-
1
-
-
0036973505
-
Synthesis of 3- Alkyl(Aryl)-4-alkylidenamino-4,5-dihydro1H-1,2,4-triazol-5-ones and 3-Alkyl-4-alkylamino-4,5-dihydro1H-1,2,4-triazol-5-ones as Antitumor Agents
-
Demirbaş, N.; Ugurluoglu, R.; Demirbaş, A. Synthesis of 3- Alkyl(Aryl)-4-alkylidenamino-4,5-dihydro1H-1,2,4-triazol-5-ones and 3-Alkyl-4-alkylamino-4,5-dihydro1H-1,2,4-triazol-5-ones as Antitumor Agents. Bioorg. Med. Chem., 2002, 10, 3717-3723.
-
(2002)
Bioorg. Med. Chem
, vol.10
, pp. 3717-3723
-
-
Demirbaş, N.1
Ugurluoglu, R.2
Demirbaş, A.3
-
2
-
-
5044249936
-
Synthesis, antitumor and antiviral properties of some1,2,4-triazole derivatives
-
Al-Saud, Y.A.; Al-Dweri, M.N.; Al-Masoudi, N.A. Synthesis, antitumor and antiviral properties of some1,2,4-triazole derivatives. Farmaco, 2004, 59, 775-783.
-
(2004)
Farmaco
, vol.59
, pp. 775-783
-
-
Al-Saud, Y.A.1
Al-Dweri, M.N.2
Al-Masoudi, N.A.3
-
3
-
-
0043158805
-
Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles
-
Shivarama Holla, B.; Veerendra, B.; Shivananda, M.K.; Poojary, B. Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles. Eur. J. Med. Chem., 2003, 38, 759-767.
-
(2003)
Eur. J. Med. Chem
, vol.38
, pp. 759-767
-
-
Shivarama, H.B.1
Veerendra, B.2
Shivananda, M.K.3
Poojary, B.4
-
4
-
-
31544472391
-
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry
-
Pagliai, F.; Pirali, T.; Del Grosso, E.; Di Brisco, R.; Tron, G.C.; Sorba, G.; Genazzani, A.A. Rapid synthesis of triazole-modified resveratrol analogues via click chemistry. J. Med. Chem., 2006, 49, 467-470.
-
(2006)
J. Med. Chem
, vol.49
, pp. 467-470
-
-
Pagliai, F.1
Pirali, T.2
Del Grosso, E.3
Di Brisco, R.4
Tron, G.C.5
Sorba, G.6
Genazzani, A.A.7
-
5
-
-
33747624715
-
Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities
-
Li, J.; Zheng, M.; Tang, W.; He, P.-L.; Zhu, W.; Li, T.; Zuo, J.-P.; Liu, H.; Jian, H. Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities. Bioorg. Med. Chem. Lett., 2006, 16, 5009-5013.
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 5009-5013
-
-
Li, J.1
Zheng, M.2
Tang, W.3
He, P.-L.4
Zhu, W.5
Li, T.6
Zuo, J.-P.7
Liu, H.8
Jian, H.9
-
6
-
-
0036510854
-
Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles
-
Kritsanida, M.; Mouroutsou, A.; Marakos, P.; Pouli, N.; Papakonstantinou-Garoufalias, S.; Pannecouque, C.; Witvrouw, M.; De Clercq, E. Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. Farmaco, 2002, 57, 253-257.
-
(2002)
Farmaco
, vol.57
, pp. 253-257
-
-
Kritsanida, M.1
Mouroutsou, A.2
Marakos, P.3
Pouli, N.4
Papakonstantinou-Garoufalias, S.5
Pannecouque, C.6
Witvrouw, M.7
de Clercq, E.8
-
7
-
-
0342647359
-
6- Benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with ibuprofen: Synthesis, characterization and evaluation of anti-inflammatory activity
-
Tozkoparan, B.; Gökhan, N.; Aktay, G.; Yeşilada, E.; Ertan, M. 6- Benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with ibuprofen: synthesis, characterization and evaluation of anti-inflammatory activity. Eur. J. Med. Chem., 2000, 34, 743-750.
-
(2000)
Eur. J. Med. Chem
, vol.34
, pp. 743-750
-
-
Tozkoparan, B.1
Gökhan, N.2
Aktay, G.3
Yeşilada, E.4
Ertan, M.5
-
8
-
-
0033617496
-
Synthesis and analgesic activity of some triazoles and triazolothiadiazines
-
Turan-Zitouni, G.; Kaplancikli, Z.A.; Erol, K.; Kiliç, F.S. Synthesis and analgesic activity of some triazoles and triazolothiadiazines. Farmaco, 1999, 54, 218-223.
-
(1999)
Farmaco
, vol.54
, pp. 218-223
-
-
Turan-Zitouni, G.1
Kaplancikli, Z.A.2
Erol, K.3
Kiliç, F.S.4
-
9
-
-
0032583456
-
Synthesis and antimicrobial activity of N-[(α-methyl)benzylidene]-(3-substituted-1,2,4-triazol-5-ylthio) acetohydrazides
-
Ersan, S.; Nacak, S.; Berkem, R. Synthesis and antimicrobial activity of N-[(α-methyl)benzylidene]-(3-substituted-1,2,4-triazol-5-ylthio) acetohydrazides. Farmaco, 1998, 53, 773-776.
-
(1998)
Farmaco
, vol.53
, pp. 773-776
-
-
Ersan, S.1
Nacak, S.2
Berkem, R.3
-
10
-
-
0032465324
-
Studies on some N-bridged heterocycles derived from bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl] alkanes
-
Shivarama Holla, B.; Gonsalves, R.; Shennoy, S. Studies on some N-bridged heterocycles derived from bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl] alkanes. Farmaco, 1998, 53, 574-578.
-
(1998)
Farmaco
, vol.53
, pp. 574-578
-
-
Shivarama, H.B.1
Gonsalves, R.2
Shennoy, S.3
-
11
-
-
4444270755
-
Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4]thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4]triazol-3-yl)methyl-5-oxo- [1,2,4]triazole derivatives
-
Demirbaş, N.; Karaoglu, S.A.; Demirbaş, A.; Sancak, K. Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4]thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4]triazol-3-yl)methyl-5-oxo- [1,2,4]triazole derivatives. Eur. J. Med. Chem., 2004, 39, 793-804.
-
(2004)
Eur. J. Med. Chem
, vol.39
, pp. 793-804
-
-
Demirbaş, N.1
Karaoglu, S.A.2
Demirbaş, A.3
Sancak, K.4
-
12
-
-
0016332583
-
Synthesis of 5-membered heterocycles and related compounds
-
Ram, V. J.; Pandey, H. N. Synthesis of 5-membered heterocycles and related compounds. Chem. Pharm. Bull., 1974, 22, 2778-2783.
-
(1974)
Chem. Pharm. Bull
, vol.22
, pp. 2778-2783
-
-
Ram, V.J.1
Pandey, H.N.2
-
13
-
-
0026500958
-
Synthesis and activity of some 1,4-disubstituted thiosemicarbazides and their 1,2,4-triazole-5-thione derivative
-
Ergenc, N.; Ilhan, E.; Otuk, G. Synthesis and activity of some 1,4-disubstituted thiosemicarbazides and their 1,2,4-triazole-5-thione derivative. Pharmazie, 1992, 47, 59-60.
-
(1992)
Pharmazie
, vol.47
, pp. 59-60
-
-
Ergenc, N.1
Ilhan, E.2
Otuk, G.3
-
14
-
-
0027104679
-
New triazole antifungal agents derived from mercaptomethylisoxazoles
-
Moreno-Manas, M.; Arredondo, Y.; Pleixats, R.; Teixido, M.; Raga, M.M.; Palacin, C.; Castello, J.M.; Oritiz, J.A. New triazole antifungal agents derived from mercaptomethylisoxazoles. J. Hetero. Chem., 1992, 29, 1557-560.
