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Volumn 24, Issue 11, 2010, Pages 1823-1833

Insights into the stem cells of chronic myeloid leukemia

Author keywords

cancer stem cell; chronic myeloid leukemia; genomic instability; leukemic stem cell; self renewal

Indexed keywords

BCR ABL PROTEIN; IMATINIB; INTERLEUKIN 2 RECEPTOR;

EID: 78149470597     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.159     Document Type: Review
Times cited : (102)

References (132)
  • 1
    • 0001639195 scopus 로고
    • Some speculations on the myeloproliferative syndromes
    • Dameshek W. Some speculations on the myeloproliferative syndromes. Blood 1951; 6: 372-375.
    • (1951) Blood , vol.6 , pp. 372-375
    • Dameshek, W.1
  • 2
    • 0000286732 scopus 로고
    • A minute chromosome in chronic granulocytic leukemia
    • Nowell PC, Hungerford DA. A minute chromosome in chronic granulocytic leukemia. Science 1960; 132: 1497.
    • (1960) Science , vol.132 , pp. 1497
    • Nowell, P.C.1    Hungerford, D.A.2
  • 3
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973; 243: 290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 5
    • 75449141216 scopus 로고
    • The distribution of the philadelphia chromosome in patients with chronic myelogenous leukemia
    • Whang J, Frei III E, Tjio JH, Carbone PP, Brecher G. The distribution of the philadelphia chromosome in patients with chronic myelogenous leukemia. Blood 1963; 22: 664-673.
    • (1963) Blood , vol.22 , pp. 664-673
    • Whang, J.1    Frei Iii, E.2    Tjio, J.H.3    Carbone, P.P.4    Brecher, G.5
  • 7
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow PJ, Jacobson RJ, Papayannopoulou T. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med 1977; 63: 125-130.
    • (1977) Am J Med , vol.63 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 9
    • 0000900855 scopus 로고
    • Persistent mitosis of transfused homologous leukocytes in children receiving antileukemic therapy
    • Levin RH, Whang J, Tjio JH, Carbone PP, Frei III E, Freireich EJ. Persistent mitosis of transfused homologous leukocytes in children receiving antileukemic therapy. Science 1963; 142: 1305-1311.
    • (1963) Science , vol.142 , pp. 1305-1311
    • Levin, R.H.1    Whang, J.2    Tjio, J.H.3    Carbone, P.P.4    Frei Iii, E.5    Freireich, E.J.6
  • 10
    • 0014949195 scopus 로고
    • Complication of bone-marrow transplantation. Graft-versus-host disease resulting from chronic-myelogenous-leukaemia leucocyte transfusions
    • Graw Jr RG, Buckner CD, Whang-Peng J, Leventhal BG, Kruger G, Berard C et al. Complication of bone-marrow transplantation. Graft-versus-host disease resulting from chronic-myelogenous-leukaemia leucocyte transfusions. Lancet 1970; 2: 338-341.
    • (1970) Lancet , vol.2 , pp. 338-341
    • Graw Jr., R.G.1    Buckner, C.D.2    Whang-Peng, J.3    Leventhal, B.G.4    Kruger, G.5    Berard, C.6
  • 11
    • 0034585920 scopus 로고    scopus 로고
    • Normal and chronic phase CML hematopoietic cells Repopulate NOD/SCID bone marrow with different kinetics and cell lineage representation
    • Dazzi F, Hasserjian R, Gordon MY, Boecklin F, Cotter F, Corbo M et al. Normal and chronic phase CML hematopoietic cells Repopulate NOD/SCID bone marrow with different kinetics and cell lineage representation. Hematol J 2000; 1: 307-315.
    • (2000) Hematol J , vol.1 , pp. 307-315
    • Dazzi, F.1    Hasserjian, R.2    Gordon, M.Y.3    Boecklin, F.4    Cotter, F.5    Corbo, M.6
  • 12
    • 20144374544 scopus 로고    scopus 로고
    • Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease
    • Eisterer W, Jiang X, Christ O, Glimm H, Lee KH, Pang E et al. Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease. Leukemia 2005; 19: 435-441.
    • (2005) Leukemia , vol.19 , pp. 435-441
    • Eisterer, W.1    Jiang, X.2    Christ, O.3    Glimm, H.4    Lee, K.H.5    Pang, E.6
  • 13
    • 0029837399 scopus 로고    scopus 로고
    • Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia
    • Petzer AL, Eaves CJ, Lansdorp PM, Ponchio L, Barnett MJ, Eaves AC. Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia. Blood 1996; 88: 2162-2171.
    • (1996) Blood , vol.88 , pp. 2162-2171
    • Petzer, A.L.1    Eaves, C.J.2    Lansdorp, P.M.3    Ponchio, L.4    Barnett, M.J.5    Eaves, A.C.6
  • 15
    • 0020581621 scopus 로고
    • Long-term marrow culture reveals chromosomally normal hema-topoietic progenitor cells in patients with Philadelphia chromosome-positive chronic myelogenous leukemia
    • Coulombel L, Kalousek DK, Eaves CJ, Gupta CM, Eaves AC. Long-term marrow culture reveals chromosomally normal hema-topoietic progenitor cells in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. N Engl J Med 1983; 308: 1493-1498.
    • (1983) N Engl J Med , vol.308 , pp. 1493-1498
    • Coulombel, L.1    Kalousek, D.K.2    Eaves, C.J.3    Gupta, C.M.4    Eaves, A.C.5
  • 16
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005; 105: 2640-2653.
    • (2005) Blood , vol.105 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 17
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • Copland M, Hamilton A, Elrick LJ, Baird JW, Allan EK, Jordanides N et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006; 107: 4532-4539.
    • (2006) Blood , vol.107 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3    Baird, J.W.4    Allan, E.K.5    Jordanides, N.6
  • 18
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002; 99: 319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6
  • 19
    • 34247843031 scopus 로고    scopus 로고
    • The challenges of targeting chronic myeloid leukemia stem cells
    • Jiang X, Smith C, Eaves A, Eaves C. The challenges of targeting chronic myeloid leukemia stem cells. Clin Lymphoma Myeloma 2007; 7 (Suppl 2): S71-S80.
    • (2007) Clin Lymphoma Myeloma , vol.7 , Issue.SUPPL. 2
    • Jiang, X.1    Smith, C.2    Eaves, A.3    Eaves, C.4
  • 20
    • 34247555482 scopus 로고    scopus 로고
    • Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
    • Jiang X, Zhao Y, Smith C, Gasparetto M, Turhan A, Eaves A et al. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 2007; 21: 926-935.
