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Volumn 110, Issue 1, 2007, Pages 441-449

Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques

Author keywords

[No Author keywords available]

Indexed keywords

PALIFERMIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SCATTER FACTOR; T LYMPHOCYTE RECEPTOR;

EID: 34347400589     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-12-065623     Document Type: Article
Times cited : (90)

References (47)
  • 1
    • 20144387499 scopus 로고    scopus 로고
    • Age-dependent incidence, time course, and consequences of thymic renewal in adults
    • Hakim FT, Memon SA, Cepeda R, et al. Age-dependent incidence, time course, and consequences of thymic renewal in adults. J Clin Invest. 2005;115:930-939.
    • (2005) J Clin Invest , vol.115 , pp. 930-939
    • Hakim, F.T.1    Memon, S.A.2    Cepeda, R.3
  • 3
    • 0033555440 scopus 로고    scopus 로고
    • Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions
    • Small TN, Papadopoulos EB, Boulad F, et al. Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood. 1999;93:467-480.
    • (1999) Blood , vol.93 , pp. 467-480
    • Small, T.N.1    Papadopoulos, E.B.2    Boulad, F.3
  • 4
    • 0031466825 scopus 로고    scopus 로고
    • Thymic aging and T-cell regeneration
    • Mackall CL, Gress RE. Thymic aging and T-cell regeneration. Immunol Rev. 1997;160:91-102.
    • (1997) Immunol Rev , vol.160 , pp. 91-102
    • Mackall, C.L.1    Gress, R.E.2
  • 5
    • 0034720664 scopus 로고    scopus 로고
    • Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution
    • Douek DC, Vescio RA, Betts MR, et al. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet. 2000;355:1875-1881.
    • (2000) Lancet , vol.355 , pp. 1875-1881
    • Douek, D.C.1    Vescio, R.A.2    Betts, M.R.3
  • 6
    • 0029922179 scopus 로고    scopus 로고
    • Analysis of T-cell repopulation after allogeneic bone marrow transplantation: Significant differences between recipients of T-cell depleted and unmanipulated grafts
    • Roux E, Helg C, Dumont-Girard F, Chapuis B, Jeannet M, Roosnek E. Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts. Blood. 1996;87:3984-3992.
    • (1996) Blood , vol.87 , pp. 3984-3992
    • Roux, E.1    Helg, C.2    Dumont-Girard, F.3    Chapuis, B.4    Jeannet, M.5    Roosnek, E.6
  • 7
    • 0034665895 scopus 로고    scopus 로고
    • Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity
    • Roux E, Dumont-Girard F, Starobinski M, et al. Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity. Blood. 2000;96:2299-2303.
    • (2000) Blood , vol.96 , pp. 2299-2303
    • Roux, E.1    Dumont-Girard, F.2    Starobinski, M.3
  • 8
    • 0027488659 scopus 로고
    • T-cell regeneration after bone marrow transplantation: Differential CD45 isoform expression on thymic-derived versus thymic-independent progeny
    • Mackall CL, Granger L, Sheard MA, Cepeda R, Gress RE. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood. 1993;82:2585-2594.
    • (1993) Blood , vol.82 , pp. 2585-2594
    • Mackall, C.L.1    Granger, L.2    Sheard, M.A.3    Cepeda, R.4    Gress, R.E.5
  • 9
    • 10344242939 scopus 로고    scopus 로고
    • Palifermin for oral mucositis after intensive therapy for hematologic cancers
    • Spielberger R, Stiff P, Bensinger W, et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med. 2004;351:2590-2598.
    • (2004) N Engl J Med , vol.351 , pp. 2590-2598
    • Spielberger, R.1    Stiff, P.2    Bensinger, W.3
  • 10
    • 0032533233 scopus 로고    scopus 로고
    • Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice
    • Panoskaltsis-Mortari A, Lacey DL, Vallera DA, Blazar BR. Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice. Blood. 1998;92:3960-3967.
    • (1998) Blood , vol.92 , pp. 3960-3967
    • Panoskaltsis-Mortari, A.1    Lacey, D.L.2    Vallera, D.A.3    Blazar, B.R.4
  • 11
    • 0037100314 scopus 로고    scopus 로고
    • Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease
    • Rossi S, Blazar BR, Farrell CL, et al. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood. 2002;100:682-691.
    • (2002) Blood , vol.100 , pp. 682-691
    • Rossi, S.1    Blazar, B.R.2    Farrell, C.L.3
  • 12
    • 33644768024 scopus 로고    scopus 로고
    • Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
