Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients 1

Journal of Immunology

Volumn 182, Issue 12, 2009, Pages 7389-7397

  Rose, Thierry ^a   Lambotte, Olivier ^b   Pallier, Coralie ^b   Delfraissy, Jean François ^b   Colle, Jean Hervé ^c  

^a INSTITUT PASTEUR   (France)

^b BICÊTRE HOSPITAL   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 7 RECEPTOR ALPHA; MEMBRANE RECEPTOR; SPLICED LEADER RNA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 7; MESSENGER RNA;

ADULT; ARTICLE; BINDING AFFINITY; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; DEGLYCOSYLATION; DOWN REGULATION; GEL ELECTROPHORESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN PURIFICATION; T LYMPHOCYTE; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; BLOOD; CELL CULTURE; CHEMISTRY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; MASS SPECTROMETRY; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN SYNTHESIS; SOLUBILITY;

ADULT; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; CELLS, CULTURED; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; INTERLEUKIN-7; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MASS SPECTROMETRY; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; SOLUBILITY;

EID: 67649158212     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900190     Document Type: Article

References (36)

1. Goodwin, R. G., D. Friend, S. F. Ziegler, R. Jerzy, B. A. Falk, S. Gimpel, D. Cosman, S. K. Dower, C. J. March, A. E. Namen, et al. 1990. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60: 941-951.
2. Noguchi, M., Y. Nakamura, S. M. Russell, S. F. Ziegler, M. Tsang, X. Cao, and W. J. Leonard. 1993. Interleukin-2 receptor γ chain: a functional component of the interleukin-7 receptor. Science 262: 1877-1880. (Pubitemid 24041859)
3. c-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol. Rev. 202: 67-83.
4. Pandey, A., K. Ozaki, H. Baumann, S. D. Levin, A. Puel, A. G. Farr, S. F. Ziegler, W. J. Leonard, and H. F. Lodish. 2000. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat. Immunol. 1: 59-64.
5. Park, L. S., U. Martin, K. Garka, B. Gliniak, J. P. Di Santo, W. Muller, D. A. Largaespada, N. G. Copeland, N. A. Jenkins, A. G. Farr, et al. 2000. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor. J. Exp. Med. 192: 659-670.
6. Fry, T. J., and C. L. Mackall. 2005. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol. 174: 6571-6576.
7. Park, J. H., Q. Yu, B. Erman, J. S. Appelbaum, D. Montoya-Durango, H. L. Grimes, and A. Singer. 2004. Suppression of IL7Rα transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 21: 289-302.
8. Alves, N. L., E. M. van Leeuwen, I. A. Derks, and R. A. van Lier. 2008. Differential regulation of human IL-7 receptor α expression by IL-7 and TCR signaling. J. Immunol. 180: 5201-5210.
9. Colle, J. H., J. L. Moreau, A. Fontanet, O. Lambotte, M. Joussemet, J. F. Delfraissy, and J. Theze. 2006. CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients-reversal by highly active anti-retroviral therapy (HAART). Clin. Exp. Immunol. 143: 398-403.
10. Colle, J. H., J. L. Moreau, A. Fontanet, O. Lambotte, J. F. Delfraissy, and J. Theze. 2007. The correlation between levels of IL-7Rα expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients. AIDS 21: 101-103.
11. Bolotin, E., G. Annett, R. Parkman, and K. Weinberg. 1999. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant. 23: 783-788. (Pubitemid 29186888)
12. Napolitano, L. A., R. M. Grant, S. G. Deeks, D. Schmidt, S. C. De Rosa, L. A. Herzenberg, B. G. Herndier, J. Andersson, and J. M. McCune. 2001. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat. Med. 7: 73-79.
13. Fry, T. J., and C. L. Mackall. 2001. Interleukin-7: master regulator of peripheral T-cell homeostasis? Trends Immunol. 22: 564-571.
14. Sportes, C., F. T. Hakim, S. A. Memon, H. Zhang, K. S. Chua, M. R. Brown, T. A. Fleisher, M. C. Krumlauf, R. R. Babb, C. K. Chow, et al. 2008. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J. Exp. Med. 205: 1701-1714.
