메뉴 건너뛰기




Volumn 21, Issue 4, 2009, Pages 454-459

Rejuvenation of the aging T cell compartment

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GOSERELIN; GROWTH HORMONE; INTERLEUKIN 12; INTERLEUKIN 15; KERATINOCYTE GROWTH FACTOR; LEUPRORELIN; RECOMBINANT INTERLEUKIN 7; SEX HORMONE; SOMATOMEDIN C;

EID: 68149148867     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2009.06.002     Document Type: Review
Times cited : (59)

References (67)
  • 1
    • 23944490475 scopus 로고    scopus 로고
    • Memory T cell homeostasis and senescence during aging
    • Akbar A.N., and Fletcher J.M. Memory T cell homeostasis and senescence during aging. Curr Opin Immunol 17 (2005) 480-485
    • (2005) Curr Opin Immunol , vol.17 , pp. 480-485
    • Akbar, A.N.1    Fletcher, J.M.2
  • 3
    • 0035902174 scopus 로고    scopus 로고
    • Haematopoietic cell transplantation as immunotherapy
    • Appelbaum F.R. Haematopoietic cell transplantation as immunotherapy. Nature 411 (2001) 385-389
    • (2001) Nature , vol.411 , pp. 385-389
    • Appelbaum, F.R.1
  • 4
    • 0022451971 scopus 로고
    • Reappearance of the thymus in old rats after orchidectomy: inhibition of regeneration by testosterone
    • Greenstein B.D., Fitzpatrick F.T., Adcock I.M., Kendall M.D., and Wheeler M.J. Reappearance of the thymus in old rats after orchidectomy: inhibition of regeneration by testosterone. J Endocrinol 110 (1986) 417-422
    • (1986) J Endocrinol , vol.110 , pp. 417-422
    • Greenstein, B.D.1    Fitzpatrick, F.T.2    Adcock, I.M.3    Kendall, M.D.4    Wheeler, M.J.5
  • 5
    • 0023134048 scopus 로고
    • Regeneration of the thymus in old male rats treated with a stable analogue of LHRH
    • Greenstein B.D., Fitzpatrick F.T., Kendall M.D., and Wheeler M.J. Regeneration of the thymus in old male rats treated with a stable analogue of LHRH. J Endocrinol 112 (1987) 345-350
    • (1987) J Endocrinol , vol.112 , pp. 345-350
    • Greenstein, B.D.1    Fitzpatrick, F.T.2    Kendall, M.D.3    Wheeler, M.J.4
  • 6
    • 23844486206 scopus 로고    scopus 로고
    • Effects of castration on thymocyte development in two different models of thymic involution
    • Heng T.S., Goldberg G.L., Gray D.H., Sutherland J.S., Chidgey A.P., and Boyd R.L. Effects of castration on thymocyte development in two different models of thymic involution. J Immunol 175 (2005) 2982-2993
    • (2005) J Immunol , vol.175 , pp. 2982-2993
    • Heng, T.S.1    Goldberg, G.L.2    Gray, D.H.3    Sutherland, J.S.4    Chidgey, A.P.5    Boyd, R.L.6
  • 8
    • 0031939430 scopus 로고    scopus 로고
    • Effects of castration on the lymphocytes of the thymus, spleen and lymph nodes
    • Windmill K.F., and Lee V.W. Effects of castration on the lymphocytes of the thymus, spleen and lymph nodes. Tissue Cell 30 (1998) 104-111
    • (1998) Tissue Cell , vol.30 , pp. 104-111
    • Windmill, K.F.1    Lee, V.W.2
  • 9
    • 0027220732 scopus 로고
    • Effect of prepubertal gonadectomy and sex steroid treatment on the growth and lymphocyte populations of the rat thymus
    • Windmill K.F., Meade B.J., and Lee V.W. Effect of prepubertal gonadectomy and sex steroid treatment on the growth and lymphocyte populations of the rat thymus. Reprod Fertil Dev 5 (1993) 73-81
    • (1993) Reprod Fertil Dev , vol.5 , pp. 73-81
    • Windmill, K.F.1    Meade, B.J.2    Lee, V.W.3
  • 13
    • 39749157700 scopus 로고    scopus 로고
    • Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade
    • This study demonstrates that the LHRH agonist goserelin significantly improves T cell reconstitution in human autologous and allogeneic transplantation patients, and increases disease-free survival in autologous recipients.
