IL-7 differentially modulates the expression of IFN-γ and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms

Journal of Immunology

Volumn 156, Issue 4, 1996, Pages 1333-1338

  Borger, Peter ^a   Kauffman, Henk F ^a   Postma, Dirkje S ^a   Vellenga, Edo ^a,b,c  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 7;

ARTICLE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN PROCESSING; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

CELLS, CULTURED; CYCLOHEXIMIDE; CYCLOSPORINE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENISTEIN; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-7; ISOFLAVONES; LYMPHOCYTE ACTIVATION; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-TYROSINE KINASES; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0030063341     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Namen, A. E., A. E. Schmierer, C. J. March, R. W. Overell, L S Park, D. L. Urdal, and D Y. Mochizuki. 1988. B cell precursor growth-promoting activity: purification and characterization of a growth-factor active on lymphocyte precursors. J. Exp Med. 167:988.
2. Touw, I., K Pouwels, T. van Agthoven, R. van Gurp, L. Budel, H Hoogerbrugge, R. Delwel, R. Goodwin, A. Namen, and B. Lowenberg. 1990 Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia. Blood 75.2097.
3. Hickman, C. J., J. A. Crim, H. S. Mostowski, and J. P Siegel. 1990. Regulation of human cytotoxic T lymphocyte development by IL-7. J Immunol. 145.2415.
4. Alderson, M R., H. M. Sassenfeld, and M. B. Widmer 1990 Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood J. Exp. Med. 172:577.
5. Grabstein, K. H , A. E. Namen, K. Shanebeck, R. F. Voice, S. G Reed, and M. B Widmer 1990, Regulation of T cell proliferation by IL-7. J. Immunol. 144:3015.
6. Armitage, R J , A. E Namen, H. M. Sassenfeld, and K. H. Grabstein. 1990. Regulation of human T cell proliferation by IL-7. J. Immunol. 144:938.
7. + natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12 Eur J. Immunol. 23:131
8. Dokter, W. H A., S. J. Sterdsema, M. T. Esselink, M. R. Halie, and E. Vellenga. 1993. IL-7 enhances the expression of IL-3 and granulocyte-macrophage-CSF mRNA in activated human T cells by post-transcriptional mechanisms. J. Immunol. 150:2584.
9. Dokter, W. H A., S. J Sierdsema, M. T Esselink, M. R. Halie, and E. Vellenga. 1994. Interleukin-4 mRNA and protein m activated human T cells are enhanced by IL-7. Exp. Hematol. 22.74.
10. + T cells through IL-12 produced by Listeria-induced macrophages Science 260:547.
11. + T cells from T cell receptor transgenic mice. J. Exp Med. 176 1091.
12. Hsieh, C. S., A. B. Heimberger, J. S. Gold, A. O'Garra, and K. M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukin 4 and 10 in an αβ T-cell receptor transgenic system. Proc. Natl Acad. Sci. USA 89: 6065.
13. Croft, M., L. Carter, S. L. Swain, and R. W. Dutton 1994. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (ID-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med 180:1715.
14. + Thelper type 2 cells. J. Exp. Med. 181:5.
15. Vellenga, E., A Rambaldi, T. J. Ernst, D. Ostapovicz, and J. D. Griffin. 1988. Independent regulation of M-CSF and G-CSF gene expression in human monocytes. Blood 71:1529.
16. Maniatis, T , E. F. Fritsch, and A. Sambrook 1982 Molecular Cloning: A Laboratory Manual Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
17. Feinberg, A. P., and B. Vogelstein. 1983. A technique for labeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem 132:6.
18. Yokota, T., T. Otsuka, T. Mosmann, J. Banchereau, T. DeFrance, D. Blanchard. J. E de Vries, F. Lee, and K. I Arai. 1986. Isolation of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulatory activities. Proc Natl Acad Sci. USA 83:5894.
19. Trinchieri, G. 1993. Interleukin-12 and its role in the generation of Th1 cells Immunol. Today 14 335.
20. Boussiotis, V. A., D. L. Barber, T Nakarai, G. J. Freeman, J. G. Gribben, G. M. Bernstein, A. D. D'Andrea, J. Ritz, and L. M. Nadler 1994 Prevention of T cell anergy by signaling through the yc chain of the IL-2 receptor Science 266:1039.
21. Ziegler, S. F., K. K. Morella, D. Anderson, N. Kumaki, W. J. Leonard, D. Cosman, and H. Baumann. 1995. Reconstitution of a functional interleukin (IL)-7 receptor demonstrates that the IL-2 receptor γ chain is required for IL-7 signal transduction. Eur. J. Immunol. 25:399.
22. Roifman, C. M., G. Wang, M. Freedman, and Z. Pan. 1992 IL-7 receptor mediates tyrosine phosphorylation but does not activate the phosphatidylinositolphospholipase c-γl pathway. J Immunol 148:1136.
23. Uctan, F M., L. Tuel-Ahlgren, V. Obuz, R. Smith, I. Dibirdik, M. Hanson, M. Chandan-Langlie, and G. A. Ledbetter. 1991. Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phosphohpid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes. Proc. Natl. Acad Sci. USA 88:6323
24. Uckun, F. M , I. Dibirdik, R Smith, L. Tuel-Ahlgren, M. Chandan-Langlie, G. L. Schieven, K. G. Waddick, M. Hanson, and J. A. Ledbetter. 1991. Interleukin 7 receptor ligation stimulates tyrosine phosphorylation. inositol phosphohpid turnover, and clonal proliferation of human B-cell precursors. Proc. Natl. Acad. Sci. USA 88:3589.
25. Ohnishi, H., J. A Ledbetter, S B. Kanner, P. S. Linsley, T Tanaka, A M. Geller, and M. Kotb. 1995. CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses. J. Immunol. 154:3180.
26. Chrivia, J. C., T. Wedijchowicz, H. A. Young, and K. H Hardy. 1990 A model of human cytokine regulation based on transfection of the γ interferon gene fragments directly into isolated peripheral blood T lymphocytes. J. Exp. Med. 172.661
27. Li-Weber, M., A. Eder, H. Krafft-Czepa, and P. H. Krammer. 1992. T-cell specific negative regulation of transcription of the human cytokine IL-4 J Immunol. 148.1913.
28. Todd, M D., M. J. Grusby, J. A. Lederer, E. Lacy, A H. Lichtman, and L. H Glimcher 1993. Transcription of the interleukin 4 gene is regulated by multiple promoter elements J. Exp. Med. 177:1663.
29. Londei, M., A. Verhoef, C. Haarylowicz, J. Groves, P De Berardinis, and M. Feldmann. 1990 Interleukin-7 is a growth factor for mature human T cells Eur. J. Immunol. 20:425
30. Benjamin, D., V. Sharma, T. J. Knobloch, R J. Armitage, M. A. Dayton, and R. G. Goodwin. 1994. B cell IL-7: human B cell lines constitutively secrete IL-7 and express IL-7 receptors J. Immunol 152:4749.
31. Sieling, P A., L Sikamura, K Uyemura, M, Yamamura, J. Oliveros, B. J. Nickoloff, T. H. Rea, and R L. Modlin. 1995. IL-7 in the cell mediated immune response to a human pathogen J. Immunol. 154-2775.