Evolution of a signaling nexus constrained by protein interfaces and conformational states

PLoS Computational Biology

Volumn 6, Issue 10, 2010, Pages

  Temple, Brenda R S ^a,b   Jones, Corbin D ^a   Jones, Alan M ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFACE STATES; MAMMALS;

CONFORMATIONAL STATE; EUKARYOTICS; EXTRACELLULAR PROTEINS; EXTRACELLULAR SIGNALS; G PROTEIN; HETEROTRIMERIC G PROTEINS; INTERFACES STATE; PROTEIN INTERFACES; SYNTHETIC SEQUENCE;

PROTEINS;

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; ADENYLATE CYCLASE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT;

AMINO ACID SEQUENCE; ARTICLE; CYTOPLASM; EUKARYOTE; EVOLUTION; HUMAN; MAMMAL; METAZOON; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; ANIMAL; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; INFORMATION SCIENCE; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PHYLOGENY; PROTEIN DATABASE; PROTEIN DOMAIN; SEQUENCE ALIGNMENT;

EUKARYOTA; MAMMALIA; METAZOA;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; DATABASES, PROTEIN; EUKARYOTA; EVOLUTION, MOLECULAR; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN BETA SUBUNITS; HUMANS; INFORMATION THEORY; MODELS, GENETIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE ANNOTATION; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 78349234247     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000962     Document Type: Article

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