    • Sutherland J.S., Spyroglou L., Muirhead J.L., Heng T.S., Prieto-Hinojosa A., Prince H.M., Chidgey A.P., Schwarer A.P., and Boyd R.L. Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade. Clin Cancer Res 14 (2008) 1138-1149. This study demonstrates that the LHRH agonist goserelin significantly improves T cell reconstitution in human autologous and allogeneic transplantation patients, and increases disease-free survival in autologous recipients.
    • (2008) Clin Cancer Res , vol.14 , pp. 1138-1149
    • Sutherland, J.S.1    Spyroglou, L.2    Muirhead, J.L.3    Heng, T.S.4    Prieto-Hinojosa, A.5    Prince, H.M.6    Chidgey, A.P.7    Schwarer, A.P.8    Boyd, R.L.9
  • 14
    • 4344609471 scopus 로고    scopus 로고
    • Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair
    • Finch P.W., and Rubin J.S. Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res 91 (2004) 69-136
    • (2004) Adv Cancer Res , vol.91 , pp. 69-136
    • Finch, P.W.1    Rubin, J.S.2
  • 17
    • 0029013942 scopus 로고
    • Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions
    • Finch P.W., Cunha G.R., Rubin J.S., Wong J., and Ron D. Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions. Dev Dyn 203 (1995) 223-240
    • (1995) Dev Dyn , vol.203 , pp. 223-240
    • Finch, P.W.1    Cunha, G.R.2    Rubin, J.S.3    Wong, J.4    Ron, D.5
  • 20
    • 0037097583 scopus 로고    scopus 로고
    • Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    • Min D., Taylor P.A., Panoskaltsis-Mortari A., Chung B., Danilenko D.M., Farrell C., Lacey D.L., Blazar B.R., and Weinberg K.I. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood 99 (2002) 4592-4600
    • (2002) Blood , vol.99 , pp. 4592-4600
    • Min, D.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Chung, B.4    Danilenko, D.M.5    Farrell, C.6    Lacey, D.L.7    Blazar, B.R.8    Weinberg, K.I.9
  • 21
    • 0037100314 scopus 로고    scopus 로고
    • Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease
    • Rossi S., Blazar B.R., Farrell C.L., Danilenko D.M., Lacey D.L., Weinberg K.I., Krenger W., and Hollander G.A. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood 100 (2002) 682-691
    • (2002) Blood , vol.100 , pp. 682-691
    • Rossi, S.1    Blazar, B.R.2    Farrell, C.L.3    Danilenko, D.M.4    Lacey, D.L.5    Weinberg, K.I.6    Krenger, W.7    Hollander, G.A.8
  • 22
    • 68149180649 scopus 로고    scopus 로고
    • Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses following murine allogeneic bone marrow transplantation
    • This study demonstrates that KGF can be used as a vaccine adjuvant to enhance tumor-killing and overall survival in tumor-bearing murine recipients of allogeneic BMT. These findings are promising for elderly patients who typically respond poorly to vaccination.
    • Jenq R.R., King C.G., Volk C., Suh D., Smith O.M., Rao U., Yim N., Holland A.M., Lu S.X., Zakrzewski J.L., et al. Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses following murine allogeneic bone marrow transplantation. Blood (2008). This study demonstrates that KGF can be used as a vaccine adjuvant to enhance tumor-killing and overall survival in tumor-bearing murine recipients of allogeneic BMT. These findings are promising for elderly patients who typically respond poorly to vaccination.
    • (2008) Blood
    • Jenq, R.R.1    King, C.G.2    Volk, C.3    Suh, D.4    Smith, O.M.5    Rao, U.6    Yim, N.7    Holland, A.M.8    Lu, S.X.9    Zakrzewski, J.L.10
  • 23
    • 34347400589 scopus 로고    scopus 로고
    • Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques
    • Using a nonhuman primate model, the authors demonstrate that pretransplant or peritransplant KGF treatment resulted in maintenance of thymic architecture and enhanced T cell numbers in autologous recipients. This study supports the findings in small animals that FDA-approved KGF may improve T cell reconstitution in humans undergoing HSCT or age-related thymic atrophy.
    • Seggewiss R., Lore K., Guenaga F.J., Pittaluga S., Mattapallil J., Chow C.K., Koup R.A., Camphausen K., Nason M.C., Meier-Schellersheim M., et al. Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 110 (2007) 441-449. Using a nonhuman primate model, the authors demonstrate that pretransplant or peritransplant KGF treatment resulted in maintenance of thymic architecture and enhanced T cell numbers in autologous recipients. This study supports the findings in small animals that FDA-approved KGF may improve T cell reconstitution in humans undergoing HSCT or age-related thymic atrophy.
