Novel mechanism of inhibition of HIV-1 reverse transcriptase by a new non-nucleoside analog, KM-1

Journal of Biological Chemistry

Volumn 279, Issue 37, 2004, Pages 38424-38432

  Wang, Louise Z ^a   Kenyon, George L ^b   Johnson, Kenneth A ^a,c  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c Institute for Cellular and Molecular Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; BIOCHEMISTRY; CATALYSTS; CONCENTRATION (PROCESS); DNA; KINETIC THEORY;

KINETIC METHODS; NON-NUCLEOSIDE REVERSE TRANSCRIPTASE;

ENZYMES;

2 NAPHTHALENESULFONIC ACID [4 HYDROXY 7 [[[5 HYDROXY 6 [(4 CINNAMYLPHENYL)AZO] 7 SULFO 2 NAPTHALENYL]AMINO]CARBONYL]AMINO] 3 (4 CINNAMYLPHENYL)AZO; EDC 11; EDC 12; KM 1; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANISOTROPY; ARTICLE; CONCENTRATION RESPONSE; DRUG DNA BINDING; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; FLUORESCENCE POLARIZATION; FLUORESCENCE SPECTROSCOPY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE;

ADENOSINE TRIPHOSPHATE; BINDING SITES; CATALYSIS; CELL LINE, TRANSFORMED; CINNAMATES; DETERGENTS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; LIGHT; MICROSCOPY, ELECTRON; MODELS, CHEMICAL; NAPHTHALENESULFONATES; OCTOXYNOL; OLIGONUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; REVERSE TRANSCRIPTASE INHIBITORS; SCATTERING, RADIATION; TIME FACTORS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MARTES PENNANTI; RNA VIRUSES;

EID: 4644270641     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406241200     Document Type: Article

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