메뉴 건너뛰기




Volumn 1, Issue 4, 1999, Pages 227-233

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PRIMER DNA; TRANSCRIPTION FACTOR RELA;

EID: 0033174072     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/12050     Document Type: Article
Times cited : (175)

References (39)
  • 1
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years after
    • Baeuerle, P. A. & Baltimore, D. NF-κB: Ten years after. Cell 87, 15-20 (1996).
    • (1996) Cell , vol.87 , pp. 15-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 2
    • 0028174061 scopus 로고
    • Function and activation of NF-ΚB in the immune system
    • Baeuerle, P. A. & Henkel, T. Function and activation of NF-ΚB in the immune system. Annu. Rev. Immunol. 12, 141-179 (1994).
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 3
    • 0029874138 scopus 로고    scopus 로고
    • The NF-ΚB and 1ΚB proteins: New discoveries and insights
    • Baldwin, A.S. Jr The NF-ΚB and 1ΚB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-483 (1996).
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-1483
    • Baldwin A.S., Jr.1
  • 4
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-ΚB
    • Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S. & Baltimore, D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-ΚB. Nature 376, 167-170 (1995).
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 5
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-ΚB in preventing TNF-α-induced cell death
    • Beg, A. A. & Baltimore, D. An essential role for NF-ΚB in preventing TNF-α-induced cell death. Science 274, 782-784 (1996).
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 6
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-αB activation prevents cell death
    • Liu, Z. G., Hsu, H., Goeddel, D. V., & Karin, M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-αB activation prevents cell death. Cell 87, 565-576 (1996).
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.G.1    Hsu, H.2    Goeddel, D.V.3    Karin, M.4
  • 8
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
    • Wang, C. Y., Mayo, M. W. & Baldwin, A. S. Jr TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274, 784-787 (1996).
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin A.S., Jr.3
  • 9
    • 0031440245 scopus 로고    scopus 로고
    • Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer
    • Sovak, M. A. et al. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J. Clin. Invest. 100, 2952-2960 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 2952-2960
    • Sovak, M.A.1
  • 10
    • 18844465632 scopus 로고    scopus 로고
    • Constitutive nuclear factor-kappa B-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
    • Bargou, R. C. et al. Constitutive nuclear factor-kappa B-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J. Clin. Invest. 100, 2961-2969 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 2961-2969
    • Bargou, R.C.1
  • 11
    • 0031596991 scopus 로고    scopus 로고
    • 3 integrin-induced endothelial cell survival
    • 3 integrin-induced endothelial cell survival. J. Cell Biol. 141, 1083-1093 (1998).
    • (1998) J. Cell Biol. , vol.141 , pp. 1083-1093
    • Scatena, M.1
  • 12
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
    • Palombella, V. J., Rando, O. J., Goldberg, A. L. & Maniatis, T. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78, 773-785 (1994).
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 13
    • 0030613646 scopus 로고    scopus 로고
    • Catalysis by a multiprotein IκB kinase complex
    • Maniatis, T. Catalysis by a multiprotein IκB kinase complex. Science 278, 818-819 (1997).
    • (1997) Science , vol.278 , pp. 818-819
    • Maniatis, T.1
  • 14
    • 0030613758 scopus 로고    scopus 로고
    • NF-κB activation: The IκB kinase revealed?
    • Stancovski, I. & Baltimore, D. NF-κB activation: the IκB kinase revealed? Cell 91, 299-302 (1997).
    • (1997) Cell , vol.91 , pp. 299-302
    • Stancovski, I.1    Baltimore, D.2
  • 15
    • 0030914691 scopus 로고    scopus 로고
    • CREB-binding protein/p300 are transcriptional coactivatorsof p65
    • Gerritsen, M. E. et al. CREB-binding protein/p300 are transcriptional coactivatorsof p65. Proc. Natl Acad. Sci. USA 94, 2927-2932 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 2927-2932
    • Gerritsen, M.E.1
  • 16
    • 0032039076 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactlvator CBP/p300
    • Zhong, H., Voll, R. E. & Ghosh, S. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactlvator CBP/p300. Mol. Cell 1, 661-671 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 661-671
    • Zhong, H.1    Voll, R.E.2    Ghosh, S.3
  • 17
    • 0030614504 scopus 로고    scopus 로고
    • Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
    • Perkins, N. D. et al. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275, 523-527 (1997).
