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Volumn 49, Issue 11, 2006, Pages 3033-3044

Medicinal chemistry of combretastatin A4: Present and future directions

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; COMBRETASTATIN A4; PACLITAXEL; PODOPHYLLOTOXIN; STEGANACIN; UNCLASSIFIED DRUG;

EID: 33744820579     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0512903     Document Type: Short Survey
Times cited : (626)

References (102)
  • 1
    • 0027368441 scopus 로고
    • Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature
    • Burrows, F. J.; Thorpe, P. E. Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 8996-9000.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 8996-9000
    • Burrows, F.J.1    Thorpe, P.E.2
  • 2
    • 2642571660 scopus 로고    scopus 로고
    • Vascular targeted therapies for treatment of malignant disease
    • Siemann, D. W.; Chaplin, D. J.; Horsman, M. R. Vascular targeted therapies for treatment of malignant disease Cancer 2004, 100, 2491-2499.
    • (2004) Cancer , vol.100 , pp. 2491-2499
    • Siemann, D.W.1    Chaplin, D.J.2    Horsman, M.R.3
  • 3
    • 20344367537 scopus 로고    scopus 로고
    • Tumor vascular targeting
    • Neri, D.; Bicknell, R. Tumor vascular targeting. Nat. Rev. Cancer 2005, 5, 436-446.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 436-446
    • Neri, D.1    Bicknell, R.2
  • 5
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara, N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 2004, 25, 581-611.
    • (2004) Endocr. Rev. , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 6
    • 0037085753 scopus 로고    scopus 로고
    • The tumor vascular targeting agent combretastatin A-4 phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
    • Kanthou, C.; Tozer, G. M. The tumor vascular targeting agent combretastatin A-4 phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. Blood 2002, 99, 2060-2069.
    • (2002) Blood , vol.99 , pp. 2060-2069
    • Kanthou, C.1    Tozer, G.M.2
  • 7
    • 4544277194 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate: Background and current clinical status
    • Young, S. L.; Chaplin, D. J. Combretastatin A4 phosphate: background and current clinical status. Expert Opin. Invest. Drugs 2004, 13, 1171-1182
    • (2004) Expert Opin. Invest. Drugs , vol.13 , pp. 1171-1182
    • Young, S.L.1    Chaplin, D.J.2
  • 8
    • 85008389252 scopus 로고    scopus 로고
    • The discovery and development of the combretastatins
    • Cragg, G. M., Kingston, D. G. I., Newman, D. J., Eds.; Brunner-Routledge Psychology Press. Taylor & Francis Group: Boca Raton, FL
    • Pinney, K. G.; Jelinek, C.; Evardsen, K.; Chaplin, D. J.; Pettit, G. R. The discovery and development of the combretastatins. In Anticancer Agents from Natural Products; Cragg, G. M., Kingston, D. G. I., Newman, D. J., Eds.; Brunner-Routledge Psychology Press. Taylor & Francis Group: Boca Raton, FL, 2005; pp 23-46.
    • (2005) Anticancer Agents from Natural Products , pp. 23-46
    • Pinney, K.G.1    Jelinek, C.2    Evardsen, K.3    Chaplin, D.J.4    Pettit, G.R.5
  • 9
    • 0036850914 scopus 로고    scopus 로고
    • Discovery and development of antimitotic agents that inhibit tubulin polymerization for the treatment of cancer
    • Li, Q.; Sham, H. L. Discovery and development of antimitotic agents that inhibit tubulin polymerization for the treatment of cancer. Expert Opin. Ther. Pat. 2002, 12, 1663-1701.
    • (2002) Expert Opin. Ther. Pat. , vol.12 , pp. 1663-1701
    • Li, Q.1    Sham, H.L.2
  • 10
    • 0024427745 scopus 로고
    • Antimitotic natural products combretastatin A-4 and combretastatin A-2: Studies on the mechanism of their inhibition of the binding of colchicine to tubulin
    • Lin, C. M.; Ho, H. H.; Pettit, G. R.; Hamel, E. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. Biochemistry 1989, 28, 6984-6991.
    • (1989) Biochemistry , vol.28 , pp. 6984-6991
    • Lin, C.M.1    Ho, H.H.2    Pettit, G.R.3    Hamel, E.4
  • 11
    • 0019988507 scopus 로고
    • Antineoplastic agents. 84. Isolation and structure of combretastatin
    • Pettit, G. R.; Cragg, G. M.; Herald, D. L.; Schmidt, J. M.; et al. Antineoplastic agents. 84. Isolation and structure of combretastatin. Can. J. Chem. 1982, 60, 1374-1376.
    • (1982) Can. J. Chem. , vol.60 , pp. 1374-1376
    • Pettit, G.R.1    Cragg, G.M.2    Herald, D.L.3    Schmidt, J.M.4
  • 12
    • 0023617466 scopus 로고
    • Antineoplastic agents. 130. Isolation, structure, and synthesis of combretastatin A-2, A-3, and B-2
    • Pettit, G. R.; Singh, S. B. Antineoplastic agents. 130. Isolation, structure, and synthesis of combretastatin A-2, A-3, and B-2. Can. J. Chem. 1987, 65, 2390-2396.