    • (2007) Blood , vol.110 , pp. 441-449
    • Seggewiss, R.1    Lore, K.2    Guenaga, F.J.3    Pittaluga, S.4    Mattapallil, J.5    Chow, C.K.6    Koup, R.A.7    Camphausen, K.8    Nason, M.C.9    Meier-Schellersheim, M.10
  • 24
    • 46149118774 scopus 로고    scopus 로고
    • Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation
    • The authors combine KGF administration with sex steroid blockade in a murine BMT model with additive benefits on T cell reconstitution.
    • Kelly R.M., Highfill S.L., Panoskaltsis-Mortari A., Taylor P.A., Boyd R.L., Hollander G.A., and Blazar B.R. Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation. Blood 111 (2008) 5734-5744. The authors combine KGF administration with sex steroid blockade in a murine BMT model with additive benefits on T cell reconstitution.
    • (2008) Blood , vol.111 , pp. 5734-5744
    • Kelly, R.M.1    Highfill, S.L.2    Panoskaltsis-Mortari, A.3    Taylor, P.A.4    Boyd, R.L.5    Hollander, G.A.6    Blazar, B.R.7
  • 25
    • 0025290445 scopus 로고
    • Immunoreactive growth hormone (GH) secretion by human lymphocytes: augmented release by exogenous GH
    • Hattori N., Shimatsu A., Sugita M., Kumagai S., and Imura H. Immunoreactive growth hormone (GH) secretion by human lymphocytes: augmented release by exogenous GH. Biochem Biophys Res Commun 168 (1990) 396-401
    • (1990) Biochem Biophys Res Commun , vol.168 , pp. 396-401
    • Hattori, N.1    Shimatsu, A.2    Sugita, M.3    Kumagai, S.4    Imura, H.5
  • 26
    • 0027460024 scopus 로고
    • Growth hormone secretion by human peripheral blood mononuclear cells detected by an enzyme-linked immunoplaque assay
    • Varma S., Sabharwal P., Sheridan J.F., and Malarkey W.B. Growth hormone secretion by human peripheral blood mononuclear cells detected by an enzyme-linked immunoplaque assay. J Clin Endocrinol Metab 76 (1993) 49-53
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 49-53
    • Varma, S.1    Sabharwal, P.2    Sheridan, J.F.3    Malarkey, W.B.4
  • 28
    • 0025076686 scopus 로고
    • Immunoreactive growth hormone-releasing hormone in rat leukocytes
    • Weigent D.A., and Blalock J.E. Immunoreactive growth hormone-releasing hormone in rat leukocytes. J Neuroimmunol 29 (1990) 1-13
    • (1990) J Neuroimmunol , vol.29 , pp. 1-13
    • Weigent, D.A.1    Blalock, J.E.2
  • 29
    • 0033305186 scopus 로고    scopus 로고
    • Growth hormone (GH) and prolactin receptors in human peripheral blood mononuclear cells: relation with age and GH-binding protein
    • Bresson J.L., Jeay S., Gagnerault M.C., Kayser C., Beressi N., Wu Z., Kinet S., Dardenne M., and Postel-Vinay M.C. Growth hormone (GH) and prolactin receptors in human peripheral blood mononuclear cells: relation with age and GH-binding protein. Endocrinology 140 (1999) 3203-3209
    • (1999) Endocrinology , vol.140 , pp. 3203-3209
    • Bresson, J.L.1    Jeay, S.2    Gagnerault, M.C.3    Kayser, C.4    Beressi, N.5    Wu, Z.6    Kinet, S.7    Dardenne, M.8    Postel-Vinay, M.C.9
  • 32
    • 0029863099 scopus 로고    scopus 로고
    • Expression of growth hormone receptors in murine lymphoid cells analyzed by flow cytofluorometry
    • Gagnerault M.C., Postel-Vinay M.C., and Dardenne M. Expression of growth hormone receptors in murine lymphoid cells analyzed by flow cytofluorometry. Endocrinology 137 (1996) 1719-1726
    • (1996) Endocrinology , vol.137 , pp. 1719-1726
    • Gagnerault, M.C.1    Postel-Vinay, M.C.2    Dardenne, M.3
  • 33
    • 0036521465 scopus 로고    scopus 로고
    • The role of growth hormone in T-cell development and reconstitution
    • Welniak L.A., Sun R., and Murphy W.J. The role of growth hormone in T-cell development and reconstitution. J Leukoc Biol 71 (2002) 381-387
    • (2002) J Leukoc Biol , vol.71 , pp. 381-387
    • Welniak, L.A.1    Sun, R.2    Murphy, W.J.3
  • 36
    • 0025907012 scopus 로고
    • Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B-lymphocytes
