Polyglutamine-Expanded Ataxin-7 Promotes Non-Cell-Autonomous Purkinje Cell Degeneration and Displays Proteolytic Cleavage in Ataxic Transgenic Mice

Journal of Neuroscience

Volumn 22, Issue 12, 2002, Pages 4897-4905

  Garden, Gwenn A ^a   Libby, Randell T ^a   Fu, Ying Hui ^b   Kinoshita, Yoshito ^a   Huang, Jing ^a   Possin, Daniel E ^a   Smith, Annette C ^a   Martinez, Refugio A ^a   Fine, Gabriel C ^a   Grote, Sara K ^a   Ware, Carol B ^a   Einum, David D ^b   Morrison, Richard S ^a   Ptacek, Louis J ^b,c   Sopher, Bryce L ^a   La Spada, Albert R ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Ataxin 7; Neurodegeneration; Non cell autonomous; Polyglutamine; Proteolytic cleavage; Purkinje cell; Truncation

Indexed keywords

ANTIBODY; ATAXIN 7; BRAIN PROTEIN; ISOPROTEIN; POLYGLUTAMINE; UNCLASSIFIED DRUG; ATAXIN-7; NERVE PROTEIN; PEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; ATAXIA; BRAIN NERVE CELL; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH; DISEASE SEVERITY; MEDICAL DOCUMENTATION; MOLECULAR DYNAMICS; MOUSE; NERVE CELL DEGENERATION; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PURKINJE CELL; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; CELL INCLUSION; GENETICS; KINETICS; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; SPINOCEREBELLAR DEGENERATION;

ANIMALS; CELL NUCLEUS; GAIT ATAXIA; INCLUSION BODIES; KINETICS; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; PEPTIDES; PURKINJE CELLS; SPINOCEREBELLAR DEGENERATIONS;

EID: 0037096365     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-12-04897.2002     Document Type: Article

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