    • (2007) Leukemia , vol.21 , pp. 926-935
    • Jiang, X.1    Zhao, Y.2    Smith, C.3    Gasparetto, M.4    Turhan, A.5    Eaves, A.6
  • 21
    • 47049127238 scopus 로고    scopus 로고
    • Emerging stem cell concepts for imatinib-resistant chronic myeloid leukaemia: Implications for the biology, management, and therapy of the disease
    • Valent P. Emerging stem cell concepts for imatinib-resistant chronic myeloid leukaemia: implications for the biology, management, and therapy of the disease. Br J Haematol 2008; 142: 361-378.
    • (2008) Br J Haematol , vol.142 , pp. 361-378
    • Valent, P.1
  • 22
    • 34249693090 scopus 로고    scopus 로고
    • Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells
    • Jiang X, Saw KM, Eaves A, Eaves C. Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells. J Natl Cancer Inst 2007; 99: 680-693.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 680-693
    • Jiang, X.1    Saw, K.M.2    Eaves, A.3    Eaves, C.4
  • 23
    • 9444264703 scopus 로고    scopus 로고
    • BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks
    • Nowicki MO, Falinski R, Koptyra M, Slupianek A, Stoklosa T, Gloc E et al. BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Blood 2004; 104: 3746-3753.
    • (2004) Blood , vol.104 , pp. 3746-3753
    • Nowicki, M.O.1    Falinski, R.2    Koptyra, M.3    Slupianek, A.4    Stoklosa, T.5    Gloc, E.6
  • 24
    • 42049086836 scopus 로고    scopus 로고
    • BCR/ABL, DNA damage and DNA repair: Implications for new treatment concepts
    • Skorski T. BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts. Leuk Lymphoma 2008; 49: 610-614.
    • (2008) Leuk Lymphoma , vol.49 , pp. 610-614
    • Skorski, T.1
  • 25
    • 77950536837 scopus 로고    scopus 로고
    • BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta
    • Pellicano F, Copland M, Jorgensen HG, Mountford J, Leber B, Holyoake TL. BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta. Blood 2009; 114: 4186-4196.
    • (2009) Blood , vol.114 , pp. 4186-4196
    • Pellicano, F.1    Copland, M.2    Jorgensen, H.G.3    Mountford, J.4    Leber, B.5    Holyoake, T.L.6
  • 26
    • 77952105211 scopus 로고    scopus 로고
    • Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
    • Zhang B, Strauss AC, Chu S, Li M, Ho Y, Shiang KD et al. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 2010; 17: 427-442.
    • (2010) Cancer Cell , vol.17 , pp. 427-442
    • Zhang, B.1    Strauss, A.C.2    Chu, S.3    Li, M.4    Ho, Y.5    Shiang, K.D.6
  • 28
    • 0003885237 scopus 로고
    • Incidence of leukemia in a fixed cohort of atomic bomb survivors and controls, Hiroshima and Nagasaki October 1950-December 1978
    • Radiation Effects Research Foundation: Hiroshima
    • Ichimaru M, Ishimaru T, Mikami M, Yamada Y, Ohkita T. Incidence of leukemia in a fixed cohort of atomic bomb survivors and controls, Hiroshima and Nagasaki October 1950-December 1978. Technical Report RERF TR 13-81. Radiation Effects Research Foundation: Hiroshima, 1981.
    • (1981) Technical Report RERF TR , pp. 13-81
    • Ichimaru, M.1    Ishimaru, T.2    Mikami, M.3    Yamada, Y.4    Ohkita, T.5
  • 29
    • 0028947219 scopus 로고
    • Leukemia mortality after X-ray treatment for ankylosing spondylitis
    • Weiss HA, Darby SC, Fearn T, Doll R. Leukemia mortality after X-ray treatment for ankylosing spondylitis. Radiat Res 1995; 142: 1-11.
    • (1995) Radiat Res , vol.142 , pp. 1-11
    • Weiss, H.A.1    Darby, S.C.2    Fearn, T.3    Doll, R.4
  • 30
    • 0028786297 scopus 로고
    • Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals
    • Biernaux C, Loos M, Sels A, Huez G, Stryckmans P. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood 1995; 86: 3118-3122.
    • (1995) Blood , vol.86 , pp. 3118-3122
    • Biernaux, C.1    Loos, M.2    Sels, A.3    Huez, G.4    Stryckmans, P.5
  • 31
    • 0032211172 scopus 로고    scopus 로고
    • The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease
    • Bose S, Deininger M, Gora-Tybor J, Goldman JM, Melo JV. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood 1998; 92: 3362-3367.
    • (1998) Blood , vol.92 , pp. 3362-3367
    • Bose, S.1    Deininger, M.2    Gora-Tybor, J.3    Goldman, J.M.4    Melo, J.V.5
  • 32
    • 0000878771 scopus 로고    scopus 로고
    • Animal models of Philadelphia-positive leukemia
    • Carella AM, Daley GQ, Eaves CJ, Goldman JM, Hehlmann R (eds) Dunitz, M.: London
    • Van Etten RA. Animal models of Philadelphia-positive leukemia. In: Carella AM, Daley GQ, Eaves CJ, Goldman JM, Hehlmann R (eds). Chronic Myeloid Leukemia: Biology and Treatment. Dunitz, M.: London, 2001, pp 101-131.
    • (2001) Chronic Myeloid Leukemia: Biology and Treatment , pp. 101-131
    • Van Etten, R.A.1
  • 33
    • 15044346433 scopus 로고    scopus 로고
    • BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice
    • Chalandon Y, Jiang X, Christ O, Loutet S, Thanopoulou E, Eaves A et al. BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice. Leukemia 2005; 19: 442-448.
    • (2005) Leukemia , vol.19 , pp. 442-448
    • Chalandon, Y.1    Jiang, X.2    Christ, O.3    Loutet, S.4    Thanopoulou, E.5    Eaves, A.6
  • 34
    • 0034641709 scopus 로고    scopus 로고
    • Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity
    • Jiang Y, Zhao RC, Verfaillie CM. Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity. Proc Natl Acad Sci USA 2000; 97: 10538-10543.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10538-10543
    • Jiang, Y.1    Zhao, R.C.2    Verfaillie, C.M.3
  • 35
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990; 247: 824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 36
    • 0033519238 scopus 로고    scopus 로고
    • The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity
    • Li S, Ilaria Jr RL, Million RP, Daley GQ, Van Etten RA. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med 1999; 189: 1399-1412.
    • (1999) J Exp Med , vol.189 , pp. 1399-1412
    • Li, S.1    Ilaria Jr., R.L.2    Million, R.P.3    Daley, G.Q.4    Van Etten, R.A.5
  • 37
    • 0025271543 scopus 로고
    • Bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemo-poietic neoplasms in mice
    • Elefanty AG, Hariharan IK, Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemo-poietic neoplasms in mice. EMBO J 1990; 9: 1069-1078.