-
(1992)
J. Hetero. Chem
, vol.29
, pp. 1557-1560
-
-
Moreno-Manas, M.1
Arredondo, Y.2
Pleixats, R.3
Teixido, M.4
Raga, M.M.5
Palacin, C.6
Castello, J.M.7
Oritiz, J.A.8
-
15
-
-
33746210083
-
Inhibitors of HIV-1 protease by using in situ click chemistry
-
Whiting, M.; Muldoon, J.; Lin, Y.C.; Silverman, S.M.; Lindstron, W.; Olson, A.J.; Kolb, H.C.; Finn, M.G.; Sharpless, K.B.; Elder, J.H.; Fokin, V.V. Inhibitors of HIV-1 protease by using in situ click chemistry. Angew. Chem. Int. Ed., 2006, 45, 1435-1439.
-
(2006)
Angew. Chem. Int. Ed
, vol.45
, pp. 1435-1439
-
-
Whiting, M.1
Muldoon, J.2
Lin, Y.C.3
Silverman, S.M.4
Lindstron, W.5
Olson, A.J.6
Kolb, H.C.7
Finn, M.G.8
Sharpless, K.B.9
Elder, J.H.10
Fokin, V.V.11
-
16
-
-
2542542164
-
Combinatorial library of peptidotriazoles: Identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease
-
Tornøe, C.W.; Sanderson, S.J.; Mottram, J.C.; Coombs, G.H.; Meldal, M. Combinatorial library of peptidotriazoles: Identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease. J. Comb. Chem., 2004, 6, 312-324.
-
(2004)
J. Comb. Chem
, vol.6
, pp. 312-324
-
-
Tornøe, C.W.1
Sanderson, S.J.2
Mottram, J.C.3
Coombs, G.H.4
Meldal, M.5
-
17
-
-
39549111477
-
Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes
-
Tron, G.C.; Pirali, T.; Billington, R.A.; Canonico, P.L.; Sorba, G.; Genazzani, A.A. Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes. Med. Res. Rev., 2008, 28, 278-308.
-
(2008)
Med. Res. Rev
, vol.28
, pp. 278-308
-
-
Tron, G.C.1
Pirali, T.2
Billington, R.A.3
Canonico, P.L.4
Sorba, G.5
Genazzani, A.A.6
-
18
-
-
0032492712
-
Pyrazoles, 1,2,4-triazoles and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors
-
Duncia, J.V.; Santella, J.B. III; Higley, C.A.; VanAtten, M.K.; Weber, P.C.; Alexander, R.S.; Kettner, C.A.; Pruitt, J.R.; Liauw, A.Y.; Quan, M.L.; Knabb, R.M.; Wexler, R.R. Pyrazoles, 1,2,4-triazoles and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors. Bioorg. Med. Chem. Lett., 1998, 8, 775-780.
-
(1998)
Bioorg. Med. Chem. Lett
, vol.8
, pp. 775-780
-
-
Duncia, J.V.1
Santella, J.B.2
Higley, C.A.3
Vanatten, M.K.4
Weber, P.C.5
Alexander, R.S.6
Kettner, C.A.7
Pruitt, J.R.8
Liauw, A.Y.9
Quan, M.L.10
Knabb, R.M.11
Wexler, R.R.12
-
19
-
-
30444445995
-
Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis
-
Somu, R.V.; Boshoff, H.; Qiao, C.; Bennett, E.M.; Barry, C.E. III; Aldrich, C.C. Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis. J. Med. Chem., 2006, 49, 31-34.
-
(2006)
J. Med. Chem
, vol.49
, pp. 31-34
-
-
Somu, R.V.1
Boshoff, H.2
Qiao, C.3
Bennett, E.M.4
Barry, C.E.5
Aldrich, C.C.6
-
20
-
-
44649103893
-
Estrogenic analogues synthesized via click chemistry
-
Pirali, T.; Gatti, S.; Di Brisco, R.; Tacchi, S.; Zaninetti, R.; Brunelli, E.; Massarotti, A.; Sorba, G.; Canonico, P.L.; Moro, L.; Genazzani, A.A.; Tron, G.C.; Billington, R.A. Estrogenic analogues synthesized via click chemistry. ChemMedChem, 2007, 2, 437-440.
-
(2007)
ChemMedChem
, vol.2
, pp. 437-440
-
-
Pirali, T.1
Gatti, S.2
Di Brisco, R.3
Tacchi, S.4
Zaninetti, R.5
Brunelli, E.6
Massarotti, A.7
Sorba, G.8
Canonico, P.L.9
Moro, L.10
Genazzani, A.A.11
Tron, G.C.12
Billington, R.A.13
-
21
-
-
0025900831
-
6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial beta-lactamase
-
Bennet, I.S.; Brooks, G.; Broom, N.J.P.; Calvert, S.H.; Coleman, K.; Francois, I. 6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial beta-lactamase. J. Antibiotics, 1991, 44, 969-977.
-
(1991)
J. Antibiotics
, vol.44
, pp. 969-977
-
-
Bennet, I.S.1
Brooks, G.2
Broom, N.J.P.3
Calvert, S.H.4
Coleman, K.5
Francois, I.6
-
22
-
-
0025963616
-
6-(Substituted methylene)penenms, potent broad spectrum inhibitors of bacterial beta lactamase
-
Bennett, I.; Broom, N.J.P.; Bruton, G.; Calvert, S.; Clarke, B.P.; Coleman, K.; Edmondson, R.; Edwards, P.; Jones, D.; Osborne, N.F.; Walker, G. 6-(Substituted methylene)penenms, potent broad spectrum inhibitors of bacterial beta lactamase. J. Antibiotics, 1991, 44, 331-337.
-
(1991)
J. Antibiotics
, vol.44
, pp. 331-337
-
-
Bennett, I.1
Broom, N.J.P.2
Bruton, G.3
Calvert, S.4
Clarke, B.P.5
Coleman, K.6
Edmondson, R.7
Edwards, P.8
Jones, D.9
Osborne, N.F.10
Walker, G.11
-
23
-
-
0027473861
-
Synthesis and structure-activity relationship of new 7-beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyminoacetamido]-cephalosporins with 1,2,3-triazole in C-3 side chain
-
Kume, M.; Kubota, T.; Kimura, Y.; Nakashimizu, K.; Motokawa, M.; Nakano, M. Synthesis and structure-activity relationship of new 7-beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyminoacetamido]-cephalosporins with 1,2,3-triazole in C-3 side chain. J. Antibiotics, 1993, 46, 177-192.
-
(1993)
J. Antibiotics
, vol.46
, pp. 177-192
-
-
Kume, M.1
Kubota, T.2
Kimura, Y.3
Nakashimizu, K.4
Motokawa, M.5
Nakano, M.6
-
24
-
-
0012143882
-
Synthesis of Darabinofuranosyl and 20-deoxy-D-ribofuranosyl 1,2,3-triazolecarboxamides
-
Makabe, O.; Suzuki, H.; Umezawa, S. Synthesis of Darabinofuranosyl and 20-deoxy-D-ribofuranosyl 1,2,3-triazolecarboxamides. Bull. Chem. Soc. Jpn., 1977, 50, 2689-2693.
-
(1977)
Bull. Chem. Soc. Jpn
, vol.50
, pp. 2689-2693
-
-
Makabe, O.1
Suzuki, H.2
Umezawa, S.3
-
25
-
-
0018968225
-
Synthesis and cytostatic activity of N-ribosylhalomethyl-1,2,3 triazoles
-
Alonso, R.; Camarasa, M.J.; Alonso, G.; De Las Heras, F.G. Synthesis and cytostatic activity of N-ribosylhalomethyl-1,2,3 triazoles. Eur. J. Med. Chem., 1980, 15, 105-109.
