Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 7, 2007, Pages 1908-1911

  Dodd, Dharmpal S ^a   Sheriff, Steven ^a   Chang, ChiehYing J ^a   Stetsko, Dawn K ^a   Phillips, Linda M ^a   Zhang, Yingru ^a   Launay, Michele ^b   Potin, Dominique ^b   Vaccaro, Wayne ^a   Poss, Michael A ^a   McKinnon, Murray ^a   Barrish, Joel C ^a   Suchard, Suzanne J ^a   Murali Dhar, T G ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b CEREP   (France)

Author keywords

2,3 Dihydro 1H pyrrolizin 5 (7aH) one; LFA 1 antagonists; LFA 1 ICAM interaction

Indexed keywords

BIRT 377; BMS 587101; HYDANTOIN DERIVATIVE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1 ANTAGONIST; PYRROLIZINE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PYRROLES; STEREOISOMERISM; TEMPERATURE; X-RAYS;

EID: 33847635289     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.036     Document Type: Article

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