Molecular analysis of the Imatinib-induced complete cytogenetic response in chronic myelogenous leukemia

Leukemia and Lymphoma

Volumn 47, Issue 7, 2006, Pages 1348-1351

  Miglino, Maurizio ^a,b   Grasso, Raffaella ^a,b   Varaldo, Riccardo ^a,b   Fugazza, Giuseppina ^a,b   Colombo, Nicoletta ^a,b   Clavio, Marino ^a,b   Canepa, Letizia ^a,b   Garuti, Anna ^a,b   Ibatici, Adalberto ^b   Pierri, Ivana ^a,b   Ballerini, Filippo ^a,b   Sessarego, Mario ^a,b   Gobbi, Marco ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

BCR ABL; Chronic myelogenous leukemia; Clonality; Humara; Imatinib

Indexed keywords

ALPHA INTERFERON; BCR ABL PROTEIN; CYTARABINE; ETOPOSIDE; FLUDARABINE; HYDROXYUREA; IMATINIB; PROTEIN P120; PROTEIN P190;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER REGRESSION; CHROMOSOME ANALYSIS; CHROMOSOME REARRANGEMENT; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CLONAL VARIATION; CONTROLLED STUDY; FEMALE; FOLLOW UP; HEMATOPOIESIS; HUMAN; MOLECULAR GENETICS; OBSERVATIONAL STUDY; PHILADELPHIA 1 CHROMOSOME; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TREATMENT OUTCOME; TUMOR CELL; X CHROMOSOME INACTIVATION;

ADULT; AGED; ANTINEOPLASTIC AGENTS; DENSITOMETRY; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, MYELOID, CHRONIC; MALE; MIDDLE AGED; PIPERAZINES; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX FACTORS; TIME FACTORS;

EID: 33747676824     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190500525607     Document Type: Article

References (18)

1. Deininger, M and Goldman, J and Melo, J. (2000) The molecular biology of chronic myeloid leukaemia. Blood, 96, pp. 3343-3356.
2. Lugo, T and Pendergast, A and Muller, A and Witte, O. (1990) Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science, 247, pp. 1079-1082.
3. Saglio, G and Pane, F and Gottardi, E and Frigeri, F and Buonaiuto, M and Guerrasio, A and (1996) Consistent amount of acute leukemia-associated P190BCR/ABL transcripts are expressed by chronic myelogenous leukemia patients at diagnosis. Blood, 87, pp. 1075-1080.
4. Claxton, D and Deisseroth, A and Talpaz, M and Reading, C and Kantarjian, H and Trujillo, J and (1992) Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia. Blood, 79, pp. 997-1002.
5. Bumm, T and Muller, C and Al-Ali, H and Krohn, K and Sheperd, P and Schmidt, E and (2003) Emergence of clonal cytogenetic abnormalities in Ph-cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood, 101, pp. 1941-1949.
6. Lyon, M. (1968) Chomosomal and subchromosomal inactivation. Annual Reviews in Genetics, 2, pp. 31-52.
7. Allen, R and Zoghbi, H and Mosoley, A and Rosenblatt, H and Belmont, J. (1992) Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. American Journal Human Genetic, 51, pp. 1229-1239.
8. Russo, D and Malagola, M and de Vivo, A and Fiacchini, M and Martinelli, G and Piccaluga, P and (2005) Multicentre phase III trial on fludarabine, cytarabine (Ara-C), and idarubicin versus idarubicin, Ara-C and etoposide for induction treatment of younger, newly diagnosed acute myeloid leukaemia patients. British Journal of Haematology, 131, pp. 172-179.
9. Sessarego, M and Fugazza, G and Bruzzone, R and Ballestrero, A and Miglino, M and Bacigalupo, A. (2000) Complex chromosome rearrangement may locate bcr/abl fusion gene sites other than 22q11. Haematologica, 85, pp. 35-39.
10. Sinclair, P and Green, A and Grace, C and Nacheva, E. (1997) Improved sensitivity of BCR-ABL detection: A triple-probe three-color fluorescence in situ hybridization system. Blood, 90, pp. 395-1402.
11. Fugazza, G and Miglino, M and Bruzzone, R and Quintino, S and Gatti, A and Grasso, R and (2004) Cytogenetic and fluorescence in situ hybridization monitoring in Ph + chronic myeloid leukemia patients treated with Imatinib mesylate. Journal of Experimental & Clinical Cancer Research, 23, pp. 295-299.
12. Maniatis, T and Fritsch, E and Sambrook, J.(1989) Molecular cloning: A Laboratory Manual. Cold Spring Harbor NY: Cold Spring Harbor Laboratory.
13. Kwok, S and Higuchi, R. (1989) Avoiding false positive with PCR. Nature, 339, pp. 237-238.
14. Van Dongen, J and Macintyre, E and Gabert, J and Delabesse, E and Rossi, V and Saglio, G and (1999) Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia, 13, pp. 1901-1928.
15. Rosti, G and Martinelli, G and Bassi, S and Amabile, M and Trabacchi, E and Giannini, B and (2004) Molecular response to imatinib in late chronic-phase chronic myeloid leukemia. Blood, 103, pp. 2284-2290.
16. Kantarjian, H and Sawyers, C and Hochhaus, A and Guilhot, F and Schiffer, C and Gambacorti-Passerini, C and (2002) Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukaemia. New England Journal Medicine, 346, pp. 645-652.
17. Serrano, J and Roman, J and Sanchez, J and Jimenez, A and Castillejo, J and Herrera, C and (2000) Molecular analysis of lineage-specific chimerism and minimal residual disease by RT-PCR of p210(BCR-ABL) and p190(BCR-ABL) after allogeneic bone marrow transplantation for chronic myeloid leukaemia: Increased mixed myeloid chimerism and p190(BCR-ABL) detection precede cytogenetic relapse. Blood, 95, pp. 2659-2665.
18. Agirre, X and Roman-Gomez, J and Vazquez, I and Jimenez-Velasco, A and Larrayoz, M and Lahortiga, I and (2005) Coexistence of different clonal populations harboring the b3a2 (p210) and e1a2 (p190) BCR-ABL1 fusion transcripts in chronic myelogenous leukemia resistant to imatinib. Cancer Genetic and Cytogenetic, 160, pp. 22-26.