    • Stuart C.A., Meehan R.T., Neale L.S., Cintron N.M., and Furlanetto R.W. Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B-lymphocytes. J Clin Endocrinol Metab 72 (1991) 1117-1122
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 1117-1122
    • Stuart, C.A.1    Meehan, R.T.2    Neale, L.S.3    Cintron, N.M.4    Furlanetto, R.W.5
  • 37
    • 0033994661 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis
    • Walsh P.T., and O'Connor R. The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis. Eur J Immunol 30 (2000) 1010-1018
    • (2000) Eur J Immunol , vol.30 , pp. 1010-1018
    • Walsh, P.T.1    O'Connor, R.2
  • 38
    • 0141707821 scopus 로고    scopus 로고
    • Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice
    • Chen B.J., Cui X., Sempowski G.D., and Chao N.J. Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. Exp Hematol 31 (2003) 953-958
    • (2003) Exp Hematol , vol.31 , pp. 953-958
    • Chen, B.J.1    Cui, X.2    Sempowski, G.D.3    Chao, N.J.4
  • 40
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 41
    • 27144468685 scopus 로고    scopus 로고
    • Developments in ghrelin biology and potential clinical relevance
    • Smith R.G., Jiang H., and Sun Y. Developments in ghrelin biology and potential clinical relevance. Trends Endocrinol Metab 16 (2005) 436-442
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 436-442
    • Smith, R.G.1    Jiang, H.2    Sun, Y.3
  • 42
    • 27544497632 scopus 로고    scopus 로고
    • Ghrelin and immunity: a young player in an old field
    • Dixit V.D., and Taub D.D. Ghrelin and immunity: a young player in an old field. Exp Gerontol 40 (2005) 900-910
    • (2005) Exp Gerontol , vol.40 , pp. 900-910
    • Dixit, V.D.1    Taub, D.D.2
  • 43
    • 67149146799 scopus 로고    scopus 로고
    • Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression: implications for age-associated increases in inflammation
    • Dixit V.D., Yang H., Cooper-Jenkins A., Giri B.B., Patel K., and Taub D.D. Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression: implications for age-associated increases in inflammation. Blood (2009)
    • (2009) Blood
    • Dixit, V.D.1    Yang, H.2    Cooper-Jenkins, A.3    Giri, B.B.4    Patel, K.5    Taub, D.D.6
  • 44
    • 34948853362 scopus 로고    scopus 로고
    • Ghrelin promotes thymopoiesis during aging
    • The authors describe for the first time that ghrelin levels decrease in the aging thymus, and that administration of ghrelin improved thymus structure and thymopoiesis in 14-month-old mice.
    • Dixit V.D., Yang H., Sun Y., Weeraratna A.T., Youm Y.H., Smith R.G., and Taub D.D. Ghrelin promotes thymopoiesis during aging. J Clin Invest 117 (2007) 2778-2790. The authors describe for the first time that ghrelin levels decrease in the aging thymus, and that administration of ghrelin improved thymus structure and thymopoiesis in 14-month-old mice.
    • (2007) J Clin Invest , vol.117 , pp. 2778-2790
    • Dixit, V.D.1    Yang, H.2    Sun, Y.3    Weeraratna, A.T.4    Youm, Y.H.5    Smith, R.G.6    Taub, D.D.7
  • 45
    • 65449128145 scopus 로고    scopus 로고
    • Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity
    • This paper demonstrates that loss of ghrelin leads to a reduction in the number of TEC and an increase in the number of adipocytes in the thymus. These findings suggest a mechanism through which ghrelin directly mediates thymic function by shaping the thymic microenvironment.
    • Youm Y.H., Yang H., Sun Y., Smith R.G., Manley N.R., Vandanmagsar B., and Dixit V.D. Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity. J Biol Chem 284 (2009) 7068-7077. This paper demonstrates that loss of ghrelin leads to a reduction in the number of TEC and an increase in the number of adipocytes in the thymus. These findings suggest a mechanism through which ghrelin directly mediates thymic function by shaping the thymic microenvironment.