    • (1990) EMBO J , vol.9 , pp. 1069-1078
    • Elefanty, A.G.1    Hariharan, I.K.2    Cory, S.3
  • 38
    • 19944385935 scopus 로고    scopus 로고
    • MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
    • Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 2004; 6: 587-596.
    • (2004) Cancer Cell , vol.6 , pp. 587-596
    • Huntly, B.J.1    Shigematsu, H.2    Deguchi, K.3    Lee, B.H.4    Mizuno, S.5    Duclos, N.6
  • 39
    • 34948839961 scopus 로고    scopus 로고
    • Leukemia stem cells in a genetically defined murine model of blast-crisis CML
    • Neering SJ, Bushnell T, Sozer S, Ashton J, Rossi RM, Wang PY et al. Leukemia stem cells in a genetically defined murine model of blast-crisis CML. Blood 2007; 110: 2578-2585.
    • (2007) Blood , vol.110 , pp. 2578-2585
    • Neering, S.J.1    Bushnell, T.2    Sozer, S.3    Ashton, J.4    Rossi, R.M.5    Wang, P.Y.6
  • 42
    • 18144451171 scopus 로고    scopus 로고
    • Chronic myeloid leukemia and interferon-alpha: A study of complete cytogenetic responders
    • Bonifazi F, de Vivo A, Rosti G, Guilhot F, Guilhot J, Trabacchi E et al. Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders. Blood 2001; 98: 3074-3081.
    • (2001) Blood , vol.98 , pp. 3074-3081
    • Bonifazi, F.1    De Vivo, A.2    Rosti, G.3    Guilhot, F.4    Guilhot, J.5    Trabacchi, E.6
  • 43
    • 0023486415 scopus 로고
    • Cell culture studies in CML
    • Hinton K (ed) 1st edn. Baillère Tindall/Saunders, W.B.: London
    • Eaves CJ, Eaves A. Cell culture studies in CML. In: Hinton K (ed). Baillière's Clinical Haematology, 1st edn. Baillère Tindall/Saunders, W.B.: London, 1987, pp 931-961.
    • (1987) Baillière's Clinical Haematology , pp. 931-961
    • Eaves, C.J.1    Eaves, A.2
  • 44
    • 0032921093 scopus 로고    scopus 로고
    • Relapse of chronic myeloid leukaemia 14 years after allogeneic bone marrow transplantation
    • Yong AS, Goldman JM. Relapse of chronic myeloid leukaemia 14 years after allogeneic bone marrow transplantation. Bone Marrow Transplant 1999; 23: 827-828.
    • (1999) Bone Marrow Transplant , vol.23 , pp. 827-828
    • Yong, A.S.1    Goldman, J.M.2
  • 45
    • 0020619429 scopus 로고
    • Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors
    • Bakhshi A, Minowada J, Arnold A, Cossman J, Jensen JP, Whang-Peng J et al. Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. N Engl J Med 1983; 309: 826-831.
    • (1983) N Engl J Med , vol.309 , pp. 826-831
    • Bakhshi, A.1    Minowada, J.2    Arnold, A.3    Cossman, J.4    Jensen, J.P.5    Whang-Peng, J.6
  • 46
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 2006; 442: 818-822.
    • (2006) Nature , vol.442 , pp. 818-822
    • Krivtsov, A.V.1    Twomey, D.2    Feng, Z.3    Stubbs, M.C.4    Wang, Y.5    Faber, J.6
  • 47
    • 34247595838 scopus 로고    scopus 로고
    • Modeling the initiation and progression of human acute leukemia in mice
    • Barabe F, Kennedy JA, Hope KJ, Dick JE. Modeling the initiation and progression of human acute leukemia in mice. Science 2007; 316: 600-604.
    • (2007) Science , vol.316 , pp. 600-604
    • Barabe, F.1    Kennedy, J.A.2    Hope, K.J.3    Dick, J.E.4
  • 48
  • 49
    • 0011633534 scopus 로고    scopus 로고
    • Progenitor cell dynamics
    • Carella AM, Daley GQ, Eaves CJ, Goldman JM, Hehlmann R (eds) Dunitz, M.: London
    • Eaves CJ, Eaves A. Progenitor cell dynamics. In: Carella AM, Daley GQ, Eaves CJ, Goldman JM, Hehlmann R (eds). Chronic Myeloid Leukemia : Biology and Treatment. Dunitz, M.: London, 2001, pp 73-100.
    • (2001) Chronic Myeloid Leukemia: Biology and Treatment , pp. 73-100
    • Eaves, C.J.1    Eaves, A.2
  • 50
    • 0032436505 scopus 로고    scopus 로고
    • Defective regulation of leukemic hematopoiesis in chronic myeloid leukemia
    • Eaves C, Cashman J, Eaves A. Defective regulation of leukemic hematopoiesis in chronic myeloid leukemia. Leuk Res 1998; 22: 1085-1096.
    • (1998) Leuk Res , vol.22 , pp. 1085-1096
    • Eaves, C.1    Cashman, J.2    Eaves, A.3
  • 51
    • 0026496231 scopus 로고
    • Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia
    • Udomsakdi C, Eaves CJ, Lansdorp PM, Eaves AC. Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia. Blood 1992; 80: 2522-2530.
    • (1992) Blood , vol.80 , pp. 2522-2530
    • Udomsakdi, C.1    Eaves, C.J.2    Lansdorp, P.M.3    Eaves, A.C.4
  • 52
    • 0027435598 scopus 로고
    • Biological strategies for the selective manipulation of normal and leukemic stem cells
    • Eaves CJ, Cashman JD, Zoumbos NC, Barnett MJ, Eaves AC. Biological strategies for the selective manipulation of normal and leukemic stem cells. Stem Cells 1993; 11 (Suppl 3): 109-121.
    • (1993) Stem Cells , vol.11 , Issue.SUPPL. 3 , pp. 109-121
    • Eaves, C.J.1    Cashman, J.D.2    Zoumbos, N.C.3    Barnett, M.J.4    Eaves, A.C.5
  • 53
    • 0035140382 scopus 로고    scopus 로고
    • Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice
    • Glimm H, Eisterer W, Lee K, Cashman J, Holyoake TL, Nicolini F et al. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest 2001; 107: 199-206.
    • (2001) J Clin Invest , vol.107 , pp. 199-206
    • Glimm, H.1    Eisterer, W.2    Lee, K.3    Cashman, J.4    Holyoake, T.L.5    Nicolini, F.6
  • 54
    • 13344262695 scopus 로고    scopus 로고
    • Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis
    • Sirard C, Lapidot T, Vormoor J, Cashman JD, Doedens M, Murdoch B et al. Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood 1996; 87: 1539-1548.