    • (1987) Can. J. Chem. , vol.65 , pp. 2390-2396
    • Pettit, G.R.1    Singh, S.B.2
  • 13
    • 0023065565 scopus 로고
    • Antineoplastic agents. Part 123. Isolation, structure, and synthesis of combretastatin A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum
    • Pettit, G. R.; Singh, S. B.; Niven, M. L.; Hamel, E.; et al. Antineoplastic agents. Part 123. Isolation, structure, and synthesis of combretastatin A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. J. Nat. Prod. 1987, 50, 119-131.
    • (1987) J. Nat. Prod. , vol.50 , pp. 119-131
    • Pettit, G.R.1    Singh, S.B.2    Niven, M.L.3    Hamel, E.4
  • 14
    • 0024513175 scopus 로고
    • Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
    • Pettit, G. R.; Singh, S. B.; Hamel, E.; Lin, C. M.; Alberts, D. S.; et al. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia 1989, 45, 209-211.
    • (1989) Experientia , vol.45 , pp. 209-211
    • Pettit, G.R.1    Singh, S.B.2    Hamel, E.3    Lin, C.M.4    Alberts, D.S.5
  • 16
    • 0037096814 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
    • Dowlati, A.; Robertson, K.; Cooney, M.; Petros, W. P.; Stratford, M.; et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res. 2002, 62, 3408-3416.
    • (2002) Cancer Res. , vol.62 , pp. 3408-3416
    • Dowlati, A.1    Robertson, K.2    Cooney, M.3    Petros, W.P.4    Stratford, M.5
  • 17
    • 0642307227 scopus 로고    scopus 로고
    • Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow
    • Stevenson, J. P.; Rosen, M.; Sun, W.; Gallagher, M.; Haller, D. G.; et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J. Clin. Oncol. 2003, 21, 4428-4438.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4428-4438
    • Stevenson, J.P.1    Rosen, M.2    Sun, W.3    Gallagher, M.4    Haller, D.G.5
  • 18
    • 0042386700 scopus 로고    scopus 로고
    • Phase I clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
    • Rustin, G. J.; Galbraith, S. M.; Anderson, H.; Stratford, M.; Folkes, L. K.; et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J. Clin. Oncol. 2003, 21, 2815-2822.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2815-2822
    • Rustin, G.J.1    Galbraith, S.M.2    Anderson, H.3    Stratford, M.4    Folkes, L.K.5
  • 19
    • 1642494772 scopus 로고    scopus 로고
    • Cardiovascular safety profile of combretastatin A4 phosphate in a single-dose phase I study in patients with advanced cancer
    • Cooney, M. M.; Radivoyevitch, T.; Dowlati, A.; Overmoyer, B.; Levitan, N.; et al. Cardiovascular safety profile of combretastatin A4 phosphate in a single-dose phase I study in patients with advanced cancer. Clin. Cancer Res. 2004, 10, 96-100.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 96-100
    • Cooney, M.M.1    Radivoyevitch, T.2    Dowlati, A.3    Overmoyer, B.4    Levitan, N.5
  • 20
    • 0042386691 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging
    • Galbraith, S. M.; Maxwell, R. J.; Lodge, M. A.; Tozer, G. M.; Wilson, J.; et al. Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging. J. Clin. Oncol. 2003, 21, 2831-2842.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2831-2842
    • Galbraith, S.M.1    Maxwell, R.J.2    Lodge, M.A.3    Tozer, G.M.4    Wilson, J.5
  • 21
    • 0042887593 scopus 로고    scopus 로고
    • Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate
    • Anderson, H. L.; Yap, J. T.; Miller, M. P.; Robbins, A.; Jones, T.; et al. Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate. J. Clin. Oncol. 2003, 21, 2823-2830.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2823-2830
    • Anderson, H.L.1    Yap, J.T.2    Miller, M.P.3    Robbins, A.4    Jones, T.5
  • 22
    • 0041885413 scopus 로고    scopus 로고
    • Functional imaging in phase I studies: Decorations or decision making?
    • Collins, J. M. Functional imaging in phase I studies: decorations or decision making? J. Clin. Oncol. 2003, 21, 2807-2809.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2807-2809
    • Collins, J.M.1
  • 23
    • 0042343848 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization
    • Nambu, H.; Nambu, R.; Melia, M.; Campochiaro, P. A. Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization. Invest. Ophthalmol. Visual Sci. 2003, 44, 3650-3655.
    • (2003) Invest. Ophthalmol. Visual Sci. , vol.44 , pp. 3650-3655
    • Nambu, H.1    Nambu, R.2    Melia, M.3    Campochiaro, P.A.4
  • 25
    • 0036120720 scopus 로고    scopus 로고
    • Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4
    • Griggs, J.; Skepper, J. N.; Smith, G. A.; Brindle, K. M.; Metcalfe, J. C.; et al. Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4. Am. J. Pathol. 2002, 160, 1097-1103.
    • (2002) Am. J. Pathol. , vol.160 , pp. 1097-1103
    • Griggs, J.1    Skepper, J.N.2    Smith, G.A.3    Brindle, K.M.4    Metcalfe, J.C.5
  • 27
    • 0037471487 scopus 로고    scopus 로고
    • A re-investigation of resveratrol synthesis by Perkin reaction. Application to the synthesis of aryl cinnamic acids
    • Solladié, G.; Pasturel-Jacopé, Y.; Maignan, J. A re-investigation of resveratrol synthesis by Perkin reaction. Application to the synthesis of aryl cinnamic acids. Tetrahedron 2003, 59, 3315-3321.
