Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2001, Pages 1202-1210

  Liu, G ^a   Huth, J R ^a   Olejniczak, E T ^a   Mendoza, R ^a   DeVries, P ^a   Leitza, S ^a   Reilly, E B ^a   Okasinski, G F ^a   Fesik, S W ^a   von Geldern, T W ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 THIOCINNAMIDE DERIVATIVE; ANTIINFLAMMATORY AGENT; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; IMMUNOPATHOLOGY; INFLAMMATORY DISEASE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ALLOSTERIC REGULATION; AMIDES; ANIMALS; CINNAMATES; COMBINATORIAL CHEMISTRY TECHNIQUES; INTERCELLULAR ADHESION MOLECULE-1; LIGANDS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; RATS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035848575     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000503f     Document Type: Article

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