    • (1996) Blood , vol.87 , pp. 1539-1548
    • Sirard, C.1    Lapidot, T.2    Vormoor, J.3    Cashman, J.D.4    Doedens, M.5    Murdoch, B.6
  • 55
    • 0031982855 scopus 로고    scopus 로고
    • Establishment of a reproducible model of chronic-phase chronic myeloid leukemia in NOD/SCID mice using blood-derived mononuclear or CD34+ cells
    • Lewis ID, McDiarmid LA, Samels LM, To LB, Hughes TP. Establishment of a reproducible model of chronic-phase chronic myeloid leukemia in NOD/SCID mice using blood-derived mononuclear or CD34+ cells. Blood 1998; 91: 630-640.
    • (1998) Blood , vol.91 , pp. 630-640
    • Lewis, I.D.1    McDiarmid, L.A.2    Samels, L.M.3    To, L.B.4    Hughes, T.P.5
  • 56
    • 0032055156 scopus 로고    scopus 로고
    • High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase
    • Wang JC, Lapidot T, Cashman JD, Doedens M, Addy L, Sutherland DR et al. High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood 1998; 91: 2406-2414.
    • (1998) Blood , vol.91 , pp. 2406-2414
    • Wang, J.C.1    Lapidot, T.2    Cashman, J.D.3    Doedens, M.4    Addy, L.5    Sutherland, D.R.6
  • 57
    • 0032943275 scopus 로고    scopus 로고
    • Multilineage outgrowth of both malignant and normal hemopoietic progenitor cells from individual chronic myeloid leukemia patients in immunodeficient mice
    • Verstegen MM, Cornelissen JJ, Terpstra W, Wagemaker G, Wognum AW. Multilineage outgrowth of both malignant and normal hemopoietic progenitor cells from individual chronic myeloid leukemia patients in immunodeficient mice. Leukemia 1999; 13: 618-628.
    • (1999) Leukemia , vol.13 , pp. 618-628
    • Verstegen, M.M.1    Cornelissen, J.J.2    Terpstra, W.3    Wagemaker, G.4    Wognum, A.W.5
  • 58
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol 2007; 7: 118-130.
    • (2007) Nat Rev Immunol , vol.7 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 59
    • 0031753237 scopus 로고    scopus 로고
    • Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain
    • Goldman JP, Blundell MP, Lopes L, Kinnon C, Di Santo JP, Thrasher AJ. Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain. Br J Haematol 1998; 103: 335-342.
    • (1998) Br J Haematol , vol.103 , pp. 335-342
    • Goldman, J.P.1    Blundell, M.P.2    Lopes, L.3    Kinnon, C.4    Di Santo, J.P.5    Thrasher, A.J.6
  • 60
    • 78149466636 scopus 로고    scopus 로고
    • Transplantation of immunodeficient mice with Chronic Myeloid Leukemia (CML) cells from chronic phase patients reveals a hierarchy of CD34+ aldehyde dehydrogenase-positive cells with short- and long-term repopulating activity and transient responsiveness to imatinib mesylate in vivo
    • Christ O, Eisterer W, Jiang X, Pang E, Leung K, Smith C et al. Transplantation of immunodeficient mice with Chronic Myeloid Leukemia (CML) cells from chronic phase patients reveals a hierarchy of CD34+ aldehyde dehydrogenase-positive cells with short- and long-term repopulating activity and transient responsiveness to imatinib mesylate in vivo. ASH Annual Meeting Abstracts 2004; 104: 2960.
    • (2004) ASH Annual Meeting Abstracts , vol.104 , pp. 2960
    • Christ, O.1    Eisterer, W.2    Jiang, X.3    Pang, E.4    Leung, K.5    Smith, C.6
  • 61
    • 30644481023 scopus 로고    scopus 로고
    • Detection of molecular targets on the surface of CD34+/CD38Fstem cells in various myeloid malignancies
    • Florian S, Sonneck K, Hauswirth AW, Krauth MT, Schernthaner GH, Sperr WR et al. Detection of molecular targets on the surface of CD34+/CD38Fstem cells in various myeloid malignancies. Leuk Lymphoma 2006; 47: 207-222.
    • (2006) Leuk Lymphoma , vol.47 , pp. 207-222
    • Florian, S.1    Sonneck, K.2    Hauswirth, A.W.3    Krauth, M.T.4    Schernthaner, G.H.5    Sperr, W.R.6
  • 63
    • 0033568250 scopus 로고    scopus 로고
    • Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia
    • Holyoake T, Jiang X, Eaves C, Eaves A. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood 1999; 94: 2056-2064.
    • (1999) Blood , vol.94 , pp. 2056-2064
    • Holyoake, T.1    Jiang, X.2    Eaves, C.3    Eaves, A.4
  • 64
    • 0027277061 scopus 로고
    • BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia
    • Bedi A, Zehnbauer BA, Collector MI, Barber JP, Zicha MS, Sharkis SJ et al. BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia. Blood 1993; 81: 2898-2902.
    • (1993) Blood , vol.81 , pp. 2898-2902
    • Bedi, A.1    Zehnbauer, B.A.2    Collector, M.I.3    Barber, J.P.4    Zicha, M.S.5    Sharkis, S.J.6
  • 65
    • 0028299945 scopus 로고
    • Variable transcription of BCR-ABL by Ph+ cells arising from hematopoietic progenitors in chronic myeloid leukemia
    • Keating A, Wang XH, Laraya P. Variable transcription of BCR-ABL by Ph+ cells arising from hematopoietic progenitors in chronic myeloid leukemia. Blood 1994; 83: 1744-1749.
    • (1994) Blood , vol.83 , pp. 1744-1749
    • Keating, A.1    Wang, X.H.2    Laraya, P.3
  • 66
    • 0033607274 scopus 로고    scopus 로고
    • Auto-crine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia
    • Jiang X, Lopez A, Holyoake T, Eaves A, Eaves C. Auto-crine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proc Natl Acad Sci USA 1999; 96: 12804-12809.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12804-12809
    • Jiang, X.1    Lopez, A.2    Holyoake, T.3    Eaves, A.4    Eaves, C.5
  • 67
    • 0021720621 scopus 로고
    • Nonclonal hemopoietic progenitor cells detected in long-term marrow cultures from a Turner syndrome mosaic with chronic myeloid leukemia
    • Dube ID, Arlin ZA, Kalousek DK, Eaves CJ, Eaves AC. Nonclonal hemopoietic progenitor cells detected in long-term marrow cultures from a Turner syndrome mosaic with chronic myeloid leukemia. Blood 1984; 64: 1284-1287.
    • (1984) Blood , vol.64 , pp. 1284-1287
    • Dube, I.D.1    Arlin, Z.A.2    Kalousek, D.K.3    Eaves, C.J.4    Eaves, A.C.5
  • 68
    • 0025201169 scopus 로고
    • Detection of breakpoint cluster region-negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow
    • Turhan AG, Humphries RK, Eaves CJ, Barnett MJ, Phillips GL, Kalousek DK et al. Detection of breakpoint cluster region-negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow. Blood 1990; 76: 2404-2410.