    • (1997) Science , vol.275 , pp. 523-527
    • Perkins, N.D.1
  • 18
    • 0029880622 scopus 로고    scopus 로고
    • Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases
    • Meikrantz, W. &Schlegel, R. Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J. Biol. Chem. 271, 10205-10209 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 10205-10209
    • Meikrantz, W.1    Schlegel, R.2
  • 19
    • 0032012062 scopus 로고    scopus 로고
    • Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade
    • Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol. Cell 1, 553-563 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 553-563
    • Levkau, B.1
  • 20
    • 0030702084 scopus 로고    scopus 로고
    • Caspases: Intracellular signaling by proteolysis
    • Salvesen, G. S. & Dixit, V. M. Caspases: intracellular signaling by proteolysis. Cell 91, 443-446 (1997).
    • (1997) Cell , vol.91 , pp. 443-446
    • Salvesen, G.S.1    Dixit, V.M.2
  • 22
    • 0030948457 scopus 로고    scopus 로고
    • Substrate specificities of caspase family proteases
    • Talanian, R. V. et al. Substrate specificities of caspase family proteases. J. Biol. Chem. 272, 9677-9682 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 9677-9682
    • Talanian, R.V.1
  • 23
    • 0032078217 scopus 로고    scopus 로고
    • Caspases: Key mediators of apoptosis
    • Thornberry, N. A. Caspases: key mediators of apoptosis. Chem. Biol. 5, R97-R103 (1998).
    • (1998) Chem. Biol. , vol.5
    • Thornberry, N.A.1
  • 24
    • 0028116117 scopus 로고
    • Structural and functional analysis of the NF-κB p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation
    • Schmitz, M. L. et al. Structural and functional analysis of the NF-κB p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation. J. Biol. Chem. 269, 25613-25620 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 25613-25620
    • Schmitz, M.L.1
  • 25
    • 0029999656 scopus 로고    scopus 로고
    • Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis
    • Grimm, S., Bauer, M. K., Baeuerle, P. A. & Schulze Osthoff, K. Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis. J. Cell Biol. 134, 13-23 (1996).
    • (1996) J. Cell Biol. , vol.134 , pp. 13-23
    • Grimm, S.1    Bauer, M.K.2    Baeuerle, P.A.3    Schulze Osthoff, K.4
  • 26
    • 0029861518 scopus 로고    scopus 로고
    • Endothelial cell death induced by tumor necrosis factor-α is inhibited by the Bcl-2 family member A1
    • Karsan, A., Yee, E. & Harlan, J. M. Endothelial cell death induced by tumor necrosis factor-α is inhibited by the Bcl-2 family member A1. J. Biol. Chem. 271, 27201-27204 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 27201-27204
    • Karsan, A.1    Yee, E.2    Harlan, J.M.3
  • 27
    • 0029666276 scopus 로고    scopus 로고
    • Interleukin-1β and glutamate activate the NF-κB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures
    • Grilli, M., Goffi, F., Memo, M. & Spano, P. Interleukin-1β and glutamate activate the NF-κB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures. J. Biol. Chem. 271, 15002-15007 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 15002-15007
    • Grilli, M.1    Goffi, F.2    Memo, M.3    Spano, P.4
  • 29
    • 0029849215 scopus 로고    scopus 로고
    • Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly( ADPribose) polymerase and restores the NF-κB signaling pathway
    • Mandal, M. et al. Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly( ADPribose) polymerase and restores the NF-κB signaling pathway. J. Biol. Chem. 271, 30354-30359 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 30354-30359
    • Mandal, M.1
  • 30
    • 0029898073 scopus 로고    scopus 로고
    • The CD95 (APO-1/Fas) receptor activates NF-KB independently of its cytotoxic function
    • Ponton, A., Cl'ement, M. V. & Stamenkovic, I. The CD95 (APO-1/Fas) receptor activates NF-KB independently of its cytotoxic function. J. Biol. Chem. 271, 8991-8995 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 8991-8995
    • Ponton, A.1    Cl'ement, M.V.2    Stamenkovic, I.3
  • 31
    • 0029096804 scopus 로고
    • Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo
    • Rensing Ehl, A. et al. Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo. Eur. J. Immunol. 25, 2253-2258 (1995).