    • (2003) Tetrahedron , vol.59 , pp. 3315-3321
    • Solladié, G.1    Pasturel-Jacopé, Y.2    Maignan, J.3
  • 28
    • 0031872051 scopus 로고    scopus 로고
    • Tubulin as a target for anticancer drugs: Agents which interact with mitotic spindle
    • Jordan, A.; Hadfield, J. A.; Lawrence, N. J.; McGown, A. T. Tubulin as a target for anticancer drugs: agents which interact with mitotic spindle. Med. Res. Rev. 1998, 18, 259-296.
    • (1998) Med. Res. Rev. , vol.18 , pp. 259-296
    • Jordan, A.1    Hadfield, J.A.2    Lawrence, N.J.3    McGown, A.T.4
  • 29
    • 0026734208 scopus 로고
    • Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4, 5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents
    • Cushman, M.; Nagarathnam, D.; Gopal, D.; He, H. M.; Lin, C. M.; et al. Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5- trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. J. Med. Chem. 1992, 35, 2293-2306.
    • (1992) J. Med. Chem. , vol.35 , pp. 2293-2306
    • Cushman, M.1    Nagarathnam, D.2    Gopal, D.3    He, H.M.4    Lin, C.M.5
  • 30
    • 0141518578 scopus 로고    scopus 로고
    • Structural requirements for the interaction of combretastatins with tubulin: How important is the trimethoxy unit?
    • Gaukroger, K.; Hadfield, J. A.; Lawrence, N. J.; Nolan, S.; McGown, A. T. Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit? Org. Biomol. Chem. 2003, 1, 3033-3037.
    • (2003) Org. Biomol. Chem. , vol.1 , pp. 3033-3037
    • Gaukroger, K.1    Hadfield, J.A.2    Lawrence, N.J.3    Nolan, S.4    McGown, A.T.5
  • 31
    • 19944433930 scopus 로고    scopus 로고
    • Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety
    • Maya, A. B.; Perez-Melero, C.; Mateo, C.; Alonso, D.; Fernandez, J. L.; et al. Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety. J. Med. Chem. 2005, 48, 556-568.
    • (2005) J. Med. Chem. , vol.48 , pp. 556-568
    • Maya, A.B.1    Perez-Melero, C.2    Mateo, C.3    Alonso, D.4    Fernandez, J.L.5
  • 32
    • 27844590753 scopus 로고    scopus 로고
    • Antineoplastic agents. 509: Synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1)
    • Pettit, G. R.; Minardi, M. D.; Rosenberg, H. J.; Hamel, E.; Bibby, M. C.; et al. Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1). J. Nat. Prod. 2005, 68, 1450-1458.
    • (2005) J. Nat. Prod. , vol.68 , pp. 1450-1458
    • Pettit, G.R.1    Minardi, M.D.2    Rosenberg, H.J.3    Hamel, E.4    Bibby, M.C.5
  • 33
    • 0037434583 scopus 로고    scopus 로고
    • Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4′-dimethoxy-3′-amino-Z- stilbene and derived amino acid amides
    • Pettit, G. R.; Anderson, C. R.; Herald, D. L.; Jung, M. K.; Lee, D. J.; et al. Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4′-dimethoxy-3′-amino-Z- stilbene and derived amino acid amides. J. Med. Chem. 2003, 46, 525-531.
    • (2003) J. Med. Chem. , vol.46 , pp. 525-531
    • Pettit, G.R.1    Anderson, C.R.2    Herald, D.L.3    Jung, M.K.4    Lee, D.J.5
  • 34
    • 0001823765 scopus 로고    scopus 로고
    • Synthesis and antineoplastic activity of combretastatin analogues: Heterocombretastatins
    • Medarde, M.; Ramos, A. C.; Caballero, E.; Pelaez, R.; Lopez, J. L.; et al. Synthesis and antineoplastic activity of combretastatin analogues: heterocombretastatins. Eur. J. Med. Chem. 1998, 33, 71-77.
    • (1998) Eur. J. Med. Chem. , vol.33 , pp. 71-77
    • Medarde, M.1    Ramos, A.C.2    Caballero, E.3    Pelaez, R.4    Lopez, J.L.5
  • 36
    • 0026047751 scopus 로고
    • Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization
    • Cushman, M.; Nagarathnam, D.; Gopal, D.; Chakraborti, A. K.; Lin, C. M.; et al. Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. J. Med. Chem. 1991, 34, 2579-2588.
    • (1991) J. Med. Chem. , vol.34 , pp. 2579-2588
    • Cushman, M.1    Nagarathnam, D.2    Gopal, D.3    Chakraborti, A.K.4    Lin, C.M.5
  • 38
    • 1642283508 scopus 로고    scopus 로고
    • Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and Al phosphate
    • Kirwan, I. G.; Loadman, P. M.; Swaine, D. J.; Anthoney, D. A.; Pettit, G. R.; et al. Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and Al phosphate. Clin. Cancer Res. 2004, 10, 1446-1453.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1446-1453
    • Kirwan, I.G.1    Loadman, P.M.2    Swaine, D.J.3    Anthoney, D.A.4    Pettit, G.R.5
  • 39
    • 20444403700 scopus 로고    scopus 로고
    • Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-4
    • Pettit, G. R.; Rhodes, M. R.; Herald, D. L.; Hamel, E.; Schmidt, J. M.; et al. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-4. J. Med. Chem. 2005, 48, 4087-4099.