    • (1990) Blood , vol.76 , pp. 2404-2410
    • Turhan, A.G.1    Humphries, R.K.2    Eaves, C.J.3    Barnett, M.J.4    Phillips, G.L.5    Kalousek, D.K.6
  • 69
    • 0019147610 scopus 로고
    • Restoration of nonclonal hematopoiesis in chronic myelogenous leukemia (CML) following a chemotherapy-induced loss of the Ph1 chromosome
    • Singer JW, Arlin ZA, Najfeld V, Adamson JW, Kempin SJ, Clarkson BD et al. Restoration of nonclonal hematopoiesis in chronic myelogenous leukemia (CML) following a chemotherapy-induced loss of the Ph1 chromosome. Blood 1980; 56: 356-360.
    • (1980) Blood , vol.56 , pp. 356-360
    • Singer, J.W.1    Arlin, Z.A.2    Najfeld, V.3    Adamson, J.W.4    Kempin, S.J.5    Clarkson, B.D.6
  • 70
    • 0038092769 scopus 로고    scopus 로고
    • Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority
    • Bumm T, Muller C, Al-Ali HK, Krohn K, Shepherd P, Schmidt E et al. Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003; 101: 1941-1949.
    • (2003) Blood , vol.101 , pp. 1941-1949
    • Bumm, T.1    Muller, C.2    Al-Ali, H.K.3    Krohn, K.4    Shepherd, P.5    Schmidt, E.6
  • 71
    • 33747676824 scopus 로고    scopus 로고
    • Molecular analysis of the Imatinib-induced complete cytogenetic response in chronic myelogenous leukemia
    • Miglino M, Grasso R, Varaldo R, Fugazza G, Colombo N, Clavio M et al. Molecular analysis of the Imatinib-induced complete cytogenetic response in chronic myelogenous leukemia. Leuk Lymphoma 2006; 47: 1348-1351.
    • (2006) Leuk Lymphoma , vol.47 , pp. 1348-1351
    • Miglino, M.1    Grasso, R.2    Varaldo, R.3    Fugazza, G.4    Colombo, N.5    Clavio, M.6
  • 72
    • 85014195943 scopus 로고    scopus 로고
    • Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia
    • Holyoake TL, Jiang X, Drummond MW, Eaves AC, Eaves CJ. Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia. Leukemia 2002; 16: 549-558.
    • (2002) Leukemia , vol.16 , pp. 549-558
    • Holyoake, T.L.1    Jiang, X.2    Drummond, M.W.3    Eaves, A.C.4    Eaves, C.J.5
  • 73
    • 0035254540 scopus 로고    scopus 로고
    • Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3
    • Holyoake TL, Jiang X, Jorgensen HG, Graham S, Alcorn MJ, Laird C et al. Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3. Blood 2001; 97: 720-728.
    • (2001) Blood , vol.97 , pp. 720-728
    • Holyoake, T.L.1    Jiang, X.2    Jorgensen, H.G.3    Graham, S.4    Alcorn, M.J.5    Laird, C.6
  • 74
    • 0036464597 scopus 로고    scopus 로고
    • Stromal-derived factor 1 inhibits the cycling of very primitive human hemato-poietic cells in vitro and in NOD/SCID mice
    • Cashman J, Clark-Lewis I, Eaves A, Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hemato-poietic cells in vitro and in NOD/SCID mice. Blood 2002; 99: 792-799.
    • (2002) Blood , vol.99 , pp. 792-799
    • Cashman, J.1    Clark-Lewis, I.2    Eaves, A.3    Eaves, C.4
  • 75
    • 0032190067 scopus 로고    scopus 로고
    • MCP-1, not MIP-1alpha, is the endogenous chemokine that cooperates with TGF-beta to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures
    • Cashman JD, Eaves CJ, Sarris AH, Eaves AC. MCP-1, not MIP-1alpha, is the endogenous chemokine that cooperates with TGF-beta to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures. Blood 1998; 92: 2338-2344.
    • (1998) Blood , vol.92 , pp. 2338-2344
    • Cashman, J.D.1    Eaves, C.J.2    Sarris, A.H.3    Eaves, A.C.4
  • 76
    • 0027146639 scopus 로고
    • Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells
    • Eaves CJ, Cashman JD, Wolpe SD, Eaves AC. Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells. Proc Natl Acad Sci USA 1993; 90: 12015-12019.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 12015-12019
    • Eaves, C.J.1    Cashman, J.D.2    Wolpe, S.D.3    Eaves, A.C.4
  • 77
    • 0037020855 scopus 로고    scopus 로고
    • Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors
    • Cashman J, Dykstra B, Clark-Lewis I, Eaves A, Eaves C. Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors. J Exp Med 2002; 196: 1141-1149.
    • (2002) J Exp Med , vol.196 , pp. 1141-1149
    • Cashman, J.1    Dykstra, B.2    Clark-Lewis, I.3    Eaves, A.4    Eaves, C.5
  • 78
    • 0025166472 scopus 로고
    • Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta
    • Cashman JD, Eaves AC, Raines EW, Ross R, Eaves CJ. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta. Blood 1990; 75: 96-101.
    • (1990) Blood , vol.75 , pp. 96-101
    • Cashman, J.D.1    Eaves, A.C.2    Raines, E.W.3    Ross, R.4    Eaves, C.J.5
  • 79
    • 0023794509 scopus 로고
    • Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines
    • Keller JR, Mantel C, Sing GK, Ellingsworth LR, Ruscetti SK, Ruscetti FW. Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines. J Exp Med 1988; 168: 737-750.
    • (1988) J Exp Med , vol.168 , pp. 737-750
    • Keller, J.R.1    Mantel, C.2    Sing, G.K.3    Ellingsworth, L.R.4    Ruscetti, S.K.5    Ruscetti, F.W.6
  • 80
    • 0026669189 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-beta on normal and leukemic human hematopoietic progenitor cells
    • Cashman JD, Eaves AC, Eaves CJ. Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-beta on normal and leukemic human hematopoietic progenitor cells. Leukemia 1992; 6: 886-892.
    • (1992) Leukemia , vol.6 , pp. 886-892
    • Cashman, J.D.1    Eaves, A.C.2    Eaves, C.J.3
  • 82
    • 43749110075 scopus 로고    scopus 로고
    • Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal
    • Zon LI. Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature 2008; 453: 306-313.