-
(1980)
Eur. J. Med. Chem
, vol.15
, pp. 105-109
-
-
Alonso, R.1
Camarasa, M.J.2
Alonso, G.3
de Las Heras, F.G.4
-
26
-
-
41149177593
-
Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumorostatic agent
-
Guo, L.; Ye, C.; Chen, W.; Ye, H.; Zheng, R.; Li, J.; Yang, H.; Yu, X.; Zhang, D. Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumorostatic agent. J. Pharm. Exp. Therap., 2008, 325, 10-16.
-
(2008)
J. Pharm. Exp. Therap
, vol.325
, pp. 10-16
-
-
Guo, L.1
Ye, C.2
Chen, W.3
Ye, H.4
Zheng, R.5
Li, J.6
Yang, H.7
Yu, X.8
Zhang, D.9
-
27
-
-
25744443263
-
Synthesis and reactions of 2-arylhydrazono-2-cyano-N,N-dialkylacetamidines
-
Schafer, H.; Gewald, K.; Bellmann, P.; Gruner, M. Synthesis and reactions of 2-arylhydrazono-2-cyano-N,N-dialkylacetamidines. Monatsh. Chem., 1991, 122, 195-207.
-
(1991)
Monatsh. Chem
, vol.122
, pp. 195-207
-
-
Schafer, H.1
Gewald, K.2
Bellmann, P.3
Gruner, M.4
-
28
-
-
70450285911
-
Synthesis and oxidative cyclization of 2-arylhydrazono-2cyanoacetamidines to 5-amino-2-aryl-2H-[1,2,3]triazole-4-carbonitrile
-
Bel'skaya, N.P.; Demina, M.A.; Sapognikova, S.G.; Fan, Z.-J.; Zhang, H.-K.; Dehaenc, W.; Bakulev V.A. Synthesis and oxidative cyclization of 2-arylhydrazono-2cyanoacetamidines to 5-amino-2-aryl-2H-[1,2,3]triazole-4-carbonitrile. ARKIVOC, 2008, xvi, 9-21.
-
(2008)
ARKIVOC
, vol.xvi
, pp. 9-21
-
-
Bel'skaya, N.P.1
Demina, M.A.2
Sapognikova, S.G.3
Fan, Z.-J.4
Zhang, H.-K.5
Dehaenc, W.6
Bakulev, V.A.7
-
29
-
-
0037099395
-
A stepwise Huisgen cycloaddition process: Copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes
-
Rostovtsev, V.V.; Green, L.G.; Fokin, V.V.; Sharpless, K.B. A stepwise Huisgen cycloaddition process: Copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Angew. Chem. Int. Ed., 2002, 41, 2596-2599.
-
(2002)
Angew. Chem. Int. Ed
, vol.41
, pp. 2596-2599
-
-
Rostovtsev, V.V.1
Green, L.G.2
Fokin, V.V.3
Sharpless, K.B.4
-
30
-
-
0037012920
-
Peptidotriazoles on solid phase: [1,2,3]-Triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides
-
Tornøe, C.W.; Christensen, C.; Meldal, M. Peptidotriazoles on solid phase: [1,2,3]-Triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. J. Org. Chem., 2002, 67, 3057-3064.
-
(2002)
J. Org. Chem
, vol.67
, pp. 3057-3064
-
-
Tornøe, C.W.1
Christensen, C.2
Meldal, M.3
-
31
-
-
0000096835
-
Click chemistry: Diverse chemical function from a few good reactions
-
Kolb, H.C.; Finn, M.G.; Sharpless, K.B. Click chemistry: Diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. Engl., 2001, 40, 2004-2021.
-
(2001)
Angew. Chem. Int. Ed. Engl
, vol.40
, pp. 2004-2021
-
-
Kolb, H.C.1
Finn, M.G.2
Sharpless, K.B.3
-
32
-
-
33750086062
-
Chemoselective formation of successive triazole linkages in one pot: "click-click"chemistry
-
Aucagne, V.; Leigh, D. Chemoselective formation of successive triazole linkages in one pot: "click-click"chemistry. Org. Lett., 2006, 8, 4505-4507.
-
(2006)
Org. Lett
, vol.8
, pp. 4505-4507
-
-
Aucagne, V.1
Leigh, D.2
-
33
-
-
4444233074
-
Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes
-
Peng, W.; Feldman, A.K.; Nugent, A.K.; Hawker, C.J.; Scheel, A.; Voit, B.; Pyun, J.; Fréchet, J.M.J.; Sharpless, K.B.; Fokin, V.V. Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes. Angew. Chem. Int. Ed., 2004, 43, 3928-3932.
-
(2004)
Angew. Chem. Int. Ed
, vol.43
, pp. 3928-3932
-
-
Peng, W.1
Feldman, A.K.2
Nugent, A.K.3
Hawker, C.J.4
Scheel, A.5
Voit, B.6
Pyun, J.7
Fréchet, J.M.J.8
Sharpless, K.B.9
Fokin, V.V.10
-
34
-
-
18744394649
-
Structurally diverse dendritic libraries: A highly efficient functionalization approach using click chemistry
-
Malkoch, M.; Schleicher, K.; Drockenmuller, E.; Hawker, C.J.; Russell, T.P.; Wu, P.; Fokin, V.V. Structurally diverse dendritic libraries: A highly efficient functionalization approach using click chemistry. Macromolecules, 2005, 38, 3663-3678.
-
(2005)
Macromolecules
, vol.38
, pp. 3663-3678
-
-
Malkoch, M.1
Schleicher, K.2
Drockenmuller, E.3
Hawker, C.J.4
Russell, T.P.5
Wu, P.6
Fokin, V.V.7
-
35
-
-
28044465418
-
Ruthenium-catalyzed cycloaddition of alkynes and organic azides
-
Zhang, L.; Chen, X.; Xue, P.; Sun, H.H.Y.; Williams, I.D.; Sharpless, K.B.; Fokin, V.V.; Jia, G. Ruthenium-catalyzed cycloaddition of alkynes and organic azides. J. Am. Chem. Soc., 2005, 127, 15998-15999.
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 15998-15999
-
-
Zhang, L.1
Chen, X.2
Xue, P.3
Sun, H.H.Y.4
Williams, I.D.5
Sharpless, K.B.6
Fokin, V.V.7
Jia, G.8
-
36
-
-
33750473044
-
Study of scope and regioselectivity of the ruthenium-catalyzed [3+2]-cycloaddition of azides with internal alkynes
-
Majireck, M.M.; Weinreb, S.M. A study of scope and regioselectivity of the ruthenium-catalyzed [3+2]-cycloaddition of azides with internal alkynes. J. Org. Chem., 2006, 71, 8680-8683.
-
(2006)
J. Org. Chem
, vol.71
, pp. 8680-8683
-
-
Majireck, M.M.1
Weinreb, S.M.A.2
-
37
-
-
33847654348
-
Design and synthesis of bmethoxyacrylate analogues via click chemistry and biological evaluations
-
Chen, H.; Taylor, J.L.; Abrams, S.R. Design and synthesis of bmethoxyacrylate analogues via click chemistry and biological evaluations. Bioorg. Med. Chem. Lett., 2007, 17, 1979-1983.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 1979-1983
-
-
Chen, H.1
Taylor, J.L.2
Abrams, S.R.3
-
38
-
-
0033577815
-
Strobilurins: Evolution of a new class of active substances
-
Sauter, H.; Steglich, W.; Anke, T. Strobilurins: Evolution of a new class of active substances. Angew. Chem. Int. Ed., 1999, 38, 1328-1349.
-
(1999)
Angew. Chem. Int. Ed
, vol.38
, pp. 1328-1349
-
-
Sauter, H.1
Steglich, W.2
Anke, T.3
-
39
-
-
38849206963
-
Synthesis and antibiotic activity of a small molecules library of 1,2,3-triazole derivatives
-
Aufort, M.; Herscovici, J.; Bouhours, P.; Moreau, N.; Girard, C. Synthesis and antibiotic activity of a small molecules library of 1,2,3-triazole derivatives. Bioorg. Med. Chem. Lett., 2008, 18, 1195-1198.
