Evolutionarily conserved Gαβγ binding surfaces support a model of the G protein-receptor complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 15, 1996, Pages 7507-7511

  Lichtarge, Olivier ^a   Bourne, Henry R ^a,b   Cohen, Fred E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Evolution; Functional motif; Protein protein interaction; Signal transduction

Indexed keywords

CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; EVOLUTION; FACTUAL DATABASE; GENETICS; MACROMOLECULE; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; GENE MAPPING; GENETIC VARIABILITY; HYDROLYSIS; PRIORITY JOURNAL; RECEPTOR BINDING; SEQUENCE ANALYSIS; X RAY ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; DATABASES, FACTUAL; EVOLUTION; GTP-BINDING PROTEINS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CELL SURFACE;

EID: 0029664921     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.15.7507     Document Type: Article

References (45)

1. Bourne, H. R., Sanders, D. A. & McCormick, F. (1991) Nature (London) 349, 117-127.
2. Birnbaumer, L. (1990) Annu. Rev. Pharmacol. Toxicol. 30, 675-705.
3. Neer, E. J. (1995) Cell 80, 249-257.
4. Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. (1994) Nature (London) 369, 621-628.
5. Coleman, D. E., Berghuis, A. M., Lee, E., Linder, M. E., Gilman, A. G. & Sprang, S. R. (1994) Science 265, 1405-1412.
6. Noel, J. P., Hamm, H. E. & Sigler, P. B. (1993) Nature (London) 366, 654-663.
7. Wall, A. M., Coleman, D. E., Lee, E., Iniguex-Liuhi, J. A., Posner, B. A., Gilman, A. G. & Sprang, S. R. (1995) Cell 83, 1047-1058.
8. Sondek, J., Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. (1994) Nature (London) 372, 276-279.
9. Lambright, D. G., Sondek, J., Bohm, A., Nikolai, P. S., Hamm, H. E. & Sigler, P. B. (1996) Nature (London) 379, 311-319.
10. Lichtarge, O., Bourne, H. R. & Cohen, F. E. (1996) J. Mol. Biol. 257, 342-358.
11. Chothia, C. & Lesk, A. M. (1986) EMBO J. 5, 823-826.
12. Ostrowski, J., Kjelsberg, M. A., Caron, M. G. & Lefkowitz, R. J. (1992) Annu. Rev. Pharmacol. Toxicol. 32, 167-183.
13. Khorana, H. G. (1992) J. Biol. Chem. 267, 1-4.
14. Wong, S. K., Parker, E. M. & Ross, E. M. (1990) J. Biol. Chem. 265, 6219-6224.
15. Namba, T., Sugimoto, Y., Negishi, M., Irie, A., Ushikubi, F., Kakizuka, A., Ito, S., Ichikawa, A. & Narumiya, S. (1993) Nature (London) 365, 166-170.
16. Conklin, B. R., Farfel, Z., Lustig, K. D., Julius, D. & Bourne, H. R. (1993) Nature (London) 363, 274-276.
17. Pearson, W. R. & Lipman, D. J. (1988) Proc. Natl. Acad. Sci. USA 85, 2444-2448.
18. Feng, D. R. & Doolittle, R. F. (1987) J. Mol. Evol. 25, 351-360.
19. Higgins, D. G. & Sharp, P. M. (1989) Comput. Appl. Biosci. 5, 151-153.
20. Devereux, J., Haeberli, P. & Smithies, O. (1984) Nucleic Acids Res. 12, 387-395.
21. Schertler, G. F., Villa, C. & Henderson, R. (1993) Nature (London) 362, 770-772.
22. Schertler, G. F. & Hargrave, P. A. (1995) Proc. Natl. Acad. Sci. USA 92, 11578-11582.
23. Taylor, J. M., Jacob-Mosier, G. G., Lawton, R. G., Remmers, A. E. & Neubig, R. R. (1994) J. Biol. Chem. 269, 27618-27624.
24. Richards, F. M. (1977) Annu. Rev. Biophys. Bioeng. 6, 151-176.
25. Dratz, E. A., Furstenau, J. E., Lambert, C. G., Thireault, D. L., Rarick, H., Schepers, T., Pakhlevaniants, S. & Hamm, H. E. (1993) Nature (London) 363, 276-281.
26. Hamm, H. E., Deretic, D., Arendt, A., Hargrave, P. A., Koenig, B. & Hofmann, K. P. (1988) Science 241, 832-835.
27. Rasenick, M. M., Watanabe, M., Lazarevic, M. B., Hatta, S. & Hamm, H. E. (1994) J. Biol. Chem. 269, 21519-21525.
28. Conklin, B. R. & Bourne, H. R. (1993) Cell 73, 631-641.
29. Garcia, P. D., Onrust, R., Bell, S. B., Sakmar, T. P. & Bourne, H. R. (1995) EMBO J. 14, 4460-4469.
30. Donnelly, D., Findlay, J. B. & Blundell, T. L. (1994) Receptors Channels 2, 61-78.
31. Bourne, H. R. (1995) Philos. Trans. R. Soc. London B 349, 283-289.
32. Whiteway, M., Clark, K. L., Leberer, E., Dignard, D. & Thomas, D. Y. (1994) Mol. Cell. Biol. 14, 3223-3229.
33. Thomas, T. C., Schmidt, C. J. & Neer, E. J. (1993) Proc. Natl. Acad. Sci. USA 90, 10295-10298.
34. Berlot, C. H. & Bourne, H. R. (1992) Cell 68, 911-922.
35. Rarick, H. M., Artemyev, N. O. & Hamm, H. E. (1992) Science 256, 1031-1033.
36. Artemyev, N. O., Mills, J. S., Thornburg, K. R., Knapp, D. R., Schey, K. L. & Hamm, H. E. (1993) J. Biol. Chem. 268, 23611-23615.
37. Faurobert, E., Otto, B. A., Chardin, P. & Chabre, M. (1993) EMBO J. 12, 4191-4198.
38. Wedegaertner, P. B. & Bourne, H. R. (1995) J. Biol. Chem. 270, 503-506.
39. Phillips, W. J. & Cerione, R. A. (1992) J. Biol. Chem. 267, 17032-17039.
40. Phillips, W. J., Wong, S. C. & Cerione, R. A. (1992) J. Biol. Chem. 267, 17040-17046.
41. Buss, J. E., Mumby, S. M., Casey, P. J., Oilman, A. G. & Sefton, B. M. (1987) Proc. Natl. Acad. Sci. USA 84, 7493-7497.
42. Mumby, S. M., Heukeroth, R. O., Gordon, J. I. & Gilman, A. G. (1990) Proc. Natl. Acad. Sci. USA 87, 728-732.
43. Leszczynski, J. F. & Rose, G. D. (1986) Science 234, 849-855.
44. Thomas, D. J. (1990) J. Mol. Biol. 216, 459-465.
45. Kuntz, I. D. (1992) Science 257, 1078-1082.