    • (2008) Nature , vol.453 , pp. 306-313
    • Zon, L.I.1
  • 83
    • 0030922086 scopus 로고    scopus 로고
    • Selective expansion of primitive normal hematopoietic cells in cytokine-supplemented cultures of purified cells from patients with chronic myeloid leukemia
    • Petzer AL, Eaves CJ, Barnett MJ, Eaves AC. Selective expansion of primitive normal hematopoietic cells in cytokine-supplemented cultures of purified cells from patients with chronic myeloid leukemia. Blood 1997; 90: 64-69.
    • (1997) Blood , vol.90 , pp. 64-69
    • Petzer, A.L.1    Eaves, C.J.2    Barnett, M.J.3    Eaves, A.C.4
  • 84
    • 0026742369 scopus 로고
    • Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level
    • Udomsakdi C, Eaves CJ, Swolin B, Reid DS, Barnett MJ, Eaves AC. Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci USA 1992; 89: 6192-6196.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6192-6196
    • Udomsakdi, C.1    Eaves, C.J.2    Swolin, B.3    Reid, D.S.4    Barnett, M.J.5    Eaves, A.C.6
  • 86
    • 77951446379 scopus 로고    scopus 로고
    • BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells
    • Schemionek M, Elling C, Steidl U, Baumer N, Hamilton A, Spieker T et al. BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells. Blood 2010; 115: 3185-3195.
    • (2010) Blood , vol.115 , pp. 3185-3195
    • Schemionek, M.1    Elling, C.2    Steidl, U.3    Baumer, N.4    Hamilton, A.5    Spieker, T.6
  • 87
    • 0026348952 scopus 로고
    • Blast crisis in a murine model of chronic myelogenous leukemia
    • Daley GQ, Van Etten RA, Baltimore D. Blast crisis in a murine model of chronic myelogenous leukemia. Proc Natl Acad Sci USA 1991; 88: 11335-11338.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 11335-11338
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 88
    • 76249087423 scopus 로고    scopus 로고
    • TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    • Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y et al. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 2010; 463: 676-680.
    • (2010) Nature , vol.463 , pp. 676-680
    • Naka, K.1    Hoshii, T.2    Muraguchi, T.3    Tadokoro, Y.4    Ooshio, T.5    Kondo, Y.6
  • 89
    • 36649002031 scopus 로고    scopus 로고
    • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    • Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 2007; 12: 528-541.
    • (2007) Cancer Cell , vol.12 , pp. 528-541
    • Zhao, C.1    Blum, J.2    Chen, A.3    Kwon, H.Y.4    Jung, S.H.5    Cook, J.M.6
  • 90
    • 50649118068 scopus 로고    scopus 로고
    • Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
    • Dierks C, Beigi R, Guo GR, Zirlik K, Stegert MR, Manley P et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008; 14: 238-249.
    • (2008) Cancer Cell , vol.14 , pp. 238-249
    • Dierks, C.1    Beigi, R.2    Guo, G.R.3    Zirlik, K.4    Stegert, M.R.5    Manley, P.6
  • 91
    • 44349166602 scopus 로고    scopus 로고
    • PML targeting eradicates quiescent leukaemia-initiating cells
    • Ito K, Bernardi R, Morotti A, Matsuoka S, Saglio G, Ikeda Y et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008; 453: 1072-1078.
    • (2008) Nature , vol.453 , pp. 1072-1078
    • Ito, K.1    Bernardi, R.2    Morotti, A.3    Matsuoka, S.4    Saglio, G.5    Ikeda, Y.6
  • 92
    • 67649861052 scopus 로고    scopus 로고
    • Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
    • Chen Y, Hu Y, Zhang H, Peng C, Li S. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet 2009; 41: 783-792.
    • (2009) Nat Genet , vol.41 , pp. 783-792
    • Chen, Y.1    Hu, Y.2    Zhang, H.3    Peng, C.4    Li, S.5
  • 93
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009; 458: 776-779.
    • (2009) Nature , vol.458 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3    Fereshteh, M.4    Abrahamsson, A.5    Blum, J.6
  • 94
    • 78149469216 scopus 로고    scopus 로고
    • A novel strategy for expanding primitive leukemic cells from chronic phase CML patients by forced overexpression of a NUP98-HOXA10 homeodomain fusion gene
    • Sloma I, Imren S, Zhao Y, Humphries K, Eaves CJ. A novel strategy for expanding primitive leukemic cells from chronic phase CML patients by forced overexpression of a NUP98-HOXA10 homeodomain fusion gene. ASH Annual Meeting Abstracts 2008; 112: 1078.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 1078
    • Sloma, I.1    Imren, S.2    Zhao, Y.3    Humphries, K.4    Eaves, C.J.5
  • 95
    • 34247329753 scopus 로고    scopus 로고
    • Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells
    • Jorgensen HG, Allan EK, Jordanides NE, Mountford JC, Holyoake TL. Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. Blood 2007; 109: 4016-4019.
    • (2007) Blood , vol.109 , pp. 4016-4019
    • Jorgensen, H.G.1    Allan, E.K.2    Jordanides, N.E.3    Mountford, J.C.4    Holyoake, T.L.5
  • 96
    • 14944367962 scopus 로고    scopus 로고
    • Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment
    • Chu S, Xu H, Shah NP, Snyder DS, Forman SJ, Sawyers CL et al. Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment. Blood 2005; 105: 2093-2098.
    • (2005) Blood , vol.105 , pp. 2093-2098
    • Chu, S.1    Xu, H.2    Shah, N.P.3    Snyder, D.S.4    Forman, S.J.5    Sawyers, C.L.6
  • 97
    • 63549121688 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia stem cells: What's new?
    • Copland M. Chronic myelogenous leukemia stem cells: What's new? Curr Hematol Malig Rep 2009; 4: 66-73.
    • (2009) Curr Hematol Malig Rep , vol.4 , pp. 66-73
    • Copland, M.1
  • 98
    • 77950959714 scopus 로고    scopus 로고
    • Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity
    • Engler JR, Frede A, Saunders VA, Zannettino AC, Hughes TP, White DL. Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity. Leukemia 2010; 24: 765-770.
    • (2010) Leukemia , vol.24 , pp. 765-770
    • Engler, J.R.1    Frede, A.2    Saunders, V.A.3    Zannettino, A.C.4    Hughes, T.P.5    White, D.L.6
  • 99
    • 57149097077 scopus 로고    scopus 로고
    • Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells
    • Konig H, Copland M, Chu S, Jove R, Holyoake TL, Bhatia R. Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells. Cancer Res 2008; 68: 9624-9633.