-
(2008)
Bioorg. Med. Chem. Lett
, vol.18
, pp. 1195-1198
-
-
Aufort, M.1
Herscovici, J.2
Bouhours, P.3
Moreau, N.4
Girard, C.5
-
40
-
-
48149086552
-
Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi
-
Da Silva, E.N. Jr.; Menna-Barreto, R.F.S.; Do Carmo, M.; Pinto, F.R.; Silva, R.S.F.; Teixeira, D.V.; De Souza, M.C.B.V.; De Simone, C.A.; De Castro, S.L.; Ferreira, V.F.; Pinto, A.V. Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi. Eur. J. Med. Chem., 2008, 43, 1774-1780.
-
(2008)
Eur. J. Med. Chem
, vol.43
, pp. 1774-1780
-
-
da Silva Jr., E.N.1
Menna-Barreto, R.F.S.2
Do Carmo, M.3
Pinto, F.R.4
Silva, R.S.F.5
Teixeira, D.V.6
de Souza, M.C.B.V.7
de Simone, C.A.8
de Castro, S.L.9
Ferreira, V.F.10
Pinto, A.V.11
-
41
-
-
38849143209
-
Hybridangiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin andaryl-1,2,3-triazoles
-
Zhou, Y.; Zhao, Y.; O'Boyle, K.M.; Murphy, P.V. Hybridangiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin andaryl-1,2,3-triazoles. Bioorg. Med. Chem. Lett., 2008, 18, 954-958.
-
(2008)
Bioorg. Med. Chem. Lett
, vol.18
, pp. 954-958
-
-
Zhou, Y.1
Zhao, Y.2
O'Boyle, K.M.3
Murphy, P.V.4
-
42
-
-
24744461365
-
4-Aryl-1,2,3-triazole: A novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo
-
Kallander, L.S.; Lu, Q.; Chen, W.; Tomaszek, T.; Yang, G.; Tew, D.; Meek, T.D.; Hofmann, G.A.; Schulz-Pritchard, C.K.; Smith, W.W.; Janson, C.A.; Ryan, M.D.; Zhang, G.-F.; Johanson, K.O.; Kirkpatrick, R.B.; Ho, T.F.; Fisher, P.W.; Mattern, M.R.; Johnson, R.K.; Hansbury, M.J.; Winkler, J.D.; Ward, K.W.; Veber, D.F.; Thompson, S.K. 4-Aryl-1,2,3-triazole: A novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo. J. Med. Chem., 2005, 48, 5644-5647.
-
(2005)
J. Med. Chem
, vol.48
, pp. 5644-5647
-
-
Kallander, L.S.1
Lu, Q.2
Chen, W.3
Tomaszek, T.4
Yang, G.5
Tew, D.6
Meek, T.D.7
Hofmann, G.A.8
Schulz-Pritchard, C.K.9
Smith, W.W.10
Janson, C.A.11
Ryan, M.D.12
Zhang, G.-F.13
Johanson, K.O.14
Kirkpatrick, R.B.15
Ho, T.F.16
Fisher, P.W.17
Mattern, M.R.18
Johnson, R.K.19
Hansbury, M.J.20
Winkler, J.D.21
Ward, K.W.22
Veber, D.F.23
Thompson, S.K.24
more..
-
43
-
-
0028981092
-
The α-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth
-
Pili, R.; Chang, J.; Partis, R.A.; Mueller, R.A.; Chrest, F.J.; Passaniti, A. The α-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth. Cancer Res., 1995, 55, 2920-2926.
-
(1995)
Cancer Res
, vol.55
, pp. 2920-2926
-
-
Pili, R.1
Chang, J.2
Partis, R.A.3
Mueller, R.A.4
Chrest, F.J.5
Passaniti, A.6
-
44
-
-
0027070694
-
1-Deoxymannojirimycin inhibits capillary tube formation in vitro. Analysis of N-linked oligosaccharides in bovine capillary endothelial cells
-
Nguyen, M.; Folkman, J.; Bischoff, J. 1-Deoxymannojirimycin inhibits capillary tube formation in vitro. Analysis of N-linked oligosaccharides in bovine capillary endothelial cells. J. Biol. Chem., 1992, 267, 26157-26165.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 26157-26165
-
-
Nguyen, M.1
Folkman, J.2
Bischoff, J.3
-
45
-
-
11144298973
-
Exploring biology with small organic molecules
-
Stockwell, B.R. Exploring biology with small organic molecules. Nature, 2004, 432, 846-854.
-
(2004)
Nature
, vol.432
, pp. 846-854
-
-
Stockwell, B.R.1
-
47
-
-
21144440283
-
Chemical genetics to chemical genomics: Small molecules offer big insights
-
Spring, D.R. Chemical genetics to chemical genomics: small molecules offer big insights. Chem. Soc. Rev., 2005, 34, 472-482.
-
(2005)
Chem. Soc. Rev
, vol.34
, pp. 472-482
-
-
Spring, D.R.1
-
48
-
-
36749014055
-
1,3-Dipolar cycloadditions. Past and future
-
Huisgen, R. 1,3-Dipolar cycloadditions. Past and future. Angew. Chem. Int. Ed. Engl., 1963, 2, 565-598.
-
(1963)
Angew. Chem. Int. Ed. Engl
, vol.2
, pp. 565-598
-
-
Huisgen, R.1
-
49
-
-
84867726453
-
CuI-catalyzed alkyne-azide click cycloadditions from a mechanistic and synthetic perspective
-
Bock, V.D.; Hiemstra, H.; van Maarseveen, J.H. CuI-catalyzed alkyne-azide click cycloadditions from a mechanistic and synthetic perspective. Eur. J. Org. Chem., 2006, 51-68.
-
(2006)
Eur. J. Org. Chem
, pp. 51-68
-
-
Bock, V.D.1
Hiemstra, H.2
van Maarseveen, J.H.3
-
50
-
-
33846060714
-
Synthesis of a benzolactone collection using click chemistry
-
Ritschel, J.; Sasse, F.; Maier M.E. Synthesis of a benzolactone collection using click chemistry. Eur. J. Org. Chem., 2007, 78-87.
-
(2007)
Eur. J. Org. Chem
, pp. 78-87
-
-
Ritschel, J.1
Sasse, F.2
Maier, M.E.3
-
51
-
-
50249092703
-
3-labeled N(τ)-histidine folate derivative with Its isostructural, clicked 1,2,3-triazole analogue
-
99mTc(CO)3-labeled N(τ)-histidine folate derivative with Its isostructural, clicked 1,2,3-triazole analogue. Bioconjug. Chem., 2008, 19, 1689-1695.
-
(2008)
Bioconjug. Chem
, vol.19
, pp. 1689-1695
-
-
Mindt, T.L.1
Müller, C.2
Melis, M.3
de Jong, M.4
Schibli, R.5
-
52
-
-
34547925204
-
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety
-
Salmon, A.J.; Williams, M.L.; Innocenti, A.; Vullo, D.; Supuran, C.T.; Poulsen, S.-A. Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety. Bioorg. Med. Chem. Lett., 2007, 17, 5032-5035.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 5032-5035
-
-
Salmon, A.J.1
Williams, M.L.2
Innocenti, A.3
Vullo, D.4
Supuran, C.T.5
Poulsen, S.-A.6
-
53
-
-
48649096568
-
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives
-
Poulsen, S.-A.; Wilkinson, B.L.; Innocenti, A.; Vullo, D.; Supuran, C.T. Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg. Med. Chem. Lett., 2008, 18, 4624-4627.
