Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumorostatic agent

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 1, 2008, Pages 10-16

  Guo, Lei ^a   Ye, Caiying ^a   Chen, Wenying ^a   Ye, Hua ^a   Zheng, Ru ^a   Li, Juan ^a   Yang, Huifen ^a   Yu, Xiaoli ^a   Zhang, Dechang ^a,b  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; ACETIC ACID; CROTON OIL; DEXAMETHASONE; FORMALDEHYDE; HISTAMINE; INTERLEUKIN 1BETA; MORPHINE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; COTTON; DRUG MECHANISM; DRUG POTENCY; EAR; EDEMA; EXPERIMENTAL TEST; FEMALE; GRANULOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; ARTHRITIS; CAPILLARY PERMEABILITY; DISEASE MODELS, ANIMAL; EDEMA; FEMALE; GRANULOMA; INTERLEUKIN-1; MALE; MICE; MICE, INBRED ICR; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; TRIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 41149177593     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.131888     Document Type: Article

References (39)

1. Arend WP and Dayer JM (1995) Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum 38:151-160.
2. Bauer KS, Figg WD, Hamilton JM, Jones EC, Premkumar A, Steinberg SM, Dyer V, Linehan WM, Pluda JM, and Reed E (1999) A pharmacokinetically guided Phase II study of carboxyamido-triazole in androgen-independent prostate cancer. Clin Cancer Res 5:2324-2329.
3. Berlin J, Tutsch KD, Arzoomanian RZ, Alberti D, Binger K, Feierabend C, Dresen A, Marnocha R, Pluda J, and Wilding G (2002) Phase I and pharmacokinetic study of a micronized formulation of carboxyamidotriazole, a calcium signal transduction inhibitor: toxicity, bioavailability and the effect of food. Clin Cancer Res 8:86-94.
4. Berlin J, Tutsch KD, Hutson P, Cleary J, Rago RP, Arzoomanian RZ, Alberti D, Feierabend C, and Wilding G (1997) Phase I clinical and pharmacokinetic study of oral carboxyamidotriazole, a signal transduction inhibitor. J Clin Oncol 15:781-789.
5. Claffey KP, Brown LF, del Aguila LF, Tognazzi K, Yeo KT, Manseau EJ, and Dvorak HF (1996) Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res 56:172-181.
6. Collier HO, Dinneen LC, Johnson CA, and Schneider C (1968) The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 32:295-310.
7. Coussens LM and Werb Z (2002) Inflammation and cancer. Nature 420:860-867.
8. Dubuisson D and Dennis SG (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4:161-174.
9. Enfissi A, Prigent S, Colosetti P, and Capiod T (2004) The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells. Cell Calcium 36:459-467.
10. Felder CC, Ma AL, Liotta LA, and Kohn EC (1991) The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J Pharmacol Exp Ther 257:967-971.
11. Feldmann M, Andreakos E, Smith C, Bondeson J, Yoshimura S, Kiriakidis S, Monaco C, Gasparini C, Sacre S, Lundberg A, et al. (2002) Is NF-κB a useful therapeutic target in rheumatoid arthritis? Ann Rheum Dis 61:13-18.
12. Griffioen AW and Molema G (2000) Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 52:237-268.
13. Hunskaar S and Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30:103-114.
14. Hupe DJ, Boltz R, Cohen CJ, Felix J, Ham E, Miller D, Soderman D, and van Skiver D (1991) The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582. J Biol Chem 266:10136-10142.
15. Jacobs W, Mikkelsen T, Smith R, Nelson K, Rosenblum ML, and Kohn EC (1997) Inhibitory effects of CAI in glioblastoma growth and invasion. J Neurooncol 32:93-101.
16. Kohn EC, Alessandro R, Spoonster J, Wersto RP, and Liotta LA (1995) Angiogenesis: role of calcium-mediated signal transduction. Proc Natl Acad Sci U S A 92:1307-1311.
17. Kohn EC, Figg WD, Sarosy GA, Bauer KS, Davis PA, Soltis MJ, Thompkins A, Liotta LA, and Reed E (1997) Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations. J Clin Oncol 15:1985-1993.
