Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 7, 1998, Pages 775-780

  Duncia, John V ^a   Santella III, Joseph B ^a   Higley, C Anne ^a   VanAtten, Mary K ^a   Weber, Patricia C ^a,b   Alexander, Richard S ^a   Kettner, Charles A ^a   Pruitt, James R ^a   Liauw, Anne Y ^a   Quan, Mimi L ^a   Knabb, Robert M ^a   Wexler, Ruth R ^a  

^a DUPONT COMPANY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; PYRAZOLE DERIVATIVE; TETRAZOLE DERIVATIVE; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CHEMICAL MODIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY;

AMIDES; BINDING SITES; BORONIC ACIDS; CRYSTALLOGRAPHY, X-RAY; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; THROMBIN; TRIAZOLES;

EID: 0032492712     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00104-8     Document Type: Article

References (13)

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