메뉴 건너뛰기




Volumn 54, Issue 5, 2010, Pages 1973-1980

Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: Assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance

Author keywords

[No Author keywords available]

Indexed keywords

DELAVIRDINE; EFAVIRENZ; NEVIRAPINE; NUCLEOSIDE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THYMIDINE DERIVATIVE; ZIDOVUDINE;

EID: 77951213245     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00870-09     Document Type: Article
Times cited : (46)

References (36)
  • 1
    • 0032506055 scopus 로고    scopus 로고
    • Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′- deoxythymidine (AZT): Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
    • Arion, D., N. Kaushik, S. McCormick, G. Borkow, and M. A. Parniak. 1998. Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′- deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry 37: 15908-15917.
    • (1998) Biochemistry , vol.37 , pp. 15908-15917
    • Arion, D.1    Kaushik, N.2    McCormick, S.3    Borkow, G.4    Parniak, M.A.5
  • 3
    • 0038182520 scopus 로고    scopus 로고
    • Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity
    • Blanca, G., F. Baldanti, S. Paolucci, A. Y. Skoblov, L. Victorova, U. Hubscher, G. Gerna, S. Spadari, and G. Maga. 2003. Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. J. Biol. Chem. 278:15469-15472.
    • (2003) J. Biol. Chem. , vol.278 , pp. 15469-15472
    • Blanca, G.1    Baldanti, F.2    Paolucci, S.3    Skoblov, A.Y.4    Victorova, L.5    Hubscher, U.6    Gerna, G.7    Spadari, S.8    Maga, G.9
  • 4
    • 0035031936 scopus 로고    scopus 로고
    • Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
    • Boyer, P. L., S. G. Sarafianos, E. Arnold, and S. H. Hughes. 2001. Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. J. Virol. 75:4832-4842.
    • (2001) J. Virol. , vol.75 , pp. 4832-4842
    • Boyer, P.L.1    Sarafianos, S.G.2    Arnold, E.3    Hughes, S.H.4
  • 5
    • 34547105526 scopus 로고    scopus 로고
    • Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3′-azido-3′-dideoxythymidine
    • Brehm, J. H., D. Koontz, J. D. Meteer, V. Pathak, N. Sluis-Cremer, and J. W. Mellors. 2007. Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3′-azido-3′-dideoxythymidine. J. Virol. 81:7852-7859.
    • (2007) J. Virol. , vol.81 , pp. 7852-7859
    • Brehm, J.H.1    Koontz, D.2    Meteer, J.D.3    Pathak, V.4    Sluis-Cremer, N.5    Mellors, J.W.6
  • 6
    • 1842509978 scopus 로고    scopus 로고
    • Positive selection detection in 40,000 human immunodeficiency virus (HIV) type 1 sequences automatically identifies drug resistance and positive fitness mutations in HIV protease and reverse transcriptase
    • Chen, L., A. Perlina, and C. J. Lee. 2004. Positive selection detection in 40,000 human immunodeficiency virus (HIV) type 1 sequences automatically identifies drug resistance and positive fitness mutations in HIV protease and reverse transcriptase. J. Virol. 78:3722-3732.
    • (2004) J. Virol. , vol.78 , pp. 3722-3732
    • Chen, L.1    Perlina, A.2    Lee, C.J.3
  • 7
    • 34250811908 scopus 로고    scopus 로고
    • Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3′-azido-3′-deoxythymidine resistance
    • Delviks-Frankenberry, K. A., G. N. Nikolenko, R. Barr, and V. K. Pathak. 2007. Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3′-azido-3′-deoxythymidine resistance. J. Virol. 81:6837-6845.
    • (2007) J. Virol. , vol.81 , pp. 6837-6845
    • Delviks-Frankenberry, K.A.1    Nikolenko, G.N.2    Barr, R.3    Pathak, V.K.4
  • 8
    • 52049107430 scopus 로고    scopus 로고
    • Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to AZT to 3′-azido-3′- deoxythymidine through both RNase H-dependent and -independent mechanisms
    • Ehteshami, M., G. L. Beilhartz, B. J. Scarth, E. P. Tchesnokov, S. McCormick, B. Wynhoven, P. R. Harrigan, and M. Gotte. 2008. Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to AZT to 3′-azido-3′-deoxythymidine through both RNase H-dependent and -independent mechanisms. J. Biol. Chem. 283:22222-22232.
