Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 3, 2007, Pages 1533-1538

  Cheng, Zhi Yi ^a   Li, Wen Jie ^a   He, Feng ^a   Zhou, Jun Min ^b   Zhu, Xiao Feng ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

1,2,3 Triazole; Breast cancer; Tyrosine kinase inhibitor

Indexed keywords

4 (2,3 DIMETHOXYPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (3 PHENOXYPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (3,4 DIMETHOXYPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (3,4,5 TRIMETHOXYPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (4 BROMOPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (4 CHLOROPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (4 FLUORO 3 PHENOXYLPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (4 FLUOROPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (4 ISOPROPYLPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (4 METHOXYPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 (4 METHYLPHENYL) 5 CYANO 2H 1,2,3 TRIAZOLE; 4 PHENYL 5 CYANO 1,2,3 TRIAZOLE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN TYROSINE KINASE INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL LINE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; SUBSTITUTION REACTION;

BREAST NEOPLASMS; CELL PROLIFERATION; ENZYME INHIBITORS; HUMANS; PHOSPHORYLATION; RECEPTOR, ERBB-2; TRIAZOLES; TUMOR CELLS, CULTURED;

EID: 33845956331     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.041     Document Type: Article

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