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Volumn 18, Issue 9, 2009, Pages 785-791

Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: A cross-sectional and longitudinal study

Author keywords

Anti nucleosomal antibody; Lymphocyte apoptosis; Lymphocyte frequencies; Pathogenesis of lupus; Systemic lupus erythematosus

Indexed keywords

AZATHIOPRINE; CD19 ANTIGEN; CD3 ANTIGEN; CYCLOPHOSPHAMIDE; HYDROXYCHLOROQUINE; INTERLEUKIN 10; LIPOCORTIN 5; NUCLEOSOME ANTIBODY; PREDNISOLONE;

EID: 67650637733     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203309103152     Document Type: Article
Times cited : (53)

References (30)
  • 1
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 1317-1330.
    • (1994) J Exp Med , vol.179 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 2
    • 0034327194 scopus 로고    scopus 로고
    • Anti-SSA/Ro and anti- SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages
    • Miranda-Carus ME, Askanase AD, Clancy RM, et al. Anti-SSA/Ro and anti- SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages. J Immunol 2000; 165: 5345-5351.
    • (2000) J Immunol , vol.165 , pp. 5345-5351
    • Miranda-Carus, M.E.1    Askanase, A.D.2    Clancy, R.M.3
  • 3
    • 27344447126 scopus 로고    scopus 로고
    • Sources of autoantigens in systemic lupus erythematosus
    • Graham KL, Utz PJ. Sources of autoantigens in systemic lupus erythematosus. Curr Opin Rheumatol 2005; 17: 513-517.
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 513-517
    • Graham, K.L.1    Utz, P.J.2
  • 4
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356: 314-317.
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 5
    • 0025939204 scopus 로고
    • Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    • Strasser A, Whittingham S, Vaux DL, et al. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci U S A 1991; 88: 8661-8665.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 8661-8665
    • Strasser, A.1    Whittingham, S.2    Vaux, D.L.3
  • 6
    • 0031278436 scopus 로고    scopus 로고
    • Fas ligand expression and function in systemic lupus erythematosus
    • McNally J, Yoo DH, Drappa J, et al. Fas ligand expression and function in systemic lupus erythematosus. J Immunol 1997; 159: 4628-4636.
    • (1997) J Immunol , vol.159 , pp. 4628-4636
    • McNally, J.1    Yoo, D.H.2    Drappa, J.3
  • 7
    • 0028330345 scopus 로고
    • Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus
    • Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994; 152: 3685-3692.
    • (1994) J Immunol , vol.152 , pp. 3685-3692
    • Emlen, W.1    Niebur, J.2    Kadera, R.3
  • 8
    • 0030778080 scopus 로고    scopus 로고
    • Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand
    • Georgescu L, Vakkalanka RK, Elkon KB, Crow MK. Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand. J Clin Invest 1997; 100: 2622-2633.
    • (1997) J Clin Invest , vol.100 , pp. 2622-2633
    • Georgescu, L.1    Vakkalanka, R.K.2    Elkon, K.B.3    Crow, M.K.4
  • 9
    • 0032862392 scopus 로고    scopus 로고
    • Lymphocyte apoptosis in systemic lupus erythematosus: Relationships with Fas expression, serum soluble Fas and disease activity
    • Courtney PA, Crockard AD, Williamson K, McConnell J, Kennedy RJ, Bell AL. Lymphocyte apoptosis in systemic lupus erythematosus: Relationships with Fas expression, serum soluble Fas and disease activity. Lupus 1999; 8: 508-513.
    • (1999) Lupus , vol.8 , pp. 508-513
    • Courtney, P.A.1    Crockard, A.D.2    Williamson, K.3    McConnell, J.4    Kennedy, R.J.5    Bell, A.L.6
  • 10
    • 0031884870 scopus 로고    scopus 로고
    • High levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosus
    • Perniok A, Wedekind F, Herrmann M, Specker C, Schneider M. High levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosus. Lupus 1998; 7: 113-118.
    • (1998) Lupus , vol.7 , pp. 113-118