    • (2005) J. Med. Chem. , vol.48 , pp. 4087-4099
    • Pettit, G.R.1    Rhodes, M.R.2    Herald, D.L.3    Hamel, E.4    Schmidt, J.M.5
  • 40
    • 0033811815 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin
    • Pinney, K. G.; Mejia, M. P.; Villalobos, V. M.; Rosenquist, B. E.; Pettit, G. R.; et al. Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin. Bioorg. Med. Chem. 2000, 8, 2417-2425.
    • (2000) Bioorg. Med. Chem. , vol.8 , pp. 2417-2425
    • Pinney, K.G.1    Mejia, M.P.2    Villalobos, V.M.3    Rosenquist, B.E.4    Pettit, G.R.5
  • 41
    • 15144356733 scopus 로고    scopus 로고
    • Novel combretastatin analogues effective against murine solid tumors: Design and structure-activity relationships
    • Ohsumi, K.; Nakagawa, R.; Fukuda, Y.; Hatanaka, T.; Morinaga, Y.; et al. Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships. J. Med. Chem. 1998, 41, 3022-3032.
    • (1998) J. Med. Chem. , vol.41 , pp. 3022-3032
    • Ohsumi, K.1    Nakagawa, R.2    Fukuda, Y.3    Hatanaka, T.4    Morinaga, Y.5
  • 42
    • 25144434945 scopus 로고    scopus 로고
    • Structure-based discovery of a boronic acid bioisostere of combretastatin A-4
    • Kong, Y.; Grembecka, J.; Edler, M. C.; Hamel, E.; Mooberry, S. L.; et al. Structure-based discovery of a boronic acid bioisostere of combretastatin A-4. Chem. Biol. 2005, 12, 1007-1014.
    • (2005) Chem. Biol. , vol.12 , pp. 1007-1014
    • Kong, Y.1    Grembecka, J.2    Edler, M.C.3    Hamel, E.4    Mooberry, S.L.5
  • 43
    • 0348109450 scopus 로고    scopus 로고
    • The growing impact of click chemistry on drug discovery
    • Kolb, H. C.; Sharpless, K. B. The growing impact of click chemistry on drug discovery. Drug Discovery Today 2003, 8, 1128-1137.
    • (2003) Drug Discovery Today , vol.8 , pp. 1128-1137
    • Kolb, H.C.1    Sharpless, K.B.2
  • 45
    • 0036253091 scopus 로고    scopus 로고
    • Combretastatin A-1 phosphate a novel tubulin-binding agent with in vivo anti vascular effects in experimental tumours
    • Holwell, S. E.; Cooper, P. A.; Grosios, K.; Lippert, J. W., 3rd; Pettit, G. R.; et al. Combretastatin A-1 phosphate a novel tubulin-binding agent with in vivo anti vascular effects in experimental tumours. Anticancer Res. 2002, 22, 707-711.
    • (2002) Anticancer Res. , vol.22 , pp. 707-711
    • Holwell, S.E.1    Cooper, P.A.2    Grosios, K.3    Lippert III, J.W.4    Pettit, G.R.5
  • 46
    • 3843090808 scopus 로고    scopus 로고
    • Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis
    • Sheng, Y.; Hua, J.; Pinney, K. G.; Garner, C. M.; Kane, R. R.; et al. Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis. Int. J. Cancer 2004, 111, 604-610.
    • (2004) Int. J. Cancer , vol.111 , pp. 604-610
    • Sheng, Y.1    Hua, J.2    Pinney, K.G.3    Garner, C.M.4    Kane, R.R.5
  • 47
    • 33644988592 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents
    • Monk, K. A.; Siles, R.; Hadimani, M. B.; Mugabe, B. E.; Ackley, J. F.; et al. Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents. Bioorg. Med. Chem. 2006, 14, 3231-3244.
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 3231-3244
    • Monk, K.A.1    Siles, R.2    Hadimani, M.B.3    Mugabe, B.E.4    Ackley, J.F.5
  • 48
    • 0032402626 scopus 로고    scopus 로고
    • Novel B-ring modified combretastatin analogues: Syntheses and antineoplastic activity
    • Hatanaka, T.; Fujita, K.; Ohsumi, K.; Nakagawa, R.; Fukuda, Y.; et al. Novel B-ring modified combretastatin analogues: syntheses and antineoplastic activity. Bioorg. Med. Chem. Lett. 1998, 8, 3371-3374.
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 3371-3374
    • Hatanaka, T.1    Fujita, K.2    Ohsumi, K.3    Nakagawa, R.4    Fukuda, Y.5
  • 50
    • 11244320417 scopus 로고    scopus 로고
    • Naphthalene combretastatin analogues: Synthesis, cytotoxicity and antitubulin activity
    • Medarde, M.; Maya, A. B.; Perez-Melero, C. Naphthalene combretastatin analogues: synthesis, cytotoxicity and antitubulin activity. J. Enzyme Inhib. Med. Chem. 2004, 19, 521-540.
    • (2004) J. Enzyme Inhib. Med. Chem. , vol.19 , pp. 521-540
    • Medarde, M.1    Maya, A.B.2    Perez-Melero, C.3
  • 52
    • 0017467023 scopus 로고
    • Epoxidation of the stilbene double bond, a major pathway in aminostilbene metabolism
    • Metzler, M.; Neumann, H. G. Epoxidation of the stilbene double bond, a major pathway in aminostilbene metabolism. Xenobiotica 1977, 7, 117-132.
