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Volumn 18, Issue 3, 2008, Pages 954-958

Hybrid angiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles

Author keywords

1 Deoxynojirimycin; Alpha glucosidase; Angiogenesis; Aryl 1,2,3 triazole; Bifunctional compound; Hybrid; Inhibitor; Methionine aminopeptidase

Indexed keywords

1 DEOXYNOJIRIMYCIN; ANGIOGENESIS INHIBITOR; FUMAGILLIN; METHIONYL AMINOPEPTIDASE 2; OLIGOSACCHARIDE; OVALICIN; PPI 2458; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 38849143209     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.034     Document Type: Article
Times cited : (47)

References (30)
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    • note
    • A regioselective reaction was not required as the benzyl group was later removed.
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    • note
    • +.
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    • 50s are shown in Table 1
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    • For other selected carbohydrate derived compounds that inhibit BAEC growth, see
    • For other selected carbohydrate derived compounds that inhibit BAEC growth, see. Rawe S.L., Zaric V., O' Boyle K.M., and Murphy P.V. Bioorg. Med. Chem. Lett. 16 (2006) 1316
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    • note
    • 5 cells were resuspended in test tubes and incubated in DPBS/1% BSA with 200 μL of 2 μg/ml Con A-FITC or L-PHA-FITC for 1 h at 4 °C. Cells were washed twice with DPBS, and fluorescence histogram profiles were determined using flow cytometry. Each experiment was carried out at least twice with each compound.
  • 30
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    • 2. Tube formation was observed and photographed under a microscope. At least five visual fields were counted and the average number of tubes per field was calculated using light microscope. The experiments were repeated at least twice for each compound
    • 2. Tube formation was observed and photographed under a microscope. At least five visual fields were counted and the average number of tubes per field was calculated using light microscope. The experiments were repeated at least twice for each compound
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    • Akalu, A.1    Roth, J.M.2    Caunt, M.3    Policarpio, D.4    Liebes, L.5    Brooks, P.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.