IL-7 and lymphopenia

Clinica Chimica Acta

Volumn 412, Issue 1-2, 2011, Pages 7-16

  Ponchel, Frederique ^a   Cuthbert, Richard J ^a   Goëb, Vincent ^a,b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ROUEN UNIVERSITY HOSPITAL   (France)

Author keywords

Autoimmunity; Cancer; Cytokine; HIV; Homeostasis; Therapy

Indexed keywords

ANTIVIRUS AGENT; CYTOKINE ANTIBODY; INTERLEUKIN 7; INTERLEUKIN 7 ANTIBODY; INTERLEUKIN 7 RECEPTOR; RECOMBINANT INTERLEUKIN 7; UNCLASSIFIED DRUG;

AGING; BONE MASS; CANCER GROWTH; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL MATURATION; CLINICAL TRIAL; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; ENTERITIS; FEVER; GENE EXPRESSION REGULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IDIOPATHIC DISEASE; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INJECTION SITE ERYTHEMA; LYMPHOCYTOPENIA; MELANOMA; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; NONHUMAN; OSTEOCLASTOGENESIS; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSORIASIS; RARE DISEASE; REVIEW; RHEUMATOID ARTHRITIS; SARCOMA; SERUM GROUP GC SYSTEM; SIGNAL TRANSDUCTION; SOLID TUMOR; SYSTEMIC LUPUS ERYTHEMATOSUS; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION; THYMUS;

ANIMALS; AUTOIMMUNITY; HOMEOSTASIS; HUMANS; INTERLEUKIN-7; LYMPHOPENIA; T-LYMPHOCYTES;

EID: 78650514849     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.09.002     Document Type: Review

References (177)

1. Napolitano L.A., Grant R.M., Deeks S.G., et al. Increased production of IL-7 accompanies HIV-l-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 2001, 7(1):73-79.
2. Fry T.J., Connick E., Falloon J., et al. A potential role for interleukin-7 in T-cell homeostasis. Blood 2001, 97(10):2983-2990.
3. Costa E., Lima M., Rocha S., et al. IL-7 serum levels and lymphopenia in hemodialysis patients, non-responders to recombinant human erythropoietin therapy. Blood Cells Mol Dis 2008, 41(1):134-135.
4. Malaspina A., Moir S., Chaitt D.G., et al. Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7. Blood 2007, 109(5):2086-2088.
5. Fry T.J., Mackall C.L. Interleukin-7: master regulator of peripheral T-cell homeostasis?. Trends Immunol 2001, 22(10):564-571.
6. Bolotin E., Annett G., Parkman R., Weinberg K. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant 1999, 23(8):783-788.
7. Cox A.L., Thompson S.A.J., Jones J.L., et al. Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis. Eur J Immunol 2005, 35(11):3332-3342.
8. Ponchel F., Verburg R., Bingham S., et al. and J. isaacs, IL-7 deficiency and therapy-induced lymphopenia in rheumatoid arthritis. Arthritis Res Ther 2005, 7:82-92.
9. Peschon J.J., Morrissey P.J., Grabstein K.H., et al. Early lymphocyte expansion is severely impaired in interleukin-7 receptor-deficient mice. J Exp Med 1994, 180(5):1955-1960.
10. Vonfreedenjeffry U., Vieira P., Lucian L.A., McNeil T., Burdach S.E.G., Murray R. Lymphopenia in interleukin (Il)-7 gene-deleted mice identifies Il-7 as a nonredundant cytokine. J Exp Med 1995, 181(4):1519-1526.
11. Suzuki H., Kundig T., Furlonger C., et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor ?. Science 1995, 268:1472-1476.
12. Rodig S., Meraz M., White J., et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell Death Differ 1998, 93:373-383.
13. Foxwell B., Beadling C., Guschin D., Kerr I., Cantrell D. Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells. Eur J Immunol 1995, 25:3041-3046.
14. Wofford J.A., Wieman H.L., Jacobs S.R., Zhao Y.X., Rathmell J.C. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 2008, 111(4):2101-2111.
15. Fresno Vara J.A., Casado E., de Castro J., Cejas P., Belda-Iniesta C., Gonzalez-Baron M. PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 2004, 30(2):193-204.