    • (1977) Xenobiotica , vol.7 , pp. 117-132
    • Metzler, M.1    Neumann, H.G.2
  • 53
    • 0026582270 scopus 로고
    • Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: Differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions
    • Getahun, Z.; Jurd, L.; Chu, P. S.; Lin, C. M.; Hamel, E. Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions. J. Med. Chem. 1992, 35, 1058-1067.
    • (1992) J. Med. Chem. , vol.35 , pp. 1058-1067
    • Getahun, Z.1    Jurd, L.2    Chu, P.S.3    Lin, C.M.4    Hamel, E.5
  • 55
    • 3843136376 scopus 로고    scopus 로고
    • Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents
    • Liou, J. P.; Chang, Y. L.; Kuo, F. M.; Chang, C. W.; Tseng, H. Y.; et al. Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents. J. Med. Chem. 2004, 47, 4247-4257.
    • (2004) J. Med. Chem. , vol.47 , pp. 4247-4257
    • Liou, J.P.1    Chang, Y.L.2    Kuo, F.M.3    Chang, C.W.4    Tseng, H.Y.5
  • 56
    • 2442639013 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents
    • Liou, J. P.; Chang, J. Y.; Chang, C. W.; Chang, C. Y.; Mahindroo, N.; et al. Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. J. Med. Chem. 2004, 47, 2897-2905.
    • (2004) J. Med. Chem. , vol.47 , pp. 2897-2905
    • Liou, J.P.1    Chang, J.Y.2    Chang, C.W.3    Chang, C.Y.4    Mahindroo, N.5
  • 57
    • 0037030604 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents
    • Liou, J. P.; Chang, C. W.; Song, J. S.; Yang, Y. N.; Yeh, C. F.; et al. Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents. J. Med. Chem. 2002, 45, 2556-2562.
    • (2002) J. Med. Chem. , vol.45 , pp. 2556-2562
    • Liou, J.P.1    Chang, C.W.2    Song, J.S.3    Yang, Y.N.4    Yeh, C.F.5
  • 58
    • 23044492692 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives
    • Kaffy, J.; Pontikis, R.; Florent, J. C.; Monneret, C. Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives. Org. Biomol. Chem. 2005, 3, 2657-2660.
    • (2005) Org. Biomol. Chem. , vol.3 , pp. 2657-2660
    • Kaffy, J.1    Pontikis, R.2    Florent, J.C.3    Monneret, C.4
  • 59
    • 0032080796 scopus 로고    scopus 로고
    • Potent antimitotic and cell growth inhinitory properties of substituted chalcones
    • Ducki, S.; Forrest, R.; Hadfield, J. A.; Kendall, A.; Lawrence, N. J.; et al. Potent antimitotic and cell growth inhinitory properties of substituted chalcones. Bioorg. Med. Chem. 1998, 8, 1051-1056.
    • (1998) Bioorg. Med. Chem. , vol.8 , pp. 1051-1056
    • Ducki, S.1    Forrest, R.2    Hadfield, J.A.3    Kendall, A.4    Lawrence, N.J.5
  • 61
    • 0037030605 scopus 로고    scopus 로고
    • One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization
    • Flynn, B. L.; Hamel, E.; Jung, M. K. One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization. J. Med. Chem. 2002, 45, 2670-2673.
    • (2002) J. Med. Chem. , vol.45 , pp. 2670-2673
    • Flynn, B.L.1    Hamel, E.2    Jung, M.K.3
  • 62
    • 18744409805 scopus 로고    scopus 로고
    • The chemistry and biology of antimitotic chalcones and related enone systems
    • Lawrence, N. J.; McGown, A. T. The chemistry and biology of antimitotic chalcones and related enone systems. Curr. Pharm. Des. 2005, 11, 1679-1693.
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 1679-1693
    • Lawrence, N.J.1    McGown, A.T.2
  • 63
    • 23644443814 scopus 로고    scopus 로고
    • Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles
    • Romagnoli, R.; Baraldi, P. G.; Jung, M. K.; Iaconinoto, M. A.; Carrion, M. D.; et al. Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles. Bioorg. Med. Chem. Lett. 2005, 15, 4048-4052.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4048-4052
    • Romagnoli, R.1    Baraldi, P.G.2    Jung, M.K.3    Iaconinoto, M.A.4    Carrion, M.D.5
  • 65
    • 0035832113 scopus 로고    scopus 로고
    • Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents
    • Gwaltney, S. L., 2nd; Imade, H. M.; Barr, K. J.; Li, Q.; Gehrke, L.; et al. Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents. Bioorg. Med. Chem. Lett. 2001, 11, 871-874.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 871-874
    • Gwaltney II, S.L.1    Imade, H.M.2    Barr, K.J.3    Li, Q.4    Gehrke, L.5
  • 66
    • 18144364379 scopus 로고    scopus 로고
    • New antitubulin derivatives in the combretastatin A4 series: Synthesis and biological evaluation
    • Borrel, C.; Thoret, S.; Cachet, X.; Guenard, D.; Tillequin, F.; et al. New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation. Bioorg. Med. Chem. 2005, 13, 3853-3864.
