Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 14, 2002, Pages 9515-9520

  Julias, John G ^a   McWilliams, Mary Jane ^a   Sarafianos, Stefan G ^b,c   Arnold, Edward ^b,c   Hughes, Stephen H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; PRIMER DNA; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; TRANSFER RNA; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; DNA STRAND; DNA SYNTHESIS; DNA TEMPLATE; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; REVERSE TRANSCRIPTION; RNA TRANSCRIPTION; VIRUS GENOME;

BASE SEQUENCE; CELL LINE; DNA, VIRAL; HIV LONG TERMINAL REPEAT; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEASE H, CALF THYMUS; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC;

DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0037047073     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.142123199     Document Type: Article

References (27)