16. Chan, T.O. and P.N. Tsichlis, PDK2: a complex tail in one Akt. Sci STKE, 2001. 2001(66): p. pe1.
17. Barata J.T., Silva A., Brandao J.G., Nadler L.M., Cardoso A.A., Boussiotis V.A. Activation of P13K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med 2004, 200(5):659-669.
18. Juntilla M.A., Koretzky G.A. Critical roles of the PI3K/Akt signaling pathway in T cell development. Immunol Lett 2008, 116(2):104-110.
19. Mazzucchelli R., Durum S. Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol 2007, 7:144-154.
20. Page T., Lali F., Foxwell B. Interleukin-7 activates p56lck and p59fyn, two tyrosine kinases associated with the p90 interleukin-7 receptor in primary human T cells. Eur J Immunol 1995, 25. 2956±60.
21. van-Oers N., Killeen N., Weiss A. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J Exp Med 1996, 183. 1053±62.
22. Crawley J., Willcocks J., Foxwell B. Interleukin-7 induces T cell proliferation in the absence of Erk/MAP kinase activity. Eur J Immunol 1996, 26:2717-2723.
23. Dudley D., Pang L., Decker S., Bridges A., Saltiel A. A synthetic inhibitor of the mitogen-activated protein kinase cas- cade. Proc Natl Acad Sci USA 1995, 92:7686-7689.
24. Crawley J., Rawlinson L., Lali F., Page T., Saklatvala J., Foxwell B. T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation. J Biol Chem 1997, 272:15023-15027.
25. Chehtane M., Khaled A.R. Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene. Am J Physiol Cell Physiol 2010, 298(6):C1560-C1571.
26. AbdulHai A., Or R., Slavin S., et al. Stimulation of immune reconstitution by interleukin-7 after syngeneic bone marrow transplantation in mice. Exp Hematol 1996, 24(12):1416-1422.
27. Ben Yehuda A., Wirtheim E., Abdulhai A., et al. Activation of the recombination activating gene 1 (RAG-1) transcript in bone marrow of senescent C57BL/6 mice by recombinant interleukin-7. J Gerontol Ser Biol Sci Med Sci 1999, 54(4):B143-B148.
28. Fry T.J., Mackall C.L. Interleukin-7: from bench to clinic. Blood 2002, 99(11):3892-3904.
29. Puel A., Ziegler S.F., Buckley R.H., Leonard W.J. Defective IL7R expression in T-B+NK+ severe combined immunodeficiency. Nat Genet 1998, 20(4):394-397.
30. Vella A.T., Dow S., Potter T., Kappler J., Marrack P. Cytokine induced survival of activated T-cells in vitro and in vivo. Proc Natl Acad Sci USA 1998, 95:3810-3815.
31. Boise L.H., Minn A.J., June C.H., Lindsten T., Thompson C.B. Growth-factors can enhance lymphocyte survival without committing the cell to undergo cell-division. Proc Natl Acad Sci USA 1995, 92(12):5491-5495.
32. Fry T.J., Christensen B.L., Komschlies K.L., Gress R.E., Mackall C.L. Interleukin-7 restores immunity in athymic T-cell-depleted hosts. Blood 2001, 97(6):1525-1533.
33. Soares M., Borthwick N., Maini M., Janossy G., Salmon M., Akbar A. IL-7 dependent extrathymic expansion of CD45RA+T cells enables preservation of a naïve repertoire. J Immunol 1998, 161:5909-5917.
34. Webb L.M.C., Foxwell B.M.J., Feldmann M. Putative role for interleukin-7 in the maintenance of the recirculating naive CD4(+) T-cell pool. Immunology 1999, 98(3):400-405.
35. Brenchley J.M., Douek D., Ambrozak D.R., Chatterjee M., Betts M.R., Davis L.S. Expansion of activiated human naive T-cells precedes effector function. Clin Exp Immunol 2002, 130:431-440.
36. Bradley L.M., Haynes L., Swain S.L. IL-7: maintaining T-cell memory and achieving homeostasis. Trends Immunol 2005, 26(3):172-176.
37. Li J., Huston G., Swain S.L. IL-7 promotes the transition of CD4 effectors to persistent memory cells. J Exp Med 2003, 198(12):1807-1815.