    • (2008) Cancer Res , vol.68 , pp. 9624-9633
    • Konig, H.1    Copland, M.2    Chu, S.3    Jove, R.4    Holyoake, T.L.5    Bhatia, R.6
  • 100
    • 4544312606 scopus 로고    scopus 로고
    • Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia
    • Sorel N, Bonnet ML, Guillier M, Guilhot F, Brizard A, Turhan AG. Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia. Biochem Biophys Res Commun 2004; 323: 728-730.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 728-730
    • Sorel, N.1    Bonnet, M.L.2    Guillier, M.3    Guilhot, F.4    Brizard, A.5    Turhan, A.G.6
  • 101
    • 25444488489 scopus 로고    scopus 로고
    • Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia
    • Barnes DJ, Palaiologou D, Panousopoulou E, Schultheis B, Yong AS, Wong A et al. Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia. Cancer Res 2005; 65: 8912-8919.
    • (2005) Cancer Res , vol.65 , pp. 8912-8919
    • Barnes, D.J.1    Palaiologou, D.2    Panousopoulou, E.3    Schultheis, B.4    Yong, A.S.5    Wong, A.6
  • 102
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • Thomas J, Wang L, Clark RE, Pirmohamed M. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004; 104: 3739-3745.
    • (2004) Blood , vol.104 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3    Pirmohamed, M.4
  • 103
    • 33745085275 scopus 로고    scopus 로고
    • OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): Reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
    • White DL, Saunders VA, Dang P, Engler J, Zannettino AC, Cambareri AC et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 2006; 108: 697-704.
    • (2006) Blood , vol.108 , pp. 697-704
    • White, D.L.1    Saunders, V.A.2    Dang, P.3    Engler, J.4    Zannettino, A.C.5    Cambareri, A.C.6
  • 104
    • 33747155024 scopus 로고    scopus 로고
    • Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate
    • Jordanides NE, Jorgensen HG, Holyoake TL, Mountford JC. Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate. Blood 2006; 108: 1370-1373.
    • (2006) Blood , vol.108 , pp. 1370-1373
    • Jordanides, N.E.1    Jorgensen, H.G.2    Holyoake, T.L.3    Mountford, J.C.4
  • 105
    • 18144370731 scopus 로고    scopus 로고
    • Mechanisms of resistance to anticancer drugs: The role of the polymorphic ABC transporters ABCB1 and ABCG2
    • Lepper ER, Nooter K, Verweij J, Acharya MR, Figg WD, Sparreboom A. Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2. Pharmacogenomics 2005; 6: 115-138.
    • (2005) Pharmacogenomics , vol.6 , pp. 115-138
    • Lepper, E.R.1    Nooter, K.2    Verweij, J.3    Acharya, M.R.4    Figg, W.D.5    Sparreboom, A.6
  • 106
    • 0036844028 scopus 로고    scopus 로고
    • The kinase inhibitor STI571 reverses the Bcr-Abl induced point mutation frequencies observed in pre-leukemic P190(Bcr-Abl) transgenic mice
    • Brain J, Saksena A, Laneuville P. The kinase inhibitor STI571 reverses the Bcr-Abl induced point mutation frequencies observed in pre-leukemic P190(Bcr-Abl) transgenic mice. Leuk Res 2002; 26: 1011-1016.
    • (2002) Leuk Res , vol.26 , pp. 1011-1016
    • Brain, J.1    Saksena, A.2    Laneuville, P.3
  • 107
    • 0041438485 scopus 로고    scopus 로고
    • Measurement of genomic instability in preleukemic P190BCR/ABL transgenic mice using inter-simple sequence repeat polymerase chain reaction
    • Brain JM, Goodyer N, Laneuville P. Measurement of genomic instability in preleukemic P190BCR/ABL transgenic mice using inter-simple sequence repeat polymerase chain reaction. Cancer Res 2003; 63: 4895-4898.
    • (2003) Cancer Res , vol.63 , pp. 4895-4898
    • Brain, J.M.1    Goodyer, N.2    Laneuville, P.3
  • 108
    • 0033614396 scopus 로고    scopus 로고
    • Mutator phenotype of BCRFABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta
    • Canitrot Y, Lautier D, Laurent G, Frechet M, Ahmed A, Turhan AG et al. Mutator phenotype of BCRFABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta. Oncogene 1999; 18: 2676-2680.
    • (1999) Oncogene , vol.18 , pp. 2676-2680
    • Canitrot, Y.1    Lautier, D.2    Laurent, G.3    Frechet, M.4    Ahmed, A.5    Turhan, A.G.6
  • 109
    • 33745608455 scopus 로고    scopus 로고
    • BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
    • Koptyra M, Falinski R, Nowicki MO, Stoklosa T, Majsterek I, Nieborowska-Skorska M et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood 2006; 108: 319-327.
    • (2006) Blood , vol.108 , pp. 319-327
    • Koptyra, M.1    Falinski, R.2    Nowicki, M.O.3    Stoklosa, T.4    Majsterek, I.5    Nieborowska-Skorska, M.6
  • 110
    • 20844448211 scopus 로고    scopus 로고
    • A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor
    • von Bubnoff N, Veach DR, van der Kuip H, Aulitzky WE, Sanger J, Seipel P et al. A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor. Blood 2005; 105: 1652-1659.
    • (2005) Blood , vol.105 , pp. 1652-1659
    • Von Bubnoff, N.1    Veach, D.R.2    Van Der Kuip, H.3    Aulitzky, W.E.4    Sanger, J.5    Seipel, P.6
  • 111
    • 21744435290 scopus 로고    scopus 로고
    • Occurrence of de novo ABL kinase domain mutations in primary bone marrow cells after BCR-ABL gene transfer and Imatinib mesylate selection
    • Flamant S, Turhan AG. Occurrence of de novo ABL kinase domain mutations in primary bone marrow cells after BCR-ABL gene transfer and Imatinib mesylate selection. Leukemia 2005; 19: 1265-1267.
    • (2005) Leukemia , vol.19 , pp. 1265-1267
    • Flamant, S.1    Turhan, A.G.2
  • 113
    • 77957196195 scopus 로고    scopus 로고
    • Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to Imatinib mesylate
    • in press
    • Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot J, Yip C et al. Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to Imatinib mesylate. Blood 2010, (in press).
    • (2010) Blood
    • Jiang, X.1    Forrest, D.2    Nicolini, F.3    Turhan, A.4    Guilhot, J.5    Yip, C.6
  • 114
    • 77954936879 scopus 로고    scopus 로고
    • Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib
    • White DL, Dang P, Engler J, Frede A, Zrim S, Osborn M et al. Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib. J Clin Oncol 2010; 28: 2761-2767.
    • (2010) J Clin Oncol , vol.28 , pp. 2761-2767
    • White, D.L.1    Dang, P.2    Engler, J.3    Frede, A.4    Zrim, S.5    Osborn, M.6
  • 116
    • 15044352222 scopus 로고    scopus 로고
    • BCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cells
    • Jongen-Lavrencic M, Salesse S, Delwel R, Verfaillie CM. BCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cells. Leukemia 2005; 19: 373-380.
