Synthesis of lead LFA-1 antagonist [14C]spyrocyclic hydantoin

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 52, Issue 6, 2009, Pages 236-242

  Tran, Scott B ^a   Maxwell, Brad D ^a   Chen, Shiang Yuan ^a   Bonacorsi, Samuel J ^a   Leith, Leslie ^a   Ogan, Marc ^a   Rinehart, J Kent ^a   Balasubramanian, Balu ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Leukocyte function associated antigen 1 antagonist; Palladium (0) catalyzed cyanation; Zn(14CN)2

Indexed keywords

CARBOXYLATION; CATALYSIS; CYCLOADDITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PALLADIUM;

CYANATION; DIPOLAR CYCLOADDITION REACTION; DRUG LEADS; HYDANTOINS; LEUCOCYTE FUNCTION-ASSOCIATED ANTIGEN 1 ANTAGONIST; LEUCOCYTES; METHOXYMETHYL; PALLADIUM (0) CATALYZED CYANATION; RADIOCHEMICAL YIELD; ZN(14CN)2;

ANTIGENS;

5 [(( 9 (4 (CARBON 14) CYAPHENYL) 3 (3,5 DICHLOROPHENYL) 1 METHYL 2,4 DIOXO 1,3,7 TRIAZASPIRO[4.4]NONAN 7 YL)METHYL] THIOPHENENE 3 CARBOXYLIC ACID; BROMIDE; CARBOXYLIC ACID DERIVATIVE; LEUKOCYTE FUNCTION ASSOCIATED ANTIGEN 1 ANTAGONIST; PALLADIUM; RADIOPHARMACEUTICAL AGENT; SPYROCYCLIC HYDANTOIN CARBON 14; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLIZATION; CYANATION; DRUG PURIFICATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; QUANTUM YIELD; RADIOCHEMISTRY;

EID: 66949115057     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1596     Document Type: Article

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