Functionally significant differences in expression of disease-associated IL-7 receptor α haplotypes in CD4 T cells and dendritic cells

Journal of Immunology

Volumn 184, Issue 5, 2010, Pages 2512-2517

  Hoe, Edwin ^a   McKay, Fiona C ^a   Schibeci, Stephen D ^a   Gandhi, Kaushal ^a   Heard, Rob N ^a   Stewart, Graeme J ^a   Booth, David R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7 RECEPTOR ALPHA; MESSENGER RNA; THYMIC STROMAL LYMPHOPOIETIN; CYTOKINE; INTERLEUKIN 17; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 7 RECEPTOR, ALPHA CHAIN; INTERLEUKIN-7 RECEPTOR, ALPHA CHAIN; ISOPROTEIN;

ARTICLE; BLOOD LEVEL; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE PREDISPOSITION; FEMALE; HAPLOTYPE; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL; ALTERNATIVE RNA SPLICING; CELL CULTURE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; GENETICS; GENOTYPE; HELPER CELL; METABOLISM; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALTERNATIVE SPLICING; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION PROFILING; GENOTYPE; HAPLOTYPES; HOMEOSTASIS; HUMANS; INTERLEUKIN-17; MALE; MULTIPLE SCLEROSIS; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, INTERLEUKIN-7; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS;

EID: 77951910573     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902900     Document Type: Article

References (41)