    • Perniok, A.1    Wedekind, F.2    Herrmann, M.3    Specker, C.4    Schneider, M.5
  • 11
    • 0030634282 scopus 로고    scopus 로고
    • Defective phagocytosis of apoptotic cells: Possible explanation for the induction of autoantibodies in SLE
    • Kalden JR. Defective phagocytosis of apoptotic cells: Possible explanation for the induction of autoantibodies in SLE. Lupus 1997; 6: 326-327.
    • (1997) Lupus , vol.6 , pp. 326-327
    • Kalden, J.R.1
  • 12
    • 0035849176 scopus 로고    scopus 로고
    • Advances in immunology: Complement: Second of two parts
    • WalporS MJ. Advances in immunology: Complement: second of two parts. N Engl J Med 2001; 344: 1140-1144.
    • (2001) N Engl J Med , vol.344 , pp. 1140-1144
    • Walport, M.J.1
  • 13
    • 1842334483 scopus 로고    scopus 로고
    • In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases
    • Lorenz HM, Grünke M, Hieronymus T, et al. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 1997; 40: 306-317.
    • (1997) Arthritis Rheum , vol.40 , pp. 306-317
    • Lorenz, H.M.1    Grünke, M.2    Hieronymus, T.3
  • 14
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation?
    • Hill AB. The environment and disease: Association or causation? Proc R Soc Med 1965; 58: 295-300.
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 15
    • 33644868337 scopus 로고    scopus 로고
    • Peripheral blood lymphocyte apoptosis and circulating dendritic cells in patients with systemic lupus erythematosus: Correlation with immunological status and disease-related symptoms
    • Robak E, Sysa-Jedrzejowska A, Robak T, Smolewski P. Peripheral blood lymphocyte apoptosis and circulating dendritic cells in patients with systemic lupus erythematosus: Correlation with immunological status and disease-related symptoms. Clin Rheumatol 2006; 25: 225-233.
    • (2006) Clin Rheumatol , vol.25 , pp. 225-233
    • Robak, E.1    Sysa-Jedrzejowska, A.2    Robak, T.3    Smolewski, P.4
  • 16
    • 33745839779 scopus 로고    scopus 로고
    • Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus
    • Xue C, Lan-Lan W, Bei C, Jie C, Wei-Hua F. Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus. Cell Immunol 2006; 239: 121-128.
    • (2006) Cell Immunol , vol.239 , pp. 121-128
    • Xue, C.1    Lan-Lan, W.2    Bei, C.3    Jie, C.4    Wei-Hua, F.5
  • 17
    • 0036024138 scopus 로고    scopus 로고
    • Increased T-lymphocyte apoptosis/necrosis and IL-10 producing cells in patients and their spouses in Icelandic systemic lupus erythematosus multicase families
    • Gröndal G, Traustadottir KH, Kristjansdottir H, et al. Increased T-lymphocyte apoptosis/necrosis and IL-10 producing cells in patients and their spouses in Icelandic systemic lupus erythematosus multicase families. Lupus 2002; 11: 435-442.
    • (2002) Lupus , vol.11 , pp. 435-442
    • Gröndal, G.1    Traustadottir, K.H.2    Kristjansdottir, H.3
  • 18
    • 0035063121 scopus 로고    scopus 로고
    • A possible role of apoptosis for regulating autoreactive responses in systemic lupus erythematosus
    • Funauchi M, Sugiyama M. SukYoo, B, et al. A possible role of apoptosis for regulating autoreactive responses in systemic lupus erythematosus. Lupus 2001; 10: 284-288.
    • (2001) Lupus , vol.10 , pp. 284-288
    • Funauchi, M.1    Sugiyama, M.2    SukYoo, B.3
  • 19
    • 0018227014 scopus 로고
    • Lymphopenia in systemic lupus erythematosus. Clinical, diagnostic, and prognostic significance
    • Rivero SJ, Díaz-Jouanen E, Alarcón-Segovia D. Lymphopenia in systemic lupus erythematosus. Clinical, diagnostic, and prognostic significance. Arthritis Rheum 1978; 21: 295-305.
    • (1978) Arthritis Rheum , vol.21 , pp. 295-305
    • Rivero, S.J.1    Díaz-Jouanen, E.2    Alarcón-Segovia, D.3
  • 20
    • 33750339734 scopus 로고    scopus 로고
    • Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: Association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual
    • Lumina Study Group
    • Vilá LM, Alarcón GS, McGwin Jr G, Bastian HM, Fessler BJ, Reveille JD; Lumina Study Group. Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: Association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual. Arthritis Rheum 2006; 55: 799-806.
    • (2006) Arthritis Rheum , vol.55 , pp. 799-806
    • Vilá, L.M.1    Alarcón, G.S.2    McGwin Jr., G.3    Bastian, H.M.4    Fessler, B.J.5    Reveille, J.D.6
  • 21
  • 23
    • 27744575802 scopus 로고    scopus 로고
    • The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus
    • Wang H, Xu J, Ji X, et al. The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus. Cell Immunol 2005; 235: 117-121.
    • (2005) Cell Immunol , vol.235 , pp. 117-121
    • Wang, H.1    Xu, J.2    Ji, X.3
  • 24
    • 0037269781 scopus 로고    scopus 로고
    • Enhancement of T cell apoptosis correlates with increased serum levels of soluble Fas (CD95/Apo-1) in active lupus
    • Silvestris F, Grinello D, Tucci M, Cafforio P, Dammacco F. Enhancement of T cell apoptosis correlates with increased serum levels of soluble Fas (CD95/Apo-1) in active lupus. Lupus 2003; 12: 8-14.
    • (2003) Lupus , vol.12 , pp. 8-14
    • Silvestris, F.1    Grinello, D.2    Tucci, M.3    Cafforio, P.4    Dammacco, F.5
  • 25
    • 0017193876 scopus 로고
    • Study of lymphocyte subpopulations in normal humans and patients with systemic lupus erythematosus by fractionation of peripheral blood lymphocytes on a discontinuous Ficoll gradient
    • Glinski W, Gershwin ME, Budman DR, Steinberg AD. Study of lymphocyte subpopulations in normal humans and patients with systemic lupus erythematosus by fractionation of peripheral blood lymphocytes on a discontinuous Ficoll gradient. Clin Exp Immunol 1976; 26: 228-238.
    • (1976) Clin Exp Immunol , vol.26 , pp. 228-238
    • Glinski, W.1    Gershwin, M.E.2    Budman, D.R.3    Steinberg, A.D.4
  • 26
    • 0015898116 scopus 로고
    • Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus
    • Messner RP, Lindström FD, Williams Jr RC. Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus. J Clin Invest 1973; 52: 3046-3056.
    • (1973) J Clin Invest , vol.52 , pp. 3046-3056
    • Messner, R.P.1    Lindström, F.D.2    Williams Jr., R.C.3
  • 27
    • 0015786877 scopus 로고
    • Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus
    • Lies RB, Messner RP, Williams Jr RC. Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus. Arthritis Rheum 1973; 16: 369-375.
    • (1973) Arthritis Rheum , vol.16 , pp. 369-375
    • Lies, R.B.1    Messner, R.P.2    Williams Jr., R.C.3
  • 28
    • 0015441547 scopus 로고
    • Age-decrease of cells sensitive to an autoantibody-specific for thymocytes and thymus-dependent lymphocytes in NZB mice
    • Shirai T, Yoshiki T, Mellors RC. Age-decrease of cells sensitive to an autoantibody-specific for thymocytes and thymus-dependent lymphocytes in NZB mice. Clin Exp Immunol 1972; 12: 455-464.
    • (1972) Clin Exp Immunol , vol.12 , pp. 455-464
    • Shirai, T.1    Yoshiki, T.2    Mellors, R.C.3
  • 29
    • 0028911126 scopus 로고
    • Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): A possible mechanism for lymphopenia
    • Amasaki Y, Kobayashi S, Takeda T, et al. Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): A possible mechanism for lymphopenia. Clin Exp Immunol. 1995; 99: 245-250.
    • (1995) Clin Exp Immunol , vol.99 , pp. 245-250
    • Amasaki, Y.1    Kobayashi, S.2    Takeda, T.3
  • 30
    • 0021367846 scopus 로고
    • Glucocorticoid activation of a calciumdependent endonuclease in thymocyte nuclei leads to cell death
    • Cohen JJ, Duke RC. Glucocorticoid activation of a calciumdependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 1984; 132: 38-42.
    • (1984) J Immunol , vol.132 , pp. 38-42
    • Cohen, J.J.1    Duke, R.C.2


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