38. Bayer A.L., Lee J.Y., de la Barrera A., Surh C.D., Malek T.R. A function for IL-7R for CD4(+)CD25(+)Foxp3(+) T regulatory cells. J Immunol 2008, 181(1):225-234.
39. Passerini L., Allan S.E., Battaglia M., et al. STAT5-signaling cytokines regulate the expression of FOXP3 in CD4(+)CD25(+) regulatory T cells and CD4(+)CD25(-) effector T cells. Int Immunol 2008, 20:421-431.
40. Broers A.E.C., Posthumus-van Sluijs S.J., Spits H., et al. Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants. Blood 2003, 102(4):1534-1540.
41. Thornton A.M., Piccirillo C.A., Shevach E.M. Activation requirements for the induction of CD4(+)CD25(+) T cell suppressor function. Eur J Immunol 2004, 34(2):366-376.
42. Churchman S., Ponchel F. IL-7 in rheumatoid arthritis. Rheumatology 2008, 6:753-759.
43. Bertolino E., Reddy K., Medina K.L., Parganas E., Ihle J., Singh H. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat Immunol 2005, 6(8):836-843.
44. Marquez C., Trigueros C., Fernandez E., Toribio M.L. The development of T-cell and non-T-cell lineages from Cd34(+) human thymic precursors can be traced by the differential expression of Cd44. J Exp Med 1995, 181(2):475-483.
45. Varas A., Vicente A., Sacedon R., Zapata A.G. Interleukin-7 influences the development of thymic dendritic cells. Blood 1998, 92(1):93-100.
46. Takahashi K., Honeyman M.C., Harrison L.C. Dendritic cells generated from human blood in granulocyte macrophage-colony stimulating factor and interleukin-7. Hum Immunol 1997, 55(2):103-116.
47. Sorg R.V., McLellan A.D., Hock B.D., Fearnley D.B., Hart D.N.J. Human dendritic cells express functional interleukin-7. Immunobiology 1998, 198(5):514-526.
48. Mehrotra P.T., Grant A.J., Siegel J.P. Synergistic effects of Il-7 and Il-12 on human t-cell activation. J Immunol 1995, 154(10):5093-5102.
49. de Saint-Vis B., Fugier-Vivier I., Massacrier C., et al. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J Immunol 1998, 160(4):1666-1676.
50. Gringhuis S.I., deLeij L., Verschuren E.W., Borger P., Vellenga E. Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1. Blood 1997, 90(7):2690-2700.
51. Borger P., Kauffman H.F., Postma D.S., Vellenga E. IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms. J Immunol 1996, 156(4):1333-1338.
52. von Freeden-Jeffry U., Davidson N., Wiler R., Fort M., Burdach S., Murray R. IL-7 deficiency prevents development of a non-T cell non-B cell-mediated colitis. J Immunol 1998, 161(10):5673-5680.
53. Kee B.L., Bain G., Murre C. IL-7R alpha and E47: independent pathways required for development of multipotent lymphoid progenitors. EMBO J 2002, 21(1-2):103-113.
54. Lum J.J., Schnepple D.J., Nie Z.L., et al. Differential effects of interleukin-7 and interleukin-15 on NK cell anti-human immunodeficiency virus activity. J Virol 2004, 78(11):6033-6042.
55. Lee S.K., Surh C.D. Role of interleukin-7 in bone and T-cell homeostasis. Immunol Rev 2005, 208:169-180.
56. Lee S., Kalinowski J.F., Cabrera-Hernandez A., Adams D., Gronowicz G., Lorenzo J.A. Interleukin-7 influences osteoclast and osteoblast function in vivo but is not a critical factor in ovariectomy-induced bone loss. J Bone Miner Res 2003, 18. S327-S327.
57. Nutt S.L., Heavey B., Rolink A.G., Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999, 401(6753):556-562.
58. Weitzmann M.N., Roggia C., Toraldo G., Weitzmann L., Pacifici R. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Investig 2002, 110(11):1643-1650.
59. Miyaura C., Onoe Y., Inada M., et al. Increased B-lymphopoiesis by IL-7 treatment induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. J Bone Miner Res 1997, 12. 93-93.
