Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: Evidence for the allosteric inhibition of a protein-protein interaction

Journal of the American Chemical Society

Volumn 123, Issue 24, 2001, Pages 5643-5650

  Last Barney, K ^a   Davidson, W ^a   Cardozo, M ^a   Frye, L L ^a   Grygon, C A ^a   Hopkins, J L ^a   Jeanfavre, D D ^a   Pav, S ^a   Qian, C ^a   Stevenson, J M ^a   Tong, L ^b   Zindell, R ^a   Kelly, T A ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES;

ADHESION; AMINO ACIDS; ANTIBODIES; ANTIGENS; CELLS; CRYSTAL STRUCTURE;

PROTEINS;

HYDANTOIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ALLOSTERISM; ARTICLE; BINDING SITE; CELL ADHESION; CRYSTAL STRUCTURE; LEUKOCYTE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR MODEL; PHOTOAFFINITY LABELING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; COMBINATORIAL CHEMISTRY TECHNIQUES; EPITOPE MAPPING; HUMANS; HYDANTOINS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MASS SPECTROMETRY; MODELS, MOLECULAR; PHOTOAFFINITY LABELS; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034816320     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0104249     Document Type: Article

References (48)