-
(2008)
Bioorg. Med. Chem. Lett
, vol.18
, pp. 4624-4627
-
-
Poulsen, S.-A.1
Wilkinson, B.L.2
Innocenti, A.3
Vullo, D.4
Supuran, C.T.5
-
54
-
-
33846575753
-
Inhibition of membraneassociated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides
-
Wilkinson, B.L.; Bornaghi, L.F.; Houston, T.A.; Innocenti, A.; Vullo, D.; Supuran, C.T.; Poulsen, S.-A. Inhibition of membraneassociated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg. Med. Chem. Lett., 2007, 17, 987-992.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 987-992
-
-
Wilkinson, B.L.1
Bornaghi, L.F.2
Houston, T.A.3
Innocenti, A.4
Vullo, D.5
Supuran, C.T.6
Poulsen, S.-A.7
-
55
-
-
34147144592
-
Carbonic anhydrase inhibitors: Inhibition of isozymes I, II, and IX with triazole-linked Oglycosides of benzene sulfonamides
-
Wilkinson, B.L.; Bornaghi, L.F.; Houston, T.A.; Innocenti, A.; Vullo, D.; Supuran, C.T.; Poulsen S.-A. Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked Oglycosides of benzene sulfonamides. J. Med. Chem., 2007, 50, 1651-1657.
-
(2007)
J. Med. Chem
, vol.50
, pp. 1651-1657
-
-
Wilkinson, B.L.1
Bornaghi, L.F.2
Houston, T.A.3
Innocenti, A.4
Vullo, D.5
Supuran, C.T.6
Poulsen, S.-A.7
-
56
-
-
41149177054
-
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides
-
Wilkinson, B.L.; Innocenti, A.; Vullo, D.; Supuran, C.T.; Poulsen S.-A. Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. J. Med. Chem., 2008, 51, 1945-1953.
-
(2008)
J. Med. Chem
, vol.51
, pp. 1945-1953
-
-
Wilkinson, B.L.1
Innocenti, A.2
Vullo, D.3
Supuran, C.T.4
Poulsen, S.-A.5
-
57
-
-
38849143765
-
Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
-
Supuran, C.T. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Discov., 2008, 7, 168-181.
-
(2008)
Nat. Rev. Drug Discov
, vol.7
, pp. 168-181
-
-
Supuran, C.T.1
-
58
-
-
3442883664
-
Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects
-
Pastorekova, S.; Parkkila, S.; Pastorek, J.; Supuran, C.T. Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J. Enzyme Inhib. Med. Chem., 2004, 19, 199-229.
-
(2004)
J. Enzyme Inhib. Med. Chem
, vol.19
, pp. 199-229
-
-
Pastorekova, S.1
Parkkila, S.2
Pastorek, J.3
Supuran, C.T.4
-
59
-
-
34248659399
-
Carbonic anhydrases as targets for medicinal chemistry
-
Supuran, C.T.; Scozzafava, A. Carbonic anhydrases as targets for medicinal chemistry. Bioorg. Med. Chem., 2007, 15, 4336-4350.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 4336-4350
-
-
Supuran, C.T.1
Scozzafava, A.2
-
60
-
-
2442579987
-
Carbonic anhidrases: Catalytic and inhibition mechanisms, distribution and physiological roles
-
Supuran, C.T.; Scozzafava, A.; Conway, J.; Eds., CRC Press: Boca Raton - FL
-
Supuran, C.T. Carbonic anhidrases: catalytic and inhibition mechanisms, distribution and physiological roles. In: Supuran, C.T.; Scozzafava, A.; Conway, J.; Eds. Carbonic anhydrase: its inhibitors and activators. CRC Press: Boca Raton - FL, 2004, pp. 1-24.
-
(2004)
Carbonic Anhydrase: Its Inhibitors and Activators
, pp. 1-24
-
-
Supuran, C.T.1
-
61
-
-
19944422139
-
Metal complexes of heterocyclic sulfonamides as carbonic anhidrase inhibitors
-
Supuran, C.T.; Scozzafava, A.; Conway, J.; Eds., CRC Press: Boca Raton - FL
-
Borras, J.; Alzuet, G.; Ferrer, S.; Supuran, C.T. Metal complexes of heterocyclic sulfonamides as carbonic anhidrase inhibitors. In: Supuran, C.T.; Scozzafava, A.; Conway, J.; Eds. Carbonic anhydrase: its inhibitors and activators. CRC Press: Boca Raton - FL, 2004, pp. 183-208.
-
(2004)
Carbonic Anhydrase: Its Inhibitors and Activators
, pp. 183-208
-
-
Borras, J.1
Alzuet, G.2
Ferrer, S.3
Supuran, C.T.4
-
62
-
-
33748514354
-
Preparation and reactions of some neutral pentamethylcyclopentadienyl-ruthenium vinylidene complexes
-
Bruce, M.I.; Hall, B.C.; Zaitseva, N.N.; Skelton, B.W.; White, A.H. Preparation and reactions of some neutral pentamethylcyclopentadienyl-ruthenium vinylidene complexes. J. Chem. Soc., Dalton Trans., 1998, 1793-1804.
-
(1998)
J. Chem. Soc., Dalton Trans
, pp. 1793-1804
-
-
Bruce, M.I.1
Hall, B.C.2
Zaitseva, N.N.3
Skelton, B.W.4
White, A.H.5
-
63
-
-
33845956331
-
Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3triazoles as inhibitor of HER2 tyrosine kinase
-
Cheng, Z.-Y; Li, W.-J.; He, F.; Zhou, J.-M.; Zhu, X.-F. Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3triazoles as inhibitor of HER2 tyrosine kinase. Bioorg. Med. Chem., 2007, 15, 1533-1538.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 1533-1538
-
-
Cheng, Z.-Y.1
Li, W.-J.2
He, F.3
Zhou, J.-M.4
Zhu, X.-F.5
-
64
-
-
67649986131
-
Chitinase inhibitors: Extraction of the active framework from natural argifin and use of in situ click chemistry
-
Hirose, T.; Sunazuka, T.; Sugawara, A.; Endo, A.; Iguchi, K.; Yamamoto, T.; Ui, H.; Shiomi, K.; Watanabe, T.; Sharpless, K.B.; Omura, S. Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry. J. Antibiot., 2009, 62, 277-282.
-
(2009)
J. Antibiot
, vol.62
, pp. 277-282
-
-
Hirose, T.1
Sunazuka, T.2
Sugawara, A.3
Endo, A.4
Iguchi, K.5
Yamamoto, T.6
Ui, H.7
Shiomi, K.8
Watanabe, T.9
Sharpless, K.B.10
Omura, S.11
-
65
-
-
0033920903
-
Argifin, a new chitinase inhibitor, produced by Gliodadium sp. FTD-0668. I. Taxonomy, fermentation, and biological activities
-
Omura, S.; Arai, N.; Yamaguchi, Y.; Masuma, R.; Iwai, Y.; Namikoshi, M.; Turberg, A.; Kölbl, H.; Shiomi, K. Argifin, a new chitinase inhibitor, produced by Gliodadium sp. FTD-0668. I. Taxonomy, fermentation, and biological activities. J. Antibiot., 2000, 53, 603-608.
-
(2000)
J. Antibiot
, vol.53
, pp. 603-608
-
-
Omura, S.1
Arai, N.2
Yamaguchi, Y.3
Masuma, R.4
Iwai, Y.5
Namikoshi, M.6
Turberg, A.7
Kölbl, H.8
Shiomi, K.9
-
66
-
-
0033923739
-
Argifin, a new chitinase inhibitor, produced by Gliodadium sp. FTD-0668. II. Isolation, physico-chemical properties, and structure elucidation
-
Arai, N.; Shiomi, K.; Iwai, Y.; Omura, S. Argifin, a new chitinase inhibitor, produced by Gliodadium sp. FTD-0668. II. Isolation, physico-chemical properties, and structure elucidation. J. Antibiot. 2000, 53, 609-614.
-
(2000)
J. Antibiot
, vol.53
, pp. 609-614
-
-
Arai, N.1
Shiomi, K.2
Iwai, Y.3
Omura, S.4
-
67
-
-
0034719795
-
Structure of argifin, a new chitinase inhibitor produced by Gliocladium sp
-
Shiomi, K.; Arai, N.; Iwai, Y.; Turberg, A.; Kölbl, H.; Omura, S. Structure of argifin, a new chitinase inhibitor produced by Gliocladium sp. Tetrahedron Lett., 2000, 41, 2141-2143.