    • (2009) J Biol Chem , vol.284 , pp. 7068-7077
    • Youm, Y.H.1    Yang, H.2    Sun, Y.3    Smith, R.G.4    Manley, N.R.5    Vandanmagsar, B.6    Dixit, V.D.7
  • 48
    • 0030874326 scopus 로고    scopus 로고
    • The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression
    • von Freeden-Jeffry U., Solvason N., Howard M., and Murray R. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7 (1997) 147-154
    • (1997) Immunity , vol.7 , pp. 147-154
    • von Freeden-Jeffry, U.1    Solvason, N.2    Howard, M.3    Murray, R.4
  • 49
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech S.M., Tan J.T., Wherry E.J., Konieczny B.T., Surh C.D., and Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 4 (2003) 1191-1198
    • (2003) Nat Immunol , vol.4 , pp. 1191-1198
    • Kaech, S.M.1    Tan, J.T.2    Wherry, E.J.3    Konieczny, B.T.4    Surh, C.D.5    Ahmed, R.6
  • 50
    • 0347594000 scopus 로고    scopus 로고
    • IL-7 promotes the transition of CD4 effectors to persistent memory cells
    • Li J., Huston G., and Swain S.L. IL-7 promotes the transition of CD4 effectors to persistent memory cells. J Exp Med 198 (2003) 1807-1815
    • (2003) J Exp Med , vol.198 , pp. 1807-1815
    • Li, J.1    Huston, G.2    Swain, S.L.3
  • 51
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
    • Schluns K.S., Kieper W.C., Jameson S.C., and Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 1 (2000) 426-432
    • (2000) Nat Immunol , vol.1 , pp. 426-432
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrancois, L.4
  • 52
    • 0029835451 scopus 로고    scopus 로고
    • Stimulation of immune reconstitution by interleukin-7 after syngeneic bone marrow transplantation in mice
    • Abdul-Hai A., Or R., Slavin S., Friedman G., Weiss L., Matsa D., and Ben-Yehuda A. Stimulation of immune reconstitution by interleukin-7 after syngeneic bone marrow transplantation in mice. Exp Hematol 24 (1996) 1416-1422
    • (1996) Exp Hematol , vol.24 , pp. 1416-1422
    • Abdul-Hai, A.1    Or, R.2    Slavin, S.3    Friedman, G.4    Weiss, L.5    Matsa, D.6    Ben-Yehuda, A.7
  • 54
    • 0035496939 scopus 로고    scopus 로고
    • Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease
    • Alpdogan O., Schmaltz C., Muriglan S.J., Kappel B.J., Perales M.A., Rotolo J.A., Halm J.A., Rich B.E., and van den Brink M.R. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 98 (2001) 2256-2265
    • (2001) Blood , vol.98 , pp. 2256-2265
    • Alpdogan, O.1    Schmaltz, C.2    Muriglan, S.J.3    Kappel, B.J.4    Perales, M.A.5    Rotolo, J.A.6    Halm, J.A.7    Rich, B.E.8    van den Brink, M.R.9
  • 55
    • 0029794831 scopus 로고    scopus 로고
    • Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7
    • Bolotin E., Smogorzewska M., Smith S., Widmer M., and Weinberg K. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood 88 (1996) 1887-1894
    • (1996) Blood , vol.88 , pp. 1887-1894
    • Bolotin, E.1    Smogorzewska, M.2    Smith, S.3    Widmer, M.4    Weinberg, K.5
  • 56
    • 0035282766 scopus 로고    scopus 로고
    • IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation
    • Mackall C.L., Fry T.J., Bare C., Morgan P., Galbraith A., and Gress R.E. IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation. Blood 97 (2001) 1491-1497
    • (2001) Blood , vol.97 , pp. 1491-1497
    • Mackall, C.L.1    Fry, T.J.2    Bare, C.3    Morgan, P.4    Galbraith, A.5    Gress, R.E.6
  • 57
    • 58149100407 scopus 로고    scopus 로고
    • The ageing immune system: is it ever too old to become young again?
    • Dorshkind K., Montecino-Rodriguez E., and Signer R.A. The ageing immune system: is it ever too old to become young again?. Nat Rev Immunol 9 (2009) 57-62
    • (2009) Nat Rev Immunol , vol.9 , pp. 57-62
    • Dorshkind, K.1    Montecino-Rodriguez, E.2    Signer, R.A.3
  • 59
    • 46949105036 scopus 로고    scopus 로고
    • Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
    • IL-7 administration to patients with nonhematologic, nonlymphoid cancers led to increased T cell production and function, with enhanced proportions of recent thymic emigrants and naïve T cells.