60. Weitzmann M.N., Cenci S., Rifas L., Brown C., Pacifici R. Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines. Blood 2000, 96(5):1873-1878.
61. Mebius R.E. Organogenesis of lymphoid tissues. Nat Rev Immunol 2003, 3(6). 509-509.
62. Yoshida H., Naito A., Inoue J., et al. Different cytokines induce surface lymphotoxin-alpha beta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches. Immunity 2002, 17(6):823-833.
63. Meier D., Bornmann C., Chappaz S., et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity 2007, 26:643-654.
64. Borghesi L.A., Yamashita Y., Kincade P.W. Heparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis. Blood 1999, 93(1):140-148.
65. Clarke D., Katoh O., Gibbs R.V., Griffiths S.D., Gordon M.Y. Interaction of interleukin-7 (Il-7) with glycosaminoglycans and its biological relevance. Cytokine 1995, 7(4):325-330.
66. Kimura K., Matsubara H., Sogoh S., et al. Role of glycosaminoglycans in the regulation of T-cell proliferation induced by thymic stroma-derived T-cell growth- factor. J Immunol 1991, 146(8):2618-2624.
67. Sempowski G.D., Hale L.P., Sundy J.S., et al. Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J Immunol 2000, 164(4):2180-2187.
68. Papadaki H.A., Kritikos H.D., Gemetzi C., et al. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. Blood 2002, 99(5):1610-1619.
69. van Roon J., Verweij M., Wenting-van Wijk M., Jacobs K., Bijlsma J., LafeberFloris P. Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4+ T cells and macrophages. Arthritis Rheum 2005, 52(6):1700-1710.
70. Harada S., Yamamura M., Okamoto H., et al. Production of interleukin-7 and interleukin-15 by fibroblast- like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum 1999, 42(7):1508-1516.
71. Rose T., Lambotte O., Pallier C., et al. Identification and Biochemical Characterization of Human Plasma Soluble IL-7R: Lower Concentrations in HIV-1-Infected Patients. J Immunol 2009, 182:7389-7397.
72. Ariizumi K., Meng Y., Bergstresser P.R., Takashima A. Ifn-gamma-dependent Il-7 gene-regulation in keratinocytes. J Immunol 1995, 154(11):6031-6039.
73. Tang J.H., Nuccie B.L., Ritterman I., Liesveld J.L., Abboud C.N., Ryan D.H. TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors. J Immunol 1997, 159(1):117-125.
74. Korte A., Moricke A., Beyermann B., et al. Extensive alternative splicing of interleukin-7 in malignant hematopoietic cells: implication of distinct isoforms in modulating IL-7 activity. J Interferon Cytokine Res 1999, 19(5):495-503.
75. Yen J.J.Y., Huang H.W., Chiang Y.J., Hung S.L. An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis. J Immunol 2006, 176. S319-S319.
76. Vudattu N.K., Magalhaes I., Hoehn H., Pan D., Maeurer M.J. Expression analysis and functional activity of interleukin-7 splice variants. Genes Immun 2009, 10(2):132-140.
77. Moors M., Vudattu N.K., Abel J., et al. Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells. Genes Immun 2010, 11(1):11-20.
78. Hoe E., McKay F.C., Schibeci S.D., et al. Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. J Immunol 2010, 184(5):2512-2517.
79. Rane L., Vudattu N., Bourcier K., et al. Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7R alpha) in peripheral blood from patients with multiple sclerosis (MS). J Neuroimmunol 2010, 222(1-2):82-86.
80. Kittipatarin C., Khaled A. Interlinking interleukin-7. Cytokine 2007, 39:75-83.
81. Seddon B., Tomlinson P., Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 2003, 4(7):680-686.
82. Surh C.D., Sprent J. Homeostasis of naive and memory T cells. Immunity 2008, 29(6):848-862.
83. Goldrath A.W., Benoist C., Mathis D. Interplay of T cell receptor and IL-7 receptor mediated survival of naive T cells. FASEB J 2002, 16(4). A345-A345.
84. Schluns K.S., Kieper W.C., Jameson S.C., Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 2000, 1(5):426-432.
85. Tan J.T., Dudl E., LeRoy E., et al. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci USA 2001, 98(15):8732-8737.