18. Kohn EC and Liotta LA (1990) L651582: a novel antiproliferative and antimetastasis agent. J Natl Cancer Inst 82:54-60.
19. Kohn EC, Reed E, Sarosy GA, Minasian L, Bauer KS, Bostick-Bruton F, Kulpa V, Fuse E, Tompkins A, Noone M, et al. (2001) A phase I trial of carboxyamidotriazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction. Clin Cancer Res 7:1600-1609.
20. Kollias G, Douni E, Kassiotis G, and Kontoyiannis D (1999) On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Immunol Rev 169:175-194.
21. Lambert PA, Somers KD, Kohn EC, and Perry RR (1997) Antiproliferative and antiinvasive effects of carboxyamido-triazole on breast cancer cell lines. Surgery 122:372-378.
22. Lu H, Ouyang W, and Huang C (2006) Inflammation, a key event in cancer development. Mol Cancer Res 4:221-233.
23. Luzzi KJ, Varghese HJ, MacDonald IC, Kohn EC, Schmidt EE, Morris VL, Chambers AF, and Groom AC (1998) Inhibition of angiogenesis in liver metastases by carboxyamidotriazole (CAI): computer assisted analysis. Angiogenesis 2:373-379.
24. Majno G (1998) Chronic inflammation: links with angiogenesis and wound healing. Am J Pathol 153:1035-1039.
25. Miles AA and Miles EM (1952) Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea pigs. J Physiol 118:228-257.
26. Moody TW, Chiles J, Moody E, Sieczkiewicz GJ, and Kohn EC (2003) CAI inhibits the growth of small cell lung cancer cells. Lung Cancer 39:279-288.
27. Newbould BB (1963) Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. Br J Pharmacol Chemother 21:127-136.
28. Olajide OA, Makinde JM, Okpako DT, and Awe SO (2000) Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark. J Ethnopharmacol 71:153-160.
29. Perabo FG, Wirger A, Kamp S, Lindner H, Schmidt DH, Muller SC, and Kohn EC (2004) Carboxyamido-triazole (CAI), a signal transduction inhibitor induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2. Anticancer Res 24:2869-2877.
30. Rotrosen D and Gallin JI (1986) Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin and promotes albumin diffusion across cultured endothelial monolayers. J Cell Biol 103:2379-2387.
31. Stefanovic-Racic M, Stadler J, and Evans CH (1993) Nitric oxide and arthritis. Arthritis Rheum 36:1036-1044.
32. Storgard CM, Stupack DG, Jonczyk A, Goodman SL, Fox RI, and Cheresh DA (1999) Decreased angiogenesis and arthritic disease in rabbits treated with an avb3 antagonist. J Clin Invest 103:47-54.
33. Swingle KF and Shideman FE (1972) Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain antiinflammatory agents. J Pharmacol Exp Ther 183:226-234.
34. Thurston G, Murphy TJ, Baluk P, Lindsey JR, and McDonald DM (1998) Strain dependent differences in angiogenesis in mice with chronic airway inflammation. Am J Pathol 153:1099-1112.
35. Tjølsen A, Berge O, Hunskaar S, Roseland JK, and Hole K (1992) The formalin test: an evaluation of the method. Pain 51:5-17.
36. Walz DT, Dimartino MJ, and Misher A (1971) Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters. J Pharmacol Exp Ther 178:223-231.
37. Wasilenko WJ, Palad AJ, Somers KD, Blackmore PF, Kohn EC, Rhim JS, Wright GL Jr, and Schellhammer PF (1996) Effects of the calcium influx inhibitor carboxy-amido-triazole on the proliferation and invasiveness of human prostate tumor cell lines. Int J Cancer 68:259-264.
38. Wu H, Yuan Y, Zawieja DC, Tinsley J, and Granger HJ (1999) Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability Am J Physiol Heart Circ Physiol 276:H535-H542.
39. Yasui H, Butscher W, Cohen M, Spriggs N, Wersto R, Kohn EC, Liotta L, and Gardner K (1997) Selective inhibition of mitogen-induced transactivation of the HIV Long Terminal Repeat by carboxyamidotriazole. J Biol Chem 272:28762-28770.