    • Sportes C., Hakim F.T., Memon S.A., Zhang H., Chua K.S., Brown M.R., Fleisher T.A., Krumlauf M.C., Babb R.R., Chow C.K., et al. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med 205 (2008) 1701-1714. IL-7 administration to patients with nonhematologic, nonlymphoid cancers led to increased T cell production and function, with enhanced proportions of recent thymic emigrants and naïve T cells.
    • (2008) J Exp Med , vol.205 , pp. 1701-1714
    • Sportes, C.1    Hakim, F.T.2    Memon, S.A.3    Zhang, H.4    Chua, K.S.5    Brown, M.R.6    Fleisher, T.A.7    Krumlauf, M.C.8    Babb, R.R.9    Chow, C.K.10
  • 60
    • 65249105408 scopus 로고    scopus 로고
    • Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    • This study demonstrates that IL-7 administration to HIV-1-infected patients with profound T cell deficiency leads to increased T cell numbers and enhanced cytokine secretion in response to HIV antigens.
    • Levy Y., Lacabaratz C., Weiss L., Viard J.P., Goujard C., Lelievre J.D., Boue F., Molina J.M., Rouzioux C., Avettand-Fenoel V., et al. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest 119 (2009) 997-1007. This study demonstrates that IL-7 administration to HIV-1-infected patients with profound T cell deficiency leads to increased T cell numbers and enhanced cytokine secretion in response to HIV antigens.
    • (2009) J Clin Invest , vol.119 , pp. 997-1007
    • Levy, Y.1    Lacabaratz, C.2    Weiss, L.3    Viard, J.P.4    Goujard, C.5    Lelievre, J.D.6    Boue, F.7    Molina, J.M.8    Rouzioux, C.9    Avettand-Fenoel, V.10
  • 62
    • 0029784453 scopus 로고    scopus 로고
    • IL-15 administration following syngeneic bone marrow transplantation prolongs survival of lymphoma bearing mice
    • Katsanis E., Xu Z., Panoskaltsis-Mortari A., Weisdorf D.J., Widmer M.B., and Blazar B.R. IL-15 administration following syngeneic bone marrow transplantation prolongs survival of lymphoma bearing mice. Transplantation 62 (1996) 872-875
    • (1996) Transplantation , vol.62 , pp. 872-875
    • Katsanis, E.1    Xu, Z.2    Panoskaltsis-Mortari, A.3    Weisdorf, D.J.4    Widmer, M.B.5    Blazar, B.R.6
  • 65
    • 0036838932 scopus 로고    scopus 로고
    • Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells
    • Rubinstein M.P., Kadima A.N., Salem M.L., Nguyen C.L., Gillanders W.E., and Cole D.J. Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells. J Immunol 169 (2002) 4928-4935
    • (2002) J Immunol , vol.169 , pp. 4928-4935
    • Rubinstein, M.P.1    Kadima, A.N.2    Salem, M.L.3    Nguyen, C.L.4    Gillanders, W.E.5    Cole, D.J.6
  • 66
    • 1342282246 scopus 로고    scopus 로고
    • IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation
    • Li L., Hsu H.C., Stockard C.R., Yang P., Zhou J., Wu Q., Grizzle W.E., and Mountz J.D. IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. J Immunol 172 (2004) 2909-2916
    • (2004) J Immunol , vol.172 , pp. 2909-2916
    • Li, L.1    Hsu, H.C.2    Stockard, C.R.3    Yang, P.4    Zhou, J.5    Wu, Q.6    Grizzle, W.E.7    Mountz, J.D.8
  • 67
    • 48349104343 scopus 로고    scopus 로고
    • Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession
    • The authors show that the administration of IL-12 to 18-month-old mice via an adenoviral vector results in enhanced cytotoxic T cell numbers, activity, and proliferation.
    • Chen J., Wang J., Li J., Wu Q., Chu Lim F., Yang P., Hsu H.C., Curiel D.T., and Mountz J.D. Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession. Mol Ther 16 (2008) 1500-1506. The authors show that the administration of IL-12 to 18-month-old mice via an adenoviral vector results in enhanced cytotoxic T cell numbers, activity, and proliferation.
    • (2008) Mol Ther , vol.16 , pp. 1500-1506
    • Chen, J.1    Wang, J.2    Li, J.3    Wu, Q.4    Chu Lim, F.5    Yang, P.6    Hsu, H.C.7    Curiel, D.T.8    Mountz, J.D.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.