ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjögrens syndrome-like MRL/lpr mice

Experimental Eye Research

Volumn 78, Issue 4, 2004, Pages 823-835

  Gao, Jianping ^a   Morgan, Grant ^a   Tieu, David ^a   Schwalb, Tammy A ^a   Luo, Jessica Y ^a   Wheeler, Larry A ^a   Stern, Michael E ^a  

^a ALLERGAN INC   (United States)

Author keywords

Anti ICAM 1; Conjunctiva; Dry eye; Epithelial cells; Inflammation; Intercellular adhesion molecule 1; Keractoconjunctivitis sicca; Lacrimal gland; Lymphocytic homing; Lymphocytic infiltration; Ocular surface

Indexed keywords

BROXURIDINE; CD69 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 2 RECEPTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MESSENGER RNA; MONOCLONAL ANTIBODY;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CELL INFILTRATION; CELL POPULATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG EFFICACY; DRY EYE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; INFLAMMATION; KERATOCONJUNCTIVITIS SICCA; LACRIMAL GLAND DISEASE; LYMPHOCYTE ACTIVATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SJOEGREN SYNDROME; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 1342287235     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2003.10.024     Document Type: Article

References (46)

1. Albietz J.M. Dry eye: an update on clinical diagnosis, management and promising new treatments. Clin. Exp. Optom. 84:2001;4-18.
2. Andrys C., Krejsek J., Slezak R., Drahosova M., Kopecky O. Serum soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and neopterin in patients with Sjogren's syndrome. Acta Medica (Hradec Kralove). 42:1999;97-101.
3. Azzarolo A.M., Wood R.L., Mircheff A.K., Richters A., Olsen E., Berkowitz M., Bachmann M., Huang Z.M., Zolfagari R., Warren D.W. Androgen influence on lacrimal gland apoptosis, necrosis, and lymphocytic infiltration. Invest. Ophthalmol. Vis. Sci. 40:1999;592-602.
4. Baudouin C. The pathology of dry eye. Surv. Ophthalmol. 45:2001;S211-S220.
5. Baudouin C., Brignole F., Becquet F., Pisella P.J., Goguel A. Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammation. Invest. Ophthalmol. Vis. Sci. 38:1997;1458-1464.
6. Baudouin C., Brignole F., Pisella P.J., De Jean M.S., Goguel A. Flow cytometric analysis of the inflammatory marker HLA DR in dry eye syndrome: results from 12 months of randomized treatment with topical cyclosporin A. Adv. Exp. Med. Biol. 506:2002;761-769.
7. Begley C.G., Chalmers R.L., Mitchell G.L., Nichols K.K., Caffery B., Simpson T., DuToit R., Portello J., Davis L. Characterization of ocular surface symptoms from optometric practices in North America. Cornea. 20:2001;610-618.
8. Brignole F., Pisella P.J., De Saint Jean M., Goldschild M., Goguel A., Baudouin C. Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A. Invest. Ophthalmol. Vis. Sci. 42:2001;90-95.
9. Brignole F., Pisella P.J., Goldschild M., De Saint Jean M., Goguel A., Baudouin C. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest. Ophthalmol. Vis. Sci. 41:2000;1356-1363.
10. van Den Engel N.K., Heidenthal E., Vinke A., Kolb H., Martin S. Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1. Blood. 95:2000;1350-1355.
11. Doughty M.J., Blades K.A., Ibrahim N. Assessment of the number of eye symptoms and the impact of some confounding variables for office staff in non-air-conditioned buildings. Ophthalmic. Physiol. Opt. 22:2002;143-155.
12. Fox R.I. Sjogren's syndrome. Controversies and progress. Clin. Lab. Med. 17:1997;431-444.
13. Gao J., Morgan G., Tieu D.D., Schwalb T.A., Ngo M., Stern M.E. ICAM-1: its role in the pathophysiology of immune activation in the MRL/LPR mouse. Adv. Exp. Med. Biol. 506:2002;777-781.
14. Gao J., Schwalb T.A., Addeo J.V., Ghosn C.R., Stern M.E. The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical cyclosporin A therapy. Cornea. 17:1998;654-663.
15. Gearing A.J.H., Newman W. Circulating adhesion molecules in disease. Immunol. Today. 14:1993;506-512.
16. Geppert T.D., Davis L.S., Gur H., Wacholtz M.C., Lipsky P.E. Accessory cell signals involved in T-cell activation. Immunol. Rev. 117:1990;5-66.
17. Gorski A. The roll of cell adhesion molecules in immunopathology. Immunol. Today. 14:1994;506-512.
18. Guo Z., Azzarolo A., Schechter J.E., Warren D.W., Wood R.L., Mirchiff A.K., Kaslow H.R. Lacrimal gland epithelial cells stimulate proliferation in autologous lymphocyte preparations. Exp. Eye Res. 71:2000;23-31.
19. Haneji N., Nakamura T., Takio K., et al. Identification of α-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science. 276:1997;604-607.