-
(2000)
Tetrahedron Lett
, vol.41
, pp. 2141-2143
-
-
Shiomi, K.1
Arai, N.2
Iwai, Y.3
Turberg, A.4
Kölbl, H.5
Omura, S.6
-
68
-
-
0033788236
-
Argadin, a new chitinase inhibitor, produced by Clonostachys sp. FO-7314
-
Arai, N.; Shiomi, K.; Yamaguchi, Y.; Masuma, R.; Iwai, Y.; Turberg, A.; Koelbl, H.; Omura, S. Argadin, a new chitinase inhibitor, produced by Clonostachys sp. FO-7314. Chem. Pharm. Bull., 2000, 48, 1442-1446.
-
(2000)
Chem. Pharm. Bull
, vol.48
, pp. 1442-1446
-
-
Arai, N.1
Shiomi, K.2
Yamaguchi, Y.3
Masuma, R.4
Iwai, Y.5
Turberg, A.6
Koelbl, H.7
Omura, S.8
-
69
-
-
15844425962
-
Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents
-
Li, J.J.; Norton, M.B.; Reinhard, E.J.; Anderson, G.D.; Gregory, S.A.; Isakson, P.C.; Koboldt, C.M.; Masferrer, J.L.; Perkins, W.E.; Seibert, K.; Zhang, Y.; Zweifel, B.S.; Reitz, D.B. Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. J. Med. Chem., 1996, 39, 1846-1856.
-
(1996)
J. Med. Chem
, vol.39
, pp. 1846-1856
-
-
Li, J.J.1
Norton, M.B.2
Reinhard, E.J.3
Anderson, G.D.4
Gregory, S.A.5
Isakson, P.C.6
Koboldt, C.M.7
Masferrer, J.L.8
Perkins, W.E.9
Seibert, K.10
Zhang, Y.11
Zweifel, B.S.12
Reitz, D.B.13
-
70
-
-
36549002356
-
Non-carboxylic analogues of naproxen: Design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives
-
Amir, M.; Kumar, H.; Javed, S.A. Non-carboxylic analogues of naproxen: design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives. Arch. Pharm. Chem. Life Sci., 2007, 340, 577-585.
-
(2007)
Arch. Pharm. Chem. Life Sci
, vol.340
, pp. 577-585
-
-
Amir, M.1
Kumar, H.2
Javed, S.A.3
-
71
-
-
56949101987
-
1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: Synthesis and preliminary evaluation of biological properties
-
Kumar, H.; Javed, S.A.; Khan, S.A.; Amir M. 1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: Synthesis and preliminary evaluation of biological properties. Eur. J. Med. Chem., 2008, 43, 2688-2698.
-
(2008)
Eur. J. Med. Chem
, vol.43
, pp. 2688-2698
-
-
Kumar, H.1
Javed, S.A.2
Khan, S.A.3
Amir, M.4
-
72
-
-
36549074250
-
Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents
-
Turan-Zitouni, G.; Kaplancikli, Z.A.; Özdemir, A.; Chevallet, P.; Kandilci, H.B.; Gümüsel, B. Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents. Arch. Pharm. Chem. Life Sci., 2007, 340, 586-590.
-
(2007)
Arch. Pharm. Chem. Life Sci
, vol.340
, pp. 586-590
-
-
Turan-Zitouni, G.1
Kaplancikli, Z.A.2
Özdemir, A.3
Chevallet, P.4
Kandilci, H.B.5
Gümüsel, B.6
-
73
-
-
33847774183
-
Preparation of 5-aryl-3-alkylthio-l,2,4-triazoles and corresponding sulfones with antiinflammatory-analgesic activity
-
Tozkoparan, B.; Küpeli, E.; Yeşilada, E.; Ertan, M. Preparation of 5-aryl-3-alkylthio-l,2,4-triazoles and corresponding sulfones with antiinflammatory-analgesic activity. Bioorg. Med. Chem., 2007, 15, 1808-1814.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 1808-1814
-
-
Tozkoparan, B.1
Küpeli, E.2
Yeşilada, E.3
Ertan, M.4
-
74
-
-
0042071946
-
Analgesic activity of acylated 2-benzoxazolinone derivatives
-
Gökhan, N.; Erdoǧan, H.; Durlu, N.T.; Demirdamar, R. Analgesic activity of acylated 2-benzoxazolinone derivatives. Farmaco, 1999, 54, 112-115.
-
(1999)
Farmaco
, vol.54
, pp. 112-115
-
-
Gökhan, N.1
Erdoǧan, H.2
Durlu, N.T.3
Demirdamar, R.4
-
75
-
-
0035416280
-
Synthesis of some novel 3-methyl-6-(2-substitutedpropanoyl/propyl)-2-benzoxazolinone derivatives and anti-nociceptive activity
-
Çaliş, Ü.; Gökhan, N.; Erdoǧan, H. Synthesis of some novel 3-methyl-6-(2-substitutedpropanoyl/propyl)-2-benzoxazolinone derivatives and anti-nociceptive activity. Farmaco, 2001, 56, 719-724.
-
(2001)
Farmaco
, vol.56
, pp. 719-724
-
-
Çaliş, U.1
Gökhan, N.2
Erdoǧan, H.3
-
76
-
-
0000183849
-
Antimicrobial properties of 6,7-dihydroxy-, 7,8-dihydroxy-, 6-hydroxy- and 8-hydroxycoumarins
-
Jund, L.; Corse, J.; King, A.S.; Bayne, H.; Mihrag, K. Antimicrobial properties of 6,7-dihydroxy-, 7,8-dihydroxy-, 6-hydroxy- and 8-hydroxycoumarins. Phytochemistry, 1971, 10, 2971-2974.
-
(1971)
Phytochemistry
, vol.10
, pp. 2971-2974
-
-
Jund, L.1
Corse, J.2
King, A.S.3
Bayne, H.4
Mihrag, K.5
-
77
-
-
34447267965
-
1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic-antiinflammatory and antimicrobial activities
-
Salgin-Gökşen, U.; Gökhan-Kelekçi, N.; Göktaş, Ö.; Köysal, Y.; Kiliç, E.; Işik, Ş.; Aktay G.; Özalp, M. 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic-antiinflammatory and antimicrobial activities. Bioorg. Med. Chem., 2007, 15, 5738-5751.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 5738-5751
-
-
Salgin-Gökşen, U.1
Gökhan-Kelekçi, N.2
Göktaş, O.3
Köysal, Y.4
Kiliç, E.5
Işik, S.6
Aktay, G.7
Özalp, M.8
-
78
-
-
53949115450
-
Synthesis, biological and computational study of new Schiff base hydrazones bearing 3-(4-pyridine)-5-mercapto-1,2,4-triazole moiety
-
Khanmohammadi, H.; Abnosi, M.H.; Hosseinzadeh, A.; Erfantalab, M. Synthesis, biological and computational study of new Schiff base hydrazones bearing 3-(4-pyridine)-5-mercapto-1,2,4-triazole moiety. Spectrochim. Acta Part A: Mol. Biomol. Spectr., 2008, 71, 1474-1480.
-
(2008)
Spectrochim. Acta Part A: Mol. Biomol. Spectr
, vol.71
, pp. 1474-1480
-
-
Khanmohammadi, H.1
Abnosi, M.H.2
Hosseinzadeh, A.3
Erfantalab, M.4
-
79
-
-
47949116720
-
Syntheses of 1, 2, 4 triazole derivatives and their biological activity
-
Havaldar, F.H.; Patil, A.R. Syntheses of 1, 2, 4 triazole derivatives and their biological activity. E-J. Chem., 2008, 5, 347-354.