    • (2005) Leukemia , vol.19 , pp. 373-380
    • Jongen-Lavrencic, M.1    Salesse, S.2    Delwel, R.3    Verfaillie, C.M.4
  • 117
    • 24044542316 scopus 로고    scopus 로고
    • Distinct molecular phenotype of malignant CD34(+) hematopoietic stem and progenitor cells in chronic myelogenous leukemia
    • Kronenwett R, Butterweck U, Steidl U, Kliszewski S, Neumann F, Bork S et al. Distinct molecular phenotype of malignant CD34(+) hematopoietic stem and progenitor cells in chronic myelogenous leukemia. Oncogene 2005; 24: 5313-5324.
    • (2005) Oncogene , vol.24 , pp. 5313-5324
    • Kronenwett, R.1    Butterweck, U.2    Steidl, U.3    Kliszewski, S.4    Neumann, F.5    Bork, S.6
  • 119
    • 33644525274 scopus 로고    scopus 로고
    • Gene expression changes associated with progression and response in chronic myeloid leukemia
    • Radich JP, Dai H, Mao M, Oehler V, Schelter J, Druker B et al. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci USA 2006; 103: 2794-2799.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2794-2799
    • Radich, J.P.1    Dai, H.2    Mao, M.3    Oehler, V.4    Schelter, J.5    Druker, B.6
  • 120
    • 0043269341 scopus 로고    scopus 로고
    • BCR/ABL-mediated increased expression of multiple known and novel genes that may contribute to the pathogenesis of chronic myelogenous leukemia
    • Salesse S, Verfaillie CM. BCR/ABL-mediated increased expression of multiple known and novel genes that may contribute to the pathogenesis of chronic myelogenous leukemia. Mol Cancer Ther 2003; 2: 173-182.
    • (2003) Mol Cancer Ther , vol.2 , pp. 173-182
    • Salesse, S.1    Verfaillie, C.M.2
  • 121
    • 30144445384 scopus 로고    scopus 로고
    • Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML
    • Yong AS, Szydlo RM, Goldman JM, Apperley JF, Melo JV. Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML. Blood 2006; 107: 205-212.
    • (2006) Blood , vol.107 , pp. 205-212
    • Yong, A.S.1    Szydlo, R.M.2    Goldman, J.M.3    Apperley, J.F.4    Melo, J.V.5
  • 123
    • 33847230958 scopus 로고    scopus 로고
    • Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase
    • Diaz-Blanco E, Bruns I, Neumann F, Fischer JC, Graef T, Rosskopf M et al. Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase. Leukemia 2007; 21: 494-504.
    • (2007) Leukemia , vol.21 , pp. 494-504
    • Diaz-Blanco, E.1    Bruns, I.2    Neumann, F.3    Fischer, J.C.4    Graef, T.5    Rosskopf, M.6
  • 124
    • 38349102790 scopus 로고    scopus 로고
    • Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: Requirement of E2F3 for BCR/ABL leukemogenesis
    • Eiring AM, Neviani P, Santhanam R, Oaks JJ, Chang JS, Notari M et al. Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. Blood 2008; 111: 816-828.
    • (2008) Blood , vol.111 , pp. 816-828
    • Eiring, A.M.1    Neviani, P.2    Santhanam, R.3    Oaks, J.J.4    Chang, J.S.5    Notari, M.6
  • 125
    • 58249120738 scopus 로고    scopus 로고
    • Beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia
    • Hu Y, Chen Y, Douglas L, Li S. beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia. Leukemia 2009; 23: 109-116.
    • (2009) Leukemia , vol.23 , pp. 109-116
    • Hu, Y.1    Chen, Y.2    Douglas, L.3    Li, S.4
  • 126
    • 38349086394 scopus 로고    scopus 로고
    • CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
    • Jin L, Tabe Y, Konoplev S, Xu Y, Leysath CE, Lu H et al. CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther 2008; 7: 48-58.
    • (2008) Mol Cancer Ther , vol.7 , pp. 48-58
    • Jin, L.1    Tabe, Y.2    Konoplev, S.3    Xu, Y.4    Leysath, C.E.5    Lu, H.6
  • 127
    • 66449122303 scopus 로고    scopus 로고
    • Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
    • Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009; 119: 1109-1123.
    • (2009) J Clin Invest , vol.119 , pp. 1109-1123
    • Bellodi, C.1    Lidonnici, M.R.2    Hamilton, A.3    Helgason, G.V.4    Soliera, A.R.5    Ronchetti, M.6
  • 128
    • 34648832173 scopus 로고    scopus 로고
    • FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
    • Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW et al. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest 2007; 117: 2408-2421.
    • (2007) J Clin Invest , vol.117 , pp. 2408-2421
    • Neviani, P.1    Santhanam, R.2    Oaks, J.J.3    Eiring, A.M.4    Notari, M.5    Blaser, B.W.6
  • 129
    • 27644569730 scopus 로고    scopus 로고
    • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
    • Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, Liu S et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 2005; 8: 355-368.
    • (2005) Cancer Cell , vol.8 , pp. 355-368
    • Neviani, P.1    Santhanam, R.2    Trotta, R.3    Notari, M.4    Blaser, B.W.5    Liu, S.6
  • 130
    • 41949088658 scopus 로고    scopus 로고
    • BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors
    • Copland M, Pellicano F, Richmond L, Allan EK, Hamilton A, Lee FY et al. BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood 2008; 111: 2843-2853.
    • (2008) Blood , vol.111 , pp. 2843-2853
    • Copland, M.1    Pellicano, F.2    Richmond, L.3    Allan, E.K.4    Hamilton, A.5    Lee, F.Y.6
  • 131
    • 78149470192 scopus 로고    scopus 로고
    • A novel AHI-1-BCR-ABL-JAK2 interaction complex mediates cellular resistance to tyrosine kinase inhibitors in CML
    • DeGeer D, Newmarch K, Zhou L, Chen M, Saw KM, Turhan AG et al. A Novel AHI-1-BCR-ABL-JAK2 Interaction Complex Mediates Cellular Resistance to Tyrosine Kinase Inhibitors in CML. ASH Annual Meeting Abstracts 2009; 114: 38.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 38
    • Degeer, D.1    Newmarch, K.2    Zhou, L.3    Chen, M.4    Saw, K.M.5    Turhan, A.G.6
  • 132
    • 58149156479 scopus 로고    scopus 로고
    • AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells
    • Zhou LL, Zhao Y, Ringrose A, DeGeer D, Kennah E, Lin AE et al. AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells. J Exp Med 2008; 205: 2657-2671.
    • (2008) J Exp Med , vol.205 , pp. 2657-2671
    • Zhou, L.L.1    Zhao, Y.2    Ringrose, A.3    Degeer, D.4    Kennah, E.5    Lin, A.E.6


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