    • (2005) Bioorg. Med. Chem. , vol.13 , pp. 3853-3864
    • Borrel, C.1    Thoret, S.2    Cachet, X.3    Guenard, D.4    Tillequin, F.5
  • 68
    • 0000732910 scopus 로고    scopus 로고
    • Synthesis of conformationary restricted combretastatins
    • Shirai, R.; Okabe, T.; Iwasaki, S. Synthesis of conformationary restricted combretastatins. Heterocycles 1997, 46, 145-148.
    • (1997) Heterocycles , vol.46 , pp. 145-148
    • Shirai, R.1    Okabe, T.2    Iwasaki, S.3
  • 69
    • 0033594356 scopus 로고    scopus 로고
    • Antineoplastic agents. 410. Asymmetric hydroxylation of transcombretastatin A-4
    • Pettit, G. R.; Toki, B. E.; Herald, D. L.; Boyd, M. R.; Hamel, E.; et al. Antineoplastic agents. 410. Asymmetric hydroxylation of transcombretastatin A-4. J. Med. Chem. 1999, 42, 1459-1465.
    • (1999) J. Med. Chem. , vol.42 , pp. 1459-1465
    • Pettit, G.R.1    Toki, B.E.2    Herald, D.L.3    Boyd, M.R.4    Hamel, E.5
  • 71
    • 0032542045 scopus 로고    scopus 로고
    • Syntheses and antitumor activity of cis-restricted combretastatins: 5-membered heterocyclic analogues
    • Ohsumi, K.; Hatanaka, T.; Fujita, K.; Nakagawa, R.; Fukuda, Y.; et al. Syntheses and antitumor activity of cis-restricted combretastatins: 5-membered heterocyclic analogues. Bioorg. Med. Chem. Lett. 1998, 8, 3153-3158.
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 3153-3158
    • Ohsumi, K.1    Hatanaka, T.2    Fujita, K.3    Nakagawa, R.4    Fukuda, Y.5
  • 72
    • 0030272619 scopus 로고    scopus 로고
    • Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents
    • ter Haar, E.; Rosenkranz, H. S.; Hamel, E.; Day, B. W. Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents. Bioorg. Med. Chem. 1996, 4, 1659-1671.
    • (1996) Bioorg. Med. Chem. , vol.4 , pp. 1659-1671
    • Haar, E.1    Rosenkranz, H.S.2    Hamel, E.3    Day, B.W.4
  • 73
    • 23044462554 scopus 로고    scopus 로고
    • Stilbenophane analogues of deoxycombretastatin A-4
    • Mateo, C.; Perez-Melero, C.; Pelaez, R.; Medarde, M. Stilbenophane analogues of deoxycombretastatin A-4. J. Org. Chem. 2005, 70, 6544-6547.
    • (2005) J. Org. Chem. , vol.70 , pp. 6544-6547
    • Mateo, C.1    Perez-Melero, C.2    Pelaez, R.3    Medarde, M.4
  • 74
    • 0041421003 scopus 로고    scopus 로고
    • Combretastatin A-4 analogues as antimitotic antitumor agents
    • Nam, N. H. Combretastatin A-4 analogues as antimitotic antitumor agents. Curr. Med. Chem. 2003, 10, 1697-1722.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1697-1722
    • Nam, N.H.1
  • 76
    • 0037061622 scopus 로고    scopus 로고
    • Potent, orally active heterocycle-based combretastatin A-4 analogues: Synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation
    • Wang, L.; Woods, K. W.; Li, Q.; Barr, K. J.; McCroskey, R. W.; et al. Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation. J. Med. Chem. 2002, 45, 1697-1711.
    • (2002) J. Med. Chem. , vol.45 , pp. 1697-1711
    • Wang, L.1    Woods, K.W.2    Li, Q.3    Barr, K.J.4    McCroskey, R.W.5
  • 77
    • 0344550356 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins
    • Bailly, C.; Bal, C.; Barbier, P.; Combes, S.; Finet, J. P.; et al. Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins. J. Med. Chem. 2003, 46, 5437-5444.
    • (2003) J. Med. Chem. , vol.46 , pp. 5437-5444
    • Bailly, C.1    Bal, C.2    Barbier, P.3    Combes, S.4    Finet, J.P.5
  • 78
    • 20444482115 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of cis-combretastatin analogs and their novel 1,2,3-triazole derivatives
    • Pati, H. N.; Wicks, M.; Holt, H. L., Jr.; LeBlanc, R.; Weisbruch, P.; et al. Synthesis and biological evaluation of cis-combretastatin analogs and their novel 1,2,3-triazole derivatives. Heterocycl. Commun. 2005, 11, 117-120.