86. Park J.-H., Yu Q., Erman B., et al. Suppression of IL7R[alpha] transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 2004, 21(2):289-302.
87. Fluur C., Rethi B., Thang P.H., et al. Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control. AIDS 2007, 21(8):1048-1050.
88. Chandele A., Joshi N.S., Zhu J.F., Paul W.E., Leonard W.J., Kaech S.M. Formation of IL-7R alpha(high) and IL-7R alpha(low) CD8 T cells during infection is regulated by the opposing functions of GABP alpha and Gfi-1. J Immunol 2008, 180(8):5309-5319.
89. Akbar A.N., Fletcher J.M. Memory T cell homeostasis and senescence during aging. Curr Opin Immunol 2005, 17(5):480.
90. Douek D.C., McFarland R.D., Keiser P.H., et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998, 396(6712):690-695.
91. Aspinall R. Age-associated thymic atrophy in the mouse due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J Immunol 1997, 158(7):3037-3045.
92. Holland A., van den Brink M. Rejuvenation of the aging T cell compartment. Curr Opin Immunol 2009, 21:1-6.
93. Duncan R., von Reyn C., Alliegro G., Toossi Z., Sugar A., Levitz S. Idiopathic CD4+ T-lymphocytopenia: four patients with opportunistic infections and no evidence of HIV infection. N Engl J Med 1993, 328:393-398.
94. Goëb V., Peter H., Sibilia J. Systemic manifestations of primary immune and Fas deficiencies. Eular compendium of rheumatic diseases 2009, BMJ Publishing group and EULAR.
95. Puri V., Chaudhry N., Gulati P., Patel N., Tatke M., Sinha S. Progressive multifocal leukoencephalopathy in a patient with idiopathic CD4±T lymphocytopenia. Neurol India 2010, 58:118-121.
96. Scott-Algara D., Balabanian K., Chakrabarti L., et al. Idiopathic CD4± T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4. Blood 2010, 115:3708-3717.
97. Yilmaz-Demirdag Y., Wilson B., Lowery-Nordberg M., Bocchini J.J., Bahna S. Interleukin-2 treatment for persistent cryptococcal meningitis in a child with idiopathic CD4(±) T lymphocytopenia. Allergy Asthma Proc 2008, 29:421-424.
98. Llano A., Barretina J., Gutierrez A., et al. Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type 1-positive individuals. J Virol 2001, 75(21):10319-10325.
99. Darcissac E.C.A., Vidal V., De La Tribonniere X., Mouton Y., Bahr G.M. Variations in serum IL-7 and 90K/Mac-2 binding protein (Mac-2 BP) levels analysed in cohorts of HIV-1 patients and correlated with clinical changes following antiretroviral therapy. Clin Exp Immunol 2001, 126(2):287-294.
100. Boulassel M.R., Smith G.H.R., Gilmore N., et al. Interleukin-7 levels may predict virological response in advanced HIV-1-infected patients receiving lopinavir/ritonavir-based therapy. HIV Med 2003, 4(4):315-320.
101. Dardalhon V., Jaleco S., Kinet S., et al. IL-7 differentially regulates cell cycle progression and HIV-1- based vector infection in neonatal and adult CD4(+) T cells. Proc Natl Acad Sci USA 2001, 98(16):9277-9282.
102. Steffens C.M., Managlia E.Z., Landay A., Al-Harthi L. Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1. Blood 2002, 99(9):3310-3318.
103. Unutmaz D., KewalRamani V.N., Marmon S., Littman D.R. Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J Exp Med 1999, 189(11):1735-1746.
104. Juffroy O., Bugault F., Lambotte O., et al. Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. J Virol 2010, 84(1):96-108.
105. Chen I., Lai Y., Wu C., et al. Immune impairment in patients with terminal cancers: influence of cancer treatments and cytomegalovirus infection. Cancer Immunol Immunother 2009, 10.1007/s00262-009-0753-0.
106. Di Carlo E., D'Antuono T., Pompa P., et al. The lack of epithelial interleukin-7 and BAFF/BLyS gene expression in prostate cancer as a possible mechanism of tumor escape from immunosurveillance. Clin Cancer Res 2009, 15.
107. Calzascia T., Pellegrini M., Lin A., et al. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci USA 2008, 105(8):2999-3004.
