Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the αl subunit of lymphocyte function-associated antigen-1

Protein Science

Volumn 15, Issue 2, 2006, Pages 290-303

  Keating, Susan M ^a,b   Clark, Kevin R ^a   Stefanich, Lisa D ^a   Arellano, Fred ^a   Edwards, Caroline P ^a,c   Bodary, Sarah C ^a,d   Spencer, Steven A ^a   Gadek, Thomas R ^b,e   Marsters Jr , James C ^b   Beresini, Maureen H ^a  

^a Department of BioAnalytical Research and Development ^*  (United States)

^b GENENTECH INC   (United States)

^c Department of Immunology ^*  (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e SARcode   (United States)

Author keywords

Antagonist; Competitive binding; ICAM 1; LFA 1; Photoaffinity labeling; Schild analysis

Indexed keywords

IMMUNOGLOBULIN G; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; SMALL MOLECULE TRANSPORT AGENT;

ALLOSTERISM; ALPHA CHAIN; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CROSS LINKING; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG INHIBITION; DRUG RECEPTOR BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR SENSITIVITY;

ALLOSTERIC REGULATION; BINDING SITES; BINDING, COMPETITIVE; CROSS-LINKING REAGENTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULIN G; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; LIGANDS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS;

EID: 31344436707     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.051583406     Document Type: Article

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