    • Alpdogan O, Hubbard VM, Smith OM, et al. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood. 2006;107:2453-2460.
    • (2006) Blood , vol.107 , pp. 2453-2460
    • Alpdogan, O.1    Hubbard, V.M.2    Smith, O.M.3
  • 13
    • 0037097583 scopus 로고    scopus 로고
    • Protection from thymic epithelial cell injury by keratinocyte growth factor: A new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    • Min D, Taylor PA, Panoskaltsis-Mortari A, et al. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood. 2002;99:4592-4600.
    • (2002) Blood , vol.99 , pp. 4592-4600
    • Min, D.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3
  • 14
    • 0033042560 scopus 로고    scopus 로고
    • Thymic microenvironments, 3-D versus 2-D?
    • van Ewijk W, Wang B, Hollander G, et al. Thymic microenvironments, 3-D versus 2-D? Semin Immunol. 1999;11:57-64.
    • (1999) Semin Immunol , vol.11 , pp. 57-64
    • van Ewijk, W.1    Wang, B.2    Hollander, G.3
  • 15
    • 0035898387 scopus 로고    scopus 로고
    • Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development
    • Lind EF, Prockop SE, Porritt HE, Petrie HT. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J Exp Med. 2001;194:127-134.
    • (2001) J Exp Med , vol.194 , pp. 127-134
    • Lind, E.F.1    Prockop, S.E.2    Porritt, H.E.3    Petrie, H.T.4
  • 16
    • 0024324070 scopus 로고
    • Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth
    • Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science. 1989;245:752-755.
    • (1989) Science , vol.245 , pp. 752-755
    • Finch, P.W.1    Rubin, J.S.2    Miki, T.3    Ron, D.4    Aaronson, S.A.5
  • 18
    • 0032030965 scopus 로고    scopus 로고
    • Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality
    • Farrell CL, Bready JV, Rex KL, et al. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res. 1998;58:933-939.
    • (1998) Cancer Res , vol.58 , pp. 933-939
    • Farrell, C.L.1    Bready, J.V.2    Rex, K.L.3
  • 19
    • 0031052385 scopus 로고    scopus 로고
    • Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis
    • Ulich TR, Whitcomb L, Tang W, et al. Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. Cancer Res. 1997;57:472-475.
    • (1997) Cancer Res , vol.57 , pp. 472-475
    • Ulich, T.R.1    Whitcomb, L.2    Tang, W.3
  • 20
    • 0034076350 scopus 로고    scopus 로고
    • KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT
    • Panoskaltsis-Mortari A, Ingbar DH, Jung P, et al. KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT. Am J Physiol Lung Cell Mol Physiol. 2000;278:L988-L999.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278
    • Panoskaltsis-Mortari, A.1    Ingbar, D.H.2    Jung, P.3
  • 21
    • 0035960336 scopus 로고    scopus 로고
    • Regulation of glutathione redox status in lung and liver by conditioning regimens and keratinocyte growth factor in murine allogeneic bone marrow transplantation
    • Ziegler TR, Panoskaltsus-Mortari A, Gu LH, et al. Regulation of glutathione redox status in lung and liver by conditioning regimens and keratinocyte growth factor in murine allogeneic bone marrow transplantation. Transplantation. 2001;72:1354-1362.
    • (2001) Transplantation , vol.72 , pp. 1354-1362
    • Ziegler, T.R.1    Panoskaltsus-Mortari, A.2    Gu, L.H.3
  • 22
    • 3142670662 scopus 로고    scopus 로고
    • Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys
    • Letvin NL, Huang Y, Chakrabarti BK, et al. Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys. J Virol. 2004;78:7490-7497.
    • (2004) J Virol , vol.78 , pp. 7490-7497
    • Letvin, N.L.1    Huang, Y.2    Chakrabarti, B.K.3
  • 23
    • 0030063293 scopus 로고    scopus 로고
    • Peripheral blood CD34+ cells differ from bone marrow CD34+ cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte colony-stimulating factor and/or stem cell factor
    • Donahue RE, Kirby MR, Metzger ME, Agricola BA, Sellers SE, Cullis HM. Peripheral blood CD34+ cells differ from bone marrow CD34+ cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte colony-stimulating factor and/or stem cell factor. Blood. 1996;87:1644-1653.
    • (1996) Blood , vol.87 , pp. 1644-1653
    • Donahue, R.E.1    Kirby, M.R.2    Metzger, M.E.3    Agricola, B.A.4    Sellers, S.E.5    Cullis, H.M.6
  • 24
