH3 ANTIGEN; SH4 ANTIGEN; THY 1 ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BONE DEVELOPMENT; BONE MARROW; CELL DIFFERENTIATION; CELL HETEROGENEITY; DILUTION; FETUS; FETUS (ANATOMY); FETUS LIVER; FETUS LUNG; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; MESENCHYME CELL; PHENOTYPE; PROTEIN EXPRESSION; SPLEEN; STEM CELL; TISSUE CULTURE CELL;

ABORTION, LEGAL; ADIPOCYTES; ANTIGENS, CD34; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; FETUS; GRANULOCYTES; HUMANS; IMMUNOPHENOTYPING; LIVER; LUNG; LYMPHOCYTES; MESODERM; MONOCYTES; MULTIPOTENT STEM CELLS; OSTEOCYTES; PREGNANCY; PREGNANCY TRIMESTER, SECOND; SPLEEN;

EID: 0141426714     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Caplan AI. The mesengenic process. Clin Plast Surg 1994;21:429-35.
2. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
3. Bianco P, Gehron RP. Marrow stromal stem cells. J Clin Invest 2000;105:1663-8.
4. Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 2000;28:875-84.
5. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-4.
6. Zvaifler NJ, Marinova-Mutafchieva L, Adams G, Edwards CJ, Moss J, Burger JA, et al. Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res 2000;2:477-88.
7. Nakahara H, Dennis JE, Bruder SP, Haynesworth SE, Lennon DP, Caplan AI. In vitro differentiation of bone and hyertrophic cartilage from per periosteal-derived cells. Exp Cell Res 1991;195:492-503.
8. Nathanson MA. Bone matrix-directed chondrogenesis of muscle in vitro. Clin Orthop 1985;200:142-58.
9. Haynesworth SE, Goldberg VM, Caplan AI. Diminution of the number of mesenchymal stem cells as a cause for skeletal aging. In: Buckwalter JA, Goldberg VM, Woo SY, eds. Musculoskeletal soft-tissue aging: impact on mobility. 1994. p. 79-86.
10. Campagnoli C, Roberts IA, Kumar S, Bennett PR, Bellantuono I, Fisk NM. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 2001;98:2396-402.
11. Noort WA, Kruger M, Wilpshaar J, Willemze R, Falkenburg JHF. A candidate mesenchymal stem cell from human fetal lung tissue. Blood 1999;94:42a[bstract].
12. Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999;5:309-13.
13. Horwitz EM, Prockop DJ, Gordon PL, Koo WW, Fitzpatrick LA, Neel MD, et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 2001;97:1227-31.
14. Noort WA, Kruisselbrink AB, in 't Anker PS, Kruger M, van Bezooijen RL, de Paus RA, et al. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol 2002;30:870.
15. Almeida-Porada G, Porada CD, Tran N, Zanjani ED. Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood 2000;95:3620-7.
16. Almeida-Porada G, Flake AW, Glimp HA, Zanjani ED. Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero. Exp Hematology 1999;27:1569-75.
17. Dennis JE, Charbord P. Origin and differentiation of human and murine stroma. Stem Cells 2002;20:205-14.
18. Gratama JW, Kraan J, Levering W, Van Bockstaele DR, Rijkers GT, van der Schoot CE. Analysis of variation in results of CD34+ hematopoietic progenitor cell enumeration in a multicenter study. Cytometry 1997;30:109-17.
19. Dang ZC, van Bezooijen RL, Karperien M, Papapoulos SE, Lowik CW. Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res 2002;17:394-405.
20. Schiller PC, D'Ippolito G, Roos BA, Howard GA. Anabolic or catabolic responses of MC3T3-E1 osteoblastic cells to parathyroid hormone depend on time and duration of treatment. J Bone Miner Res 1999;14:1504-12.
21. Labarca C, Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 1980;102:344-52.
22. Bonnefoix T, Bonnefoix P, Verdiel P, Sotto JJ. Fitting limiting dilution experiments with generalized linear models results in a test of the single-hit Poisson assumption. J Immunol Methods 1996;194:113-9.
23. Simmons PJ, Torok-Storb B. CD34 expression by stromal precursors in normal human adult bone marrow. Blood 1991;78:2848-53.
24. Waller EK, Olweus J, Lund-Johansen F, Huang S, Nguyen M, Guo GR, et al. The "common stem cell" hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors. Blood 1995;85:2422-35.
25. Simmons PJ, Gronthos S, Zannettino A, Ohta S, Graves S. Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis. Prog Clin Biol Res 1994;389:271-80.
26. Kaiser S, Hackanson B, Follo M, Geiger K, Guo Y, Engelhardt M, et al. Mesenchymal stem cells can be isolated form the CD34 positive fraction of human bone marrow cells. Blood 2001;98:83a [abstract].
27. Huss R. Isolation of primary and immortalized CD34-hematopoietic and mesenchymal stem cells from various sources. Stem Cells 2000;18:1-9.