An orally active, primate selective antagonist of LFA-1 inhibits delayed-type hypersensitivity in a humanized-mouse model

European Journal of Pharmacology

Volumn 534, Issue 1-3, 2006, Pages 233-240

  Panzenbeck, Maret J ^a   Jeanfavre, Deborah D ^a   Kelly, Terence A ^a   Lemieux, Rene ^a   Nabozny, Gerald ^a   Reilly, Patricia L ^a   Desai, Sudha ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Cell adhesion molecule; Delayed hypersensitivity; Lymphocyte function associated antigen 1; Receptor antagonist; T lymphocyte

Indexed keywords

1 (3,5 DICHLORO PHENYL) 3 METHYL 5 (PIPERAZINE 1 SULFONYL) 3 (4 PYRIMIDIN 5 YL BENZYL) 1H IMIDAZO[1,2 A]IMIDAZOL 2 ONE; CYCLOSPORIN; IMMUNOGLOBULIN G; LYMPHOCYTE ANTIBODY; LYMPHOCYTE FUNCTION ASSOCIATED ANTIBODY 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; TETANUS TOXOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG BLOOD LEVEL; DRUG STRUCTURE; ENANTIOMER; FEMALE; FOOT PAD; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SWELLING;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, MONOCLONAL; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FEMALE; HYPERSENSITIVITY, DELAYED; IMIDAZOLES; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; MICE, SCID; MODELS, ANIMAL; TETANUS TOXIN;

EID: 33644889890     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.01.004     Document Type: Article

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