108. Dias A.M., do Couto M.C., Duarte C.C., Ines L.P., Malcata A.B. White blood cell count abnormalities and infections in one-year follow-up of 124 patients with SLE. Ann NY Acad Sci 2009, 1173:103-107.
109. Goëb V., Salle V., Duhaut P., et al. Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrom. Clin Exp Immunol 2007, 148:281-287.
110. Kao A., Manzi S., Ramsey-Goldman R. Review of ACR hematologic criteria in systemic lupus erythematosus. Lupus 2004, 13865-13868.
111. Dhir V., Singh A., Aggarwal A., N.S., Misra R. Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: a cross-sectional and longitudinal study. Lupus 2009, 18:785-791.
112. Tikly M., Navarra S. Lupus in the developing world: is it any different?. Best Pract Res Clin Rheumatol 2008, 22:643-655.
113. Schulze-Koops H. Lymphopenia and autoimmune diseases. Arthritis Res Ther 2004, 6(4):178-180.
114. Ruiz-Argüelles A. The role of complement regulatory proteins (CD55 and CD59) in the pathogenesis of autoimmune hemocytopenias. Autoimmun Rev 2007, 6:155-161.
115. Lim M., Sheen D., Kim S., et al. IAN5 polymorphisms are associated with systemic lupus erythematosus. Lupus 2009, 18:1045-1052.
116. Hellquist A., Zucchelli M., Kivinen K., et al. The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus. J Med Genet 2007, 44:314-321.
117. Baechler E.C., Gregersen P.K., Behrens T.W. The emerging role of interferon in human systemic lupus erythematosus. Curr Opin Immunol 2004, 16:801-807.
118. Massardo L., Metz C., Pardo E., et al. Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Lupus 2009, 18:539-546.
119. Bertero M.T., Converso M., Aimo G., Merico F. Serum levels of cytokines and soluble (S) CD23 in systemic lupus-erythematosus. Fundam Clin Immunol 1994, 2(1):37-43.
120. Graninger W.B., Steiner C.W., Graninger M.T., Aringer M., Smolen J.S. Cytokine regulation of apoptosis and Bcl-2 expression in lymphocytes of patients with systemic lupus erythematosus. Cell Death Differ 2000, 7(10):966-972.
121. Cosenza L., Gorgun G., Urbano A., et al. Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cell Signal 2002, 14:317-325.
122. Lundmark F., Duvefelt K., Hillert J. Genetic association analysis of the interleukin 7 gene (IL7) in multiple sclerosis. J Neuroimmunol 2007, 192(1-2):171-173.
123. Harley J. IL-7Rβ and multiple sclerosis risk. Nat Genet 2007, 39:1053-1054.
124. Lu A., Clark J., Ran R., et al. Down-regulation of interleukin 7 mRNA by hypoxia is calcium dependent. Neurol Res 2009, 31:545-549.
125. Rane L., Vudattu N., Bourcier K., et al. Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Rα) in peripheral blood from patients with multiple sclerosis (MS). J Neuroimmunol 2010, 222:82-86.
126. Moors M., Vudattu N.K., Abel J., et al. Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells. Genes Immun 2010, 11:11-20.
127. Muraro P., Douek D., Packer A., et al. Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J Exp Med 2005, 201:805-816.
128. Isaacs J.D., Greer S., Sharma S., et al. Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia. Arthritis Rheum 2001, 44(9):1998-2008.
129. Bingham S., Veale D., Fearon U., et al. Long-term follow-up of highly selected autologous stem cell transplantation in severe rheumatoid arthritis with studies of peripheral blood reconstitution and macroscopic and histological arthroscopic appearances. Arthritis Rheum 2000, 43(9):1340.
130. Verburg R.J., van den Hoogen F.H.J., Schattenberg A., et al. High dose cyclophosphamide followed by autologous stem cell transplantation for the treatment of intractable rheumatoid arthritis (RA). Arthritis Rheum 2000, 43(9):1339.
131. Mackall C.L., Fry T.J., Bare C., Morgan P., Galbraith A., Gress R.E. IL-7 increases both thymic-dependent and thymic-independent T- cell regeneration after bone marrow transplantation. Blood 2001, 97(5):1491-1497.