20. Hayashi Y., Haneji N., Yanagi K., Higashiyama H., Yagita H., Hamano H. Prevention of adoptive transfer of murine Sjogren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). Clin. Exp. Immunol. 102:1995;360-367.
21. Holmlund A., Hulthe J., Millgard J., Sarabi M., Kahan T., Lind L. Soluble intercellular adhesion molecule-1 is related to endothelial vasodilatory function in healthy individuals. Atherosclerosis. 165:2002;271-276.
22. Jones D.T., Monroy D., Ji Z., Atherton S.S., Pflugfelder S.C. Sjogren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium. Invest. Ophthalmol. Vis. Sci. 35:1994;3493-3504.
23. Krejsek J., Slezak R., Kopecky O., Derner V., Andrys C. Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and beta-2-microglobulin in Sjogren's syndrome. Clin. Rheumatol. 16:1997;149-153.
24. Li Y.X., Li N., Li Y.S., Wu B., Li J.S. Upregulated intragraft gene expression, ICAM-1 and IL-2R molecules, and apoptotic epithelial cells during rejection of rat small intestine allografts. Transplant Proc. 32:2000;1283-1286.
25. Li Y., Li N., Li Y., Wu B., Li J. Up-regulated intragraft gene expression, ICAM-1 and IL-2R molecules, and apoptotic epithelial cells during rejection of rat small intestine allografts. Chin. Med. J. (Engl.). 114:2001;1089-1094.
26. Marsh P., Pflugfelder S.C. Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren syndrome. Ophthalmology. 106:1999;811-816.
27. McNamara M.P., Bjornstad K.A., Chang P.Y., Chou W., Lockett S.J., Blakely E.A. Modulation of lens cell adhesion molecules by particle beams. Phys. Med. 17:2001;247-248.
28. Mizgerd J.P., Spieker M.R., Lupa M.M. Exon truncation by alternative splicing of murine ICAM-1. Physiol. Genomics. 12:2002;47-51.
29. Nelson J.D., Helms H., Fiscella R., Southwell Y., Hirsch J.D. A new look at dry eye disease and its treatment. Adv. Ther. 17:2000;84-93.
30. Oh J.W., Shin J.C., Jang S.J., Lee H.B. Expression of ICAM-1 on conjunctival epithelium and ECP in tears and serum from children with allergic conjunctivitis. Ann. Allergy Asthma Immunol. 82:1999;579-585.
31. Patel S.J., Lundy D.C. Ocular manifestations of autoimmune disease. Am. Fam. Physician. 66:2002;991-998.
32. Pflugfelder S.C., Solomon A., Stern M.E. The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 19:2000;644-649.
33. Pisella P.J., Brignole F., Debbasch C., Lozato P.A., Creuzot-Garcher C., Bara J., Saiag P., Warnet J.M., Baudouin C. Flow cytometry analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca. Ophthalmology. 107:2000;1841-1849.
34. Rieckmann P., Weber F., Guenther A., Michel U., Martin S., Felgenhauer K. Soluble forms of intercellular adhesion molecule-1 (ICAM -1) block cellular adhesion and cytokine production in multiple sclerosis. Neurology. 45:1995;A164.
35. Rosenbaum J.T., Brito B., Han Y.B., Park J., Planck S.R. Cytokines: an overview. Adv. Exp. Med. Biol. 438:1998;441-446.
36. Saito I., Terauchi K., Shimuta M., Nishiimura S., Yoshino K., Takeuchi T., Tsubota K., Miyasaka N. Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndrome. J. Clin. Lab. Anal. 7:1993;180-187.
37. Sall K., Stevenson O.D., Mundorf T.K., Reis B.L. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology. 107:2000;631-639.
38. Springer T.A. Adhesion receptors of the immune system. Nature. 346:1990;425-434.
39. Stern M.E., Beuerman R.W., Fox R.I., Gao J., Mircheff A.K., Pflugfelder S.C. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 17:1998;584-589.
40. Stern M.E., Gao J., Schwalb T.A., Ngo M., Tieu D.D., Chan C.C., Reis B.L., Whitcup S.M., Thompson D., Smith J.A. Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye. Invest. Ophthalmol. Vis. Sci. 43:2002;2609-2614.
41. Takahashi M., Mimura Y., Hayashi Y. Role of the ICAM-1/LFA-1 pathway during the development of autoimmune dacryoadenitis in an animal model of Sjogren's syndrome. Pathobiology. 64:1996;269-274.
42. Terry M.A. Dry eye in the elderly. Drugs Aging. 18:2001;101-107.
43. Tsubota K., Fujita H., Tsuzaka K., Takeuchi T. Quantitative analysis of lacrimal gland function, apoptotic figures, Fas and Fas ligand expression of lacrimal glands in dry eye patients. Exp. Eye Res. 76:2003;233-240.
44. Tsubota K., Fukagawa K., Fujihara T., Shimmura S., Saito I., Saito K., Takeuchi T. Regulation of human leukocyte antigen expression in human conjunctival epithelium. Invest. Ophthalmol. Vis. Sci. 40:1999;28-34.
45. Westermann J., Engelhardt B., Hoffmann J.C. Migration of T cells in vivo: molecular mechanisms and clinical implication. Ann. Intern. Med. 135:2001;279-295.
46. Wilson S.E., Mohan R.R., Hong J., Lee J., Choi R., Liu J.J., Mohan R.R. Apoptosis in the cornea in response to epithelial injury: significance to wound healing and dry eye. Adv. Exp. Med. Biol. 506:2002;821-826.