N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

PLoS Medicine

Volumn 4, Issue 12, 2007, Pages 1887-1900

  Yap, Soo Huey ^a,b   Sheen, Chih Wei ^c   Fahey, Jonathan ^a,d   Zanin, Mark ^a   Tyssen, David ^a   Lima, Viviane Dias ^e   Wynhoven, Brian ^e   Kuiper, Michael ^f   Sluis Cremer, Nicolas ^c   Harrigan, P Richard ^e   Tachedjian, Gilda ^a,d,g  

^a MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

^b UNIVERSITY OF BALLARAT   (Australia)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d MONASH UNIVERSITY   (Australia)

^e BRITISH COLUMBIA CENTRE FOR EXCELLENCE IN HIV AIDS   (Canada)

^f Victorian Parnership for Advanced Computing VPAC   (Australia)

^g MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DELAVIRDINE; DNA POLYMERASE; EFAVIRENZ; LAMIVUDINE; NEVIRAPINE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ARTICLE; CD4 LYMPHOCYTE COUNT; CODON; CONTROLLED STUDY; DNA SYNTHESIS; DRUG RESISTANCE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREVALENCE; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; STATISTICAL ANALYSIS; VIRUS LOAD; VIRUS MUTATION; WILD TYPE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MULTIDRUG RESISTANCE; MUTATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; RETROSPECTIVE STUDY; TIME; TREATMENT OUTCOME; VIROLOGY;

CELL LINE; DRUG RESISTANCE, MULTIPLE, VIRAL; GENOTYPE; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MODELS, MOLECULAR; MUTATION; NEVIRAPINE; PHENOTYPE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE INHIBITORS; TIME FACTORS; TREATMENT OUTCOME; VIRAL LOAD; ZIDOVUDINE;

EID: 38049028352     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0040335     Document Type: Article

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