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2253-2258
    • Rensing Ehl, A.1
  • 32
    • 0028001530 scopus 로고
    • Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death
    • Schulze Osthoff, K., Krammer, P. H. & Droge, W. Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J. 13, 4587-4596 (1994).
    • (1994) EMBO J. , vol.13 , pp. 4587-4596
    • Schulze Osthoff, K.1    Krammer, P.H.2    Droge, W.3
  • 33
    • 0032032627 scopus 로고    scopus 로고
    • CD95 (Fas)-induced caspase-media ted proteolysis of NF-κB
    • Ravi, R., Bedi, A., Fuchs, E. J. & Bedi, A. CD95 (Fas)-induced caspase-media ted proteolysis of NF-κB. Cancer Res. 58, 882-886 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 882-886
    • Ravi, R.1    Bedi, A.2    Fuchs, E.J.3    Bedi, A.4
  • 34
    • 0031465443 scopus 로고    scopus 로고
    • Conversion of Bcl-2 to a Bax-like death effector by caspases
    • Cheng, E. H. et al. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278, 1966-1968 (1997).
    • (1997) Science , vol.278 , pp. 1966-1968
    • Cheng, E.H.1
  • 35
    • 0030613770 scopus 로고    scopus 로고
    • Phosphorylation of IκB-α inhibits its cleavage by caspase CPP32 in vitro
    • Barkett, M., Xue, D., Horvitz, H. R. & Gilmore, T. D. Phosphorylation of IκB-α inhibits its cleavage by caspase CPP32 in vitro. J. Biol. Chem. 272, 29419-29422 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 29419-29422
    • Barkett, M.1    Xue, D.2    Horvitz, H.R.3    Gilmore, T.D.4
  • 36
    • 0028986193 scopus 로고
    • NF-κB: A lesson in family values
    • Thanos, D. & Maniatis, T. NF-κB: a lesson in family values. Cell 80, 529-532 (1995).
    • (1995) Cell , vol.80 , pp. 529-532
    • Thanos, D.1    Maniatis, T.2
  • 37
    • 0028073962 scopus 로고
    • Fibronectin attachment activates the NF-κB p50/p65 heterodimer in fibroblasts and smooth muscle cells
    • Qwarnstrom, E. E., Ostberg, C. O., Turk, G. L., Richardson, C. A. & Bomsztyk, K. Fibronectin attachment activates the NF-κB p50/p65 heterodimer in fibroblasts and smooth muscle cells. J. Biol. Chem. 269, 30765-30768 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 30765-30768
    • Qwarnstrom, E.E.1    Ostberg, C.O.2    Turk, G.L.3    Richardson, C.A.4    Bomsztyk, K.5
  • 38
    • 0028943216 scopus 로고
    • Identification of a rasactivated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity correlates with the metastatic potential of the cell
    • Guo, X., Zhang, Y. P., Mitchell, D. A., Denhardt, D. T. & Chambers, A. F. Identification of a rasactivated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity correlates with the metastatic potential of the cell. Mol. Cell. Biol. 15, 476-487 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 476-487
    • Guo, X.1    Zhang, Y.P.2    Mitchell, D.A.3    Denhardt, D.T.4    Chambers, A.F.5
  • 39
    • 0023895357 scopus 로고
    • A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing
    • Lee, K. A., Bindereif, A. & Green, M. R. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene. Anal. Tech. 5, 22-31 (1988).
    • (1988) Gene. Anal. Tech. , vol.5 , pp. 22-31
    • Lee, K.A.1    Bindereif, A.2    Green, M.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.