132. Goldberg G., Zakrzewski J., Perales M., van den Brink M. Clinical strategies to enhance T cell reconstitution. Semin Immunol 2007, Epub ahead of print.
133. Seggewiss R., Lore K., Guenaga F., et al. Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 2007, 110:441-449.
134. Weigent D., Baxter J., Wear W., Smith L., Bost K., Blalock J. Production of immunoreactive growth hormone by mononuclear leukocytes. FASEB J 1988, 2:2812-2818.
135. Alpdogan O., Schmaltz C., Muriglan S.J., et al. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 2001, 98(7):2256-2265.
136. Bolotin E., Smogorzewska M., Smith S., Widmer M., Weinberg K. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood 1996, 88(5):1887-1894.
137. Sportes C., Hakim F., Memon S., et al. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med 2008, 205:1701-1714.
138. Rosenberg S., Sportes C., Ahmadzadeh M., Fry T., Ngo L., Schwarz S., et al. IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells. J Immunother 2006, 29:313-319.
139. Davis C., Marti L., Sempowski G., Jeyaraj D., Szabolcs P. Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation. Cancer Res 2010, 70:5249-5258.
140. Theze J. CD4 lymphocytes as targets and actors in the pathogenesis of HIV infection-therapeutic implications. Bull Acad Natl Méd 2008, 192:1453-1468.
141. Levy Y., Lacabaratz C., Weiss L., et al. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest 2009, 119(4):997-1007.
142. Sereti I., Dunham R.M., Spritzler J., et al. IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood 2009, 113(25):6304-6314.
143. Younes S., Yassine-Diab B., Dumont A., Boulassel M., Grossman Z., et al. HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+T cells endowed with proliferative capacity. J Exp Med 2003, 198:1909-1922.
144. Iyasere C., Tilton J., Johnson A., Younes S., Yassine-Diab B., et al. Diminished proliferation of human immunodeficiency virus-specific CD4+T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2. J Virol 2003, 77:10900-10909.
145. Schwartz R.H. T-cell anergy. Sci Am 1993, 269(2). 62-&.
146. Beverly B., Kang S., Lenardo M., Schwartz R. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int Immunol 1992, 4:661-671.
147. Gu X., Yue F., Kovacs C., Ostrowsk M. The role of cytokines which signal through the common γ chain cytokine receptor in the reversal of HIV specific CD4+ and CD8+ T cell anergy. PLoS ONE 2007, e300. 10.1371/journal.pone.0000300.
148. El Kassar N., Gress R. An overview of IL-7 biology and its use in immunotherapy. J Immunotoxicol 2009, 10.3109/15476910903453296.
149. Melchionda F., Fry T., Milliron M., McKirdy M., Tagaya Y., Mackall C. Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool. J Clin Invest 2005, 115:1177-1187.
150. Gattinoni L., Finkelstein S., Klebanoff C., et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J Exp Med 2005, 202:907-912.
151. Fry T.J., Mackall C.L. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol 2005, 174(11):6571-6576.
152. Baxevanis C.N., Perez S.A., Papamichail M. Cancer immunotherapy. Crit Rev Clin Lab Sci 2009, 46(4):167-189.
153. Lynch D.H., Miller R.E. Interleukin-7 promotes long-term in-vitro growth of antitumor cytotoxic T-lymphocytes with immunotherapeutic efficacy in-vivo. J Exp Med 1994, 179(1):31-42.
154. Bielekova B., Muraro P.A., Golestaneh L., Pascal J., McFarland H.F., Martin R. Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7. J Neuroimmunol 1999, 100(1-2):115-123.
155. Traggiai E., Biagioli T., Rosati E., Ballerini C., Mazzanti B., Ben Nun A., Massacesi L., Vergelli M. IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis. J Neuroimmunol 2001, 121(1-2):111-119.
156. Bebo B., Schuster J., Adlard K., Vandenbark A., Offner H. IL-7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis. Cytokine 2000, 12:324-331.
157. Liu X., Leung S., Wang C., Tan Z., Wang J., Guo T., Fang L., Zhao Y., Wan B., Qin X., Lu L., Li R., Pan H., Song M., Liu A., Hong J., Lu H., Zhang J. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med 2010, 16:191-198.
