The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38700-38709

  Schuckmann, Matthew M ^a   Marchand, Bruno ^a   Hachiya, Atsuko ^a,b   Kodama, Eiichi N ^c   Kirby, Karen A ^a   Singh, Kamalendra ^a   Sarafianos, Stefan G ^a  

^a University of Missouri   (United States)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION RATES; BINDING POCKETS; BIOCHEMICAL MECHANISMS; CATALYTIC EFFICIENCIES; CATALYTIC RATES; CATALYTIC TURNOVER; DNA POLYMERIZATION; DNA SYNTHESISS; DRUG RESISTANCE; ENZYMATIC PROPERTIES; FINE TUNING; HETERODIMERS; HIV-1 REVERSE TRANSCRIPTASE; IN-VITRO; PROCESSIVITY; RNASE H; SUBDOMAIN; TRANSIENT KINETICS;

BIOMOLECULES; NUCLEIC ACIDS; RNA;

DNA;

DNA; NEVIRAPINE; NUCLEIC ACID; PROTEIN P51; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE;

ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CATALYSIS; DNA SYNTHESIS; DRUG BINDING; DRUG RESISTANCE; ENZYME KINETICS; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; POLYMERIZATION; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BINDING SITES; CATALYTIC DOMAIN; DNA; DNA, VIRAL; DRUG RESISTANCE, VIRAL; HIV REVERSE TRANSCRIPTASE; HUMANS; MUTATION, MISSENSE; NEVIRAPINE; REVERSE TRANSCRIPTASE INHIBITORS; REVERSE TRANSCRIPTION; RIBONUCLEASE H; RNA, VIRAL;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78649659732     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.153783     Document Type: Article

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