Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 307-310

  Zhong, Min ^a   Hanan, Emily J ^a   Shen, Wang ^a   Bui, Minna ^a   Arkin, Michelle R ^a   Barr, Kenneth J ^a   Evanchik, Marc J ^a   Hoch, Ute ^a   Hyde, Jennifer ^a   Martell, Jose R ^a   Oslob, Johan D ^a   Paulvannan, Kumar ^a   Prabhu, Saileta ^a   Silverman, Jeffrey A ^a   Wright, Jasmin ^a   Yu, Chul H ^a   Zhu, Jiang ^a   Flanagan, W Mike ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

Author keywords

Amino acid; (S) 2,3 Diaminopropanoic acid replacement; LFA 1 ICAM 1 antagonist; Structure activity relationship; Tetrahydroisoquinoline

Indexed keywords

2,3 DIAMINOPROPANOIC ACID; ALPHA AMINO ACID; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PROPIONIC ACID; TETRAHYDROISOQUINOLINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

AMINO ACIDS; ANIMALS; BETA-ALANINE; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 78650516916     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.014     Document Type: Article

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