    • 33747600086 scopus 로고    scopus 로고
    • In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques
    • Lore K, Seggewiss R, Guenaga FJ, et al. In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques. Stem Cells. 2006;24:1539-1548.
    • (2006) Stem Cells , vol.24 , pp. 1539-1548
    • Lore, K.1    Seggewiss, R.2    Guenaga, F.J.3
  • 25
    • 0036135578 scopus 로고    scopus 로고
    • Development and homeostasis of T cell memory in rhesus macaque
    • Pitcher CJ, Hagen SI, Walker JM, et al. Development and homeostasis of T cell memory in rhesus macaque. J Immunol. 2002;168:29-43.
    • (2002) J Immunol , vol.168 , pp. 29-43
    • Pitcher, C.J.1    Hagen, S.I.2    Walker, J.M.3
  • 27
    • 0027162407 scopus 로고
    • Conserved T-cell receptor repertoire in simian immunodeficiency virus-infected rhesus monkeys
    • Chen ZW, Kou ZC, Shen L, Reimann KA, Letvin NL. Conserved T-cell receptor repertoire in simian immunodeficiency virus-infected rhesus monkeys. J Immunol. 1993;151:2177-2187.
    • (1993) J Immunol , vol.151 , pp. 2177-2187
    • Chen, Z.W.1    Kou, Z.C.2    Shen, L.3    Reimann, K.A.4    Letvin, N.L.5
  • 28
    • 0027026509 scopus 로고
    • Recovery of mononuclear cell subsets after bone marrow transplantation: Overabundance of CD4+CD8+ dual-positive T cells reminiscent of ontogeny
    • Storek J, Ferrara S, Rodriguez C, Saxon A. Recovery of mononuclear cell subsets after bone marrow transplantation: overabundance of CD4+CD8+ dual-positive T cells reminiscent of ontogeny. J Hematother. 1992;1:303-316.
    • (1992) J Hematother , vol.1 , pp. 303-316
    • Storek, J.1    Ferrara, S.2    Rodriguez, C.3    Saxon, A.4
  • 29
    • 0019408257 scopus 로고
    • T lymphocyte characteristics in bone marrow-transplanted patients. II. Analysis with monoclonal antibodies
    • de Bruin HG, Astaldi A, Leupers T, et al. T lymphocyte characteristics in bone marrow-transplanted patients. II. Analysis with monoclonal antibodies. J Immunol. 1981;127:244-251.
    • (1981) J Immunol , vol.127 , pp. 244-251
    • de Bruin, H.G.1    Astaldi, A.2    Leupers, T.3
  • 30
    • 17444372347 scopus 로고    scopus 로고
    • Changes in thymic function with age and during the treatment of HIV infection
    • Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396:690-695.
    • (1998) Nature , vol.396 , pp. 690-695
    • Douek, D.C.1    McFarland, R.D.2    Keiser, P.H.3
  • 31
    • 0027251463 scopus 로고
    • The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments
    • Pannetier C, Cochet M, Darche S, Casrouge A, Zoller M, Kourilsky P. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci U S A. 1993;90:4319-4323.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 4319-4323
    • Pannetier, C.1    Cochet, M.2    Darche, S.3    Casrouge, A.4    Zoller, M.5    Kourilsky, P.6
  • 32
    • 20944444088 scopus 로고    scopus 로고
    • Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates
    • Santra S, Seaman MS, Xu L, et al. Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates. J Virol. 2005;79:6516-6522.
    • (2005) J Virol , vol.79 , pp. 6516-6522
    • Santra, S.1    Seaman, M.S.2    Xu, L.3
  • 33
    • 0021666221 scopus 로고
    • Procedures for Comparing Samples with Multiple Endpoints
    • O'Brian PC. Procedures for Comparing Samples with Multiple Endpoints. Biometrics. Vol. 40;1984:1079-1087.
    • (1984) Biometrics , vol.40 , pp. 1079-1087
    • O'Brian, P.C.1
  • 34
    • 0031042008 scopus 로고    scopus 로고
    • Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts
    • Storek J, Gooley T, Witherspoon RP, Sullivan KM, Storb R. Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am J Hematol. 1997;54:131-138.
    • (1997) Am J Hematol , vol.54 , pp. 131-138
    • Storek, J.1    Gooley, T.2    Witherspoon, R.P.3    Sullivan, K.M.4    Storb, R.5
  • 35
    • 0028812436 scopus 로고
    • Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy
    • Mackall CL, Fleisher TA, Brown MR, et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med. 1995;332:143-149.
    • (1995) N Engl J Med , vol.332 , pp. 143-149
    • Mackall, C.L.1    Fleisher, T.A.2    Brown, M.R.3
  • 36
    • 0032402158 scopus 로고    scopus 로고
    • Reconstitution of the T-cell compartment after bone marrow transplantation: Restoration of the repertoire by thymic emigrants
