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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 1, 2005, Pages 195-201

Amino-substituted heterocycles as isosteres of trans-cinnamides: Design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding

(7) Wang, Gary T a Wang, Sheldon a Gentles, Robert a Sowin, Thomas a Leitza, Sandra a Reilly, Edward B a Von Geldern, Thomas W a

a ABBOTT LABORATORIES (United States)

Author keywords

Cell adhesion; LFA 1 ICAM 1 binding; trans Cinnamide isostere

Indexed keywords

CINNAMIC ACID DERIVATIVE; HETEROCYCLIC COMPOUND; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SULFIDE;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; PROTEIN BINDING;

AMIDES; AMINES; CELL LINE; CINNAMATES; HETEROCYCLIC COMPOUNDS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; PROTEIN BINDING;

EID: 9644290863 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2004.10.008 Document Type: Article

Times cited : (20)

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