Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 17, 2006, Pages 4444-4449

  De La Rosa, Martha ^a   Kim, Hong Woo ^a   Gunic, Esmir ^a   Jenket, Cheryl ^a   Boyle, Uyen ^a   Koh, Yung hyo ^a   Korboukh, Ilia ^a   Allan, Matthew ^a   Zhang, Weijian ^a   Chen, Huanming ^a   Xu, Wen ^a   Nilar, Shahul ^a   Yao, Nanhua ^a   Hamatake, Robert ^a   Lang, Stanley A ^a   Hong, Zhi ^a   Zhang, Zhijun ^a   Girardet, Jean Luc ^a  

^a Valeant Research and Development   (United States)

Author keywords

Antiviral; HIV 1; K103N; NNRTI; Triazole; Y181C; Y188L

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; EFAVIRENZ; ISOTHIOCYANIC ACID DERIVATIVE; NEVIRAPINE; PHENYLTHIOSEMICARBAZIDE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SEMICARBAZIDE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; POLYMERIZATION; SUBSTITUTION REACTION; VIRUS MUTANT;

ENZYME INHIBITORS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MOLECULAR STRUCTURE; NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33746233238     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.06.048     Document Type: Article

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