    • Dumont-Girard F, Roux E, van Lier RA, et al. Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. Blood. 1998;92:4464-4471.
    • (1998) Blood , vol.92 , pp. 4464-4471
    • Dumont-Girard, F.1    Roux, E.2    van Lier, R.A.3
  • 37
    • 0029943897 scopus 로고    scopus 로고
    • Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing
    • Mackall CL, Bare CV, Granger LA, Sharrow SO, Titus JA, Gress RE. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J Immunol. 1996;156:4609-4616.
    • (1996) J Immunol , vol.156 , pp. 4609-4616
    • Mackall, C.L.1    Bare, C.V.2    Granger, L.A.3    Sharrow, S.O.4    Titus, J.A.5    Gress, R.E.6
  • 38
    • 0028267677 scopus 로고
    • Turnover of naive- and memory-phenotype T cells
    • Tough DF, Sprent J. Turnover of naive- and memory-phenotype T cells. J Exp Med. 1994;179:1127-1135.
    • (1994) J Exp Med , vol.179 , pp. 1127-1135
    • Tough, D.F.1    Sprent, J.2
  • 39
    • 0030833497 scopus 로고    scopus 로고
    • Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells
    • Hakim FT, Cepeda R, Kaimei S, et al. Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood. 1997;90:3789-3798.
    • (1997) Blood , vol.90 , pp. 3789-3798
    • Hakim, F.T.1    Cepeda, R.2    Kaimei, S.3
  • 40
    • 4644342929 scopus 로고    scopus 로고
    • CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    • Brenchley JM, Schacker TW, Ruff LE, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200:749-759.
    • (2004) J Exp Med , vol.200 , pp. 749-759
    • Brenchley, J.M.1    Schacker, T.W.2    Ruff, L.E.3
  • 41
    • 4644289983 scopus 로고    scopus 로고
    • Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    • Mehandru S, Poles MA, Tenner-Racz K, et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med. 2004;200:761-770.
    • (2004) J Exp Med , vol.200 , pp. 761-770
    • Mehandru, S.1    Poles, M.A.2    Tenner-Racz, K.3
  • 42
    • 18144388318 scopus 로고    scopus 로고
    • Vaccination of stem cell transplant recipients: Recommendations of the Infectious Diseases Working Party of the EBMT
    • Ljungman P, Engelhard D, de la Camara R, et al. Vaccination of stem cell transplant recipients: recommendations of the Infectious Diseases Working Party of the EBMT. Bone Marrow Transplant. 2005;35:737-746.
    • (2005) Bone Marrow Transplant , vol.35 , pp. 737-746
    • Ljungman, P.1    Engelhard, D.2    de la Camara, R.3
  • 43
    • 20144381205 scopus 로고    scopus 로고
    • De novo generation of CD4 T cells against viruses present in the host during immune reconstitution
    • Kalina T, Lu H, Zhao Z, et al. De novo generation of CD4 T cells against viruses present in the host during immune reconstitution. Blood. 2005;105:2410-2414.
    • (2005) Blood , vol.105 , pp. 2410-2414
    • Kalina, T.1    Lu, H.2    Zhao, Z.3
  • 44
    • 0037963554 scopus 로고    scopus 로고
    • Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys
    • Storek J, Gillespy T III, Lu H, et al. Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys. Blood. 2003;101:4209-4218.
    • (2003) Blood , vol.101 , pp. 4209-4218
    • Storek, J.1    Gillespy III, T.2    Lu, H.3
  • 45
    • 0034672365 scopus 로고    scopus 로고
    • Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury
    • Panoskaltsis-Mortari A, Taylor PA, Rubin JS, et al. Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury. Blood. 2000;96:4350-4356.
    • (2000) Blood , vol.96 , pp. 4350-4356
    • Panoskaltsis-Mortari, A.1    Taylor, P.A.2    Rubin, J.S.3
  • 46
    • 10744220237 scopus 로고    scopus 로고
    • A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors
    • Eyrich M, Leiler C, Lang P, et al. A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors. Bone Marrow Transplant. 2003;32:379-390.
    • (2003) Bone Marrow Transplant , vol.32 , pp. 379-390
    • Eyrich, M.1    Leiler, C.2    Lang, P.3
  • 47
    • 0033566285 scopus 로고    scopus 로고
    • Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease
    • Krijanovski OI, Hill GR, Cooke KR, et al. Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease. Blood. 1999;94:825-831.
    • (1999) Blood , vol.94 , pp. 825-831
    • Krijanovski, O.I.1    Hill, G.R.2    Cooke, K.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.