Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 8, 2001, Pages 973-976

  Link, James T ^a   Sorensen, Bryan ^a   Liu, Gang ^a   Pei, Zhonghua ^a   Reilly, Edward B ^a   Leitza, Sandra ^a   Okasinski, Greg ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPROPANE DERIVATIVE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; SULFIDE CYCLOPROPYLAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMIDES; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CELL COMMUNICATION; CYCLOPROPANES; ENDOTHELIUM; INHIBITORY CONCENTRATION 50; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035938374     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00105-6     Document Type: Article

References (14)