Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits

Nature

Volumn 416, Issue 6883, 2002, Pages 878-881

  Kimple, Randall J ^a   Kimple, Michelle E ^a   Betts, Laurie ^a   Sondek, John ^a,b   Siderovski, David P ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CRYSTAL STRUCTURE; PROTEINS;

PROTEIN SIGNALLING;

CELLS;

ARGININE; ASPARTIC ACID; GLUTAMIC ACID; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

PROTEIN;

ARTICLE; COMPUTER PREDICTION; CRYSTAL STRUCTURE; DISSOCIATION; HUMAN; INHIBITION KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; RGS PROTEINS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037171778     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/416878a     Document Type: Article

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