    • (2005) Heterocycl. Commun. , vol.11 , pp. 117-120
    • Pati, H.N.1    Wicks, M.2    Holt Jr., H.L.3    Leblanc, R.4    Weisbruch, P.5
  • 79
    • 0037169988 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones
    • Kim, Y.; Nam, N. H.; You, Y. J.; Ahn, B. Z. Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones. Bioorg. Med. Chem. Lett. 2002, 12, 719-722.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 719-722
    • Kim, Y.1    Nam, N.H.2    You, Y.J.3    Ahn, B.Z.4
  • 80
    • 0035803041 scopus 로고    scopus 로고
    • Combretoxazolones: Synthesis, cytotoxicity and antitumor activity
    • Nam, N. H.; Kim, Y.; You, Y. J.; Hong, D. H.; Kim, H. M.; et al. Combretoxazolones: synthesis, cytotoxicity and antitumor activity. Bioorg. Med. Chem. Lett. 2001, 11, 3073-3076.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 3073-3076
    • Nam, N.H.1    Kim, Y.2    You, Y.J.3    Hong, D.H.4    Kim, H.M.5
  • 81
    • 0037025445 scopus 로고    scopus 로고
    • Synthesis and anti-tumor activity of novel combretastatins: Combretocyclopentenones and related analogues
    • Nam, N. H.; Kim, Y.; You, Y. J.; Hong, D. H.; Kim, H. M.; et al. Synthesis and anti-tumor activity of novel combretastatins: combretocyclopentenones and related analogues. Bioorg. Med. Chem. Lett. 2002, 12, 1955-1958.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 1955-1958
    • Nam, N.H.1    Kim, Y.2    You, Y.J.3    Hong, D.H.4    Kim, H.M.5
  • 82
    • 13444267332 scopus 로고    scopus 로고
    • Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines
    • Simoni, D.; Grisolia, G.; Giannini, G.; Roberti, M.; Rondanin, R.; et al. Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. J. Med. Chem. 2005, 48, 723-736.
    • (2005) J. Med. Chem. , vol.48 , pp. 723-736
    • Simoni, D.1    Grisolia, G.2    Giannini, G.3    Roberti, M.4    Rondanin, R.5
  • 83
    • 0035801759 scopus 로고    scopus 로고
    • The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4
    • Flynn, B. L.; Flynn, G. P.; Hamel, E.; Jung, M. K. The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4. Bioorg. Med. Chem. Lett. 2001, 11, 2341-2343.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 2341-2343
    • Flynn, B.L.1    Flynn, G.P.2    Hamel, E.3    Jung, M.K.4
  • 84
    • 0038702250 scopus 로고    scopus 로고
    • Novel 5,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents
    • Sharma, V. M.; Adi Seshu, K. V.; Krishna, C. V.; Prasanna, P.; Sekhar, V. C.; et al. Novel 5,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents. Bioorg. Med. Chem. Lett. 2003, 13, 1679-1682.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 1679-1682
    • Sharma, V.M.1    Adi Seshu, K.V.2    Krishna, C.V.3    Prasanna, P.4    Sekhar, V.C.5
  • 85
    • 0002453760 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 1,1-dichloro-2,3- diarylcyclopropanes as antitubulin and anti-breast cancer agents
    • Jonnalagadda, S. S.; ter Haar, E.; Hamel, E.; Lin, C. M.; Magarian, R. A.; et al. Synthesis and biological evaluation of 1,1-dichloro-2,3- diarylcyclopropanes as antitubulin and anti-breast cancer agents. Bioorg. Med. Chem. 1997, 5, 715-722.
    • (1997) Bioorg. Med. Chem. , vol.5 , pp. 715-722
    • Jonnalagadda, S.S.1    Ter Haar, E.2    Hamel, E.3    Lin, C.M.4    Magarian, R.A.5
  • 86
    • 1842741030 scopus 로고    scopus 로고
    • Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design
    • Sun, L.; Vasilevich, N. I.; Fuselier, J. A.; Hocart, S. J.; Coy, D. H. Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design. Bioorg. Med. Chem. Lett. 2004, 14, 2041-2046.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2041-2046
    • Sun, L.1    Vasilevich, N.I.2    Fuselier, J.A.3    Hocart, S.J.4    Coy, D.H.5
  • 87
    • 25844473382 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins
    • LeBlanc, R.; Dickson, J.; Brown, T.; Stewart, M.; Pati, H. N.; et al. Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins. Bioorg. Med. Chem. 2005, 13, 6025-6034.
    • (2005) Bioorg. Med. Chem. , vol.13 , pp. 6025-6034
    • Leblanc, R.1    Dickson, J.2    Brown, T.3    Stewart, M.4    Pati, H.N.5
  • 88
    • 19844363802 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents
    • Bhat, B. A.; Dhar, K. L.; Puri, S. C.; Saxena, A. K.; Shanmugavel, M.; et al. Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents. Bioorg. Med. Chem. Lett. 2005, 15, 3177-3180.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3177-3180
    • Bhat, B.A.1    Dhar, K.L.2    Puri, S.C.3    Saxena, A.K.4    Shanmugavel, M.5
  • 89
    • 0141433360 scopus 로고    scopus 로고
    • The total synthesis of an aurone isolated from Uvaria hamiltonii: Aurones and flavones as anticancer agents
    • Lawrence, N. J.; Rennison, D.; McGown, A. T.; Hadfield, J. A. The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents. Bioorg. Med. Chem. Lett. 2003, 13, 3759-3763.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 3759-3763
    • Lawrence, N.J.1    Rennison, D.2    McGown, A.T.3    Hadfield, J.A.4
  • 90
    • 27644444372 scopus 로고    scopus 로고
    • Conformationally restricted analogs of combretastatin A-4 derived from SU5416
    • Li, P. K.; Xiao, Z.; Hu, Z.; Pandit, B.; Sun, Y.; et al. Conformationally restricted analogs of combretastatin A-4 derived from SU5416. Bioorg. Med. Chem. Lett. 2005, 15, 5382-5385.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 5382-5385
    • Li, P.K.1    Xiao, Z.2    Hu, Z.3    Pandit, B.4    Sun, Y.5
  • 91
    • 23944525888 scopus 로고    scopus 로고
    • A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin
    • Rizzi, E.; Dallavalle, S.; Merlini, L.; Beretta, G. L.; Pratesi, G.; et al. A new synthesis of isoaurones: cytotoxic activity of compounds related to the alleged structure of isoaurostatin. Bioorg. Med. Chem. Lett. 2005, 15, 4313-4316.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4313-4316
    • Rizzi, E.1    Dallavalle, S.2    Merlini, L.3    Beretta, G.L.4    Pratesi, G.5
  • 92
    • 0032858830 scopus 로고    scopus 로고
    • The synthesis of (E) and (Z)-combretastatin A-4 and a phenanthrene from Combretum caffrum
    • Lawrence, N. J.; Ghani, F. A.; Hepworth, L. A.; Hadfield, J. A.; McGown, A. T.; et al. The synthesis of (E) and (Z)-combretastatin A-4 and a phenanthrene from Combretum caffrum. Synthesis 1999, 1656-1660.