-
(2008)
E-J. Chem
, vol.5
, pp. 347-354
-
-
Havaldar, F.H.1
Patil, A.R.2
-
80
-
-
38849090006
-
Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies
-
Ezabadi, I.R.; Camoutsis, C.; Zoumpoulakis, P.; Geronikaki, A.; Sokovic, M.; Glamocilija, J.; Ciric, A. Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and conformational studies. Bioorg. Med. Chem., 2008, 16, 1150-1161.
-
(2008)
Bioorg. Med. Chem
, vol.16
, pp. 1150-1161
-
-
Ezabadi, I.R.1
Camoutsis, C.2
Zoumpoulakis, P.3
Geronikaki, A.4
Sokovic, M.5
Glamocilija, J.6
Ciric, A.7
-
81
-
-
0842334482
-
Chemical analysis and antifungal activity of Thymus striatus
-
Couladis, M.; Tzakou, O.; Kujundzic, S.; Sokovic, M.; Mimica-Dukic, N. Chemical analysis and antifungal activity of Thymus striatus. Phytother. Res., 2004, 18, 40-42.
-
(2004)
Phytother. Res
, vol.18
, pp. 40-42
-
-
Couladis, M.1
Tzakou, O.2
Kujundzic, S.3
Sokovic, M.4
Mimica-Dukic, N.5
-
82
-
-
67650503541
-
Synthesis, crystal structure and biological activity of 1-(β-Dglucopyranosyl)-3-amino-5-methyl-1H-1,2,4-triazole
-
Yang, C.-L.; Wang, X.-F.; Jin, Z.-P.; Meng F.-G.; Xu S.-P. Synthesis, crystal structure and biological activity of 1-(β-Dglucopyranosyl)-3-amino-5-methyl-1H-1,2,4-triazole. Chinese J. Struct. Chem., 2009, 28, 471-476.
-
(2009)
Chinese J. Struct. Chem
, vol.28
, pp. 471-476
-
-
Yang, C.-L.1
Wang, X.-F.2
Jin, Z.-P.3
Meng, F.-G.4
Xu, S.-P.5
-
83
-
-
56949104357
-
Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases
-
Bagihalli, G.B.; Gouda Avaji, P.; Patil, S.A.; Badami, P.S. Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases. Eur. J. Med. Chem., 2008, 43, 2639-2649.
-
(2008)
Eur. J. Med. Chem
, vol.43
, pp. 2639-2649
-
-
Bagihalli, G.B.1
Avaji, G.P.2
Patil, S.A.3
Badami, P.S.4
-
84
-
-
0038736950
-
Hypervalent iodine mediated synthesis of 1-aryl/hetryl-1,2,4triazolo[4,3-a]pyridines and 1-aryl/hetryl 5-methyl-1,2,4-triazolo[4,3a]quinolines as antibacterial agents
-
Sadana, A.K.; Miraza, Y.; Aneja, K.R.; Prakash, O. Hypervalent iodine mediated synthesis of 1-aryl/hetryl-1,2,4triazolo[4,3-a]pyridines and 1-aryl/hetryl 5-methyl-1,2,4-triazolo[4,3a]quinolines as antibacterial agents. Eur. J. Med. Chem., 2003, 38, 533-536.
-
(2003)
Eur. J. Med. Chem
, vol.38
, pp. 533-536
-
-
Sadana, A.K.1
Miraza, Y.2
Aneja, K.R.3
Prakash, O.4
-
85
-
-
12344286977
-
Quantitative structure-activity relationship (5D-QSAR) study of combretastatinlike analogues as inhibitors of tubulin assembly
-
Ducki, S.; Mackenzie, G.; Lawrence, N.J.; Snyder, J.P. Quantitative structure-activity relationship (5D-QSAR) study of combretastatinlike analogues as inhibitors of tubulin assembly. J. Med. Chem., 2005, 48, 457-465.
-
(2005)
J. Med. Chem
, vol.48
, pp. 457-465
-
-
Ducki, S.1
Mackenzie, G.2
Lawrence, N.J.3
Snyder, J.P.4
-
86
-
-
33847399088
-
Highly potent triazole-based tubulin polymerization inhibitors
-
Zhang, Q.; Peng, Y.; Wang, X.I.; Keenan, S.M.; Arora, S.; Welsh, W.J. Highly potent triazole-based tubulin polymerization inhibitors. J. Med. Chem., 2007, 50, 749-754.
-
(2007)
J. Med. Chem
, vol.50
, pp. 749-754
-
-
Zhang, Q.1
Peng, Y.2
Wang, X.I.3
Keenan, S.M.4
Arora, S.5
Welsh, W.J.6
-
87
-
-
0023801309
-
Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: A structure-activity study
-
Lin, C.M.; Singh, S.B.; Chu, P.S.; Dempcy, R.O.; Schmidt, J.M.; Pettit, G.R.; Hamel, E. Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study. Mol. Pharmacol., 1988, 34, 200-208.
-
(1988)
Mol. Pharmacol
, vol.34
, pp. 200-208
-
-
Lin, C.M.1
Singh, S.B.2
Chu, P.S.3
Dempcy, R.O.4
Schmidt, J.M.5
Pettit, G.R.6
Hamel, E.7
-
88
-
-
20444403700
-
Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41
-
Pettit, G.R.; Rhodes, M.R.; Herald, D.L.; Hamel, E.; Schmidt, J.M.; Pettit, R.K. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. J. Med. Chem., 2005, 48, 4087-4099.
-
(2005)
J. Med. Chem
, vol.48
, pp. 4087-4099
-
-
Pettit, G.R.1
Rhodes, M.R.2
Herald, D.L.3
Hamel, E.4
Schmidt, J.M.5
Pettit, R.K.6
-
89
-
-
0025326011
-
Differential cytotoxicity of combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines
-
McGown, A.T.; Fox, B.W. Differential cytotoxicity of combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines. Cancer Chemother. Pharmacol., 1990, 26, 79-81.
-
(1990)
Cancer Chemother. Pharmacol
, vol.26
, pp. 79-81
-
-
McGown, A.T.1
Fox, B.W.2
-
90
-
-
15144356733
-
Novel combretastatin analogues effective against murine solid tumors: Design and structure-activity relationships
-
Ohsumi, K.; Nakagawa, R.; Fukuda, Y.; Hatanaka, T.; Morinaga, Y.; Nihei, Y.; Ohishi, K.; Suga, Y.; Akiyama, Y.; Tsuji, T. Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships. J. Med. Chem., 1998, 41, 3022-3032.
-
(1998)
J. Med. Chem
, vol.41
, pp. 3022-3032
-
-
Ohsumi, K.1
Nakagawa, R.2
Fukuda, Y.3
Hatanaka, T.4
Morinaga, Y.5
Nihei, Y.6
Ohishi, K.7
Suga, Y.8
Akiyama, Y.9
Tsuji, T.10
-
91
-
-
0041421003
-
Combretastatin A-4 analogues as antimitotic antitumor agents
-
Nam, N.H. Combretastatin A-4 analogues as antimitotic antitumor agents. Curr. Med. Chem., 2003, 10, 1697-1722.
-
(2003)
Curr. Med. Chem
, vol.10
, pp. 1697-1722
-
-
Nam, N.H.1
-
92
-
-
33744820579
-
Medicinal chemistry of combretastatin A4: Present and future directions
-
Tron, G.C.; Pirali, T.; Sorba, G.; Pagliai, F.; Busacca, S.; Genazzani, A.A. Medicinal chemistry of combretastatin A4: present and future directions. J. Med. Chem., 2006, 49, 3033-3044.
-
(2006)
J. Med. Chem
, vol.49
, pp. 3033-3044
-
-
Tron, G.C.1
Pirali, T.2
Sorba, G.3
Pagliai, F.4
Busacca, S.5
Genazzani, A.A.6
-
93
-
-
0026047751
-
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization
-
Cushman, M.; Nagarathnam, D.; Gopal, D.; Chakraborti, A.K.; Lin, C.M.; Hamel, E. Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. J. Med. Chem., 1991, 34, 2579-2588.