    • (2008) J. Biol. Chem. , vol.283 , pp. 22222-22232
    • Ehteshami, M.1    Beilhartz, G.L.2    Scarth, B.J.3    Tchesnokov, E.P.4    McCormick, S.5    Wynhoven, B.6    Harrigan, P.R.7    Gotte, M.8
  • 9
    • 77951234887 scopus 로고    scopus 로고
    • Beyond codon 240: Mutations in the HIV-1 reverse transcriptase selected after exposure to antiretrovirals
    • Galli, R., B. Wynhoven, B. Sattha, G. Tachedjian, and P. Harrigan. 2004. Beyond codon 240: mutations in the HIV-1 reverse transcriptase selected after exposure to antiretrovirals. eJIAS 1.
    • (2004) EJIAS , vol.1
    • Galli, R.1    Wynhoven, B.2    Sattha, B.3    Tachedjian, G.4    Harrigan, P.5
  • 10
    • 0024999452 scopus 로고
    • Retroviral reverse transcriptase: Synthesis, structure, and function
    • Goff, S. P. 1990. Retroviral reverse transcriptase: synthesis, structure, and function. J. Acquir. Immune Defic. Syndr. 3:817-831.
    • (1990) J. Acquir. Immune Defic. Syndr. , vol.3 , pp. 817-831
    • Goff, S.P.1
  • 11
    • 41149145592 scopus 로고    scopus 로고
    • Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors
    • Hachiya, A., E. N. Kodama, S. G. Sarafianos, M. M. Schuckmann, Y. Sakagami, M. Matsuoka, M. Takiguchi, H. Gatanaga, and S. Oka. 2008. Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. J. Virol. 82: 3261-3270.
    • (2008) J. Virol. , vol.82 , pp. 3261-3270
    • Hachiya, A.1    Kodama, E.N.2    Sarafianos, S.G.3    Schuckmann, M.M.4    Sakagami, Y.5    Matsuoka, M.6    Takiguchi, M.7    Gatanaga, H.8    Oka, S.9
  • 12
    • 64749091545 scopus 로고    scopus 로고
    • Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients
    • Hachiya, A., K. Shimane, S. G. Sarafianos, E. N. Kodama, Y. Sakagami, F. Negishi, H. Koizumi, H. Gatanaga, M. Matsuoka, M. Takiguchi, and S. Oka. 2009. Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients. Antiviral Res. 82:115-121.
    • (2009) Antiviral Res. , vol.82 , pp. 115-121
    • Hachiya, A.1    Shimane, K.2    Sarafianos, S.G.3    Kodama, E.N.4    Sakagami, Y.5    Negishi, F.6    Koizumi, H.7    Gatanaga, H.8    Matsuoka, M.9    Takiguchi, M.10    Oka, S.11
  • 14
    • 0026693137 scopus 로고
    • Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
    • Kohlstaedt, L. A., J. Wang, J. M. Friedman, P. A. Rice, and T. A. Steitz. 1992. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256:1783-1790.
    • (1992) Science , vol.256 , pp. 1783-1790
    • Kohlstaedt, L.A.1    Wang, J.2    Friedman, J.M.3    Rice, P.A.4    Steitz, T.A.5
  • 15
    • 0343811737 scopus 로고    scopus 로고
    • Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC
    • Krebs, R., U. Immendorfer, S. H. Thrall, B. M. Wohrl, and R. S. Goody. 1997. Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC. Biochemistry 36:10292-10300.
    • (1997) Biochemistry , vol.36 , pp. 10292-10300
    • Krebs, R.1    Immendorfer, U.2    Thrall, S.H.3    Wohrl, B.M.4    Goody, R.S.5
  • 16
    • 0345306634 scopus 로고    scopus 로고
    • Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure
    • Marcelin, A. G., C. Delaugerre, M. Wirden, P. Viegas, A. Simon, C. Katlama, and V. Calvez. 2004. Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure. J. Med. Virol. 72:162-165.
    • (2004) J. Med. Virol. , vol.72 , pp. 162-165
    • Marcelin, A.G.1    Delaugerre, C.2    Wirden, M.3    Viegas, P.4    Simon, A.5    Katlama, C.6    Calvez, V.7
  • 17
    • 0033165851 scopus 로고    scopus 로고
    • A mechanism of AZT resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
    • Meyer, P. R., S. E. Matsuura, A. M. Mian, A. G. So, and W. A. Scott. 1999. A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol. Cell 4:35-43.
    • (1999) Mol. Cell , vol.4 , pp. 35-43
    • Meyer, P.R.1    Matsuura, S.E.2    Mian, A.M.3    So, A.G.4    Scott, W.A.5
  • 19
    • 13844312476 scopus 로고    scopus 로고
    • Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision
    • Nikolenko, G. N., S. Palmer, F. Maldarelli, J. W. Mellors, J. M. Coffin, and V. K. Pathak. 2005. Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision. Proc. Natl. Acad. Sci. U. S. A. 102:2093-2098.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 2093-2098
    • Nikolenko, G.N.1    Palmer, S.2    Maldarelli, F.3    Mellors, J.W.4    Coffin, J.M.5    Pathak, V.K.6
  • 20
    • 35848960087 scopus 로고    scopus 로고
    • Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine
    • Ntemgwa, M., M. A. Wainberg, M. Oliveira, D. Moisi, R. Lalonde, V. Micheli, and B. G. Brenner. 2007. Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine. Antimicrob. Agents Chemother. 51:3861-3869.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 3861-3869
    • Ntemgwa, M.1    Wainberg, M.A.2    Oliveira, M.3    Moisi, D.4    Lalonde, R.5    Micheli, V.6    Brenner, B.G.7
  • 21
    • 0037625913 scopus 로고    scopus 로고
    • Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy
    • Paolucci, S., F. Baldanti, M. Tinelli, G. Maga, and G. Gerna. 2003. Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy. AIDS 17:924-927.
    • (2003) AIDS , vol.17 , pp. 924-927
    • Paolucci, S.1    Baldanti, F.2    Tinelli, M.3    Maga, G.4    Gerna, G.5
  • 25
    • 0026318387 scopus 로고
    • Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture
    • Richman, D., C. K. Shih, I. Lowy, J. Rose, P. Prodanovich, S. Goff, and J. Griffin. 1991. Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc. Natl. Acad. Sci. U. S. A. 88:11241-11245.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 11241-11245
    • Richman, D.1    Shih, C.K.2    Lowy, I.3    Rose, J.4    Prodanovich, P.5    Goff, S.6    Griffin, J.7
  • 27
    • 33846804137 scopus 로고    scopus 로고
    • Relationship between mutations in HIV-1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in naive and pre-treated HIV infected patients
    • Roquebert, B., M. Wirden, A. Simon, J. Deval, C. Katlama, V. Calvez, and A. G. Marcelin. 2007. Relationship between mutations in HIV-1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in naive and pre-treated HIV infected patients. J. Med. Virol. 79:207-211.
    • (2007) J. Med. Virol. , vol.79 , pp. 207-211
    • Roquebert, B.1    Wirden, M.2    Simon, A.3    Deval, J.4    Katlama, C.5    Calvez, V.6    Marcelin, A.G.7
  • 29
    • 0025325983 scopus 로고
    • The "megaprimer" method of sitedirected mutagenesis
    • Sarkar, G., and S. S. Sommer. 1990. The "megaprimer" method of sitedirected mutagenesis. Biotechniques 8:404-407.
    • (1990) Biotechniques , vol.8 , pp. 404-407
    • Sarkar, G.1    Sommer, S.S.2
  • 30
    • 0033770149 scopus 로고    scopus 로고
    • Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs)
    • Sluis-Cremer, N., D. Arion, and M. A. Parniak. 2000. Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs). Cell. Mol. Life Sci. 57:1408-1422.
    • (2000) Cell. Mol. Life Sci. , vol.57 , pp. 1408-1422
    • Sluis-Cremer, N.1    Arion, D.2    Parniak, M.A.3
  • 32
    • 0035912717 scopus 로고    scopus 로고
    • Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase
    • Tachedjian, G., M. Orlova, S. G. Sarafianos, E. Arnold, and S. P. Goff. 2001. Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase. Proc. Natl. Acad. Sci. U. S. A. 98:7188-7193.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 7188-7193
    • Tachedjian, G.1    Orlova, M.2    Sarafianos, S.G.3    Arnold, E.4    Goff, S.P.5
  • 33
    • 0028172345 scopus 로고
    • Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance
    • Tantillo, C., J. Ding, A. Jacobo-Molina, R. G. Nanni, P. L. Boyer, S. H. Hughes, R. Pauwels, K. Andries, P. A. Janssen, and E. Arnold. 1994. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. J. Mol. Biol. 243:369-387.
    • (1994) J. Mol. Biol. , vol.243 , pp. 369-387
    • Tantillo, C.1    Ding, J.2    Jacobo-Molina, A.3    Nanni, R.G.4    Boyer, P.L.5    Hughes, S.H.6    Pauwels, R.7    Andries, K.8    Janssen, P.A.9    Arnold, E.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.