    • (1999) Synthesis , pp. 1656-1660
    • Lawrence, N.J.1    Ghani, F.A.2    Hepworth, L.A.3    Hadfield, J.A.4    McGown, A.T.5
  • 93
    • 0142036683 scopus 로고    scopus 로고
    • Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin
    • Hamel, E. Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin. Cell Biochem. Biophys. 2003, 38, 1-22.
    • (2003) Cell Biochem. Biophys. , vol.38 , pp. 1-22
    • Hamel, E.1
  • 94
    • 0038155176 scopus 로고    scopus 로고
    • Novel benzylidene-9-(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization
    • Prinz, H.; Ishii, Y.; Hirano, T.; Stoiber, T.; Camacho Gomez, J. A.; et al. Novel benzylidene-9-(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J. Med. Chem. 2003, 46, 3382-3394.
    • (2003) J. Med. Chem. , vol.46 , pp. 3382-3394
    • Prinz, H.1    Ishii, Y.2    Hirano, T.3    Stoiber, T.4    Camacho Gomez, J.A.5
  • 95
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • Dark, G. G.; Hill, S. A.; Prise, V. E.; Tozer, G. M.; Petit, G. R.; Chaplin, D. J. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res. 1997, 57, 1829-1834.
    • (1997) Cancer Res. , vol.57 , pp. 1829-1834
    • Dark, G.G.1    Hill, S.A.2    Prise, V.E.3    Tozer, G.M.4    Petit, G.R.5    Chaplin, D.J.6
  • 96
    • 27944510554 scopus 로고    scopus 로고
    • Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression
    • Wehbe, H.; Kearney, C. M.; Pinney, K. G. Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression. Anticancer Res. 2005, 25, 3865-3870.
    • (2005) Anticancer Res. , vol.25 , pp. 3865-3870
    • Wehbe, H.1    Kearney, C.M.2    Pinney, K.G.3
  • 97
    • 9144254574 scopus 로고    scopus 로고
    • Microtubulin binding sites as target for developing anticancer agents
    • Islam, M. N.; Iskander, M. N. Microtubulin binding sites as target for developing anticancer agents. Mini-Rev. Med. Chem. 2004, 4, 1077-1104.
    • (2004) Mini-Rev. Med. Chem. , vol.4 , pp. 1077-1104
    • Islam, M.N.1    Iskander, M.N.2
  • 98
    • 27644466314 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signalling
    • Vincent, L.; Kermani, P.; Young, L. M.; Cheng, J.; Zhang, F.; et al. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signalling. J. Clin. Invest. 2005, 115, 2992-3006
    • (2005) J. Clin. Invest. , vol.115 , pp. 2992-3006
    • Vincent, L.1    Kermani, P.2    Young, L.M.3    Cheng, J.4    Zhang, F.5
  • 100
    • 0027483113 scopus 로고
    • "Combretatropones", hybrids of combretastatin and colchicine, synthesis and biochemical evaluation
    • Andres, C. J.; Bernardo, J. E.; Yan, Q.; Hastie, S. B.; Macdonald, T. L. "Combretatropones", hybrids of combretastatin and colchicine, synthesis and biochemical evaluation. Bioarg. Med. Chem. Lett. 1993, 3, 565-570.
    • (1993) Bioarg. Med. Chem. Lett. , vol.3 , pp. 565-570
    • Andres, C.J.1    Bernardo, J.E.2    Yan, Q.3    Hastie, S.B.4    Macdonald, T.L.5
  • 101
    • 0036009887 scopus 로고    scopus 로고
    • Synthesis and antimicrotubule activity of combretatropone derivatives
    • Janik, M. E.; Bane, S. L. Synthesis and antimicrotubule activity of combretatropone derivatives. Bioorg. Med. Chem. 2002, 10, 1895-1903.
    • (2002) Bioorg. Med. Chem. , vol.10 , pp. 1895-1903
    • Janik, M.E.1    Bane, S.L.2
  • 102
    • 23144456813 scopus 로고    scopus 로고
    • Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
    • Sengupta, S.; Eavarone, D.; Capila, I.; Zhao, G.; Watson, N.; et al. Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature 2005, 436, 568-572.
    • (2005) Nature , vol.436 , pp. 568-572
    • Sengupta, S.1    Eavarone, D.2    Capila, I.3    Zhao, G.4    Watson, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.