1. Robertson, N. P., J. I. O'Riordan, J. Chataway, D. P. Kingsley, D. H. Miller, D. Clayton, and D. A. Compston. 1997. Offspring recurrence rates and clinical characteristics of conjugal multiple sclerosis. Lancet 349: 1587-1590.
2. Booth, D. R., A. T. Arthur, S. M. Teutsch, C. Bye, J.Rubio, P. J. Armati, J. D. Pollard, R. N. Heard, G. J. Stewart, and Southern MS Genetics Consortium. 2005. Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. J. Mol. Med. 83: 822-830.
3. International Multiple Sclerosis Genetics Consortium. 2008. Refining genetic associations in multiple sclerosis. Lancet Neurol. 7: 567-569.
4. Australia and New Zealand Multiple Sclerosis Genetics Consortium. 2009. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat. Genet. 41: 824-828.
5. De Jager, P. L., X. Jia, J. Wang, P. I. de Bakker, L. Ottoboni, N. T. Aggarwal, L. Piccio, S. Raychaudhuri, D. Tran, C. Aubin, et al. 2009. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat. Genet. 41: 776-782.
6. Teutsch, S. M., D. R. Booth, B. H. Bennetts, R. N. Heard, and G. J. Stewart. 2003. Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis. Eur. J. Hum. Genet. 11: 509-515.
7. McKay, F. C., L. I. Swain, S. D. Schibeci, J. P. Rubio, T. J. Kilpatrick, R. N. Heard, G. J. Stewart, and D. R. Booth. 2008. Haplotypes of the interleukin 7 receptor a gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes Immun. 9: 1-6.
8. Gregory, S. G., S. Schmidt, P. Seth, J. R. Oksenberg, J. Hart, A. Prokop, S. J. Caillier, M. Ban, A. Goris, L. F. Barcellos, et al. 2007. Interleukin 7 receptor a chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat. Genet. 39: 1083-1091.
9. Todd, J. A., N. M. Walker, J. D. Cooper, D. J. Smyth, K. Downes, V. Plagnol, R. Bailey, S. Nejentsev, S. F. Field, F. Payne, et al. 2007. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat. Genet. 39: 857-864.
10. Shamim, Z., L. P. Ryder, C. Heilmann, H. Madsen, H. Lauersen, P. K. Andersen, A. Svejgaard, N. Jacobsen, and K. Müller. 2006. Genetic polymorphisms in the genes encoding human interleukin-7 receptor-a: prognostic significance in allogeneic stem cell transplantation. Bone Marrow Transplant. 37: 485-491.
11. Liu, Y. J., V. Soumelis, N. Watanabe, T. Ito, Y. H. Wang, Rde. W. Malefyt, M. Omori, B. Zhou, and S. F. Ziegler. 2007. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu. Rev. Immunol. 25: 193-219.
12. Giliani, S., P. Mella, G. Savoldi, and E. Mazzolari. 2005. Cytokine-mediated signalling and early defects in lymphoid development. Curr. Opin. Allergy Clin. Immunol. 5: 519-524.
13. Weiner, H. L. 2009. The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann. Neurol. 65: 239-248.
14. Trickett, A., and Y. L. Kwan. 2003. T cell stimulation and expansion using anti- CD3/CD28 beads. J. Immunol. Methods 275: 251-255. (Pubitemid 36351559)
15. Harbertson, J., E. Biederman, K. E. Bennett, R. M. Kondrack, and L. M. Bradley. 2002. Withdrawal of stimulation may initiate the transition of effector to memory CD4 cells. J. Immunol. 168: 1095-1102. (Pubitemid 34094473)
16. Bettelli, E., T. Korn, and V. K. Kuchroo. 2007. Th17: the third member of the effector T cell trilogy. Curr. Opin. Immunol. 19: 652-657.
17. + regulatory T cells suppress Th1 mediated experimental colitis. Gut 55: 671-680.
18. + T cells: IL-2 and IL-7 differentially regulate the balance between proliferation and Fas-mediated apoptosis. J. Immunol. 171: 61-68.
19. Swainson, L., E. Verhoeyen, F. L. Cosset, and N. Taylor. 2006. IL-7Rα gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes. J. Immunol. 176: 6702-6708. (Pubitemid 43787853)
20. Gringhuis, S. I., L. F. de Leij, E. W. Verschuren, P. Borger, and E. Vellenga. 1997. Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1. Blood 90: 2690-2700.
21. Willems, F., F. Andris, D. Xu, D. Abramowicz, M. Wissing, M. Goldman, and O. Leo. 1995. The induction of human T cell unresponsiveness by soluble anti- CD3 mAb requires T cell activation. Int. Immunol. 7: 1593-1598.
22. Langenkamp, A., M. Messi, A. Lanzavecchia, and F. Sallusto. 2000. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat. Immunol. 1: 311-316.
23. Abbas, A. R., D. Baldwin, Y. Ma, W. Ouyang, A. Gurney, F. Martin, S. Fong, M. van Lookeren Campagne, P. Godowski, P. M. Williams, et al. 2005. Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data. Genes Immun. 6: 319-331.
24. Hashimoto, S. I., T. Suzuki, S. Nagai, T. Yamashita, N. Toyoda, and K. Matsushima. 2000. Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression. Blood 96: 2206-2214.
25. Norton, N., N. M.Williams, H. J.Williams, G. Spurlock, G. Kirov, D.W. Morris, B. Hoogendoorn, M. J. Owen, and M. C. O'Donovan. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Hum. Genet. 110: 471-478.
26. Yan, H., W. Yuan, V. E. Velculescu, B. Vogelstein, and K. W. Kinzler. 2002. Allelic variation in human gene expression. Science 297: 1143.
27. Wang, J., and F. Xing. 2008. Human TSLP-educated DCs. Cell. Mol. Immunol. 5: 99-106.
28. Haas, J., B. Fritzsching, P. Trübswetter, M. Korporal, L. Milkova, B. Fritz, D.Vobis, P. H. Krammer, E. Suri-Payer, and B. Wildemann. 2007. Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J. Immunol. 179: 1322-1330.
29. Vandenbark, A. A., and H. Offner. 2008. Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored? Immunology 125: 1-13.
30. Levine, S. J. 2004. Mechanisms of soluble cytokine receptor generation. J. Immunol. 173: 5343-5348.
31. Goodwin, R. G., D. Friend, S. F. Ziegler, R. Jerzy, B. A. Falk, S. Gimpel, D. Cosman, S. K. Dower, C. J. March, A. E. Namen, et al. 1990. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60: 941-951.
32. Liu, Y. J. 2009. TSLP in epithelial cell and dendritic cell cross-talk. Adv. Immunol. 101: 1-25.
33. Fry, T. J., and C. L. Mackall. 2002. Interleukin-7: from bench to clinic. Blood 99: 3892-3904.
34. Surh, C. D., and J. Sprent. 2008. Homeostasis of naive and memory T cells. Immunity 29: 848-862.
35. Mackall, C. L., T. J. Fry, C. Bare, P. Morgan, A. Galbraith, and R. E. Gress. 2001. IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation. Blood 97: 1491-1497.
36. + memory cell pool. J. Clin. Invest. 115: 1177-1187.
37. + T-regulatory cells. J. Immunother. 29: 313-319.
38. Sportès, C., F. T. Hakim, S. A. Memon, H. Zhang, K. S. Chua, M. R. Brown, T. A. Fleisher, M. C. Krumlauf, R. R. Babb, C. K. Chow, et al. 2008. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J. Exp. Med. 205: 1701-1714.
39. Sereti, I., R. M. Dunham, J. Spritzler, E. Aga, M. A. Proschan, K. Medvik, C. A. Battaglia, A. L. Landay, S. Pahwa, M. A. Fischl, et al. 2009. IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood 113: 6304-6314.
40. De Jager, P. L., C. Baecher-Allan, L. M. Maier, A. T. Arthur, L. Ottoboni, L. Barcellos, J. L.McCauley, S. Sawcer, A. Goris, J. Saarela, et al. 2009. The role of the CD58 locus in multiple sclerosis. Proc. Natl. Acad. Sci. USA 106: 5264-5269.
41. International Multiple Sclerosis Genetics Consortium. 2009. The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun. 10: 11-14.