-
(1991)
J. Med. Chem
, vol.34
, pp. 2579-2588
-
-
Cushman, M.1
Nagarathnam, D.2
Gopal, D.3
Chakraborti, A.K.4
Lin, C.M.5
Hamel, E.6
-
94
-
-
0026734208
-
Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents
-
Cushman, M.; Nagarathnam, D.; Gopal, D.; He, H.M.; Lin, C.M.; Hamel, E. Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. J. Med. Chem., 1992, 35, 2293-2306.
-
(1992)
J. Med. Chem
, vol.35
, pp. 2293-2306
-
-
Cushman, M.1
Nagarathnam, D.2
Gopal, D.3
He, H.M.4
Lin, C.M.5
Hamel, E.6
-
95
-
-
19944433930
-
Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety
-
Maya, A.B.; Perez-Melero, C.; Mateo, C.; Alonso, D.; Fernandez, J.L.; Gajate, C.; Mollinedo, F.; Pelaez, R.; Caballero, E.; Medarde, M. Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety. J. Med. Chem., 2005, 48, 556-568.
-
(2005)
J. Med. Chem
, vol.48
, pp. 556-568
-
-
Maya, A.B.1
Perez-Melero, C.2
Mateo, C.3
Alonso, D.4
Fernandez, J.L.5
Gajate, C.6
Mollinedo, F.7
Pelaez, R.8
Caballero, E.9
Medarde, M.10
-
96
-
-
0035801759
-
The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4
-
Flynn, B.L.; Flynn, G.P.; Hamel, E.; Jung, M.K. The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4. Bioorg. Med. Chem. Lett, 2001, 11, 2341-2343.
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, pp. 2341-2343
-
-
Flynn, B.L.1
Flynn, G.P.2
Hamel, E.3
Jung, M.K.4
-
97
-
-
0037030605
-
One-pot synthesis of benzo-[b]furan and indole inhibitors of tubulin polymerization
-
Flynn, B.L.; Hamel, E.; Jung, M.K. One-pot synthesis of benzo-[b]furan and indole inhibitors of tubulin polymerization. J. Med. Chem., 2002, 45, 2670-2673.
-
(2002)
J. Med. Chem
, vol.45
, pp. 2670-2673
-
-
Flynn, B.L.1
Hamel, E.2
Jung, M.K.3
-
98
-
-
3843136376
-
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents
-
Liou, J.P.; Chang, Y.L.; Kuo, F.M.; Chang, C.W.; Tseng, H.Y.; Wang, C.C.; Yang, Y.N.; Chang, J.Y.; Lee, S.J.; Hsieh, H.P. Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents. J. Med. Chem., 2004, 47, 4247-4257.
-
(2004)
J. Med. Chem
, vol.47
, pp. 4247-4257
-
-
Liou, J.P.1
Chang, Y.L.2
Kuo, F.M.3
Chang, C.W.4
Tseng, H.Y.5
Wang, C.C.6
Yang, Y.N.7
Chang, J.Y.8
Lee, S.J.9
Hsieh, H.P.10
-
99
-
-
0037061622
-
Potent, orally active heterocycle-based combretastatin A-4 analogues: Synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation
-
Wang, L.; Woods, K.W.; Li, Q.; Barr, K.J.; McCroskey, R.W.; Hannick, S.M.; Gherke, L.; Credo, R.B.; Hui, Y.H.; Marsh, K.; Warner, R.; Lee, J.Y.; Zielinski-Mozng, N.; Frost, D.; Rosenberg, S.H.; Sham, H.L. Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation. J. Med. Chem., 2002, 45, 1697-1711.
-
(2002)
J. Med. Chem
, vol.45
, pp. 1697-1711
-
-
Wang, L.1
Woods, K.W.2
Li, Q.3
Barr, K.J.4
McCroskey, R.W.5
Hannick, S.M.6
Gherke, L.7
Credo, R.B.8
Hui, Y.H.9
Marsh, K.10
Warner, R.11
Lee, J.Y.12
Zielinski-Mozng, N.13
Frost, D.14
Rosenberg, S.H.15
Sham, H.L.16
-
100
-
-
34548512846
-
Mono- and polynuclear complexes of Pt(II) with polypyridyl ligands synthesis, spectroscopic and structural characterization and cytotoxic activity
-
Rubino, S.; Portanova, P.; Albanese, A.; Calvaruso, G.; Orecchio, S.; Fontana, G.; Stocco, G.C. Mono- and polynuclear complexes of Pt(II) with polypyridyl ligands synthesis, spectroscopic and structural characterization and cytotoxic activity. J. Inorg. Biochem., 2007, 101, 1473-1482.
-
(2007)
J. Inorg. Biochem
, vol.101
, pp. 1473-1482
-
-
Rubino, S.1
Portanova, P.2
Albanese, A.3
Calvaruso, G.4
Orecchio, S.5
Fontana, G.6
Stocco, G.C.7
-
101
-
-
34247616687
-
Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L) Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl-1,2,4-triazole): Aquation, redox properties, protein binding, and antiproliferative activity
-
Groessl, M.; Reisner, E.; Hartinger, C.G.; Eichinger, R.; Semenova, O.; Timerbaev, A.R.; Jakupec, M.A.; Arion, V.B.; Keppler, B.K. Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L) Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity. J. Med. Chem., 2007, 50, 2185-2193.
-
(2007)
J. Med. Chem
, vol.50
, pp. 2185-2193
-
-
Groessl, M.1
Reisner, E.2
Hartinger, C.G.3
Eichinger, R.4
Semenova, O.5
Timerbaev, A.R.6
Jakupec, M.A.7
Arion, V.B.8
Keppler, B.K.9
-
102
-
-
33746233238
-
Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase
-
De La Rosa, M.; Kim, H.W.; Gunic, E.; Jenket, C.; Boyle, U.; Koh, Y.-H.; Korboukh, I.; Allan, M.; Zhang, W.; Chen, H.; Xu, W.; Nilar, S.; Yao, N.; Hamatake, R.; Lang, S.A.; Hong, Z.; Zhang, Z.; Girardet, J.-L. Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase. Bioorg. Med. Chem. Lett., 2006, 16, 4444-4449.
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 4444-4449
-
-
de la Rosa, M.1
Kim, H.W.2
Gunic, E.3
Jenket, C.4
Boyle, U.5
Koh, Y.-H.6
Korboukh, I.7
Allan, M.8
Zhang, W.9
Chen, H.10
Xu, W.11
Nilar, S.12
Yao, N.13
Hamatake, R.14
Lang, S.A.15
Hong, Z.16
Zhang, Z.17
Girardet, J.-L.18
-
103
-
-
33745727133
-
Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors
-
Wang, Z.; Wu, B.; Kuhen, K.L.; Bursulaya, B.; Nguyen, T.N.; Nguyen, D.G.; He, Y. Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett., 2006, 16, 4174-4177.
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 4174-4177
-
-
Wang, Z.1
Wu, B.2
Kuhen, K.L.3
Bursulaya, B.4
Nguyen, T.N.5
Nguyen, D.G.6
He, Y.7
-
104
-
-
34548388846
-
Synthesis of Novel Derivatives of 4-Amino-3-(2-Furyl)-5-Mercapto-1,2,4-Triazole as Potential HIV-1 NNRTIs
-
Wu, J.; Liu, X.; Cheng, X.; Cao, Y.; Wang, D.; Li, Z.; Xu, W.; Pannecouque, C.; Witvrouw, M.; De Clercq, E. Synthesis of Novel Derivatives of 4-Amino-3-(2-Furyl)-5-Mercapto-1,2,4-Triazole as Potential HIV-1 NNRTIs. Molecules, 2007, 12, 2003-2016.
-
(2007)
Molecules
, vol.12
, pp. 2003-2016
-
-
Wu, J.1
Liu, X.2
Cheng, X.3
Cao, Y.4
Wang, D.5
Li, Z.6
Xu, W.7
Pannecouque, C.8
Witvrouw, M.9
de Clercq, E.10
|