158. Hartgring S.A.Y., Bijlsma J.W.J., Lafeber F., van Roon J.A.G. Interleukin-7 induced immunopathology in arthritis. Ann Rheum Dis 2006, 65:69-74.
159. Dalloul A., Laroche L., Bagot M., et al. Interleukin-7 is a growth-factor for sezary lymphoma-cells. J Clin Investig 1992, 90(3):1054-1060.
160. Watanabe M., Ueno Y., Yajima T., et al. Interleukin-7 is produced by human intestinal epithelial-cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Investig 1995, 95(6):2945-2953.
161. Szepietowski J.C., Bielicka E., Nockowski P., Noworolska A., Wasik F. Increased interleukin-7 levels in the sera of psoriatic patients: lack of correlations with interleukin-6 levels and disease intensity. Clin Exp Dermatol 2000, 25(8):643-647.
162. Pietrzak A., Zalewska A., Chodorowska G., et al. Genes and structure of selected cytokines involved in pathogenesis of psoriasis. Folia Histochem Cytobiol 2008, 46(1):11-21.
163. Okada E., Yamazaki M., Tanabe M., et al. IL-7 exacerbates chronic colitis with expansion of memory IL-7R(high) CD4(+) mucosal T cells in mice. Am J Physiol Gastrointest Liver Physiol 2005, 288(4):G745-G754.
164. Tomita T., Kanai T., Totsuka T., et al. IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol 2009, 39(10):2737-2747.
165. Capitini C.M., Chisti A.A., Mackall C.L. Modulating T-cell homeostasis with IL-7: preclinical and clinical studies. J Intern Med 2009, 266(2):141-153.
166. Natsumeda M., Nishiya K., Ota Z. Stimulation by interleukin-7 of mononuclear-cells in peripheral-blood, synovial-fluid and synovial tissue from patients with rheumatoid-arthritis. Acta Med Okayama 1993, 47(6):391-397.
167. Timmer T., Baltus B., Vondenhoff M., et al. Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis. Arthritis Rheum 2007, 56:2492-2502.
168. Kraan T., van Gaalen F.A., Kasperkovitz P.V., et al. Rheumatoid arthritis is a heterogeneous disease-evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. Arthritis Rheum 2003, 48(8):2132-2145.
169. Makino T., Fukushima S., Wakasugi S., Ihn H. Decreased serum IL-7 levels in patients with systemic sclerosis. Clin Exp Rheumatol 2009, 27(3 Suppl 54):68-69.
170. van Roon J.A.G., Glaudemans K., Bijlsma J.W.J., Lafeber F. Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis. Ann Rheum Dis 2003, 62(2):113-119.
171. van Roon J.A.G., Glaudemans C.A., Bijlsma J.W.J., Lafeber F. Differentiation of naive CD4(+) T cells towards T helper 2 cells is not impaired in rheumatoid arthritis patients. Arthritis Res Ther 2003, 5(5):R269-R276.
172. Lee S., Kalinowski J., Adams D.J., Aguila H.L., Lorenzo J.A. Osteoblast specific overexpression of human interleukin-7 rescues the bone phenotype of interleukin-7 deficient female mice. J Bone Miner Res 2005, 20(9). S48-S48.
173. Sawa S., Kamimura D., Jin G.H., et al. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4(+) T cells. J Exp Med 2006, 203(6):1459-1470.
174. van Roon, J., S. Hartgring, F. Broere, et al., Blockade of the high affinity Il-7 receptor inhibits proteoglycan-induced arthritis. Annals of the Rheumatic Disease 2009. EWRR Annual Meeting-A64.
175. Hartgring, S., G. Willis, J. Bijlsma, F. Lafeber, and J. van Roon, IL-7 receptor ligands IL-7 and thymic stromal lymphopoietin promote collagen-induced arthritis in the absence of T-cell expansion. Annals of the Rheumatic Disease 2009. EWRR annual meeting - A71.
176. Jones E., English A., Kinsey S., Straszynski L., Emery P., Ponchel F., McGonagle D. Optimization of a flow cytometry-based protocol for detection and phenotypic characterisation of uncultured multipotent mesenchymal stromal cells from human bone marrow. JCC 2006.
177. Reece R., Canete J., Parsons W., et al. Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis. Arthritis Rheum 1999, 42:1481-1484.