Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC

Biochemistry

Volumn 36, Issue 33, 1997, Pages 10292-10300

  Krebs, Ruth ^a   Immendörfer, Ulrike ^a   Thrall, Sara H ^a,b   Wöhrl, Birgitta M ^a   Goody, Roger S ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYADENOSINE TRIPHOSPHATE; 2',3' DIDEOXYCYTIDINE 5' TRIPHOSPHATE; 3' AMINO 3' DEOXYTHYMIDINE; DIDANOSINE; LAMIVUDINE; MUTANT PROTEIN; OLIGODEOXYNUCLEOTIDE; PRIMER DNA; PRIMER RNA; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

ARTICLE; CROSS RESISTANCE; DNA TEMPLATE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ESCHERICHIA COLI; FLUORESCENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; VIRUS RESISTANCE;

ANTI-HIV AGENTS; DRUG RESISTANCE, MICROBIAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; LAMIVUDINE; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS; ZIDOVUDINE;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0343811737     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970512z     Document Type: Article

References (33)

1. Boyer, P. L., & Hughes, S. H. (1995) Antimicrob. Agents Chemother. 39, 1624.
2. Cammack, N., Rouse, P., Marr, C. L., Reid, P. J., Boehme, R. E., Coates, J. A., Penn, C. R., & Cameron, J. M. (1992) Biochem. Pharmacol. 43, 2059.
3. Coates, J. A., Cammack, N., Jenkinson, H. J., Jowett, A. J., Jowett, M. I., Pearson, B. A., Penn, C. R., Rouse, P. L., Viner, K. C., & Cameron, J. M. (1992) Antimicrob. Agents Chemother. 36, 733.
4. Cretton, E. M., Xie, M. Y., Bevan, R. J., Goudgaon, N. M., Schinazi, R. F., & Sommadossi, J. P. (1991) Mol. Pharmacol. 39, 258.
5. D'Aquila, R. T., Johnson, V. A., Welles, S. L., Japour, A. J., Kuritzkes, D. R., DeGruttola, V., Reichelderfer, P. S., Coombs, R. W., Crumpacker, C. S., Kahn, J. O., et al. (1995) Ann. Intern. Med. 122, 401.
6. Furman, P. A., Fyfe, J. A., St Clair, M. H., Weinhold, K., Rideout, J. L., Freeman, G. A., Lehrman, S. N., Bolognesi, D. P., Broder, S., Mitsuya, H., et al. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 8333.
7. Gao, Q., Gu, Z., Parniak, M. A., Cameron, J., Cammack, N., Boucher, C., & Wainberg, M. A. (1993) Antimicrob. Agents Chemother. 37, 1390.
8. Goody, R. S., Muller, B., & Restle, T. (1991) FEBS Lett. 291, 1.
9. Gray, N. M., Marr, C. L., Penn, C. R., Cameron, J. M., & Bethell, R. C. (1995) Biochem. Pharmacol. 50, 1043.
10. Gu, Z., Gao, Q., Li, X., Parniak, M. A., & Wainberg, M. A. (1992) J. Virol. 66, 7128.
11. Gu, Z., Gao, Q., Fang, H., Parniak, M. A., Brenner, B. G., & Wainberg, M. A. (1994) Leukemia 8, Suppl 1:S166.
12. Hart, G. J., Orr, D. C., Penn, C. R., Figueiredo, H. T., Gray, N. M., Boehme, R. E., & Cameron, J. M. (1992) Antimicrob. Agents Chemother. 36, 1688.
13. Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M., & Markowitz, M. (1995) Nature 373, 123.
14. Johnson, M. A., & Fridland, A. (1989) Mol. Pharmacol. 36, 291.
15. Johnson, M. A., Ahluwalia, G., Connelly, M. C., Cooney, D. A., Broder, S., Johns, D.G., & Fridland, A. (1988) J. Biol. Chem. 263, 15354.
16. Kati, W. M., Johnson, K. A., Jerva, L. F., & Anderson, K. S. (1992) J. Biol. Chem. 267, 25988.
17. Kellam, P., Boucher, C. A., & Larder, B. A. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 1934.
18. Larder, B. A., & Kemp, S. D. (1989) Science 246, 1155.
19. Larder, B. A., Darby, G., & Richman, D. D. (1989) Science 243, 1731.
20. Larder, B. A., Kemp, S. D., & Harrigan, P. R. (1995) Science 269, 696.
21. Müller, B., Restle, T., Weiss, S., Gautel, M., Sczakiel, G., & Goody, R. S. (1989) J. Biol. Chem. 264, 13975.
22. Müller, B., Restle, T., Reinstein, J., & Goody, R. S. (1991a) Biochemistry 30, 3709.
23. Müller, B., Restle, T., Kühnel, H., & Goody, R. S. (1991b) J. Biol. Chem. 266, 14709.
24. Placidi, L., Cretton, E. M., Placidi, M., & Sommadossi, J. P. (1993) Clin. Pharmacol. Ther. 54, 168.
25. Quan, Y., Gu, Z., Li, X., Li, Z., Morrow, C. D., & Wainberg, M. A. (1996) J. Virol. 70, 5642.
26. Restle, T., Müller, B., & Goody, R. S. (1990) J. Biol. Chem. 265, 8986.
27. Rittinger, K., Divita, G., & Goody, R. S. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 8046.
28. Schinazi, R. F., Lloyd, R. M., Jr., Nguyen, M. H., Cannon, D. L., McMillan, A., Ilksoy, N., Chu, C. K., Liotta, D. C., Bazmi, H. Z., & Mellors, J. W. (1993) Antimicrob. Agents Chemother. 37, 875.
29. Skalski, V., Chang, C. N., Dutschman, G., & Cheng, Y. C. (1993) J. Biol. Chem. 268, 23234.
30. St Clair, M. H., Martin, J. L., Tudor-Williams, G., Bach, M. C., Vavro, C. L., King, D. M., Kellam, P., Kemp, S. D., & Larder, B. A. (1991) Science 253, 1557.
31. Wainberg, M. A., Salomon, H., Gu, Z., Montaner, J. S., Cooley, T. P., McCaffrey, R., Ruedy, J., Hirst, H. M., Cammack, N., Cameron, J., et al. (1995) AIDS 9, 351.
32. Wakefield, J. K., Jablonski, S. A., & Morrow, C. D. (1992) J. Virol. 66, 6806.
33. Wei, X., Ghosh, S. K., Taylor, M. E., Johnson, V. A., Emini, E. A., Deutsch, P., Lifson, J. D., Bonhoeffer, S., Nowak, M. A., Hahn, B. H., et al. (1995) Nature 373, 117.