15. -/- mice. Cell 89: 1011-1019.
16. Khaled, A. R., W. Q. Li, J. Huang, T. J. Fry, A. S. Khaled, C. L. Mackall, K. Muegge, H. A. Young, and S. K. Durum. 2002. Bax deficiency partially corrects interleukin-7 receptor α deficiency. Immunity 17: 561-573.
17. Jiang, Q., W. Q. Li, R. R. Hofmeister, H. A. Young, D. R. Hodge, J. R. Keller, A. R. Khaled, and S. K. Durum. 2004. Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members. Mol. Cell. Biol. 24: 6501-6513.
18. Heaney, M. L., and D. W. Golde. 1996. Soluble cytokine receptors. Blood 87: 847-857.
19. Levine, S. J. 2008. Molecular mechanisms of soluble cytokine receptor generation. J. Biol. Chem. 283: 14177-14181.
20. Peters, M., A. M. Muller, and S. Rose-John. 1998. Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis. Blood 92: 3495-3504. (Pubitemid 28525172)
21. Pleiman, C. M., S. D. Gimpel, L. S. Park, H. Harada, T. Taniguchi, and S. F. Ziegler. 1991. Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter. Mol. Cell. Biol. 11: 3052-3059.
22. Colle, J. H., P. B. Falanga, M. Singer, B. Hevin, and G. Milon. 1997. Quantitation of messenger RNA by competitive RT-PCR: a simplified read out assay. J. Immunol. Methods 210: 175-184.
23. Pfaffl, M. W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29: e45.
24. Choumet, V., A. Carmi-Leroy, C. Laurent, P. Lenormand, J. C. Rousselle, A. Namane, C. Roth, and P. T. Brey. 2007. The salivary glands and saliva of Anopheles gambiae as an essential step in the Plasmodium life cycle: a global proteomic study. Proteomics 7: 3384-3394.
25. Taylor, K. M., A. R. Trimby, and A. K. Campbell. 1997. Mutation of recombinant complement component C9 reveals the significance of the N-terminal region for polymerization. Immunology 91: 20-27.
26. Meissner, U., H. Blum, M. Schnare, M. Rollinghoff, and A. Gessner. 2001. A soluble form of the murine common γ chain is present at high concentrations in vivo and suppresses cytokine signaling. Blood 97: 183-191.
27. Colle, J. H., J. L. Moreau, A. Fontanet, O. Lambotte, M. Joussemet, S. Jacod, J. F. Delfraissy, and J. Theze. 2006. Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients- effects of antiretroviral therapy. J. Acquir/ Immune Defic. Syndr. 42: 277-285.
28. + T cells is reduced in HIV infection and partially restored with effective antiretroviral therapy. J Acquir. Immune Defic. Syndr. 28: 454-457.
29. Sasson, S. C., J. J. Zaunders, G. Zanetti, E. M. King, K. M. Merlin, D. E. Smith, K. K. Stanley, D. A. Cooper, and A. D. Kelleher. 2006. Increased plasma interleukin-7 level correlates with decreased CD127 and increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. J. Infect. Dis. 193: 505-514.
30. + T cells. Int. Immunol. 19: 1329-1339.
31. Fujita, N., Y. Okamoto, Y. Gotoh, Y. Yada, Y. Suzuki, T. Ando, H. Togari, and M. Nishida. 2005. Serum evaluation of the balance between soluble interleukin-2 and interleukin-4 receptors. Cytokine 32: 143-148.
32. Rickert, M., M. J. Boulanger, N. Goriatcheva, and K. C. Garcia. 2004. Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its α, β, and γ(c) receptors. J. Mol. Biol. 339: 1115-1128.
33. Hafler, D. A., A. Compston, S. Sawcer, E. S. Lander, M. J. Daly, P. L. De Jager, P. I. de Bakker, S. B. Gabriel, D. B. Mirel, A. J. Ivinson, et al. 2007. Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 357: 851-862.
34. Gregory, S. G., S. Schmidt, P. Seth, J. R. Oksenberg, J. Hart, A. Prokop, S. J. Caillier, M. Ban, A. Goris, L. F. Barcellos, et al. 2007. Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat. Genet. 39: 1083-1091.
35. Lundmark, F., K. Duvefelt, E. Iacobaeus, I. Kockum, E. Wallstrom, M. Khademi, A. Oturai, L. P. Ryder, J. Saarela, H. F. Harbo, et al. 2007. Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis. Nat Genet. 39: 1108-1113.
36. McKay, F. C., L. I. Swain, S. D. Schibeci, J. P. Rubio, T. J. Kilpatrick, R. N. Heard, G. J. Stewart, and D. R. Booth. 2008. Haplotypes of the interleukin 7 receptor α gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes Immun. 9: 1-6.